Citral and carvone chemotypes from the essential oils of Colombian Lippia alba (Mill.) N.E. Brown: composition, cytotoxicity and antifungal activity.

Abstract:

:Two essential oils of Lippia alba (Mill.) N.E. Brown (Verbenacea), the carvone and citral chemotypes and 15 of their compounds were evaluated to determine cytotoxicity and antifungal activity. Cytotoxicity assays for both the citral and carvone chemotypes were carried out with tetrazolium-dye, which showed a dose-dependent cytotoxic effect against HeLa cells. Interestingly, this effect on the evaluated cells (HeLa and the non-tumoural cell line, Vero) was lower than that of commercial citral alone. Commercial citral showed the highest cytotoxic activity on HeLa cells. The antifungal activity was evaluated against Candida parapsilosis, Candida krusei, Aspergillus flavus and Aspergillus fumigatus strains following the standard protocols, Antifungal Susceptibility Testing Subcommittee of the European Committee on Antibiotic Susceptibility Testing and CLSI M38-A. Results demonstrated that the most active essential oil was the citral chemotype, with geometric means-minimal inhibitory concentration (GM-MIC) values of 78.7 and 270.8 microg/mL for A. fumigatus and C. krusei, respectively. Commercial citral showed an antifungal activity similar to that of the citral chemotype (GM-MIC values of 62.5 microg/mL for A. fumigatus and 39.7 microg/mL for C. krusei). Although the citronellal and geraniol were found in lower concentrations in the citral chemotype, they had significant antifungal activity, with GM-MIC values of 49.6 microg/mL for C. krusei and 176.8 microg/mL for A. fumigatus.

journal_name

Mem Inst Oswaldo Cruz

authors

Mesa-Arango AC,Montiel-Ramos J,Zapata B,Durán C,Betancur-Galvis L,Stashenko E

doi

10.1590/s0074-02762009000600010

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

878-84

issue

6

eissn

0074-0276

issn

1678-8060

pii

S0074-02762009000600010

journal_volume

104

pub_type

杂志文章
  • When are we going to celebrate the centenary of the discovery of efficient treatment for congenital toxoplasmosis?

    abstract::In 2008, we have celebrated the centenary of the discovery of Toxoplasma gondii.Although this ubiquitous protozoan can generate devastating damage in foetuses and newborns, its treatment is the only field in which we have made little progress, despite a huge body of research, and has not yet been validated. Pregnant w...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02762009000200028

    authors: Peyron F

    更新日期:2009-03-01 00:00:00

  • On cytoadhesion of Plasmodium vivax: raison d'être?

    abstract::It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02762011000900010

    authors: Costa FT,Lopes SC,Ferrer M,Leite JA,Martin-Jaular L,Bernabeu M,Nogueira PA,Mourão MP,Fernandez-Becerra C,Lacerda MV,del Portillo H

    更新日期:2011-08-01 00:00:00

  • Colorimetric microwell plate reverse-hybridization assay for Mycobacterium tuberculosis detection.

    abstract::Direct smear examination using Ziehl-Neelsen staining for pulmonary tuberculosis (PTB) diagnosis is inexpensive and easy to use, but has the major limitation of low sensitivity. Rapid molecular methods are becoming more widely available in centralized laboratories, but they depend on timely reporting of results and st...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000200013

    authors: Michelon CT,Rosso F,Schmid KB,Sperhacke RD,Oliveira MM,Kritski AL,Rezende L Jr,Costa ER,Ribeiro AW,Verza M,Cafrune PI,Silva MS,Kuhleis D,Zaha A,Rossetti ML

    更新日期:2011-03-01 00:00:00

  • Interrelationship between ectoparasites and wild rodents from Tijucas do Sul, state of Paraná, Brazil.

    abstract::Sixteen species of ectoparasites were collected from 50 wild rodents, from August 1990 to August 1991, in an area of Araucaria augustifolia forest, in the municipality of Tijucas do Sul, State of Paraná, Brazil. Ectoparasites infested 98% of the rodents, with the highest indices of infestation found in the drycool sea...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761998000600003

    authors: Barros-Battesti DM,Arzua M,Linardi PM,Botelho JR,Sbalqueiro IJ

    更新日期:1998-11-01 00:00:00

  • A comparative study on IgG-ELISA, IgM-IFT and Kato-Katz methods for epidemiological purposes in a low endemic area for schistosomiasis.

    abstract::The high sensitivity and the possibility of automation of the enzyme-linked-immunosorbent-assay (ELISA) has indicated this technique as one of the most useful serological test for epidemiological studies. In the present study, an ELISA for detection of IgG antibodies against adult worm antigens (IgG-ELISA) was investi...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761998000700054

    authors: da Silva RM,Kanamura HY,Camargo ED,Chiodelli SG,Nakamura PM,Gargioni C,Vellosa SA,Antunes JL

