Abstract:
BACKGROUND:Our aim was to determine whether there is a relationship between serum brain-derived neurotrophic factor (BDNF) and postpartum depression (PPD) in a cohort Chinese population. METHODS:From May 1, 2014, to September 30, 2014, all eligible women not on medication for depression giving birth at the Fourth Affiliated Hospital of Harbin Medical University were consecutively recruited and followed up for 3 months. At 3 months postpartum, women were screened for depression using the Edinburgh Postnatal Depression Scale (EPDS). The primary outcome measure was an EPDS score of > or =12. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of BDNF at admission. Multivariate analyses were performed using logistic regression models. RESULTS:During the study period, 340 women were enrolled and completed follow-up. In those women, 37 women (10.9%) were considered as meeting criteria for PPD. Serum BDNF levels in women without PPD were significantly higher than those in women with PPD (P<0.0001). Based on the ROC curve, the optimal cutoff value of serum BDNF levels as an indicator for screening of PPD was estimated to be 12.0ng/ml, which yielded a sensitivity of 82.8% and a specificity of 72.6%, with the area under the curve at 0.809 (95%CI, 0.731-0.887). In multivariate analysis, there was an increased risk of PPD associated with BDNF levels ≤12.0ng/ml (OR 7.243, 95% CI: 3.883-12.746; P<0.0001) after adjusting for possible confounders. CONCLUSION:The present study demonstrates a strong relationship between reduced serum BDNF levels at admission and the development of PPD within the 3 months.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Gao X,Wang J,Yao H,Cai Y,Cheng Rdoi
10.1016/j.jad.2016.04.002subject
Has Abstractpub_date
2016-08-01 00:00:00pages
25-30eissn
0165-0327issn
1573-2517pii
S0165-0327(15)31304-5journal_volume
200pub_type
杂志文章abstract::Using multiple variables of illness, comparisons were made between 17 postpartum depressives with recurrent affective disorder and 37 women with children and recurrent affective disorder but no postpartum depressions. An earlier age of onset in patients with postpartum depression was the only variable that was signifi...
journal_title:Journal of affective disorders
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doi:10.1016/0165-0327(83)90002-2
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abstract::41 patients who took part in a withdrawal programme from long-term treatment with diazepam in a controlled clinical trial were followed up five years later. Assessments were made of outcome derived from clinical symptomatology, formal psychiatric diagnosis, psychotropic drug use and frequency of contact with both prim...
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 传,历史文章,杂志文章
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abstract:BACKGROUND:Crying, a complex neurobiological behavior with psychosocial and communication features, has been little studied in relationship to the menstrual cycle. METHODS:In the Mood and Daily Life study (MiDL), a community sample of Canadian women aged 18-43 years, n=76, recorded crying proneness and crying frequenc...
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journal_title:Journal of affective disorders
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更新日期:1996-07-08 00:00:00
abstract:BACKGROUND:The aim of the present study was to obtain comprehensive information on steroid metabolism in depressed patients. METHODS:24-h urinary steroids were measured by gas chromatography in patients with unipolar recurrent major depression (URMD) compared to controls, and an index of relative activity of the 11bet...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/S0165-0327(03)00199-X
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abstract:BACKGROUND:There have been few systematic studies of the treatment of bipolar II depression. While divalproex sodium (DVPX) is effective in acute mania, there are few data on the antidepressant effects of DVPX. Similarly, little is known regarding the use of DVPX administered in a single daily dose. METHOD:We performe...
journal_title:Journal of affective disorders
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更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Calls to implement measurement-based care (MBC) in psychiatry are increasing. A recent Cochrane meta-analysis concluded that there is insufficient evidence that routine application of patient reported outcomes (PROs) improves treatment outcomes for common psychiatric disorders. There is a particular paucity ...
