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Treatment of major depression with metyrapone and hydrocortisone.

Abstract：

:Eight inpatients with Major Depression were treated with metyrapone and hydrocortisone in a balanced order placebo-controlled single-blind cross-over study. The hydrocortisone dose (30 mg daily) was a physiological replacement dose and the metyrapone dose was titrated against plasma cortisol in order to keep cortisol within physiological limits. The treatment resulted in a significant reduction in depressive symptoms. This placebo-controlled study replicates the results of several uncontrolled studies but leaves open for further study the mechanism by which the combined administration of metyrapone and hydrocortisone might exert its antidepressant effect.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

O'Dwyer AM,Lightman SL,Marks MN,Checkley SA

doi

10.1016/0165-0327(94)00082-k

subject

Has Abstract

pub_date

1995-02-21 00:00:00

pages

123-8

issue

2

eissn

0165-0327

issn

1573-2517

pii

016503279400082K

journal_volume

33

pub_type

临床试验,杂志文章,随机对照试验

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