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Suppressive effects of dexamethasone on hypothalamic-pituitary-thyroid axis function in depressed patients.

Abstract：

:This study investigated the effects of dexamethasone (1 mg orally) on the function of the hypothalamic-pituitary-thyroid (HPT) axis. We determined pre- and post-dexamethasone thyroid-secreting hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), reverse T3 and cortisol levels in 61 depressed inpatients. Dexamethasone had a pronounced suppressive effect on basal TSH and FT3 levels. It had a significant stimulating effect on rT3 levels. No differences were found between melancholic and minor depressives in the effects of dexamethasone on basal TSH, FT3 and rT3. Cortisol non-suppressors were characterized by less suppression of basal TSH values.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Maes M,Vandewoude M,Schotte C,Martin M,Blockx P

doi

10.1016/0165-0327(90)90049-e

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

55-61

issue

1

eissn

0165-0327

issn

1573-2517

pii

0165-0327(90)90049-E

journal_volume

20

pub_type

杂志文章

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