The rational search for natural neolignans.

abstract：:An important point in paleoparasitology is the correct diagnosis of the origin of coprolites found in archaeological sites. The identification of human and animal coprolites, through the study of the shape, size, characteristics after rehydration, alimentary contents, and the presence of parasites, has proved to be ac...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ferreira LF,Araújo A,Confalonieri U,Chame M

更新日期：1989-04-01 00:00:00

abstract：:Tungiasis is a parasitic skin disease widespread in resource-poor urban and rural communities in Brazil. Inhabitants of an urban slum in Northeast Brazil were examined for the presence of tungiasis lesions and followed-up twice a week for a period of three weeks. Each time the number, stages, and topographic localizat...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Feldmeier H,Kehr JD,Poggensee G,Heukelbach J

更新日期：2006-02-01 00:00:00

abstract：:From October 2000 to April 2001, insecticide bioassays were conducted in 18 ranches from 10 counties in the states of Mato Grosso and Mato Grosso do Sul, in Central Brazil. Horn flies from wild populations were exposed to diazinon-impregnated filter papers immediately after collection on cattle, and mortality was reco...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Barros AT,Gomes A,Ismael AP,Koller WW

更新日期：2002-09-01 00:00:00

abstract：:Two essential oils of Lippia alba (Mill.) N.E. Brown (Verbenacea), the carvone and citral chemotypes and 15 of their compounds were evaluated to determine cytotoxicity and antifungal activity. Cytotoxicity assays for both the citral and carvone chemotypes were carried out with tetrazolium-dye, which showed a dose-depe...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mesa-Arango AC,Montiel-Ramos J,Zapata B,Durán C,Betancur-Galvis L,Stashenko E

更新日期：2009-09-01 00:00:00

abstract：:The objectives of this work were to determine the prevalence of Babesia bovis, Babesia bigemina, and Anaplasma marginale detecting antibodies in cattle raised in the semi-arid region of the state of Bahia, Brazil, through indirect enzyme linked immunosorbent assays (ELISA) and to compare the performances of indirect e...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Barros SL,Madruga CR,Araújo FR,Menk CF,de Almeida MA,Melo EP,Kessler RH

更新日期：2005-10-01 00:00:00

abstract：:In 2004, the urban presence of Lutzomyia longipalpis was recorded for the first time in Formosa province. In 2006, the first autochthonous case of human urban visceral leishmaniasis (VL) was recorded in Misiones in the presence of the vector, along with some canine VL cases. After this first case, the vector began to ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Bravo AG,Quintana MG,Abril M,Salomón OD

更新日期：2013-12-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Senger MR,Evangelista TCS,Dantas RF,Santana MVDS,Gonçalves LCS,de Souza Neto LR,Ferreira SB,Silva-Junior FP

更新日期：2020-10-02 00:00:00

abstract：:Although human T-lymphotropic virus type I (HTLV-I) exhibits high genetic stability, as compared to other RNA viruses and particularly to human immunodeficiency virus (HIV), genotypic subtypes of this human retrovirus have been characterized in isolates from diverse geographical areas. These are currently believed not...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Segurado AA,Biasutti C,Zeigler R,Rodrigues C,Damas CD,Jorge ML,Marchiori PE

更新日期：2002-04-01 00:00:00

abstract：:The kidney trematode Paratanaisia bragai is reported for the first time parasitizing the ring-necked pheasant (Phasianus colchicus L., 1758) and the pathological alterations associated to the parasitism are referred on the basis of 50 specimens of this bird from backyard flocks in 11 counties of the state of Rio de Ja...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Gomes DC,Menezes RC,Tortelly R,Pinto RM

更新日期：2005-05-01 00:00:00

abstract：:The effects of radiation on the reproductive capacity and the longevity of Panstrongylus megistus were studied. An indirect correlation between longevity and radiation doses was observed. Males were more affected than females. Longevity of females submitted to 10 Gy was not different when compared to controls. Some of...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Verçosa P,Falcão PH,Furtado AF

更新日期：1993-04-01 00:00:00

abstract：:Three Yersinia pestis strains isolated from humans and one laboratory strain (EV76) were grown in rich media at 28 degrees C and 37 degrees C and their outer membrane protein composition compared by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Several proteins with molecular weights ranging f...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Abath FG,de Almeida AM,Ferreira LC

更新日期：1990-01-01 00:00:00

abstract：:Scientists have increasingly recognised that low methodological and analytical rigour combined with publish-or-perish incentives can make the published scientific literature unreliable. As a response to this, large-scale systematic replications of the literature have emerged as a way to assess the problem empirically....

