Abstract：
:Since (a) obsessive-compulsive disorder (OCD) may involve serotonergic neural transmission abnormalities also though to be related to regulation of suicide and aggression, (b) comorbidity between OCD and depression is substantial, and (c) depression is a major risk factor for suicide, a comprehensive analysis of clinical trial data was undertaken to assess the potential association of fluoxetine, a serotonin uptake inhibitor, and suicidality (suicidal acts and ideation). Pooled data from clinical trials comparing fluoxetine (n = 266) and placebo (n = 89) in patients with DSM-IIIR OCD were analyzed retrospectively. No suicidal acts occurred during placebo lead-in or double-blind therapy. Mean Hamilton Depression Scale item 3 (suicide item) scores improved statistically significantly with fluoxetine compared with placebo. Worsening in suicidal ideation was statistically significantly more frequent with placebo than with fluoxetine. Emergence of substantial suicidal ideation (change in baseline item 3 score of 0 or 1 to 3 or 4) was numerically greater with placebo than with fluoxetine (3.6% vs. 1.7%; not statistically significant). The incidence of suicidality in fluoxetine-treated patients with OCD was low, compared favorably with rates in corresponding placebo-treated patients, and was well within the range of estimates in previous studies of patients with OCD. These controlled clinical trial results suggest no undue risk of suicidality in patients with OCD treated with fluoxetine.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Beasley CM Jr,Potvin JH,Masica DN,Wheadon DE,Dornseif BE,Genduso LAdoi
10.1016/0165-0327(92)90054-asubject
Has Abstractpub_date
1992-01-01 00:00:00pages
1-10issue
1eissn
0165-0327issn
1573-2517pii
0165-0327(92)90054-Ajournal_volume
24pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：BACKGROUND:The predictors of onset of major depressive disorder (MDD) and generalized anxiety disorder (GAD) are well-characterized. However the factors that predict remission from these conditions are less clear, and the study of this area is further complicated by differing definitions of remission. METHODS:Data com...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.10.042
更新日期：2017-01-15 00:00:00
abstract：BACKGROUND:The daily pattern of motor activity and the autonomic cardiovascular regulation were studied in major depression to quantify changes in psychomotor function and autonomic cardiac functioning. Additionally, relationships between motor activity parameters, cardiovascular measures and specific clinical features...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(02)00066-6
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Major depressive disorder may be a heterogeneous disorder, yet melancholic depression is the most consistently described subtype, regarded as qualitatively different to non-melancholic depression in terms of cognitive and motor impairments. Eye movement studies in depression are infrequent and findings are i...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.03.018
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:We used resting-state functional magnetic resonance imaging to examine possible amygdala-prefrontal cortex functional connectivity abnormalities and to clarify the correlation of the abnormal connectivity with response to antidepressant medications. METHODS:We recruited 40 drug-naïve patients with first-epi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.05.053
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:This study aims to examine associations between serum 25-hydroxyvitamin D [25(OH)D] concentrations and depressive symptoms in an older Korean population. METHODS:The study used data from the Korean Urban Rural Elderly study, which enrolled 2942 participants aged 65 years or older from urban and rural commun...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.09.043
更新日期：2016-01-01 00:00:00
abstract：:Major depression (MD) and bipolar disorder (BD) are severe and potentially life-threating mood disorders whose etiology is to date not completely understood. MicroRNAs (miRNAs) are small non-coding RNAs that regulate protein synthesis post-transcriptionally by base-pairing to target gene mRNAs. Growing evidence indica...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.04.021
更新日期：2016-08-01 00:00:00
abstract：INTRODUCTION:Studies focusing on anxiety temporal patterns and cortisol activity in older adults are scarce. The objectives of this study were to examine in older adults the relationship between anxiety temporal patterns and cortisol activity and ascertain the presence of sex differences. METHODS:Data were retrieved f...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.08.020
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. METHODS:Data were from 9716 COPDGene subjects with ≥10 pack-year history. Depression was defi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.09.003
更新日期：2019-01-15 00:00:00
abstract：BACKGROUND:Major depressive disorder (MDD) and bipolar disorder (BD) are the two most common mood disorders. Given the recognized involvement of catecholamines in depression, genetic research focused on the evaluation of polymorphisms in genes coding for proteins that regulate neurotransmitter release, transport and de...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.02.016
更新日期：2015-05-15 00:00:00
abstract：:41 patients who took part in a withdrawal programme from long-term treatment with diazepam in a controlled clinical trial were followed up five years later. Assessments were made of outcome derived from clinical symptomatology, formal psychiatric diagnosis, psychotropic drug use and frequency of contact with both prim...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(92)90109-j
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND:Interpersonal sensitivity is a personality trait that describes as excessive awareness of both the behaviour and feelings of others. High interpersonal sensitivity has been associated with the development and maintenance of mental health problems. This study aimed to examine whether the Italian version of th...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.12.012
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Emotional and cognitive functioning have been involved in insomnia etiology, and sleep disturbances are closely related to psychiatric disorders and personality traits. This study investigates the association of temperament with subjective sleep parameters. METHODS:In this web-survey, 5129 subjects (25.3% m...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2010.06.014
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Recent studies on the pathophysiology of major depression (MD) indicate that degenerative and inflammatory processes may play a role. This finding is supported by magnetic resonance imaging (MRI)-based meta-analysis that show volume reductions in circumscribed areas of the brain in patients with MD. Using op...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.11.077
更新日期：2018-02-01 00:00:00
