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Association analysis of COMT/MTHFR polymorphisms and major depressive disorder in Chinese Han population.

Abstract：

BACKGROUND:In several previous biochemical and genetic studies, the Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) and the C677T polymorphism of Methylenetetrahydrofolate reductase (MTHFR) have been suggested to be involved in the pathogenesis as well as the treatment response of major depressive disorder (MDD), but the results have been inconsistent. In this study, we investigate the association of COMT/MTHFR and their interactions with MDD and antidepressant response in Chinese Han population. METHODS:Three hundred and sixty eight depressed patients who met DSM-IV criteria for MDD were recruited for the study. Two hundred and nineteen normal controls were recruited from the local community. Patients and normal controls were genotyped for the functional COMT val158met and MTHFR C677T polymorphisms. Patients were characterized for clinical response to antidepressant treatment as measured by intra-individual changes of Hamilton Depression (HAMD-17) scores over 6 weeks. RESULTS:The T allele (OR=1.81; CI95%=1.40-2.34, P<0.001) and C/T genotype (OR=3.66; CI95% =2.53-5.28, P<0.001) of MTHFR C677T were significantly different between case and control groups. The COMT Met/Val genotype was more common among depressed individuals than among controls (OR=1.52, CI95%=1.04-2.21, P=0.02). LIMITATION:There is disequilibrium in age and sex between case and control groups. Though we control the two variables in the statistic analysis, to be more accurate, we need to increase sample size in further study. CONCLUSION:Individuals with the genotype COMT Met/Val and MTHFR C/T have more probability of suffering from MDD. However, there is no association between gene polymorphism and treatment response.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Shen X,Wu Y,Guan T,Wang X,Qian M,Lin M,Shen Z,Sun J,Zhong H,Yang J,Li L,Yuan Y

doi

10.1016/j.jad.2014.03.008

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

73-8

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(14)00110-4

journal_volume

161

pub_type

杂志文章

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