Abstract：
BACKGROUND:Serotonin transporter promoter (5-HTTLPR) genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD:Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. RESULTS:Children who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing. LIMITATIONS:The sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles. CONCLUSIONS:5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the "stress-sensitivity" conferred by this genotype.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Hayden EP,Dougherty LR,Maloney B,Olino TM,Sheikh H,Durbin CE,Nurnberger JI Jr,Lahiri DK,Klein DNdoi
10.1016/j.jad.2007.07.028subject
Has Abstractpub_date
2008-04-01 00:00:00pages
227-30issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(07)00281-9journal_volume
107pub_type
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