Hopelessness and its correlates with clinical outcomes in an outpatient setting.

Abstract:

INTRODUCTION:This study examined whether patients with hopelessness and those without may significantly differ regarding their main presentations and clinical course in a large Italian population. METHODS:The recruited sample included 583 currently euthymic outpatients with major affective disorders. The Beck Hopelessness Scale (BHS) assessed hopelessness using a cutoff score of 9 or higher. Participants were categorized based on the presence/absence of hopelessness. A binary logistic regression analysis -accounting for age and gender and considering history of psychotherapy, emotional/physical abuse, depressive symptoms, Toronto Alexithymia Scale (TAS) total score, difficulties identifying and communicating feelings as potential predictors- was carried out in order to detect the variables associated with hopelessness. RESULTS:Individuals with hopelessness, compared to those without, were more likely to be older (p=0.005), females (p=0.01), to have a unipolar depressive disorder (p≤0.05), be prescribed antidepressants and psychotherapy in the past (p=0.001 and p≤0.05). Moreover, individuals with hopelessness scored higher on the Montgomery-Asberg Depression Rating Scale (p≤0.05) and on the emotional (p=<0.001), physical abuse (p≤0.01) and physical neglect (p≤0.05) subscales of the Childhood Trauma Questionnaire - Short form, and reported more difficulties identifying (p≤0.001) and communicating feelings (p≤0.001) than those without hopelessness. The multivariate analysis showed that having difficulties identifying feelings is independently associated with hopelessness. DISCUSSION:These findings indicate that individuals with difficulties identifying feelings are at higher risk of hopelessness and of negative outcomes. Further studies need to explore the impact of alexithymia on hopelessness and clinical outcomes in the lifetime illness course.

journal_name

J Affect Disord

authors

Serafini G,Lamis DA,Aguglia A,Amerio A,Nebbia J,Geoffroy PA,Pompili M,Amore M

doi

10.1016/j.jad.2019.11.144

subject

Has Abstract

pub_date

2020-02-15 00:00:00

pages

472-479

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(19)32309-2

journal_volume

263

pub_type

杂志文章
  • Evaluating the first 1000 patients referred to a specialist depression clinic: a case for tertiary referral facilities.

    abstract:BACKGROUND:We report on the assessment and outcome of the first 1000 patients referred to a tertiary referral depression clinic established to assess the utility of diagnostic sub-typing on clinical course of illness. METHODS:Diagnostic, treatment recommendations, prognostic judgments and 12-week outcome data were exa...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2010.11.004

    authors: Parker G,Fletcher K,Barrett M,Breakspear M,Rees AM

    更新日期:2011-06-01 00:00:00

  • Rumination and executive functions: Understanding cognitive vulnerability for psychopathology.

    abstract:INTRODUCTION:Both rumination, a pattern of repetitive, self-focused thought in response to distress, and deficits in executive functions (EFs), a set of cognitive abilities that facilitate higher-order thinking, have transdiagnostic associations with psychopathology. Although empirical studies suggest associations betw...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.06.026

    authors: du Pont A,Rhee SH,Corley RP,Hewitt JK,Friedman NP

    更新日期:2019-09-01 00:00:00

  • Effects of antidepressant medication on emotion regulation in depressed patients: an iSPOT-D report.

    abstract:BACKGROUND:Antidepressant medication (ADM) is thought to reduce depressive symptoms by altering emotion-generative brain systems. However, it is unknown whether successful ADM treatment is associated with changes in psychobehavioral strategies used to regulate emotions. We examined depressive symptoms and emotion regul...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jad.2013.12.037

    authors: McRae K,Rekshan W,Williams LM,Cooper N,Gross JJ

    更新日期:2014-04-01 00:00:00

  • Features of dissociation differentially predict antidepressant response to ketamine in treatment-resistant depression.

    abstract:BACKGROUND:Ketamine induces rapid and robust antidepressant effects, and many patients also describe dissociation, which is associated with antidepressant response. This follow-up study investigated whether antidepressant efficacy is uniquely related to dissociative symptom clusters. METHODS:Treatment-resistant patien...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.jad.2018.02.049

    authors: Niciu MJ,Shovestul BJ,Jaso BA,Farmer C,Luckenbaugh DA,Brutsche NE,Park LT,Ballard ED,Zarate CA Jr

    更新日期:2018-05-01 00:00:00

  • The clinical picture of the depressed form of puerperal psychosis.

    abstract::The clinical features of 104 patients admitted to a mother and baby unit over a 5-year period with RDC diagnoses of depression or schizoaffective depression were studied by self-ratings, measurements of non-verbal behaviour from standardised videotaped interviews, and observer ratings based on multiple information sou...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(88)90006-7

    authors: Brockington IF,Margison FR,Schofield E,Knight RJ

    更新日期:1988-07-01 00:00:00

  • Antidepressant efficacy of Sudarshan Kriya Yoga (SKY) in melancholia: a randomized comparison with electroconvulsive therapy (ECT) and imipramine.

