Rho GTPase activity modulates paramyxovirus fusion protein-mediated cell-cell fusion.

abstract：:The function of rice dwarf virus segment 11 and the corresponding segments of other phytoreoviruses is not yet determined. The amino acid sequence of Pns11, encoded by segment 11, contains a putative zinc finger and five flanking basic regions at the C-terminus. The full-length Pns11 protein and three truncated deriva...

journal_title：Virology

authors： Xu H,Li Y,Mao Z,Li Y,Wu Z,Qu L,An C,Ming X,Schiemann J,Casper R,Chen Z

更新日期：1998-01-20 00:00:00

abstract：:Following mechanical inoculation of leaves with turnip yellow mosaic virus (TYMV), a significant proportion of the retained inoculum is uncoated within 45 sec, and the process is more or less complete after 2 min. At least 80-90% of the uncoating takes place in the epidermis. The application of virus to the intact lea...

journal_title：Virology

authors： Matthews RE,Witz J

更新日期：1985-07-30 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV-68) replicates robustly in cell culture, providing a model for studying viral genome replication during de novo infection of tumor-associated herpesviruses. We have previously identified a 1.25-kb origin of lytic replication (oriLyt) for MHV-68. To further investigate the molecular mech...

journal_title：Virology

authors： Gong D,Qi J,Arumugaswami V,Sun R,Deng H

更新日期：2009-05-10 00:00:00

abstract：:Previously, we studied the envelope (E) gene of dengue virus and reported that dengue-3 virus is present as a quasispecies. To investigate the extent of intrahost sequence variation of other dengue viral genes, we examined in this study the capsid (C) gene and the nonstructural gene, NS2B, derived directly from plasma...

journal_title：Virology

authors： Wang WK,Sung TL,Lee CN,Lin TY,King CC

更新日期：2002-11-10 00:00:00

abstract：:Guinea pig cytomegalovirus (GPCMV) immediate early proteins, IE1 and IE2, demonstrated structural and functional homologies with human cytomegalovirus (HCMV). GPCMV IE1 and IE2 co-localized in the nucleus with each other, the viral polymerase and guinea pig ND10 components (gpPML, gpDaxx, gpSp100, gpATRX). IE1 showed ...

journal_title：Virology

authors： Hornig J,Choi KY,McGregor A

更新日期：2017-04-01 00:00:00

abstract：:Coronavirus E protein is a small viral envelope protein that plays an essential role in coronavirus assembly; coexpression of coronavirus M and E proteins results in the production of virus-like particles. The present study demonstrated that mouse hepatitis virus (MHV) E protein was released as an integral membrane pr...

journal_title：Virology

authors： Maeda J,Maeda A,Makino S

更新日期：1999-10-25 00:00:00

abstract：:We have previously shown that the late promoter of the human papovavirus BK (prototype) is contained within the three 68-bp repeats and a 66-bp region to the late side of the repeats which together constitute the early promoter enhancer. We have now carried out unidirectional deletion and linker scan analyses of these...

journal_title：Virology

authors： Cassill JA,Deyerle KL,Subramani S

更新日期：1989-03-01 00:00:00

abstract：:Mouse mammary tumour virus (MMTV) encodes a viral superantigen (Sag) and a negative acting factor (Naf) which share parts of their coding sequence. Using 2-dimensional gel electrophoresis (2D-DIGE), we could show that at least 10 different cellular proteins were differentially expressed in Naf positive cells. Also, lu...

journal_title：Virology

authors： Metzner C,Salmons B,Gunzburg WH,Gemeiner M,Miller I,Gesslbauer B,Kungl A,Dangerfield JA

更新日期：2006-03-01 00:00:00

abstract：:Processing of the transmembrane glycoprotein (GP) of Marburg virus involved the conversion of an endo H-sensitive, ER-specific form into an endo H-resistant, Golgi-specific precursor that was cleaved into GP(1) and GP(2). Cleavage was mediated by furin or another subtilisin-like endoprotease with similar substrate spe...

journal_title：Virology

authors： Volchkov VE,Volchkova VA,Ströher U,Becker S,Dolnik O,Cieplik M,Garten W,Klenk HD,Feldmann H

更新日期：2000-03-01 00:00:00

abstract：:Viruses of the family Luteoviridae are ssRNA plant viruses that have particles that exhibit icosahedral symmetry. To identify the residues that might be exposed on the surface of the Potato leafroll virus (PLRV; genus Polerovirus, family Luteoviridae) capsid, and therefore involved in biological interactions, we perfo...

