The thalamic intergeniculate leaflet mediates locomotor activity-induced reversal of phenotype in photoperiod nonresponsive Siberian hamsters.

abstract：:Circadian clocks drive daily rhythms of physiology and behavior in multiple organisms and synchronize these rhythms to environmental cycles of light and temperature. The basic mechanism of the clock consists of a transcription-translation feedback loop, in which key clock proteins negatively regulate their own transcr...

journal_title：Journal of biological rhythms

authors： Shakhmantsir I,Sehgal A

更新日期：2019-12-01 00:00:00

abstract：:The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

journal_title：Journal of biological rhythms

authors： Rohling J,Wolters L,Meijer JH

更新日期：2006-08-01 00:00:00

abstract：:A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...

journal_title：Journal of biological rhythms

authors： Pilorz V,Kolms B,Oster H

更新日期：2020-12-01 00:00:00

abstract：:The safety and efficacy of chemotherapeutics can vary as a function of the time of their delivery during the day. This study aimed to improve the treatment of glioblastoma (GBM), the most common brain cancer, by testing whether the efficacy of the DNA alkylator temozolomide (TMZ) varies with the time of its administra...

journal_title：Journal of biological rhythms

authors： Slat EA,Sponagel J,Marpegan L,Simon T,Kfoury N,Kim A,Binz A,Herzog ED,Rubin JB

更新日期：2017-04-01 00:00:00

abstract：:Sleep disturbances are an all-too-familiar symptom of jet lag and a prime source of complaints for transmeridian travelers and flight crews alike. They are the result of a temporary loss of synchrony between an abruptly shifted sleep period, timed in accordance with the new local day-night cycle, and a gradually reent...

journal_title：Journal of biological rhythms

authors： Boulos Z,Campbell SS,Lewy AJ,Terman M,Dijk DJ,Eastman CI

更新日期：1995-06-01 00:00:00

abstract：:Temperature compensation of circadian rhythms in neuronal firing rate was investigated in the suprachiasmatic nucleus (SCN) of ground squirrels and rats in vitro. A reduction in SCN temperature from 37 to 25 degrees C reduced peak firing rates by > 70% in rats but only by approximately 21% in squirrels; trough firing ...

journal_title：Journal of biological rhythms

authors： Ruby NF,Heller HC

更新日期：1996-06-01 00:00:00

abstract：:A 12-hr dark period, at a temperature high enough to permit time measurement to occur, is necessary for maximal induction of larval diapause in the European corn borer, Ostrinia nubilalis. In the present study, induction of diapause only occurred in a periodic environment. This was in the form of certain (1) light-dar...

journal_title：Journal of biological rhythms

authors： Skopik SD,Cain W,Patel NG,Newswanger DL

更新日期：1986-07-01 00:00:00

abstract：:Abstract The cyanobacterial clock protein KaiC regulates the circadian cycle by exhibiting rhythms in transcription, translation, and phosphorylation. KaiC phosphorylation persists in circadian cycling even under transcription-less conditions and was reconstituted in vitro by incubating KaiC, KaiA, and KaiB. This pres...

journal_title：Journal of biological rhythms

authors： Takigawa-Imamura H,Mochizuki A

更新日期：2006-10-01 00:00:00

abstract：:Past research has shown that there is a circadian oscillator in laboratory rats that is entrained by restricted feeding schedules. However, in laboratory rats at least, the light-dark (LD) cycle is the dominant zeitgeber in the entrainment of wheel-running activity rhythms. Given that dasyurid marsupials are predomina...

journal_title：Journal of biological rhythms

authors： Coleman GJ,O'Reilly HM,Armstrong SM

更新日期：1989-04-01 00:00:00

abstract：:DEC1 and DEC2-basic helix-loop-helix transcription factors-exhibit a circadian expression in the suprachiasmatic nucleus and other peripheral tissues and seem to play roles in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated promoters of Per1, Dec1, and Dec2. The authors present data ...

journal_title：Journal of biological rhythms

authors： Noshiro M,Furukawa M,Honma S,Kawamoto T,Hamada T,Honma K,Kato Y

更新日期：2005-10-01 00:00:00

abstract：:Most of the anatomical and molecular substrates of the system that encodes changes in photoperiod in the duration of melatonin secretion, and the receptor molecules that read this signal, have been shown to be conserved in monkeys and humans, and the functions of this system appear to be intact from the level of the r...