    更新日期:1998-01-01 00:00:00

  • Fibrosis: a distinguishing feature in the pathology of neural leprosy.

    abstract:BACKGROUND:Fibrosis in the peripheral nerve is the end stage of leprous neuropathy and the cause of the resulting permanent neural function impairments. Preventive measures to avoid this irreversible pathological state are a relief strategy for leprosy sufferers. OBJECTIVES:The present study describes the frequency of...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760190056

    authors: Antunes SLG,Jardim MR,Vital RT,Pascarelli BMO,Nery JADC,Amadeu TP,Sales AM,da Costa EAF,Sarno EN

    更新日期:2019-01-01 00:00:00

  • Differential regulation of granuloma size and hepatic fibrosis in schistosome infections.

    abstract::Granuloma size is the variable most frequently used to evaluate the immunopathogenesis of schistosome infections. However, hepatic fibrosis is at the least an equally relevant variable. Hepatic fibrosis and the size of circumoval granulomas are frequently dissociated in experimental murine Schistosoma mansoni and S. j...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02761997000500024

    authors: Cheever AW

    更新日期:1997-09-01 00:00:00

  • Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis.

    abstract::Hepatosplenic schistosomiasis was the first human disease in which the possibility of extensive long standing hepatic fibrosis being degraded and removed has been demonstrated. When such changes occurred, the main signs of portal hypertension (splenomegaly, esophageal varices) progressively disappeared, implying that ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762006000900041

    authors: Andrade ZA,Baptista AP,Santana TS

    更新日期:2006-09-01 00:00:00

  • The role of cytokines in the pathogenesis of hepatic granulomatous disease in Schistosoma mansoni infected mice.

    abstract::Cytokines are important in the cell-mediated response to Schistosoma mansoni eggs. We have found that Th2 cytokine responses (e.g. IL-4 and IL-5) are augmented after egg laying begins while Th1 responses (IL-2 and IFN-gamma) are down regulated in S. mansoni infected mice. Treatment of mice with anti-IL-5 monoclonal an...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761992000800011

    authors: Cheever AW,Xu Y,Macedonia JG,Cox T,Hieny S,Sher A

    更新日期:1992-01-01 00:00:00

  • Development of a cyanobacterial biolarvicide.

    abstract::Results of studies on a larvicidal cyanobacterium that expresses a Bti cryIVD gene fusion are reported. Genetically altered Agmenellum quadruplicatum PR-6 is shown to be toxic to larvae of three major genera of disease-bearing mosquitos. Factors affecting expression of Bti genes in cyanobacteria are discussed. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761995000100021

    authors: Murphy RC,Stevens SE Jr

    更新日期:1995-01-01 00:00:00

  • The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives.

    abstract::Lapachol was chemically modified to obtain its thiosemicarbazone and semicarbazone derivatives. These compounds were tested for antimicrobial activity against several bacteria and fungi by the broth microdilution method. The thiosemicarbazone and semicarbazone derivatives of lapachol exhibited antimicrobial activity a...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/S0074-02762013000300013

    authors: Souza MA,Johann S,Lima LA,Campos FF,Mendes IC,Beraldo H,Souza-Fagundes EM,Cisalpino PS,Rosa CA,Alves TM,de Sá NP,Zani CL

    更新日期:2013-05-01 00:00:00

  • [Fecal coliforms in sewage. II. Transfer of markers and the presence of plasmids].

    abstract::The transference of the genetic markers and the presence of DNA plasmidial in 240 cultures of Escherichia coli was investigated. The strains were originated from Waste Treatment Plant (inffluent and effluents) located in Ilha do Governador, Rio de Janeiro. By conjugation analysis, E. coli K 12 allowed the isolation of...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761988000100004

    authors: Vincente AC,Dias JC,Hofer E

    更新日期:1988-01-01 00:00:00

  • Evaluation of a monoclonal antibody affinity purified antigen for zymodeme specific serological diagnosis of Trypanosoma cruzi infection.

    abstract::Theoretically, serological assays with affinity purified marker antigens can allow strain-specific diagnosis even when parasites cannot be retrieved from an infected host. A Trypanosoma cruzi antigen was purified by affinity chromatography using a zymodeme (Z) 2 specific monoclonal antibody (2E2C11). An indirect enzym...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761987000100014

    authors: Schechter M

    更新日期:1987-01-01 00:00:00

  • Scanning electron microscopic study of Prosorhynchoides arcuatus (Linton, 1990) (Bucephalidae: Digenea).

