Abstract：
:Hibernating animals have been a successful model system for elucidating fundamental properties of many physiological systems. Over the past 50 years, a diverse literature has emerged on the role of the circadian system in control and expression of winter torpor in several orders of birds and mammals. This body of research has also provided insights to circadian function in non-hibernating species. The aim of this review is to examine how this work applies to questions of general interest to chronobiologists, such as temperature compensation, the 2-oscillator model of entrainment, and suprachiasmatic nucleus (SCN) function. Convergent lines of evidence suggest a role for the SCN in timing daily torpor and controlling several parameters of hibernation. In addition to its role as a circadian pacemaker, the SCN may serve a noncircadian function in hibernators related to maintenance of energy balance.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Ruby NFdoi
10.1177/0748730403254971subject
Has Abstractpub_date
2003-08-01 00:00:00pages
275-86issue
4eissn
0748-7304issn
1552-4531journal_volume
18pub_type
杂志文章,评审abstract：:Honey bee workers care for ("nurse") the brood around the clock without circadian rhythmicity, but then they forage outside with strong circadian rhythms and a consolidated nightly rest. This chronobiological plasticity is associated with variation in the expression of the canonical "clock genes" that regulate the cir...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730411431404
更新日期：2012-02-01 00:00:00
abstract：:Since the advent of techniques to investigate gene expression on a large scale, numerous circadian rhythms in mRNA amount have been reported. These rhythms generally differ in amplitude and phase. The authors investigated how far a parameter not regulated by the circadian clock can influence the phase of a rhythm in R...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730408325753
更新日期：2008-12-01 00:00:00
abstract：:Many mammalian cell types show daily rhythms in gene expression driven by a circadian pacemaker. For example, cultured astrocytes display circadian rhythms in Period1 and Period2 expression. It is not known, however, how or which intercellular factors synchronize and sustain rhythmicity in astrocytes. Because astrocyt...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730409332042
更新日期：2009-04-01 00:00:00
abstract：:In isolated slices of hypothalamus, suprachiasmatic nucleus (SCN) neurons were recorded intracellularly. Blockade of Ca++ channels increased spike duration, eliminating an early component of the afterhyperpolarization (AHP) that followed evoked spikes. The duration and reversal potential of AHPs were, however, unaffec...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049000500106
更新日期：1990-04-01 00:00:00
abstract：:A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730420965291
更新日期：2020-12-01 00:00:00
abstract：:Several authors have suggested that the transcriptional regulatory protein c-Fos might be part of the mechanism for photic entrainment of the circadian pacemaker in the suprachiasmatic nucleus (SCN) to environmental light:dark cycles. This hypothesis has been based on evidence gathered using single light pulses admini...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049601100104
更新日期：1996-03-01 00:00:00
abstract：:Systematic treatment of hamsters with triazolam (TRZ) or novel wheel (NW) access will yield PRCs similar to those for neuropeptide Y. Both TRZ and NW access require an intact intergeniculate leaflet (IGL) to modulate circadian rhythm phase. It is commonly suggested that both stimulus types influence rhythm phase respo...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873098129000327
更新日期：1998-12-01 00:00:00
abstract：:Perhaps the most observable of the many circadian oscillations that have been described in both vertebrate and invertebrate animals is the daily alterations in periods of rest and activity. Recent studies in the fruit fly Drosophila melanogaster suggest that these periods of inactivity are not simply rest but share ma...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730402239672
更新日期：2003-02-01 00:00:00
abstract：:A 24-h treatment with the cytokine tumor necrosis factor-alpha (TNF-alpha) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet unknown molecul...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730409336579
更新日期：2009-08-01 00:00:00
abstract：:An intricate transcription-translation feedback loop (TTFL) governs cellular circadian rhythms in mammals. Here, we report that the zinc finger transcription factor Krüppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modu...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730420913205
更新日期：2020-06-01 00:00:00
abstract：:A single light episode during the first larval stage can set the phase of adult Drosophila activity rhythms, showing that a light-sensitive circadian clock is functional in larvae and is capable of keeping time throughout development. These behavioral data are supported by the finding that neurons expressing clock pro...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730403260621
更新日期：2004-02-01 00:00:00
abstract：:Two major approaches have been used to model circadian clocks. Qualitative modeling, used prior to the recent wealth of detailed molecular knowledge, makes general predictions but cannot provide detailed mechanistic insights. The more recent biophysical approach, on the other hand, incorporates the biochemical events ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730407301823
更新日期：2007-06-01 00:00:00
abstract：:The mammalian endogenous circadian clock, the suprachiasmatic nuclei, receives environmental inputs, namely the light-dark cycle, through photopigments located in the eye and from melanopsin-expressing retinal ganglion cells. The authors investigated the influence of light wavelength and intensity on the synchronizati...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730410368244
更新日期：2010-06-01 00:00:00
abstract：:Nonphotic stimuli can reset and entrain circadian activity rhythms in hamsters and mice, and serotonin is thought to be involved in the phase-resetting effects of these stimuli. In the present study, the authors examined the effect of the serotonin agonist quipazine on circadian activity rhythms in three inbred strain...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873099129000524
更新日期：1999-04-01 00:00:00
abstract：:Rats anticipate a fixed daily feeding time by entrainment of a component of their multioscillatory circadian system. The range of stimuli capable of entraining this component is little studied. Previous studies suggest that restricted water access is not an effective entrainment stimulus, as measured by general locomo...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049200700206
更新日期：1992-07-01 00:00:00
abstract：:Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730415582127
更新日期：2015-06-01 00:00:00
abstract：:While the rapid development of personal computers and high-throughput recording systems for circadian rhythms allow chronobiologists to produce huge amounts of data, the software to analyze them often lags behind. Here, we announce newly developed chronobiology software that is easy to use, compatible with many differ...
