当前位置： SCI文献检索 > JOURNAL OF AFFECTIVE DISORDERS期刊下所有文献 > Heritability estimates of individual psychological distress symptoms from genetic variation.

Heritability estimates of individual psychological distress symptoms from genetic variation.

Abstract：

BACKGROUND:Psychological distress symptoms are associated with an increased risk of psychiatric disorders and medical illness. Although psychological distress is influenced by environmental factors, such as socioeconomic status, lifetime events, or interpersonal relationships, substantial interindividual variation also exists. However, heritability and genetic determinants of distress are poorly understood. METHODS:In the Korean Genome and Epidemiology Study sample (n = 12,680), we estimated the heritability of individual psychological distress symptoms using the GCTA-REML method and carried out a genome-wide association study of individual psychological distress symptoms showing significant heritability. RESULTS:We found three psychological distress items showing significant heritability: subjective well-being (9%), fatigue and appetite (11%), and enjoying daily life (8%). Additionally, we found genome-wide significant associations of rs6735649 located between STEAP3 and C1QL2 on chromosome 2 with subjective well-being (P = 1.32 × 10-8, odds ratio [OR] = 1.18, 95% confidence interval [CI]: 1.12-1.25) and rs35543418 located between SYT16 and KCNH5 on chromosome 14 with enjoying daily life (P = 1.33 × 10-8, OR = 1.59, 95% CI: 1.35-1.86). LIMITATIONS:The lack of replication in independent cohorts and longitudinal assessment of distress may limit generalizability. CONCLUSIONS:Our results indicate that distress symptoms are partly heritable. Further analysis in larger cohorts investigating gene-environment interactions is required to identify genetic variants that explain the proportion of variation in distress.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Kim S,Jang HJ,Myung W,Kim K,Cha S,Lee H,Cho SK,Kim B,Ha TH,Kim JW,Kim DK,Stahl EA,Won HH

doi

10.1016/j.jad.2019.04.011

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

413-420

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(18)31017-6

journal_volume

252

pub_type

杂志文章

相关文献

JOURNAL OF AFFECTIVE DISORDERS文献大全
  • Prevalence of suicide ideation, planning and attempts among Supplemental Nutrition Assistance Program participants in the United States.

    abstract：BACKGROUND:Suicide represents a substantial public health problem in the U.S. Programs like the Supplemental Nutrition Assistance Program (SNAP)-which provides services for U.S. adults who are food insecure-could be an appropriate venue for suicide prevention strategies targeting high-risk individuals. METHODS:This cr...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.07.129

    authors： Bergmans RS,Jannausch M,Ilgen MA

    更新日期：2020-12-01 00:00:00

  • Fluoxetine: no association with suicidality in obsessive-compulsive disorder.

    abstract：:Since (a) obsessive-compulsive disorder (OCD) may involve serotonergic neural transmission abnormalities also though to be related to regulation of suicide and aggression, (b) comorbidity between OCD and depression is substantial, and (c) depression is a major risk factor for suicide, a comprehensive analysis of clini...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/0165-0327(92)90054-a

    authors： Beasley CM Jr,Potvin JH,Masica DN,Wheadon DE,Dornseif BE,Genduso LA

    更新日期：1992-01-01 00:00:00

  • Parents' behavioral inhibition moderates association of preschoolers' BI with risk for age 9 anxiety disorders.

    abstract：BACKGROUND:Temperamental behavioral inhibition (BI) in children predicts later anxiety disorders. However, many children with BI do not develop anxiety disorders, suggesting the importance of identifying moderating factors. The current study examined whether parents' history of BI moderates the associations between pre...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2016.12.008

    authors： Stumper A,Danzig AP,Dyson MW,Olino TM,Carlson GA,Klein DN

    更新日期：2017-03-01 00:00:00

  • Prefrontal hemodynamic response to verbal-fluency task and hyperventilation in bipolar disorder measured by multi-channel near-infrared spectroscopy.

    abstract：BACKGROUND:Many neuroimaging studies of patients with bipolar disorder have demonstrated functional hypofrontality (reduced activation of the frontal cortex), although this finding is still controversial. We previously found hypoactivation of the left prefrontal region in remitted subjects with bipolar disorder measure...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2003.10.004

    authors： Matsuo K,Watanabe A,Onodera Y,Kato N,Kato T

    更新日期：2004-10-01 00:00:00

  • The use of the GBI in a population of adolescent offspring of parents with a bipolar disorder.

    abstract：OBJECTIVE:To assess the psychometric properties and the usefulness of the General Behavior Inventory (GBI) in the adolescent age range. METHOD:The GBI, the Schedule for Affective Disorders and Schizophrenia for School Age Children, Kiddie-SADS-Present and Lifetime Version (K-SADS-PL) and the Youth Self-Report (YSR) we...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/S0165-0327(03)00115-0

    authors： Reichart CG,van der Ende J,Wals M,Hillegers MH,Ormel J,Nolen WA,Verhulst FC

