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Psychiatric context of human immunodeficiency virus infection among former plasma donors in rural China.

Abstract：

BACKGROUND:China's HIV epidemic commenced in its agrarian provinces through contaminated commercial plasma donation centers and is now becoming a public health concern nationwide. Little is known of the psychiatric and substance use disorder characteristics of this population, or their impact on everyday function, employment, and life quality. METHODS:HIV-infected (HIV+) former plasma donors (N=203) and HIV-negative (HIV-) donor controls (N=198) completed the World Mental Health Survey Composite International Diagnostic Interview to determine lifetime major depressive disorder (MDD), substance use disorders, and suicidality. Current mood and suicidality were assessed with the Beck Depression Inventory-II. Everyday function was measured by an Activity of Daily Living questionnaire; life quality was evaluated by the Medical Outcomes Study-HIV. RESULTS:HIV+ participants had known their infected status for 2 years on average. Most were taking antiretroviral treatment and had frank AIDS. Rates of current MDD were similar across groups (1-2%), but HIV+ had a higher frequency of lifetime MDD (14% vs. 5%, p<.05). Its onset preceded date of known infection in one-third of cases. Alcoholism was the only substance use disorder detected; HIV+ had a higher proportion of lifetime substance use diagnoses (14% vs. 6%, p<.05). Depression and AIDS independently predicted worse daily functioning and life quality, and unemployment. LIMITATIONS:The epicenter of China HIV has moved into urban injection drug users, limiting the representativeness of this sample. CONCLUSIONS:High rates of MDD and its impact suggest that in China, as elsewhere, comprehensive care requires detection and treatment of mood disorder.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Atkinson JH,Jin H,Shi C,Yu X,Duarte NA,Casey CY,Franklin DR Jr,Vigil O,Cysique L,Wolfson T,Riggs PK,Gupta S,Letendre S,Marcotte TD,Grant I,Wu Z,Heaton RK,HIV Neurobehavioral Research Center Group.

doi

10.1016/j.jad.2010.10.039

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

421-8

issue

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(10)00668-3

journal_volume

130

pub_type

杂志文章

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Psychiatric context of human immunodeficiency virus infection among former plasma donors in rural China.