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abstract:BACKGROUND:Rapid cycling (RC) bipolar disorder (BD) is associated with more disability and worse global functioning than non-rapid cycling BD (NRC) and is understudied. This study aims to investigate clinical characteristics associated to RC in a Latin-American sample and secondarily, to generate a clinical model to te...
journal_title:Journal of affective disorders
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abstract:BACKGROUND:Deficits in executive functioning (EF) are implicated in neurobiological and cognitive-processing theories of depression. EF deficits are also associated with Attention-deficit/hyperactivity disorder (ADHD) in adults, who are also at increased risk for depressive disorders. Given debate about the ecological ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.05.064
更新日期:2013-02-20 00:00:00
abstract::We examined the onsets of comorbid psychiatric disorders in patients with panic disorder (PD) (N = 54). In 42 patients (77.8%), PD was preceded by another psychiatric condition (secondary PD group), while in 12 patients (22.2%), PD occurred first or was the only diagnosed mental disorder (primary PD group). Patients w...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(93)90080-4
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:This study assessed the direction of the relationship between symptoms of insomnia disorder, depression, various anxiety disorders and obsessive compulsive disorder (OCD) in adolescents after controlling for age, gender, chronotype, and outcome variable at baseline. METHODS:Data was collected in eight high ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.08.032
更新日期:2017-01-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析
doi:10.1016/j.jad.2017.12.103
更新日期:2018-03-15 00:00:00
abstract:OBJECTIVE:To determine prevalence rates and clinical correlates of current DSM-5 eating disorders in patients with bipolar disorder (BP). METHODS:Prevalence rates of current DSM-5- and DSM-IV-defined binge eating disorder (BED), bulimia nervosa (BN), and anorexia nervosa (AN) were assessed with the Eating Disorder Dia...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.11.010
更新日期:2016-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析
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journal_title:Journal of affective disorders
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更新日期:2020-09-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.06.025
更新日期:2017-10-15 00:00:00
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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abstract:BACKGROUND:The aim of this naturalistic study was to compare the effectiveness of quetiapine and classical mood stabilizers, as mono- or combination therapy, in the long-term treatment of Bipolar Disorder (BD). METHODS:232 DSM-IV BD I (n=91) or BD II (n=141) patients, treated and followed up for four years, were studi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.01.017
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:While major depressive disorder (MDD) is considered to be a heterogeneous disorder, the nature of the heterogeneity remains unclear. Studies have attempted to classify patients with MDD using latent variable techniques, yet the empirical approaches to symptom-based subtyping of MDD have not provided conclusi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.03.053
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:This study aimed to compare adolescents diagnosed with major depressive disorder (MDD) and healthy adolescents with regard to cyberbullying, cyber victimization, internet addiction, and digital game addiction. MATERIALS AND METHODS:This cross-sectional study was performed in Selçuk University Hospital. The s...
journal_title:Journal of affective disorders
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更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Few strictly prospective-longitudinal community studies examined the role of traumatic events for risk of developing a broad range of incident mental disorders over several years. METHOD:A representative community sample of adolescents and young adults (n = 2797, baseline age 14-24) was prospectively examin...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2017.10.004
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The transition from adolescence to adulthood is associated with stressful adaptation experiences that may increase symptoms of depression. We explored the prevalence and sex differences of depressive symptoms and suicidal ideation in freshmen Latino college students in Puerto Rico, and identified stressful l...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.08.010
更新日期:2013-03-05 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.11.025
更新日期:2019-02-15 00:00:00
abstract::Despite advances in the pharmacologic treatment of bipolar disorder, it is clear that additional strategies are needed to provide patients with longer-term mood stability. Recent years have witnessed the development of a number of psychosocial strategies for bipolar disorder that are design as adjuncts to ongoing phar...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To examine the efficacy and tolerability of aripiprazole treatment for acute bipolar depression. METHODS:A six-week prospective, nonrandomized, open label study was conducted in depressed bipolar outpatients (types I, II, and NOS), as diagnosed by DSM-IV criteria. Previous treatments were continued unchanged...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
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更新日期:2008-09-01 00:00:00
abstract::Because depression is commonly observed in the chronic fatigue syndrome (CFS), the present study sought to determine whether the symptom pattern is similar to that seen in clinically depressed subjects (DEP). Individuals with multiple sclerosis (MS) were chosen as an additional comparison group because MS is a fatigui...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(96)00015-8
更新日期:1996-06-20 00:00:00