Abstract:
BACKGROUND:This paper extends previous work describing course in depression using a recommended operational model that defines remission onset and relapse. We test whether a similar course pattern would emerge using this model in a new cohort of depressed participants. METHODS:We recruited a cohort of 86 participants, first-time inpatients, with DSM-IV major depression. Outcome was assessed prospectively over a 13-month minimum follow-up period. Remission onset was defined as a Ham-D score <8 for two consecutive weeks; relapse as a Ham-D score >16 for two consecutive weeks and meeting DSM-IV criteria for major depressive disorder. RESULTS:The cumulative probability of remission onset was 0.62 (SE=0.05) and 0.80 (SE=0.05) at 3 and 6 months following study entry. The relapse risk was 0.28 (SE=0.05) at 6 months post remission onset; 53% of those relapsing did so in the first 2 months post remission onset. Predictors of longer times to remission onset included: longer illness length, higher anxiety scores and unemployment; higher anxiety scores predicted relapse. The course pattern is similar to that reported previously. LIMITATIONS:These findings apply to inpatients only. Course was not rated blind to all of the participants' baseline data. CONCLUSIONS:Defining remission onset and relapse using this model is associated with a replicable course pattern. A singular clinical advantage of the model is the identification of those participants at highest risk of relapse 2 months post remission onset.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
O'Leary D,Hickey T,Lagendijk M,Webb Mdoi
10.1016/j.jad.2010.02.107subject
Has Abstractpub_date
2010-09-01 00:00:00pages
221-6issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(10)00209-0journal_volume
125pub_type
杂志文章abstract:BACKGROUND:Comorbidity between Attention-Deficit/Hyperactivity Disorder (ADHD) and depression is high, also in older adults. Thus far it is not well understood why ADHD and depression are so strongly interrelated. One factor that may play a role in older adults with ADHD is an increased risk of experiencing adverse lif...
journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2015-03-15 00:00:00
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更新日期:1991-02-01 00:00:00
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析
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更新日期:2013-08-15 00:00:00
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doi:10.1016/s0165-0327(01)00468-2
更新日期:2002-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.11.079
更新日期:2019-02-15 00:00:00
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.11.035
更新日期:2012-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.05.009
更新日期:2014-09-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2020.07.121
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Several studies from different epidemiological backgrounds have shown that unipolar depression is more prevalent in females than in males. This study examines gender differences in depression in a sample of 4075 probands recruited representatively from the general population in the northern German epidemiolo...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(02)00121-0
更新日期:2003-12-01 00:00:00
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2019.08.037
更新日期:2019-12-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.04.076
更新日期:2018-09-01 00:00:00
abstract:INTRODUCTION:Sleep disturbance is a core feature of bipolar disorder. To date there are a limited number of studies that compare subjective and objective measures of sleep in populations of subjects with mood disorders. This study evaluated the relationship between subjective and objective measurements of total sleep t...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.02.013
更新日期:2013-07-01 00:00:00
abstract:AIM:Even though numerous studies have focused on the effects of self-stigma on patients with schizophrenia, little is known about self-stigma of patients with bipolar disorder (BD). In this study, a self-administered scale of self-stigmatising attitudes of patients with BD and schizophrenia was used to explore these at...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.05.038
更新日期:2015-09-15 00:00:00
abstract:INTRODUCTION:The subgenual cingulate gyrus (Brodmann's Area 25: BA25) is hypermetabolic in depression and has been targeted successfully with deep brain stimulation. Two of the white matter tracts that play a role in treatment response are the uncinate fasciculus (UF) and the cingulum bundle. The UF has three prefronta...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.04.055
更新日期:2018-08-01 00:00:00
abstract:BACKGROUNDS:Several cross-sectional studies suggested a link between endometriosis and mood disorders. However, the temporal association between endometriosis and mood disorders (depression and anxiety disorders) is still unclear. METHODS:Using the Taiwan National Health Insurance Research Database, 10,439 women with ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.10.030
更新日期:2016-01-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.03.010
更新日期:2015-07-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.10.002
更新日期:2013-07-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.02.028
更新日期:2020-04-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.04.039
更新日期:2019-06-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.12.001
更新日期:2008-08-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.04.006
更新日期:2014-08-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jad.2017.10.007
更新日期:2018-01-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.11.016
更新日期:2021-02-01 00:00:00