    abstract:BACKGROUND:Sudarshan Kriya Yoga (SKY) is a procedure that involves essentially rhythmic hyperventilation at different rates of breathing. The antidepressant efficacy of SKY was demonstrated in dysthymia in a prospective, open clinical trial. This study compared the relative antidepressant efficacy of SKY in melancholia...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0165-0327(99)00079-8

    authors: Janakiramaiah N,Gangadhar BN,Naga Venkatesha Murthy PJ,Harish MG,Subbakrishna DK,Vedamurthachar A

    更新日期:2000-01-01 00:00:00

  • Relationships of coping styles and sleep quality with anxiety symptoms among Chinese adolescents: A cross-sectional study.

    abstract:BACKGROUND:Limited published research has examined the relationships of coping styles and sleep quality with anxiety symptoms in Chinese school adolescents. We aimed to explore the effect of coping styles and sleep quality on anxiety symptoms. Furthermore, we investigated the interactions of coping styles and sleep qua...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.07.032

    authors: Xiong W,Liu H,Gong P,Wang Q,Ren Z,He M,Zhou G,Ma J,Guo X,Fan X,Liu M,Yang X,Shen Y,Zhang X

    更新日期:2019-10-01 00:00:00

  • Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin.

    abstract:BACKGROUND:There is evidence that inflammatory pathways and cell-mediated immunity (CMI) play an important role in the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Activation of inflammatory and CMI pathways, including increased levels of cytokines, is known to induce fatigue and soma...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2011.09.004

    authors: Maes M,Twisk FN,Kubera M,Ringel K

    更新日期:2012-02-01 00:00:00

  • Teaching front-line health and voluntary workers to assess and manage suicidal patients.

    abstract:BACKGROUND:To devise and evaluate the retention of a new brief training package for non-psychiatrically trained multidisciplinary staff to assess suicide risk and manage suicidal patients, including referral of patients at significant risk to psychiatric staff. METHOD:8 h of interview skills training, using role play ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/s0165-0327(98)00080-9

    authors: Morriss R,Gask L,Battersby L,Francheschini A,Robson M

    更新日期:1999-01-01 00:00:00

  • Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?

    abstract:BACKGROUND:Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects. METHODS:BD individuals with family history of suicidal behavior and personal hist...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2007.12.225

    authors: Carballo JJ,Harkavy-Friedman J,Burke AK,Sher L,Baca-Garcia E,Sullivan GM,Grunebaum MF,Parsey RV,Mann JJ,Oquendo MA

    更新日期:2008-07-01 00:00:00

  • Personality disorders and suicide attempts in unipolar and bipolar mood disorders.

    abstract:BACKGROUND:Comorbid personality disorders may predispose patients with mood disorders to suicide attempts (SAs), but factors mediating this effect are not well known. METHODS:Altogether 597 patients from three prospective cohort studies (Vantaa Depression Study, Jorvi Bipolar Study, and Vantaa Primary Care Depression ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2015.11.006

    authors: Jylhä P,Rosenström T,Mantere O,Suominen K,Melartin T,Vuorilehto M,Holma M,Riihimäki K,Oquendo MA,Keltikangas-Järvinen L,Isometsä ET

    更新日期:2016-01-15 00:00:00

  • The association between psychological strain and suicidal behaviors among college students: A mental health survey in Jilin Province, Northeast China.

    abstract:BACKGROUND:Suicide is a major global mental health problem among college students. The aim of the current study was to explore the association between the psychological strains of the strain theory of suicide and suicidal behaviors among college students. METHODS:Participants comprised 1912 college students (16-28 yea...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.08.042

    authors: Song Y,Bai W,Wang M,Liu X,Zhang L,Yu W,Li Y,Hua W,Lew B,Talib MA,Kou C

    更新日期:2019-12-01 00:00:00

  • The association between body mass index and postpartum depression: A population-based study.

    abstract:BACKGROUND:Postpartum depression (PPD) reportedly affects between 6.5-19% of all new mothers. Identifying those at greatest risk for PPD has implications for prevention, early detection and intervention. While the relationship between extremes of body mass index (BMI) and depression has been frequently studied, the ass...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2018.07.063

    authors: Silverman ME,Smith L,Lichtenstein P,Reichenberg A,Sandin S

    更新日期:2018-11-01 00:00:00

  • Treatment credibility, expectancy, and preference: Prediction of treatment engagement and outcome in a randomized clinical trial of hatha yoga vs. health education as adjunct treatments for depression.