    更新日期：2004-06-01 00:00:00

  • High fatality rates of late-life depression associated with cardiovascular disease.

    abstract：:Sixty-two elderly depressives were located one year after discharge. Eight patients (13%) had died, 2.6 times higher than the expected mortality rate. Patients dying were more likely to have had a diagnosis of cardiovascular disease (P less than 0.001). ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(85)90096-5

    authors： Rabins PV,Harvis K,Koven S

    更新日期：1985-09-01 00:00:00

  • The sales of antidepressants and suicide rates in Norway and its counties 1980-2004.

    abstract：BACKGROUND:Suicide is a major public health problem and depression is among the most important risk factors for suicide. Treatment of depression might prevent suicide. To study this hypothesis further we conducted an ecological study. METHODS:An ecological study using sales data for antidepressants and numbers of suic...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2006.12.002

    authors： Bramness JG,Walby FA,Tverdal A

    更新日期：2007-09-01 00:00:00

  • Proposed delusional depression subtypes: preliminary evidence from a retrospective study of phenomenology and treatment course.

    abstract：:An analysis of the phenomenology and treatment course of 52 subjects with delusional depression suggests that there may be various subtypes: bipolar, early-onset unipolar and possibly a late-onset unipolar. The bipolar subgroup tended to relapse in different but always psychotic directions, and was resistant to lithiu...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(88)90073-0

    authors： Aronson TA,Shukla S,Hoff A,Cook B

    更新日期：1988-01-01 00:00:00

  • Fusion analysis of gray matter and white matter in bipolar disorder by multimodal CCA-joint ICA.

    abstract：BACKGROUND:Bipolar disorder (BD) patients show morphological abnormalities in gray matter (GM) and white matter (WM), which can be revealed by structure MRI (sMRI) and diffusion tensor imaging (DTI) respectively. However, previous studies on BD mainly relied on separated analysis of single neuroimaging modality, and it...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2019.11.119

    authors： Tang F,Yang H,Li L,Ji E,Fu Z,Zhang Z

    更新日期：2020-02-15 00:00:00

  • Is coping well a matter of personality? A study of euthymic unipolar and bipolar patients.

    abstract：BACKGROUND:Euthymic bipolar disorder (BD) patients often demonstrate better clinical outcomes than remitted patients with unipolar illness (UP). Reasons for this are uncertain, however, personality and coping styles are each likely to play a key role. This study examined differences between euthymic BD and UP patients ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2012.07.012

    authors： Coulston CM,Bargh DM,Tanious M,Cashman EL,Tufrey K,Curran G,Kuiper S,Morgan H,Lampe L,Malhi GS

    更新日期：2013-02-15 00:00:00

  • Cognitive behavioral social rhythm group therapy versus present centered group therapy for veterans with posttraumatic stress disorder and major depressive disorder: A randomized controlled pilot trial.

    abstract：BACKGROUND:Cognitive Behavioral Social Rhythm Group Therapy (CBSRT) is a chronobiologically-informed group therapy designed to stabilize social rhythms in veterans with comorbid combat-related PTSD and major depressive disorder (MDD). This randomized controlled pilot trial is the first to examine feasibility and prelim...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.09.009

    authors： Haynes PL,Burger SB,Kelly M,Emert S,Perkins S,Shea MT

    更新日期：2020-12-01 00:00:00

  • Trends in lithium prescription in Spain from 1985 to 2003.

    abstract：:Lithium use for bipolar disorder has decreased in the United States. We aimed at studying lithium prescription in Spain from 1985 to 2003. Prescription data, expressed in daily defined dose per 1,000 inhabitants per day, were obtained. Lithium prescription increased uninterruptedly from 0.21 to 0.79 DID. The psychiatr...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2006.01.005

    authors： Castells X,Vallano A,Rigau D,Pérez J,Casas M,Capellà D

    更新日期：2006-04-01 00:00:00

  • Prognostic factors determining response to antidepressant drugs in psychiatric out-patients and general practice.

    abstract：:The outcome of antidepressant drug treatment was measured in 200 patients, 145 seen in psychiatric out-patient clinics and 55 in general practice, after 4 weeks of therapy. The results of the 200 patients taken together suggested that prognosis was largely determined by factors dependent on the natural history of the ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(80)90001-4

    authors： Tyrer PJ,Lee I,Edwards JG,Steinberg B,Elliott EJ,Nightingale JH

    更新日期：1980-09-01 00:00:00

  • Correlation between plasma cortisol and CSF catecholamines in endogenous depressed dexamethasone nonsuppressors.

