Depression in children and adolescents: new data on 'undertreatment' and a literature review on the efficacy of available treatments.


:This article reports on the treatment received by 38 adolescents during an episode of major depression which had a median duration of 4 months. The one subject who received any pharmacologic treatment was prescribed an antianxiety agent. Sixteen percent received psychotherapy. These results are consistent with evidence from studies of adults indicating that depression is underrecognized and undertreated. An important caveat is that the small sample size limits the generalizability of these findings. Moreover, which medication should be prescribed when a diagnosis of depression is made is not yet known with certainty, as literature reviews indicate that more controlled trials of psychotherapeutic and psychopharmacologic treatments for adolescents with depression are needed to better understand the efficacy of treating depressed adolescents.


J Affect Disord


Keller MB,Lavori PW,Beardslee WR,Wunder J,Ryan N




Has Abstract


1991-03-01 00:00:00














  • High fatality rates of late-life depression associated with cardiovascular disease.

    abstract::Sixty-two elderly depressives were located one year after discharge. Eight patients (13%) had died, 2.6 times higher than the expected mortality rate. Patients dying were more likely to have had a diagnosis of cardiovascular disease (P less than 0.001). ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Rabins PV,Harvis K,Koven S

    更新日期:1985-09-01 00:00:00

  • CACNB2 rs11013860 polymorphism correlates of prefrontal cortex thickness in bipolar patients with first-episode mania.

    abstract:BACKGROUND:The β2 subunit of the voltage-gated l-type calcium channel gene(CACNB2) rs11013860 polymorphism is a putative genetic susceptibility marker for bipolar disorder (BD). However, the neural effects of CACNB2 rs11013860 in BD are largely unknown. METHODS:Forty-six bipolar patients with first-episode mania and e...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Chen J,Tan J,Greenshaw AJ,Sawalha J,Liu Y,Zhang X,Zou W,Cheng X,Deng W,Zhang Y,Cui L,Liu C,Sun J,Cheng X,Wu Q,Li S,Mai S,Lan X,Chen Y,Cai Y,Zheng C,Cheng D,Zhang B,Yang C,Li X,Li X,Ye B,Yousefnezhad

    更新日期:2020-05-01 00:00:00

  • Spatial complexity of brain signal is altered in patients with generalized anxiety disorder.

    abstract:BACKGROUND:Is it healthy to be chaotic? Recent studies have argued that mental disorders are associated with more orderly neural activities, corresponding to a less flexible functional system. These conclusions were derived from altered temporal complexity. However, the relationship between spatial complexity and healt...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Wang Y,Wang X,Ye L,Yang Q,Cui Q,He Z,Li L,Yang X,Zou Q,Yang P,Liu D,Chen H

    更新日期:2019-03-01 00:00:00

  • Childhood trauma associates with clinical features of bipolar disorder in a sample of Chinese patients.

    abstract:OBJECTIVES:Childhood trauma is a major public health problem which has a long-term consequence, a few studies have examined the relationship between childhood trauma and clinical features of bipolar disorder, most in western culture, with no such studies done in Chinese culture. METHODS:The CTQ-SF was administered to ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Li XB,Liu JT,Zhu XZ,Zhang L,Tang YL,Wang CY

    更新日期:2014-10-01 00:00:00

  • Prevalence and comorbidity of affective disorders in persons making suicide attempts in Hungary: importance of the first depressive episodes and of bipolar II diagnoses.

    abstract:BACKGROUND:The purpose of this study was to investigate the prevalence and comorbidity of affective disorders, especially current major depressive episode and bipolar disorder among suicide attempters in Hungary. METHODS:Using a structured interview (Mini International Neuropsychiatric Interview) determining 16 Axis I...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Balázs J,Lecrubier Y,Csiszér N,Koszták J,Bitter I

    更新日期:2003-09-01 00:00:00

  • A meta-analysis of the efficacy of vortioxetine in patients with major depressive disorder (MDD) and high levels of anxiety symptoms.

    abstract:BACKGROUND:Coexisting anxiety is common in major depressive disorder (MDD) and more difficult to treat than depression without anxiety. This analysis assessed the efficacy, safety, and tolerability of vortioxetine in MDD patients with high levels of anxiety (baseline Hamilton Anxiety Rating Scale [HAM-A] total score ≥2...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,meta分析


    authors: Baldwin DS,Florea I,Jacobsen PL,Zhong W,Nomikos GG

    更新日期:2016-12-01 00:00:00

  • Assessment of prevalence and determinants of posttraumatic stress disorder in survivors of earthquake in Pakistan using Davidson Trauma Scale.

    abstract:INTRODUCTION:Pakistan's 2005 earthquake claimed almost 87,000 lives and displaced millions. The present study sought to assess PTSD prevalence among earthquake survivors, to evaluate its determinants, and to identify protective factors that suggest future interventions in the aftermath of disasters. METHODS:In a cross...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Ali M,Farooq N,Bhatti MA,Kuroiwa C

    更新日期:2012-02-01 00:00:00

  • Emotion reactivity, nonsuicidal self-injury, and regulatory emotional self-efficacy: A moderated mediation model of suicide ideation.

    abstract:BACKGROUND:Adolescent suicide ideation (SI) has received increased attention in recent years, and emotion reactivity (ER) has been found to be a risk factor for SI. However, little is known about the mediating and moderating mechanisms underlying this relationship. The aim of this study is to test a moderated mediation...