journal_title：Journal of biological rhythms

authors： Wehr TA

更新日期：2001-08-01 00:00:00

abstract：:Despite the omnipresence of artificial and natural light exposure, there exists little guidance in the United States and elsewhere on light exposure in terms of timing, intensity, spectrum, and other light characteristics known to affect human health, performance, and well-being; in parallel, there is little informati...

journal_title：Journal of biological rhythms

authors： Mason IC,Boubekri M,Figueiro MG,Hasler BP,Hattar S,Hill SM,Nelson RJ,Sharkey KM,Wright KP,Boyd WA,Brown MK,Laposky AD,Twery MJ,Zee PC

更新日期：2018-10-01 00:00:00

abstract：:Ground squirrels, Spermophilus tridecemlineatus, were kept in a 12:12 h light-dark cycle. As expected for a diurnal species, their locomotor activity occurred almost entirely in the daytime. Expression of mPer1 and mPer2 in the suprachiasmatic nucleus was studied at six time points by in situ hybridization. For both t...

journal_title：Journal of biological rhythms

authors： Mrosovsky N,Edelstein K,Hastings MH,Maywood ES

更新日期：2001-10-01 00:00:00

abstract：:How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to va...

journal_title：Journal of biological rhythms

authors： Butler MP,Silver R

更新日期：2009-10-01 00:00:00

abstract：:The aim of this study was to replicate and extend previous work in which the authors observed lower, shorter, and advanced nocturnal melatonin secretion patterns in premenstrually depressed patients compared to those in healthy control women. The authors also sought to test the hypothesis that the therapeutic effect o...

journal_title：Journal of biological rhythms

authors： Parry BL,Berga SL,Mostofi N,Klauber MR,Resnick A

更新日期：1997-02-01 00:00:00

abstract：:Two major approaches have been used to model circadian clocks. Qualitative modeling, used prior to the recent wealth of detailed molecular knowledge, makes general predictions but cannot provide detailed mechanistic insights. The more recent biophysical approach, on the other hand, incorporates the biochemical events ...

journal_title：Journal of biological rhythms

authors： Forger D,Gonze D,Virshup D,Welsh DK

更新日期：2007-06-01 00:00:00

abstract：:The circadian system in higher organisms temporally orchestrates rhythmic changes in a vast number of genes and gene products in different organs. Complex interactions between these components, both within and among cells, ultimately lead to rhythmic behavior and physiology. Identifying the plethora of circadian targe...

journal_title：Journal of biological rhythms

authors： De Haro L,Panda S

更新日期：2006-12-01 00:00:00

abstract：:Aging alters numerous aspects of circadian biology, including the amplitude of rhythms generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, the site of the central circadian pacemaker in mammals, and the response of the pacemaker to environmental stimuli such as light. Although previous studies have desc...

journal_title：Journal of biological rhythms

authors： Kolker DE,Fukuyama H,Huang DS,Takahashi JS,Horton TH,Turek FW

更新日期：2003-04-01 00:00:00

abstract：:The hematologic system performs a number of essential functions, including oxygen transport, the execution of the immune response against tumor cells and invading pathogens, and hemostasis (blood clotting). These roles are performed by erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (p...

journal_title：Journal of biological rhythms

authors： Pritchett D,Reddy AB

更新日期：2015-10-01 00:00:00

abstract：:Numerous studies have demonstrated sleep-promoting effects of melatonin treatment in humans, as evidenced by subjects' self-reports, polysomnographic recordings, and continuous actigraphic registration of motor activity. The sleep-promoting effects of either physiological or pharmacological doses of melatonin typicall...

journal_title：Journal of biological rhythms

authors： Zhdanova IV,Wurtman RJ

更新日期：1997-12-01 00:00:00

abstract：:In Drosophila melanogaster, disruption of night by even short light exposures results in degradation of the clock protein TIMELESS (TIM), leading to shifts in the fly molecular and behavioral rhythms. Several lines of evidence indicate that light entrainment of the brain clock involves the blue-light photoreceptor cry...