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Neves K,Carneiro CF,Wasilewska-Sampaio AP,Abreu M,Valério-Gomes B,Tan PB,Amaral OB

更新日期：2020-10-23 00:00:00

abstract：:We present filaria-nested polymerase chain reaction (PCR), which is based on amplification of first internal transcribed spacer rDNA to distinguish three parasitic filarial species (Onchocerca volvulus, Mansonella ozzardi and Mansonella perstans) that can be found in the Amazon Region. Nested PCR-based identifications...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Tang TH,López-Vélez R,Lanza M,Shelley AJ,Rubio JM,Luz SL

更新日期：2010-09-01 00:00:00

abstract：:BACKGROUND The main strategy to control human malaria still relies on specific drug treatment, limited now by Plasmodium falciparum-resistant parasites, including that against artemisinin derivatives. Despite the large number of active compounds described in the literature, few of them reached full development against...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Penna-Coutinho J,Aguiar AC,Krettli\/ AU

更新日期：2018-12-06 00:00:00

abstract：:Leptoconops nosopheris sp. n. (Diptera: Ceratopogonidae) is described from a blood-filled female biting midge in Early Cretaceous Burmese amber. The new species is characterized by a very elongate terminal flagellomere, elongate cerci, and an indistinct spur on the metatibia. This biting midge contained digenetic tryp...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Poinar G Jr

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Occult hepatitis B virus (HBV) - characterized by the absence of detectable HBsAg in the presence of HBV DNA - represents a potential threat for blood safety. OBJECTIVES:This study was conducted with the aim to investigate the serological and molecular characterization of occult HBV infection (OBI) among bl...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Mabunda N,Zicai AF,Ismael N,Vubil A,Mello F,Blackard JT,Lago B,Duarte V,Moraes M,Lewis L,Jani I

更新日期：2020-09-23 00:00:00

abstract：:Lutzomyia evandroi Costa Lima and Antunes, 1936 is found in Rio Grande do Norte, northeastern Brazil, in areas of visceral and mucocutaneous leishmaniasis and follows the same geographic distribution of L. longipalpis. The biological cycle, oviposition, morphological and behavioral characteristics of the species were ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Melo Ximenes Mde F,Maciel JC,Jerônimo SM

更新日期：2001-08-01 00:00:00

abstract：:A shift from large to small average sizes was observed in Triatoma infestans and Rhodnius domesticus between field and domestic (or laboratory) conditions of life. It was more pronounced in the female specimens, leading to a subsequent reduction of sexual size dimorphism. This feature is discussed in terms of genetic ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Dujardin J,Steinden M,Chavez T,Machane M,Schofield C

更新日期：1999-07-01 00:00:00

abstract：:Multi-resistant gram-negative rods are important pathogens in intensive care units (ICU), cause high rates of mortality, and need infection control measures to avoid spread to another patients. This study was undertaken prospectively with all of the patients hospitalized at ICU, Anesthesiology of the Hospital São Paul...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Martins ST,Moreira M,Furtado GH,Marino CG,Machado FR,Wey SB,Medeiros EA

更新日期：2004-05-01 00:00:00

abstract：:Mutations in the rpoB locus confer conformational changes leading to defective binding of rifampin (RIF) to rpoB and consequently resistance in Mycobacterium tuberculosis. Polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) was established as a rapid screening test for the detection of mutatio...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Isfahani BN,Tavakoli A,Salehi M,Tazhibi M

更新日期：2006-09-01 00:00:00

abstract：:The role of intracellular free polyamine (putrescine and spermidine) pools in multiple resistance to aminoglycoside antibiotics was investigated among in vitro selected kanamycin-resistant Escherichia coli J53 mutants expressing diminished oligopeptide-binding protein (OppA) levels and/or defective ornithine decarboxy...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Acosta MB,Ferreira RC,Ferreira LC,Costa SO

