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Functional connectivity of the prefrontal cortex and amygdala is related to depression status in major depressive disorder.

Abstract：

BACKGROUND:We used resting-state functional magnetic resonance imaging to examine possible amygdala-prefrontal cortex functional connectivity abnormalities and to clarify the correlation of the abnormal connectivity with response to antidepressant medications. METHODS:We recruited 40 drug-naïve patients with first-episode depression, had a 17-item Hamilton Rating Scale for Depression (HRSD17) score>17 for participation in a magnetic resonance imaging scan. Remission was defined as an HRSD17 score <7 following 8 weeks of fluoxetine antidepressant treatment. Gender- and age-matched healthy subjects (n = 26) also underwent MRI scanning. Finally, the association between the change in HRSD17 scores and a change in connectivity between the amygdala and prefrontal cortex from pre to post-treatment was evaluated in major depressive disorder (MDD). RESULTS:After controlling for age, gender and years of education, a statistically significant increase in functional connectivity to the right prefrontal cortex from the amygdala was observed in the MDD group compared with the healthy control group (p<0.05, corrected). After 8 weeks of antidepressant treatment and remission in the MDD group, a significant decrease in functional connectivity to the right prefrontal cortex and the left prefrontal cortex from the amygdala was observed, compared with the level of connectivity in the drug-naïve MDD group(p<0.05,corrected). There were no significant associations between the difference in HRSD17 scores rMDD and fMDD with the change in connectivity. LIMITATIONS:The design of this study lack resistance to treatment for the depressed group. CONCLUSIONS:Increased functional connectivity of PFC-AMY is a promise to be a biomarker of MDD, however weather it could be a biomarker of fluoxetine treatment needs future studying.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Zhang A,Yang C,Li G,Wang Y,Liu P,Liu Z,Sun N,Zhang K

doi

10.1016/j.jad.2020.05.053

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

897-902

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(19)33642-0

journal_volume

274

pub_type

杂志文章

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