    abstract:BACKGROUND:Hatha yoga may be helpful for alleviating depression symptoms. The purpose of this analysis is to determine whether treatment program preference, credibility, or expectancy predict engagement in depression interventions (yoga or a control class) or depression symptom severity over time. METHODS:This is a se...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jad.2018.05.009

    authors: Uebelacker LA,Weinstock LM,Battle CL,Abrantes AM,Miller IW

    更新日期:2018-10-01 00:00:00

  • Trajectories of maternal stress and anxiety from pregnancy to three years and child development at 3 years of age: Findings from the All Our Families (AOF) pregnancy cohort.

    abstract:BACKGROUND:Existing literature on maternal distress has focused on stress and anxiety during the pregnancy or postnatally and their relationship with child development. However, few studies have investigated the association between maternal stress and anxiety symptoms over time and child development in preschool childr...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2018.02.095

    authors: Mughal MK,Giallo R,Arnold P,Benzies K,Kehler H,Bright K,Kingston D

    更新日期:2018-07-01 00:00:00

  • The interaction of drug- and psychotherapy in the long-term treatment of depression.

    abstract::Recent advances in our understanding of both short- and long-term therapeutic interventions for depressive disorders have necessitated greater precision in defining appropriate therapeutic interventions. While these remarkable changes in treatment have been based on the introduction of newer antidepressant agents, the...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-0327(00)00357-8

    authors: Kupfer DJ,Frank E

    更新日期:2001-01-01 00:00:00

  • Cortical mechanisms of the symptomatology in major depressive disorder: a resting EEG study.

    abstract:BACKGROUND:Diagnosis and treatment rely on symptom criteria in modern psychiatry. However, the cortical mechanisms of symptomatology in major depressive disorder (MDD) are still not clear. This study examined neural correlates of symptom clusters of MDD by electroencephalography (EEG). METHODS:Resting state eye-closed...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2010.12.015

    authors: Lee TW,Yu YW,Chen MC,Chen TJ

    更新日期:2011-06-01 00:00:00

  • [3H] imipramine binding in brain samples from depressed suicides and controls: 5-HT uptake sites compared with sites defined by desmethylimipramine.

    abstract::Using desmethylimipramine (DMI) defined and Na+ dependent [3H]imipramine binding, we have examined both 5-HT uptake sites and sites unrelated to 5-HT uptake, in frontal cortex, putamen and substantia nigra of suicides with a firm retrospective diagnosis of depression and matched controls. No differences were seen betw...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/s0165-0327(97)00126-2

    authors: Lawrence KM,Kanagasundaram M,Lowther S,Katona CL,Crompton MR,Horton RW

    更新日期:1998-01-01 00:00:00

  • Association of subsyndromal and depressive symptoms with inflammatory markers among different ethnic groups: the multi-ethnic study of atherosclerosis (MESA).

    abstract:OBJECTIVE:Depressive symptoms are associated with inflammation yet the association between inflammation and different levels of depression remains unclear. Therefore, we studied the association of subsyndromal and depressive symptoms with inflammatory markers in a large multi-ethnic cohort. METHODS:C-reactive protein ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2014.04.018

    authors: Camacho Á,Larsen B,McClelland RL,Morgan C,Criqui MH,Cushman M,Allison MA

    更新日期:2014-08-01 00:00:00

  • Efficacy and tolerability of antidepressants for sub-threshold depression and for mild major depressive disorder.

    abstract:BACKGROUND:It is commonly assumed that robust evidence exists for the lack of efficacy of antidepressants at the milder end of the depression severity spectrum. In light of specific limitations of existing reviews, we assess if antidepressants are efficacious and tolerable for sub-threshold or mild major depressive dis...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.jad.2014.04.078

    authors: Cameron IM,Reid IC,MacGillivray SA

    更新日期:2014-09-01 00:00:00

  • Differential change on depressive symptom factors with antidepressant medication and cognitive behavior therapy for major depressive disorder.

    abstract:BACKGROUND:Major depressive disorder (MDD) is a heterogeneous condition and individual patients are likely to be differentially responsive to specific treatments. In an exploratory factor analysis of three rating scales, the Genome-based Therapeutic Drugs for Depression (GENDEP) trial identified three factors that were...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2017.12.035

    authors: Dunlop BW,Cole SP,Nemeroff CB,Mayberg HS,Craighead WE

    更新日期:2018-03-15 00:00:00

  • The associations between problematic Facebook use, psychological distress and well-being among adolescents and young adults: A systematic review and meta-analysis.