更新日期：2005-11-01 00:00:00

abstract：:A survey was conducted in a blood donor population of Central Brazil aiming to investigate the prevalence of GB virus C (GBV-C)/hepatitis G virus (HGV) infection and also to analyze the virus genotypes distribution. A total of 241 voluntary blood donors were interviewed at the State Blood Bank in Goiânia, State of Goi...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Oliveira LA,Martins RM,Carneiro MA,Teles SA,Silva SA,Cardoso DD,Lampe E,Yoshida CF

更新日期：2002-10-01 00:00:00

abstract：:The nuclear phenotypes of Malpighian tubule cells in fifth instar nymphs of Triatoma infestans, one of the most important vectors of Chagas disease, were studied following sequential shocks at 0 degrees C, separated by intervals of 8 h and 24 h at 30 degrees C, under conditions of moderate fasting and full nourishment...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Campos SG,Rodrigues VL,Mello ML

更新日期：2002-09-01 00:00:00

abstract：:In this study we investigated the larval dispersal associated with larval predation in experimental populations of Chrysomya albiceps and Cochliomyia macellaria. Frequency distribution of sampling units (G test) in the substrate was used to evaluate variation in larval dispersal. An experimental acrylic channel (1 x 0...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： de Andrade JB,Rocha FA,Rodrigues P,Rosa GS,Faria Ldel B,Von Zuben CJ,Rossi MN,Godoy WA

更新日期：2002-12-01 00:00:00

abstract：:Twenty six coprolites from an archaeological site in the province of Iquique, northern Chile, were examined for parasites. Coprolites were found in two excavation units, I and II (Tiliviche site), dated respectively at 5,900 B.C. to 4,110 B.C. and 4,110 B.C. to 1,950 B.C., and identified as of human origin. Only at th...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Ferreira LF,de Araújo AJ,Confalonieri UE,Nuñez L

更新日期：1984-04-01 00:00:00

abstract：:The Global Burden of Disease Study 2010 listed schistosomiasis among the leading 100 causes of death in Brazil, responsible for 3.6% of the estimated total of deaths globally. Eye and adnexa are very rarely affected by schistosomiasis mansoni, with limited documentation of ocular pathology in this setting. This short ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Fidelis TAA,Brasileiro-Filho G,Santos HH,Vasconcelos-Santos DV,Parreiras PM,Coelho PMZ,Araujo N,Chaud MV,Lambertucci JR

更新日期：2019-01-01 00:00:00

abstract：:An epidemic of sporotrichosis, a subcutaneous mycosis caused by the fungus Sporothrix schenckii, is ongoing in Rio de Janeiro, Brazil, in which cases of human infection are related to exposure to cats. In an attempt to demonstrate the zoonotic character of this epidemic using molecular methodology, we characterised by...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Reis RS,Almeida-Paes R,Muniz Mde M,Tavares PM,Monteiro PC,Schubach TM,Gutierrez-Galhardo MC,Zancopé-Oliveira RM

更新日期：2009-08-01 00:00:00

abstract：:A new species of Brazilian phlebotomine sandfly found in Brazil, municipality of Diamantina, state of Minas Gerais, is described based on males and females collected in a quartzite cave. The body of spermathecae is continuous to the individual duct, lanky and tapering at the end, with conical shaped, not striated and ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Barata RA,Serra e Meira PC,Carvalho GM

更新日期：2012-12-01 00:00:00

abstract：:Two of the major problems facing the Amazon - human migration from the other areas and uncontrolled deforestation - constitute the greatest risk for the establishment of endemic Chagas disease in this part of Brazil. At least 18 species of triatomines had been found in the Brazilian Amazon, 10 of them infected with Tr...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Coura JR,Junqueira AC,Boia MN,Fernandes O

更新日期：1999-01-01 00:00:00

abstract：:Nitroarylidenemalononitriles and their cyanoacetamide derivatives with remarkable anti-epimastigote properties, were synthesized attempting to obtain new 3,5-diamino-4-(5'-nitroarylidene)-4H-thiadiazine 1,1-dioxide derivatives, which in previous reports had shown anti-Trypanosoma cruzi activity. Tests to evaluate the ...

journal_title：Memorias do Instituto Oswaldo Cruz

authors： Muelas-Serrano S,Le-Senne A,Fernandez-Portillo C,Nogal JJ,Ochoa C,Gomez-Barrio A

更新日期：2002-06-01 00:00:00