    abstract::Prosorhynchoides arcuatus (Linton, 1900) from the intestine of Pomatomus saltator (L.) from the Atlantic coast of the State of Rio de Janeiro is studied by scanning electron microscopy, with detailed description of tegumental spines. Comments on the synonymy of this species with Bucephalopsis callicotyle Kohn, 1962 ar...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761995000100007

    authors: Cohen SC,Kohn A,Barth OM

    更新日期:1995-01-01 00:00:00

  • Genetic compatibility between Anopheles lesteri from Korea and Anopheles paraliae from Thailand.

    abstract::To assess differentiation and relationships between Anopheles lesteri and Anopheles paraliae we established three and five iso-female lines of An. lesteri from Korea and An. paraliae from Thailand, respectively. These isolines were used to investigate the genetic relationships between the two taxa by crossing experime...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/S0074-02762013000300009

    authors: Taai K,Baimai V,Saeung A,Thongsahuan S,Min GS,Otsuka Y,Park MH,Fukuda M,Somboon P,Choochote W

    更新日期:2013-05-01 00:00:00

  • Biochemistry and mode of action of the Bacillus sphaericus toxins.

    abstract::Bacillus sphaericus produces at least two toxins which are highly toxic to mosquito larvae. The binary toxin, which is comprised of proteins of 51.4 and 41.9 kDa, is present in all highly insecticidal strains. The 100 kDa SSII-1 toxin is present in most highly insecticidal as well as the weakly insecticidal strains. T...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761995000100018

    authors: Davidson EW

    更新日期:1995-01-01 00:00:00

  • Certifying the interruption of Chagas disease transmission by native vectors: cui bono?

    abstract::Certifying the absence of Chagas disease transmission by native vectors lacks scientific grounds and weakens long-term control-surveillance systems to the detriment of people living under risk conditions. Instead, a regular "certification of good practice" (including vector control-surveillance, case detection/patient...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-0276108022013022

    authors: Abad-Franch F,Diotaiuti L,Gurgel-Gonçalves R,Gürtler RE

    更新日期:2013-04-01 00:00:00

  • Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil.

    abstract::Few studies are available on hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection in populations living in small and medium-sized Brazilian cities. We evaluated the seroprevalence of these viruses in selected individuals from a clinic of infectology, who were referred to...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762009000700003

    authors: Portelinha Filho AM,Nascimento CU,Tannouri TN,Troiani C,Ascêncio EL,Bonfim R,D'Andrea LA,Prestes-Carneiro LE

    更新日期:2009-11-01 00:00:00

  • Characterization of the hemagglutinin receptor specificity and neuraminidase substrate specificity of clinical isolates of human influenza A viruses.

    abstract::Six clinical isolates of influenza A viruses were examined for hemagglutinin receptor specificity and neuraminidase substrate specificity. All of the viral isolates minimally passaged in mammalian cells demonstrated preferential agglutination of human erythrocytes enzymatically modified to contain NeuAc alpha 2,6Gal s...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761994000400015

    authors: Couceiro JN,Baum LG

    更新日期:1994-10-01 00:00:00

  • Toxocara canis and the allergic process.

    abstract::The protective effect of infectious agents against allergic reactions has been thoroughly investigated. Current studies have demonstrated the ability of some helminths to modulate the immune response of infected hosts. The objective of the present study was to investigate the relationship between Toxocara canis infect...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760150051

    authors: Zaia MG,Oliveira SR,Castro CA,Soares EG,Afonso A,Monnazzi LG,Peitl Filho O,Faccioli LH,Anibal Fde F

    更新日期:2015-09-01 00:00:00

  • First genotyping of Giardia lamblia from human and animal feces in Argentina, South America.

    abstract::The purpose of this study was to investigate the genotypes of Giardia lamblia from human and animal feces and their epidemiological and clinical characteristics in Argentina, South America. Seventy isolates, 60 from humans (adults and children), eight from dogs and two from cows were processed by polymerase chain reac...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762008000100015

    authors: Minvielle MC,Molina NB,Polverino D,Basualdo JA

    更新日期:2008-02-01 00:00:00

  • Phylogeny, ultrastructure, histopathology and prevalence of Myxobolus oliveirai sp. nov., a parasite of Brycon hilarii (Characidae) in the Pantanal wetland, Brazil.

    abstract::This paper presents the morphological, histological and ultrastructural characteristics of Myxobolus oliveirai sp. nov., a parasite of the gill filaments in Brycon hilarii from the Brazilian Pantanal. Out of 216 B. hilariispecimens examined (126 wild and 90 cultivated), 38.1% of wild specimens (n = 48) were infected. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762010000600006

    authors: Milanin T,Eiras JC,Arana S,Maia AA,Alves AL,Silva MR,Carriero MM,Ceccarelli PS,Adriano EA