    abstract：:Nineteen endogenous depressive in-patients (13 with major depression and 6 with bipolar disorder-depressed) and 10 other patients with dysthymic disorder serving as the control group were given the dexamethasone suppression test (DST, 1 mg/subject). The results showed that the DST sensitivity in endogenous depressives...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(86)90002-9

    authors： Lu RB,Ho SL,Ho BT,Leu SY,Shian LR,Chen WL

    更新日期：1986-05-01 00:00:00

  • Treatment-emergent mania in pediatric bipolar disorder: a retrospective case review.

    abstract：BACKGROUND:Pediatric bipolar disorder (BPD) can be misdiagnosed as a depressive, attention, conduct, or anxiety disorder and treatment with antidepressants and stimulants is common. Risk of adverse outcomes related to such treatment remains poorly defined. METHODS:We analyzed clinical records of 82 children (mean age ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2003.12.011

    authors： Faedda GL,Baldessarini RJ,Glovinsky IP,Austin NB

    更新日期：2004-10-01 00:00:00

  • Exercise and severe depression: preliminary results of an add-on study.

    abstract：BACKGROUND:Physical exercise has been extensively researched as a therapeutic option for treatment of major depression. METHODS:In a randomized controlled trial, we analyze the effects of aerobic physical exercise as an add-on strategy for treatment of severe depressed inpatients. The exercise has a "Dose" of 16.5 kca...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jad.2011.04.030

    authors： Schuch FB,Vasconcelos-Moreno MP,Borowsky C,Fleck MP

    更新日期：2011-10-01 00:00:00

  • Effects of morning light treatment on subjective sleepiness and mood in winter depression.

    abstract：:The effects of morning light treatment on mood, subjective sleepiness and body temperature were investigated with 13 outpatients with winter depression and 13 healthy controls. Bright light for 1 h daily for 2 weeks resulted in a significant reduction in depression ratings and evening subjective sleepiness in the pati...

    journal_title：Journal of affective disorders

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0165-0327(94)90037-x

    authors： Partonen T

    更新日期：1994-02-01 00:00:00

  • Guilt is more strongly associated with suicidal ideation among military personnel with direct combat exposure.

    abstract：BACKGROUND:Suicide rates in the U.S. military have been rising rapidly in the past decade. Research suggests guilt is a significant predictor of suicidal ideation among military personnel, and may be especially pronounced among those who have been exposure to combat-related traumas. The current study explored the inter...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2012.11.044

    authors： Bryan CJ,Ray-Sannerud B,Morrow CE,Etienne N

    更新日期：2013-05-15 00:00:00

  • Characteristics of interpretation bias and relationship with suicidality in a psychiatric hospital sample.

    abstract：BACKGROUND:Interpretation bias, the tendency to interpret ambiguous situations negatively (or to lack a positive bias), is a cognitive vulnerability associated with psychopathology. However, there is a lack of research characterizing this bias in psychiatric samples, including whether it is also a risk factor for suici...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2016.09.021

    authors： Beard C,Rifkin LS,Björgvinsson T

    更新日期：2017-01-01 00:00:00

  • Dilated Virchow-Robin spaces in the hippocampus impact behaviors and effects of anti-depressant treatment in model of depressed rats.

    abstract：:The occurrences of dilated Virchow-Robin spaces (dVRSs) and inflammatory factors were closely related with development of depression and antidepressants. The present study indicated accumulation of inflammatory factors in dVRSs played a practical role in behaviors and the treatment-resistant in rats with depression. E...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2017.04.035

    authors： Li Y,Yan J,Zhu X,Zhu Y,Yao S,Xu Y,Ju S

    更新日期：2017-09-01 00:00:00

  • Iowa Gambling Task performance in euthymic bipolar I disorder: a meta-analysis and empirical study.

    abstract：BACKGROUND:The Iowa Gambling Task (IGT) has been recommended as an index of reward sensitivity, which is elevated in bipolar disorder. We conducted a meta-analysis of IGT performance in euthymic bipolar I disorder compared with control participants. Findings indicated that people with bipolar disorder make more risky c...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jad.2012.11.027

    authors： Edge MD,Johnson SL,Ng T,Carver CS

    更新日期：2013-08-15 00:00:00

  • Regional cortical thinning and cerebral hypoperfusion in patients with panic disorder.

    abstract：BACKGROUND:Although recent neuroimaging studies have suggested that functional deficits in facial perception are associated with panic disorder (PD), the possibility of cortical thickness and perfusion abnormalities have not been studied in patients with PD. We aimed to investigate alterations in cortical thickness and...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2020.07.139

    authors： Ni MF,Wang XM,Wang HY,Chang Y,Huang XF,Zhang BW

    更新日期：2020-12-01 00:00:00

  • Depression in adolescents and young adults--polysomnographic and neuroendocrine aspects.