    abstract:BACKGROUND:A growing body of research has analyzed the potential risks of problematic Facebook use for mental health and well-being. The current meta-analysis is the first to examine the associations between problematic Facebook use, psychological distress (i.e., depression, anxiety, etc.) and well-being (life satisfac...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.jad.2017.10.007

    authors: Marino C,Gini G,Vieno A,Spada MM

    更新日期:2018-01-15 00:00:00

  • Should 'non-Feighner schizophrenia' be classified with affective disorder?

    abstract::Narrow definitions of schizophrenia increase homogeneity at the expense of leaving unclassified many patients with shizophrenic symptoms. Family history and follow-up studies indicate that many such patients ought to be classified with those having affective disorders. This study determines morbid risks for affective ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(79)90020-x

    authors: Coryell W,Tsuang MT

    更新日期:1979-03-01 00:00:00

  • Investigation of the emotional network in depression after stroke: A study of multivariate Granger causality analysis of fMRI data.

    abstract:OBJECTIVE:Depression after stroke (DAS) is a serious complication of stroke that significantly restricts rehabilitation. Brain imaging technology is an important method for studying the emotional network of DAS. However, few studies have focused on dynamic interactions within the network. The aim of this study was to i...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.02.020

    authors: Shi Y,Liu W,Liu R,Zeng Y,Wu L,Huang S,Cai G,Yang J,Wu W

    更新日期:2019-04-15 00:00:00

  • Psychosocial functioning in patients with psychotic and non-psychotic bipolar I disorder. A comparative study with individuals with schizophrenia.

    abstract:BACKGROUND:More than 50% of individuals with bipolar disorder (BD) do not reach full psychosocial functioning, even during periods of euthymia. It has been suggested that history of psychotic symptoms is one of the factors which are associated with a worse functional outcome. The objective was to compare psychosocial f...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2017.12.094

    authors: Jiménez-López E,Sánchez-Morla EM,Aparicio AI,López-Villarreal A,Martínez-Vizcaíno V,Rodriguez-Jimenez R,Vieta E,Santos JL

    更新日期:2018-03-15 00:00:00

  • Association between serum 25-hydroxyvitamin D concentrations and depressive symptoms in an older Korean population: A cross-sectional study.

    abstract:BACKGROUND:This study aims to examine associations between serum 25-hydroxyvitamin D [25(OH)D] concentrations and depressive symptoms in an older Korean population. METHODS:The study used data from the Korean Urban Rural Elderly study, which enrolled 2942 participants aged 65 years or older from urban and rural commun...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2015.09.043

    authors: Song BM,Kim HC,Rhee Y,Youm Y,Kim CO

    更新日期:2016-01-01 00:00:00

  • A double-blind, placebo-controlled, efficacy, safety, and pharmacokinetic study of INN 00835, a novel antidepressant peptide, in the treatment of major depression.

    abstract:BACKGROUND:INN 00835 is a synthetic pentapeptide with a potential for rapid onset of action as an antidepressant. Its efficacy was investigated in a pilot study in patients diagnosed with major depression. METHODS:Fifty two patients received either active drug - INN 00835 (26 patients) - or placebo (26 patients), subc...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0165-0327(99)00187-1

    authors: Feighner JP,Ehrensing RH,Kastin AJ,Leonard BE,Sverdlov L,Nicolau G,Patel A,Hlavka J,Abajian H,Noble JF

    更新日期:2000-12-01 00:00:00

  • Differential abnormalities of functional connectivity of the amygdala and hippocampus in unipolar and bipolar affective disorders.

    abstract:OBJECTIVE:The amygdala and hippocampus - two structures intimately associated with mood and cognition - have been reported to exhibit altered neural activity or volume in affective disorders. We hypothesized the amygdala and hippocampus would show altered and differential patterns of connectivity in patients with bipol...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2014.05.045

    authors: Benson BE,Willis MW,Ketter TA,Speer A,Kimbrell TA,Herscovitch P,George MS,Post RM

    更新日期:2014-10-01 00:00:00

  • Evidence of cost-effective treatments for depression: a systematic review.

    abstract:BACKGROUND:High levels of public spending, rising costs of treatments and scarcity of mental health resources have intensified the need for information on the cost-effectiveness of interventions for depression. There have been few reviews that consider the cost-effectiveness of all treatments for depression together. ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.jad.2004.10.003

    authors: Barrett B,Byford S,Knapp M

    更新日期:2005-01-01 00:00:00

  • Late-life depression in people from ethnic minority backgrounds: Differences in presentation and management.

    abstract:BACKGROUND:An elevated risk of late-life depression has been suggested in older adults from minority ethnic groups, but little is known about ethnic group differences in symptom and treatment profiles. The current study aimed to compare symptoms and types of treatment between ethnic groups in patients with late-life de...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.12.031

    authors: Mansour R,Tsamakis K,Rizos E,Perera G,Das-Munshi J,Stewart R,Mueller C

    更新日期:2020-03-01 00:00:00