    更新日期:2010-09-01 00:00:00

  • Immune response in cattle vaccinated against rabies.

    abstract::In order to determine the best type of rabies vaccine to use as a booster, 78 serological samples from singly vaccinated cattle were analyzed by counterimmunoelectrophoresis technique. The animals were divided into several groups, received the first vaccine dose with modified live virus vaccine (ERA strain) and were r...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762000000100013

    authors: Oliveira AN,Andrade MC,Silva MV,Moura WC,Cortez Contreiras E

    更新日期:2000-01-01 00:00:00

  • Triatoma jatai sp. nov. in the state of Tocantins, Brazil (Hemiptera: Reduviidae: Triatominae).

    abstract::Triatoma jatai sp. nov. is the first new species of triatomine to be described in the state of Tocantins, in the northern region of Brazil. It was caught on rock outcrops in the wild environment and, more recently, invading homes. While T. jatai sp. nov. is morphologically similar to Triatoma costalimai, it is disting...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/S0074-0276108042013006

    authors: Gonçalves TC,Teves-Neves SC,Santos-Mallet JR,Carbajal-de-la-Fuente AL,Lopes CM

    更新日期:2013-06-01 00:00:00

  • Comparative analysis by polymerase chain reaction amplified minicircles of kinetoplast DNA of a stable strain of Trypanosoma cruzi from São Felipe, Bahia, its clones and subclones: possibility of predominance of a principal clone in this area.

    abstract::Molecular characterization of one stable strain of Trypanosoma cruzi, the 21 SF, representative of the pattern of strains isolated from the endemic area of São Felipe, State of Bahia, Brazil, maintained for 15 years in laboratory by serial passages in mice and classified as biodeme Type II and zymodeme 2 has been inve...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761999000100009

    authors: Campos RF,Gonçalves MS,dos Reis EA,dos Reis MG,Andrade SG

    更新日期:1999-01-01 00:00:00

  • A comparison of simian rotavirus SA11 preparations maintained in different laboratories.

    abstract::Preparations of simian rotavirus SA11 maintained in different laboratories were compared with each other by polyacrylamide gel electrophoresis of genomic RNA. Differences in the migration of genome segments 4, 5 and 7 allowed the classification of eight virus preparations into four electrophoretic types. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761986000400005

    authors: Pereira HG,Gouvea VS,Fialho AM

    更新日期:1986-10-01 00:00:00

  • COI barcode versus morphological identification of Culex (Culex) (Diptera: Culicidae) species: a case study using samples from Argentina and Brazil.

    abstract::Sequences of the cytochrome c oxidase subunit I (COI) mitochondrial gene from adults of 22 Culex (Culex) species from Argentina and Brazil were employed to assess species identification and to test the usefulness of COI for barcoding using the best close match (BCM) algorithm. A pairwise Kimura two-parameter distance ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-0276130457

    authors: Laurito M,Oliveira TM,Almirón WR,Sallum MA

    更新日期:2013-01-01 00:00:00

  • Leprosy, a neglected disease that causes a wide variety of clinical conditions in tropical countries.

    abstract::Leprosy is an ancient disease that remains endemic and continues to be a major public health problem in some tropical countries, where it has been internationally recognized as being linked to the underdevelopment conditions. The natural course of the disease covers a wide variety of clinical conditions with systemic ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02762012000900006

    authors: Foss NT,Motta AC

    更新日期:2012-12-01 00:00:00

  • [Complement fixation reaction in the typing of influenza viruses isolated in Rio de Janeiro].

    abstract::The author studied by the complement fixation test the influenza virus strains isolated in Rio de Janeiro during the 1973 epidemic. He prepared immunesera in hamsters by the inoculation of the allantoic fluid from infected chick embryos with each of the 7 isolated strains and the standard strains. The soluble antigens...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761976000200004

    authors: Lacorte JG

    更新日期:1976-01-01 00:00:00

  • Acute Chagas disease in the state of Pará, Amazon Region: is it increasing?

    abstract::Acute Chagas disease (ACD) has a distinct epidemiological profile in the Amazon Region, with cases and outbreaks of Trypanosoma cruzi infection being possibly related to the ingestion of contaminated food. Data on ACD in the state of Pará retrieved from 2000 to 2016 from the Brazilian Notifiable Diseases Information S...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-02760170298

    authors: Santos VRCD,Meis J,Savino W,Andrade JAA,Vieira JRDS,Coura JR,Junqueira ACV

    更新日期:2018-01-01 00:00:00