    abstract：:The comparison of polysomnographic data between a group of nine major depressive adolescents, 12 minor depressive adolescents and 12 controls showed a significant difference in sleep efficiency index and in percentage of awakenings. Sleep efficiency was reduced in major depressive adolescents and the percentage of awa...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(88)90069-9

    authors： Appelboom-Fondu J,Kerkhofs M,Mendlewicz J

    更新日期：1988-01-01 00:00:00

  • The effectiveness of internet-delivered cognitive behavioural therapy for health anxiety in routine care.

    abstract：INTRODUCTION:Randomised controlled trials have shown that internet-delivered cognitive behavioural treatment (iCBT) is an effective treatment for health anxiety, but the effectiveness of these programs in routine care has not been investigated. This study examined the effectiveness of iCBT for health anxiety symptoms i...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2019.11.087

    authors： Newby JM,Haskelberg H,Hobbs MJ,Mahoney AEJ,Mason E,Andrews G

    更新日期：2020-03-01 00:00:00

  • New pathways of increased cardiovascular risk in depression: a pilot study on the association of high-sensitivity C-reactive protein with pro-atherosclerotic markers in patients with depression.

    abstract：BACKGROUND:An elevation of inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) can be found in patients with depressive disorders. Inflammatory processes are known to influence atherosclerosis and might also mediate the link between depression and diabetes. The present study aimed at comparing hs-...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2012.07.030

    authors： Zahn D,Petrak F,Uhl I,Juckel G,Neubauer H,Hägele AK,Wiltfang J,Herpertz S

    更新日期：2013-04-25 00:00:00

  • Proton magnetic resonance spectroscopic imaging of gray and white matter in bipolar-I and schizophrenia.

    abstract：BACKGROUND:Glutamine plus glutamate (Glx), as well as N-acetylaspartate compounds, (NAAc), a marker of neuronal viability, are quantified with proton magnetic resonance spectroscopy (1H-MRS) and have been reported altered in psychotic disorders. However, few studies have compared these neurometabolites in bipolar disor...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2018.12.064

    authors： Bustillo JR,Jones T,Qualls C,Chavez L,Lin D,Lenroot RK,Gasparovic C

    更新日期：2019-03-01 00:00:00

  • Mania and ADHD: comorbidity or confusion.

    abstract：:The frequency of occurrence of prepubertal mania is contingent on how much adherence to episodic disorder with separate periods of mania and depression is required. While manic symptoms superimposed on other psychiatric disorders is not uncommon, non-comorbid bipolar disorder is rare. A number of developmental, phenom...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章,评审

    doi：10.1016/s0165-0327(98)00179-7

    authors： Carlson GA

    更新日期：1998-11-01 00:00:00

  • Alterations of functional connectivity and intrinsic activity within the cingulate cortex of suicidal ideators.

    abstract：:The 'default mode network' (DMN), a collection of brain regions including the posterior cingulate cortex (PCC), shows reliable inter-regional functional connectivity at rest. It has been implicated in rumination and other negative affective states, but its role in suicidal ideation is not well understood. We employed ...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2017.01.013

    authors： Chase HW,Segreti AM,Keller TA,Cherkassky VL,Just MA,Pan LA,Brent DA

    更新日期：2017-04-01 00:00:00

  • The relationship between DSM-IV alcohol use disorders and DSM-IV major depression: examination of the primary-secondary distinction in a general population sample.

    abstract：:This study examined the primary-secondary distinction with respect to DSM-IV alcohol use disorders and major depression in a large representative sample of the USA. Primary, secondary and concurrent depressives (i.e. the comorbid groups), respondents classified with major depression only and respondents classified wit...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/0165-0327(96)00002-x

    authors： Grant BF,Hasin DS,Dawson DA

    更新日期：1996-06-05 00:00:00

  • Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls.

    abstract：INTRODUCTION:The aim of this study was to investigate the psychometric properties of the original 54 item version (ALS-54) and the short 18 item version (ALS-18) of the Affective Lability Scale (ALS) in patients with bipolar disorders, their first-degree relatives and healthy controls. Internal Consistency and Confirma...

    journal_title：Journal of affective disorders

    pub_type： 杂志文章

    doi：10.1016/j.jad.2014.10.028

    authors： Aas M,Pedersen G,Henry C,Bjella T,Bellivier F,Leboyer M,Kahn JP,Cohen RF,Gard S,Aminoff SR,Lagerberg TV,Andreassen OA,Melle I,Etain B

    更新日期：2015-02-01 00:00:00