journal_title：Journal of biological rhythms
pub_type： 信件
doi：10.1177/0748730411414264
更新日期：2011-10-01 00:00:00
abstract：:In vertebrates, reproductive output often increases with age. Unlike older birds, first-year photoperiodic birds lack experience with the reproductively stimulatory effects of long day lengths (photostimulation). We examined whether age-related differences in annual reproductive development could be partially attribut...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730412468087
更新日期：2013-02-01 00:00:00
abstract：:African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730409360963
更新日期：2010-04-01 00:00:00
abstract：:The circadian rhythm of eclosion activity and its pacemaker were analyzed in a series of latitudinal races of Drosophila auraria ranging from 34.2 degrees to 42.9 degrees N in Japan. The phase of the rhythm (psi EL) to the daily photoperiod (PP) changes as daylength is increased, and the slope of psi EL (PP) changes w...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:Male rose-ringed parakeets (Psittacula krameri) were transferred to a long photoperiod (LP; LD 16:8) or a short photoperiod (SP; LD 8:16) for 45 or 90 days on four dates corresponding to the beginnings of different reproductive phases in an annual testicular cycle, and testicular responsiveness was evaluated by compar...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049200700102
更新日期：1992-04-01 00:00:00
abstract：:The Drosophila clock relies on transcriptional feedback loops that generate daily oscillations of the clock gene expression at mRNA and protein levels. In the evening, the CLOCK (CLK) and CYCLE (CYC) basic helix-loop-helix (bHLH) PAS-domain transcription factors activate the expression of the period (per) and timeless...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730407313817
更新日期：2008-04-01 00:00:00
abstract：:Austrovenus stutchburyi is an intertidal, burrowing, filter-feeding bivalve. It exhibits a strong, approximately tidal pattern in the time of gaping of its valves when in constant laboratory conditions. Individuals that have been held in laboratory conditions long enough to lose their overt gaping pattern will respond...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049701200208
更新日期：1997-04-01 00:00:00
abstract：:The safety and efficacy of chemotherapeutics can vary as a function of the time of their delivery during the day. This study aimed to improve the treatment of glioblastoma (GBM), the most common brain cancer, by testing whether the efficacy of the DNA alkylator temozolomide (TMZ) varies with the time of its administra...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417696788
更新日期：2017-04-01 00:00:00
abstract：:The measurement of circulating levels of brain-derived neurotrophic factor (BDNF) has been proposed to be a marker of disease and an indicator of recovery. Thus, knowing the temporal pattern and influence of potential circadian rhythms is important. Although several studies have measured BDNF at different times of day...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417693124
更新日期：2017-02-01 00:00:00
abstract：:Numerous studies have used the classic van der Pol oscillator, which contains a cubic nonlinearity, to model the effect of light on the human circadian pacemaker. Jewett and Kronauer demonstrated that Aschoff's rule could be incorporated into van der Pol type models and used a van der Pol type oscillator with higher o...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873099129000867
更新日期：1999-12-01 00:00:00
abstract：:Past research has shown that there is a circadian oscillator in laboratory rats that is entrained by restricted feeding schedules. However, in laboratory rats at least, the light-dark (LD) cycle is the dominant zeitgeber in the entrainment of wheel-running activity rhythms. Given that dasyurid marsupials are predomina...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873048900400104
更新日期：1989-04-01 00:00:00
abstract：:Whether the circatidal rhythm is generated by a machinery common to the circadian clock is one of the important and interesting questions in chronobiology. The mangrove cricket Apteronemobius asahinai shows a circatidal rhythm generating active and inactive phases and a circadian rhythm modifying the circatidal rhythm...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730413516309
更新日期：2014-02-01 00:00:00
abstract：:Although pineal "synaptic" ribbons (SR) are frequently examined by means of quantitative electron microscopy, their functional significance remains unclear. The same is true for related structures--"synaptic" spherules (SPH). In the course of such studies, it has been noted that SR counts may differ from laboratory to...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873048800300103
更新日期：1988-04-01 00:00:00
abstract：:The hematologic system performs a number of essential functions, including oxygen transport, the execution of the immune response against tumor cells and invading pathogens, and hemostasis (blood clotting). These roles are performed by erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (p...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/0748730415592729
更新日期：2015-10-01 00:00:00
