Abstract:
:Coronavirus E protein is a small viral envelope protein that plays an essential role in coronavirus assembly; coexpression of coronavirus M and E proteins results in the production of virus-like particles. The present study demonstrated that mouse hepatitis virus (MHV) E protein was released as an integral membrane protein in lipid vesicles from E-protein-expressing mammalian cells, in the absence of other MHV proteins. Furthermore, our data indicated that the E-protein-containing vesicles, which had a slightly lighter buoyant density than that of MHV, were released from MHV-infected cells. These data implied that E protein alone can drive the production and release of coronavirus envelope in the absence of M protein.
journal_name
Virologyjournal_title
Virologyauthors
Maeda J,Maeda A,Makino Sdoi
10.1006/viro.1999.9955subject
Has Abstractpub_date
1999-10-25 00:00:00pages
265-72issue
2eissn
0042-6822issn
1096-0341pii
S0042-6822(99)99955-5journal_volume
263pub_type
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