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    pub_type: 杂志文章


    authors: Liu S,You J,Ying J,Li X,Shi Q

    更新日期:2020-04-01 00:00:00

  • Sex-specific time patterns of suicidal acts on the German railway system. An analysis of 4003 cases.

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    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Erazo N,Baumert J,Ladwig KH

    更新日期:2004-11-15 00:00:00

  • Risk factors for recurrence in depression in the Lundby population, 1947-1997.

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    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Nöbbelin L,Bogren M,Mattisson C,Brådvik L

    更新日期:2018-03-01 00:00:00

  • Factors predicting long-term outcome after chronic benzodiazepine therapy.

    abstract::41 patients who took part in a withdrawal programme from long-term treatment with diazepam in a controlled clinical trial were followed up five years later. Assessments were made of outcome derived from clinical symptomatology, formal psychiatric diagnosis, psychotropic drug use and frequency of contact with both prim...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Holton A,Riley P,Tyrer P

    更新日期:1992-04-01 00:00:00

  • Gender patterns in cost effectiveness of quality improvement for depression: results of a randomized, controlled trial.

    abstract:BACKGROUND:Little is known about gender differences in the costs and outcomes of primary care quality improvement strategies for depression. METHODS:Intent-to-treat analysis of data from a group-level controlled trial, in which matched primary care clinics in the US were randomized to usual care or to one of two inter...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Schoenbaum M,Sherbourne C,Wells K

    更新日期:2005-08-01 00:00:00

  • Serum BDNF concentration after delivery is associated with development of postpartum depression: A 3-month follow up study.

    abstract:BACKGROUND:Our aim was to determine whether there is a relationship between serum brain-derived neurotrophic factor (BDNF) and postpartum depression (PPD) in a cohort Chinese population. METHODS:From May 1, 2014, to September 30, 2014, all eligible women not on medication for depression giving birth at the Fourth Affi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Gao X,Wang J,Yao H,Cai Y,Cheng R

    更新日期:2016-08-01 00:00:00

  • Obesity and anxiety during pregnancy and postpartum: A systematic review.

    abstract:BACKGROUND:Obesity and anxiety during the perinatal period are common and associated with poor health outcomes for the mother and the child. Despite the well-documented health risks of both pregnancy obesity and anxiety, associations between the two have rarely been explored. With this review we aim to provide a system...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Nagl M,Linde K,Stepan H,Kersting A

    更新日期:2015-11-01 00:00:00

  • Emotional complexity across the life story: Elevated negative emodiversity and diminished positive emodiversity in sufferers of recurrent depression.

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    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Werner-Seidler A,Hitchcock C,Hammond E,Hill E,Golden AM,Breakwell L,Ramana R,Moore R,Dalgleish T

    更新日期:2020-08-01 00:00:00

  • Depression and vulnerability to incident physical illness across 10 years.

    abstract:BACKGROUND:While considerable research exists on the role of physical illness in initiating depressive reactions, the role of depression in the onset of physical illness is much less studied. Moreover, whereas almost all previous research on depression and incident physical illness has involved specific physical illnes...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Holahan CJ,Pahl SA,Cronkite RC,Holahan CK,North RJ,Moos RH

    更新日期:2010-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Benedetti F,Dallaspezia S,Colombo C,Lorenzi C,Pirovano A,Smeraldi E

    更新日期:2010-09-01 00:00:00

  • Atypical cognitive profile in patients with depression after myocardial infarction.

    abstract:BACKGROUND:We evaluated the cognitive profile of 48 patients with major depression following their first myocardial infarction (MI). METHODS:The cognitive performance of the patients was compared with the performance of 48 non-depressed MI patients and 48 healthy controls. RESULTS:Depressed MI patients performed slow...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Dijkstra JB,Strik JJ,Lousberg R,Prickaerts J,Riedel WJ,Jolles J,van Praag HM,Honig A

    更新日期:2002-07-01 00:00:00

  • Hypothalamic-pituitary-adrenal reactivity in prepubertal children with social phobia.

    abstract:BACKGROUND:The aim of this study was to investigate whether a different pattern of HPA axis activity is found between children with social phobia (SP) and healthy control children. METHODS:A total of 50 prepubertal subjects (25 children with SP and 25 healthy control subjects) were studied. The effects of stress were ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: van West D,Claes S,Sulon J,Deboutte D

    更新日期:2008-12-01 00:00:00

  • Religiosity and depressive symptoms in older adults compared to younger adults: Moderation by age.

