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Correlations between brain-derived neurotrophic factor and clinical symptoms in medicated patients with major depression.

Abstract：

BACKGROUND:Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family and plays a critical role in growth, differentiation, maintenance and synaptic plasticity of neuronal systems. Previous studies have demonstrated lower serum BDNF concentrations in major depressive disorder (MDD), with concentrations negatively correlating with the severity of the disease. However, few investigations have examined the relationship between serum BDNF and detailed clinical symptoms. The aim of present study was to clarify the magnitudes of the relationships between various depressive symptom and serum BDNF. METHODS:Serum BDNF concentrations were evaluated from 109 inpatients with MDD and 163 healthy controls. Depressive symptoms were assessed using the Hamilton rating scale for depression (HAM-D), and symptoms were categorized into four groups: "anxiety somatization"; "cognitive disturbance"; "retardation"; and "sleep disturbance". RESULTS:Serum BDNF concentration was significantly lower in patients with MDD compared to controls (p<0.001). We identified significant negative correlations between serum BDNF concentration and both total score (R=-0.19, p=0.044) and "anxiety somatization" sub-score (R=-0.32, p=0.001) from the HAM-D in patients with MDD. LIMITATIONS:All patients in the present study were on antidepressant medications. CONCLUSIONS:These results suggest that serum BDNF level may offer a biological marker for anxiety symptoms in medicated patients with MDD.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Satomura E,Baba H,Nakano Y,Maeshima H,Suzuki T,Arai H

doi

10.1016/j.jad.2011.06.041

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

332-5

issue

1-3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(11)00392-2

journal_volume

135

pub_type

杂志文章

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