journal_title：Virology

authors： Terradot L,Souchet M,Tran V,Giblot Ducray-Bourdin D

更新日期：2001-07-20 00:00:00

abstract：:Incubation of membrane vesicles from normal and Rous sarcoma virus-transformed chick embryo fibroblasts (CEF) with [gamma-32P]ATP resulted in the phosphorylation of a large number of proteins. The major differences observed between the membrane vesicles of untransformed and transformed cells were: (1) a 5- to 10-fold ...

journal_title：Virology

authors： Garber EA,Krueger JG,Hanafusa H,Goldberg AR

更新日期：1983-04-15 00:00:00

abstract：:Recently, we reported that PrP(Sc), a surrogate marker for prion disease, is associated with the cellular fraction of blood from scrapie-infected sheep using a ligand-based immunoassay. In the study reported here, we found that a subset of peripheral blood mononuclear cells is most likely to sequester PrP(Sc) during b...

journal_title：Virology

authors： Edwards JC,Moore SJ,Hawthorn JA,Neale MH,Terry LA

更新日期：2010-09-15 00:00:00

abstract：:Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein characterized by its ability to depurinate the sarcin/ricin (S/R) loop of the large rRNA of prokaryotic and eukaryotic ribosomes. Here, a series of PAP mutants were used to examine the relationship between depurination of the S/R loop and inhibition o...

journal_title：Virology

authors： Hudak KA,Hammell AB,Yasenchak J,Tumer NE,Dinman JD

更新日期：2001-01-05 00:00:00

abstract：:It is likely that phylogroup 2 lyssaviruses circulate within bat reservoirs. We adapted a pseudotype (pt) neutralisation assay (PNA) to a multiplex format enabling serosurveillance for Lagos bat virus (LBV), Mokola virus (MOKV) and West Caucasian bat virus (WCBV) in a potential reservoir, the African straw-coloured fr...

journal_title：Virology

authors： Wright E,Hayman DT,Vaughan A,Temperton NJ,Wood JL,Cunningham AA,Suu-Ire R,Weiss RA,Fooks AR

更新日期：2010-12-20 00:00:00

abstract：:The PstI-N genomic fragment of Autographa californica nuclear polyhedrosis virus (AcNPV) encodes an immediate-early protein, IE2, that functions as a promiscuous transactivator of other early viral promoters and heterologous promoters both in vivo and in vitro. IE2 contains several sequence motifs that are common to t...

journal_title：Virology

authors： Yoo S,Guarino LA

更新日期：1994-07-01 00:00:00

abstract：:The surface of the mature dengue virus (DENV) particle consists of 90 envelope (E) protein dimers that mediate both receptor binding and fusion. The E protein ectodomain can be divided into three structural domains designated ED1, ED2, and ED3, of which ED3 contains the critical and dominant virus-specific neutralizat...

journal_title：Virology

authors： Gromowski GD,Barrett AD

更新日期：2007-09-30 00:00:00

abstract：:To better understand the evolution of the viral envelope glycoproteins (Env) in HIV-1 infected individuals who progress to AIDS maintaining an exclusive CCR5-using (R5) virus population, we cloned and sequenced the env gene of longitudinally obtained primary isolates. A shift in the electrostatic potential towards an ...

journal_title：Virology

authors： Repits J,Sterjovski J,Badia-Martinez D,Mild M,Gray L,Churchill MJ,Purcell DF,Karlsson A,Albert J,Fenyö EM,Achour A,Gorry PR,Jansson M

更新日期：2008-09-15 00:00:00

abstract：:Cell lines persistently infected with foot-and-mouth disease virus (FMDV) have been established by growth of BHK-21 (c-13) or IBRS-2 (c-26) that survived standard cytolytic infections with FMDV. They maintain cytoplasmic FMDV RNA sequences, as shown by dot blot hybridization tests, using cloned FMDV cDNA as probes. Ce...

journal_title：Virology

authors： de la Torre JC,Dávila M,Sobrino F,Ortín J,Domingo E

更新日期：1985-08-01 00:00:00

abstract：:At least three human cytomegalovirus polypeptides are targets for virus neutralizing antibody; a single protein of 86,000 molecular weight (p86) and two coimmunoprecipitating proteins of 130,000 and 55,000 molecular weight (p130/55). These polypeptides have been isolated by immunoaffinity chromatography and tested for...

journal_title：Virology

authors： Rasmussen L,Mullenax J,Nelson M,Merigan TC

更新日期：1985-08-01 00:00:00

abstract：:Nucleotide sequence determination of the coat protein cistron of the alfalfa mosaic virus (AIMV) temperature-sensitive mutant, Tbts 7 (uv) revealed a small number of point mutations of which only one results in the replacement of an amino acid: the asparagine residue at position 126 is replaced by an aspartate residue...

