Abstract:
BACKGROUND:Suicide is a major cause of death throughout the world. Approximately 60% of all suicides have a history of depression. Previous studies of structural brain imaging have shown that suicide is often associated with abnormal fronto-limbic networks. However, the mechanism underlying suicide in depression remains poorly understood. METHOD:Twenty sex- and age-matched suicidal unipolar patients were compared with 18 non-suicidal unipolar patients and 28 healthy controls. High-resolution T1-weighted 3T magnetic resonance imaging (MRI) scans were acquired. Hamilton Depressive Rating Scale (HAMD) and Self-Rating Depression scale (SDS) were evaluated. The criterion for suicidality was one or more documented lifetime suicide attempts. A whole-brain optimized voxel-based morphometry (VBM) approach was applied. The Dysfunctional Attitude Scale (DAS) was used to measure cognitive scheme in depressive patients. RESULTS:Compared with controls, patients without suicide history showed significant decreased gray matter volume in the left insula lobe [-35 18 9], whereas patients with suicide history showed significantly decreased gray matter volume in the right middle temporal gyrus [60 -53 -8] and increased gray matter volume in the right parietal lobe [39 -39 60]. Compared with the non-suicidal depressed patient group, the suicidal group showed significant decreased gray matter volume in left limbic cingulated gyrus [-2 -21 28]. Moreover, the gray matter volume values in this significantly different brain region were negatively correlated with dysfunctional attitude scores in suicidal depressed patients. LIMITATIONS:This study needs replication and further clarification in a larger patient population. CONCLUSIONS:Suicide attempts in young depressed patients may be related to abnormal gray matter volumes in temporal-parietal-limbic networks. Specifically, small left limbic cingulate gyrus volumes may be a candidate for the prediction of suicide in young depressed patients.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Peng H,Wu K,Li J,Qi H,Guo S,Chi M,Wu X,Guo Y,Yang Y,Ning Ydoi
10.1016/j.jad.2014.04.046subject
Has Abstractpub_date
2014-08-01 00:00:00pages
69-73eissn
0165-0327issn
1573-2517pii
S0165-0327(14)00240-7journal_volume
165pub_type
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