Abstract:
BACKGROUND:Ketamine has rapid-acting antidepressant and antisuicidal properties, while a proportion of patients do not adequately achieve a complete response to ketamine. Our aim was to explore the applicability of using clinical factors and serum tryptophan (TRP) metabolites to predict the response to six doses of ketamine for depression with suicidal ideation. METHODS:Seventy-three depressed patients with suicidal ideation received a thrice-weekly infusion regimen of subanaesthetic doses of ketamine. Clinical symptoms were assessed by the Montgomery-Asberg Depression Rating Scale (MADRS), Beck's Scale for Suicide Ideation (SSI) and Patient Health Questionnaire-9 (PHQ-9), and serum levels of TRP, kynurenine (KYN) and kynurenic acid (KYNA) were detected by liquid chromatography-tandem mass spectrometry at baseline and day 1 (1 day after the first infusion). The potential predictors of response was evaluated using receiver operating characteristic (ROC) curve analyses. RESULTS:The area under the curve (AUC = 0.959) implied a good accuracy of the combination of early clinical response and day 1 KYN and KYNA levels as a predictor of acute antidepressant response. The combination of early clinical response and day 1 KYNA levels showed moderate discrimination of acute antisuicidal response with an AUC of 0.825 and short-term antidepressant response with an AUC of 0.813. LIMITATIONS:The patients continued receiving previous medications during ketamine treatment, which may have impacted the TRP metabolites. CONCLUSION:The combination of early clinical response and TRP metabolites at the early stage of repeated ketamine treatment could be considered an eligible predictor for acute- and short-term response for treating depression with suicidal ideation.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Zhou Y,Liu W,Zheng W,Wang C,Zhan Y,Lan X,Zhang B,Zhang C,Ning Ydoi
10.1016/j.jad.2020.01.001subject
Has Abstractpub_date
2020-03-01 00:00:00pages
263-271eissn
0165-0327issn
1573-2517pii
S0165-0327(19)33105-2journal_volume
264pub_type
杂志文章abstract::Endogenously depressed in-patients were treated for four weeks with either lithium + L-tryptophan (N = 22) or amitriptyline (N = 21) in an open study. Before and weekly during treatment the patients were evaluated by means of Hamilton rating scale, and blood samples were collected for determination of serum concentrat...
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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abstract:INTRODUCTION:The objective was to estimate the rate of subjects who tested positive at a screening for bipolar disorders among the people insured by a French Health Company, and subsequently to measure treatment patterns. METHODS:Cross-sectional postal survey on the "Mutuelle Générale de l'Education Nationale" (MGEN) ...
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2020-04-01 00:00:00
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journal_title:Journal of affective disorders
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更新日期:2016-09-15 00:00:00
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Bipolar disorders are frequently diagnosed and treated as unipolar depression initially and accurate diagnosis is often delayed by 8 to 10years. It has been demonstrated that the bipolar spectrum disorders are associated with notable disability and that the current diagnostic gold standard, the Structured Cl...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2011.12.033
更新日期:2012-11-01 00:00:00
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.09.025
更新日期:2012-06-01 00:00:00
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Depression is associated with greater cardiac morbidity and mortality. One of the contributory factors for this may be altered cardiac autonomic activity in depression. However, cardiac autonomic involvement in depression remains controversial because of methodological issues. In this study, alteration of ca...
journal_title:Journal of affective disorders
pub_type: 杂志文章
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章
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