journal_title：Virology

authors： Huisman MJ,Cornelissen BJ,Groenendijk CF,Bol JF,van Vloten-Doting L

更新日期：1989-08-01 00:00:00

abstract：:The major late promoter (MLP) of the subgroup C human adenoviruses is a preeminent model for the study of the mechanisms of basal and activated transcription, both in vivo and in vitro. However, while the structure and function of the human virus MLP has been the subject of extensive investigation, the conservation of...

journal_title：Virology

authors： Song B,Hu SL,Darai G,Spindler KR,Young CS

更新日期：1996-06-15 00:00:00

abstract：:Within the family of Poxviridae, the entomopoxviruses are the most distant relatives of the more well-known and intensively studied orthopoxviruses (vaccinia and variola). The growth of the entomopoxvirus from Amsacta moorei (AmEPV) has been characterized in cell culture and compared to that of vaccinia virus (VV), th...

journal_title：Virology

authors： Winter J,Hall RL,Moyer RW

更新日期：1995-08-20 00:00:00

abstract：:Full-length cDNA clones of RNA 2 of tobacco rattle virus (TRV) strain PLB have been cloned into the transcription vector pPM1. Products of in vitro transcription by Escherichia coli RNA polymerase, either capped or uncapped, were as infectious as native RNA 2 when coinoculated with RNA 1 of TRV strain TCM. At least 70...

journal_title：Virology

authors： Angenent GC,Posthumus E,Bol JF

更新日期：1989-11-01 00:00:00

abstract：:We have used cells infected with the HIV-1 molecular clone HX10 to study the binding of monoclonal antibodies (mAbs) to different epitopes within the extracellular domain of the HIV-1 transmembrane glycoprotein gp41. Gp41 mAb binding to the infected cells at 4 degrees was variable but weaker than the binding of an ant...

journal_title：Virology

authors： Sattentau QJ,Zolla-Pazner S,Poignard P

更新日期：1995-01-10 00:00:00

abstract：:Cells infected with a reassortant (113/Ho, H7N2) between A/fowl plague/Rostock/34 (FPV, H7N1) and A/Hong Kong/1/68 (H3N2) carrying RNA segments 1 and 6 of the Hong Kong virus and the residual genes of FPV, synthesized at 40 degrees a neuraminidase (NA) which is enzymatically not active and which is not incorporated in...

journal_title：Virology

authors： Breuning A,Scholtissek C

更新日期：1986-04-15 00:00:00

abstract：:Gene transfer into human hematopoietic stem cells using Ad5 is inefficient due to lack of the primary receptor CAR and the secondary receptors alphavbeta3 integrin and alphavbeta5 integrin, and due to the high seroprevalence of Ad5 antibodies in most adults, resulting in diminished gene transduction. In the present st...

journal_title：Virology

authors： Mei YF,Segerman A,Lindman K,Hörnsten P,Wahlin A,Wadell G

更新日期：2004-10-25 00:00:00

abstract：:Phylogenetic analysis of the N8 neuraminidase (NA) genes from 18 influenza A viruses, representing equine and avian hosts in different geographic locations, revealed three major lineages: (i) currently circulating equine 2 viruses; (ii) avian viruses isolated in the Eurasian region, including A/Equine/Jilin/1/89, a re...

journal_title：Virology

authors： Saito T,Kawaoka Y,Webster RG

更新日期：1993-04-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68) is used as a model to study gammaherpesvirus pathogenesis both in tissue culture systems and in vivo. We used a gene-trapping approach to get insight into cellular factors involved in MHV68 infection. By generating a library of gene-trapped CHO cells, we were able to isolate several ...

journal_title：Virology

authors： Jarousse N,Coscoy L

更新日期：2008-04-10 00:00:00

abstract：:It is unknown which HIV proteins to target by vaccination in order to generate the most effective CD8 T-cell immunity. We recently immunized SIV(mac251)-infected pigtail macaques with Gag peptides or a cocktail of peptides spanning all SIV proteins, including SIV Env. High-level SIV Env-specific CD8 T-cell responses w...

journal_title：Virology

authors： Peut V,Kent SJ

更新日期：2009-02-05 00:00:00

abstract：:The 3' end of hepatitis E virus (HEV) contains cis-acting regulatory element, which plays an important role in viral replication. To develop specific replication inhibitor at the molecular level, mono- and di-hammerhead ribozymes (Rz) were designed and synthesized against the conserved 3' end sequences of HEV, which c...

journal_title：Virology

authors： Sriram B,Thakral D,Panda SK

更新日期：2003-08-01 00:00:00