abstract：INTRODUCTION:Many studies of patients with major depression have reported that a significant decrease in serum free T(4) index is associated with specific treatments; what has been unanswered is whether these observations are generalizable. This study evaluated baseline thyroid function and its relationship to rapidity...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.10.012
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:To assess the risk of headache associated with commonly prescribed antidepressant medications and to examine the impact of medication class, pharmacodynamics and dosage on risk of headache. METHODS:We searched PubMed to identify all randomized, double-blind, placebo-controlled trials examining the efficacy ...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2018.04.047
更新日期：2018-08-15 00:00:00
abstract：BACKGROUND:Absence due to mental disease in the workplace has become a global public health problem. We aimed to evaluate the influence of presenteeism on depression and absence due to mental disease. METHODS:A prospective study of 1831 Japanese employees from all areas of Japan was conducted. Presenteeism and depress...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.03.034
更新日期：2015-07-15 00:00:00
abstract：OBJECTIVE:Many studies report high prevalence rates for co-morbid alcohol problems in bipolar disorder (BP). Some hypothesize that individuals use alcohol to self-medicate, but few studies examine the range of possible reasons and none explicitly explores the role of mood state. We examined drinking motives in BP depre...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.09.005
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Asylum seekers show high prevalence of depressive disorders compared to native populations. For the assessment of depression, the Patient Health Questionnaire-9 (PHQ-9) is a widely used instrument that has shown high validity and reliability. However, it is largely unknown whether PHQ-9 scores are comparable...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.055
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Roughly 8% of the U.S. population report moderate or severe depression for two or more weeks and Latinos (3.7%) report higher rates of severe depression compared to non-Hispanic whites (2.6%) (Pratt and Brody, 2014). As the Latino population continues to grow in the U.S., there is little research on the mani...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2017.10.046
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:The incidence of depression is difficult to determine because of low clinical depression detection rates in the primary care setting. This low level of detection is a significantly greater problem in people from ethnic minority communities. The availability of culturally validated screening questionnaires mi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.08.068
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:We aimed to assess the subjective quality of life (QOL) in depressed patients after discharge from inpatient treatment and to investigate the net impact of self-related constructs (self-esteem, response styles to depressed mood) and of social support on specific subjective QOL domains. METHOD:Four weeks aft...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2005.01.014
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Findings from three decades of epidemiological studies suggest that media diffusion of stories about suicide is related to increases in suicidal behaviours in the population exposed to the media reports. However, we still know little about the psychological processes and personal vulnerabilities that prompt ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.04.050
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Social network, loneliness, generalized anxiety disorder (GAD) and major depression disorder (MDD) are interrelated. However, as the directions of these associations are still unclear, we examined them prospectively using community-based data. METHODS:Data on 5066 adults aged ≥50 years from The Irish Longit...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.12.043
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Studying the phenotypic manifestations of increased genetic liability for Bipolar Disorder (BD) can increase understanding of this disorder. AIMS:We assessed whether genetic risk for BD was associated with childhood psychopathology and features of hypomania in young adulthood within a large population-based...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.12.091
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Several lines of evidence are pointing towards an involvement of the vascular endothelial growth factor (VEGF) in the pathophysiology of depression. There are studies analyzing blood levels of VEGF in patients with depression compared to controls, but a data on cerebrospinal fluid (CSF) levels of VEGF in pat...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.04.080
更新日期：2019-06-15 00:00:00
abstract：BACKGROUND:We tested if duration and intensity of episodes in treatment-resistant affectively ill patients were related to cerebrospinal fluid (CSF) concentrations of monoamine metabolites. METHOD:In retrospective life charts were recorded every previous episode of 37 patients with severe treatment-refractory affectiv...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(02)00011-3
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:This study aimed to test the validity of using the Hypomania Checklist-16 [HCL-16] to measure hypomania in a British adolescent community sample. Limited research is available concerning the characterization of hypomania among community adolescent samples, particularly in the UK, despite its potential import...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.08.033
更新日期：2017-01-01 00:00:00
abstract：:The advisability of continuing breastfeeding is an important issue for women with postpartum depression or psychosis. A review of the literature on psychotropic drugs in breast milk is presented. All of the major classes of psychotropic drugs (antidepressants, antipsychotics, antianxiety agents, lithium, hypnotics) ha...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/0165-0327(90)90092-m
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:Prevention of recurrence is a challenge in the management of major depressive disorder (MDD). The long-term effects of Preventive Cognitive Therapy (PCT) in preventing recurrence in MDD are not known. METHODS:A RCT comparing the addition of PCT to Treatment As Usual (TAU), versus TAU including patients with...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2015.06.048
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Many studies have demonstrated that major depression is related to an activation of the inflammatory response system (IRS) with an increased production of proinflammatory cytokines. It has been shown that tricyclic antidepressants and serotonin reuptake inhibitors suppress the activation of the IRS in depres...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(99)00076-2
更新日期：2000-04-01 00:00:00