    abstract:BACKGROUND:Previous research has suggested that individuals tend to become more religious with age. Research has also shown that as individuals become more religious, they report decreases in depressive symptoms, suggesting that increased levels of religiosity might help to improve one's mental health. The following st...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Stearns M,Nadorff DK,Lantz ED,McKay IT

    更新日期:2018-10-01 00:00:00

  • Heart rate variability for treatment response between patients with major depressive disorder versus panic disorder: A 12-week follow-up study.

    abstract:BACKGROUND:Heart Rate Variability (HRV) parameters have been used to evaluate the autonomic nervous system. We hypothesized that patients with major depressive disorder (MDD) and panic disorder (PD) showed different HRV profiles compared to healthy controls. We also hypothesized that we could predict the responder grou...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章


    authors: Choi KW,Jang EH,Kim AY,Fava M,Mischoulon D,Papakostas GI,Kim DJ,Kim K,Yu HY,Jeon HJ

    更新日期:2019-03-01 00:00:00

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    abstract:AIMS:Earlier studies show that participation in mind and body exercises (MBE) is cross-sectionally associated with high levels of depressive symptoms and antidepressants. This study investigates the longitudinal interrelationship between depressive symptoms, MBE and antidepressants. METHODS:3269 men and 4318 women age...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Rådmark L,Hanson LM,Montgomery S,Bojner Horwitz E,Osika W

    更新日期:2020-03-15 00:00:00

  • Comments on "Malondialdehyde: A novel predictive biomarker for post-stroke depression".

    abstract::In a recent work by Liu et al. (2017) appeared in this journal, malondialdehyde levels proposed as a novel biomarker. Despite of wide usage of malondialdehyde as a biomarker, there are some points from analytical viewpoint which should be considered in future works. This work aimed to discuss the points briefly. ...

    journal_title:Journal of affective disorders

    pub_type: 评论,信件


    authors: Jouyban A,Khoubnasabjafari M

    更新日期:2018-01-01 00:00:00

  • History of perinatal loss: A study of psychological outcomes in mothers and fathers after subsequent healthy birth.

    abstract:BACKGROUND:The loss of an expected child is a psychologically difficult and potentially traumatic life event. While most women will become pregnant again within a year following the loss, data are limited regarding the mental health of parents with a history of perinatal loss, especially in the period following the bir...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Faleschini S,Aubuchon O,Champeau L,Matte-Gagné C

    更新日期:2021-02-01 00:00:00

  • Psychological distress profiles in expectant mothers: What is the association with pregnancy-related and relational variables?

    abstract:INTRODUCTION:Research has progressively focused on antenatal psychological disease of expectant mothers, showing that anxiety and depression as well as fear of childbirth occur frequently during pregnancy. Some studies have investigated the connection between anxiety, depression, and fear of childbirth with contrasting...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Molgora S,Fenaroli V,Saita E

    更新日期:2020-02-01 00:00:00

  • Aggression and impulsivity as predictors of stress generation in bipolar spectrum disorders.

    abstract:BACKGROUND:Some evidence suggests that individuals with bipolar spectrum disorders (BSD) generate stressful life events, contributing to a more severe course of disorder. A recent update to the Behavioral Approach System (BAS) dysregulation theory of BSD highlights the need to investigate anger as approach motivation. ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Molz AR,Black CL,Shapero BG,Bender RE,Alloy LB,Abramson LY

    更新日期:2013-04-05 00:00:00

  • Comorbidity of ADHD and suicide attempts among adolescents and young adults with bipolar disorder: A nationwide longitudinal study.

    abstract:BACKGROUND:Suicide is among the leading causes of death among people with bipolar disorder and has gained substantial attention in the psychiatric and public health fields. However, the role of attention deficit hyperactivity disorder (ADHD) in suicide among adolescents and young adults with bipolar disorder remains un...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Lan WH,Bai YM,Hsu JW,Huang KL,Su TP,Li CT,Yang AC,Lin WC,Chang WH,Chen TJ,Tsai SJ,Chen MH

    更新日期:2015-05-01 00:00:00

  • Gender differences in the short-term course of unipolar depression in a follow-up sample of depressed inpatients.

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    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Kuehner C

    更新日期:1999-12-01 00:00:00

  • Mental health scales and psychiatric diagnoses: responses to GHQ-12, K-10 and CIDI across the lifespan.

    abstract:BACKGROUND:Surveys based on complex interviews like CIDI report very low rates of affective disorder in older people, perhaps because the lengthy, convoluted questions present a special challenge to aged respondents. By contrast, mental health scales like the GHQ-12 and K-10 show much less change in score with age. Bef...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: O'Connor DW,Parslow RA

    更新日期:2010-03-01 00:00:00

  • A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression.

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    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Fitzgerald PB,Hoy KE,Herring SE,McQueen S,Peachey AV,Segrave RA,Maller J,Hall P,Daskalakis ZJ

    更新日期:2012-07-01 00:00:00