Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder.

Abstract:

:Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor function in 12 additional patients with PDA. Lower cyclic AMP responses to isoproterenol were significantly correlated with milder agoraphobia and better response to naturalistic treatment. Lower beta-receptor density tended to correlate similarly with agoraphobia and treatment response. These findings further support the hypothesis that decreased peripheral beta-receptor function in PDA reflects an adaptive process associated with greater resistance to agoraphobia and greater capacity for recovery with treatment.

journal_name

J Affect Disord

authors

Maddock RJ,Gietzen DW,Goodman TA

doi

10.1016/0165-0327(93)90115-z

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

27-32

issue

1

eissn

0165-0327

issn

1573-2517

pii

0165-0327(93)90115-Z

journal_volume

29

pub_type

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