journal_title：Journal of biological rhythms

authors： Ivanchenko M,Stanewsky R,Giebultowicz JM

更新日期：2001-06-01 00:00:00

abstract：:Crustaceans have frequently been used to study the neuroethology of both agonistic behavior and circadian rhythms, but whether their highly stereotyped and quantifiable agonistic activity is controlled by circadian pacemakers has, so far, not been investigated. Isolated marbled crayfish (Procambarus spec.) displayed r...

journal_title：Journal of biological rhythms

authors： Farca Luna AJ,Hurtado-Zavala JI,Reischig T,Heinrich R

更新日期：2009-02-01 00:00:00

abstract：:The circadian rhythm of eclosion activity and its pacemaker were analyzed in a series of latitudinal races of Drosophila auraria ranging from 34.2 degrees to 42.9 degrees N in Japan. The phase of the rhythm (psi EL) to the daily photoperiod (PP) changes as daylength is increased, and the slope of psi EL (PP) changes w...

journal_title：Journal of biological rhythms

authors： Pittendrigh CS,Takamura T

更新日期：1989-07-01 00:00:00

abstract：:A physiologically based mathematical model of a putative sleep-wake regulatory network is used to investigate the transition from typical human sleep patterns to spontaneous internal desynchrony behavior observed under temporal isolation conditions. The model sleep-wake regulatory network describes the neurotransmitte...

journal_title：Journal of biological rhythms

authors： Gleit RD,Diniz Behn CG,Booth V

更新日期：2013-10-01 00:00:00

abstract：:In mammals, the suprachiasmatic nucleus (SCN) is the central pacemaker organizing circadian rhythms of behavior and physiology. At the cellular level, the mammalian clock consists of autoregulatory feedback loops involving a set of "clock genes," including the Cryptochrome (Cry) genes, Cry1 and Cry2. Experimental evid...

journal_title：Journal of biological rhythms

authors： Evans JA,Pan H,Liu AC,Welsh DK

更新日期：2012-12-01 00:00:00

abstract：:The measurement of circulating levels of brain-derived neurotrophic factor (BDNF) has been proposed to be a marker of disease and an indicator of recovery. Thus, knowing the temporal pattern and influence of potential circadian rhythms is important. Although several studies have measured BDNF at different times of day...

journal_title：Journal of biological rhythms

authors： Cain SW,Chang AM,Vlasac I,Tare A,Anderson C,Czeisler CA,Saxena R

更新日期：2017-02-01 00:00:00

abstract：:Hibernating animals have been a successful model system for elucidating fundamental properties of many physiological systems. Over the past 50 years, a diverse literature has emerged on the role of the circadian system in control and expression of winter torpor in several orders of birds and mammals. This body of rese...

journal_title：Journal of biological rhythms

authors： Ruby NF

更新日期：2003-08-01 00:00:00

abstract：:An outstanding unresolved issue in chronobiology is how the level of locomotor activity influences length of the free-running, endogenous circadian period (tau). To address this issue, the authors studied a novel model, 4 replicate lines of laboratory house mice (Mus domesticus) that had been selectively bred for high...

journal_title：Journal of biological rhythms

authors： Koteja P,Swallow JG,Carter PA,Garland T Jr

更新日期：2003-12-01 00:00:00

abstract：:Mice homozygous for a dominant-negative allele of the Clock gene (Clock (Δ19/Δ19)) have slightly but significantly decreased male fertility. The molecular mechanism for this reduction in fertility is unknown. In the present study, we used a small hairpin RNA (shRNA) strategy to specifically knock down the Clock gene e...

journal_title：Journal of biological rhythms

authors： Liang X,Cheng S,Jiang X,He X,Wang Y,Jiang Z,Hou W,Li S,Liu Y,Wang Z

更新日期：2013-06-01 00:00:00

abstract：:Using quantitative autoradiography, 2-(125)I-melatonin binding was investigated throughout the light:dark cycle in the suprachiasmatic nuclei (SCN), paraventricular nuclei (PVT), and pars tuberalis (PT) of adult female Siberian hamsters kept for 10 weeks in either long or short photoperiods (LP or SP, respectively). P...

journal_title：Journal of biological rhythms

authors： Recio J,Pévet P,Vivien-Roels B,Míguez JM,Masson-Pévet M

更新日期：1996-12-01 00:00:00