Light treatment for sleep disorders: consensus report. VII. Jet lag.


:Sleep disturbances are an all-too-familiar symptom of jet lag and a prime source of complaints for transmeridian travelers and flight crews alike. They are the result of a temporary loss of synchrony between an abruptly shifted sleep period, timed in accordance with the new local day-night cycle, and a gradually reentraining circadian system. Scheduled exposure to bright light can, in principle, alleviate the symptoms of jet lag by accelerating circadian reentrainment to new time zones. Laboratory simulations, in which sleep time is advanced by 6 to 8 h and the subjects exposed to bright light for 3 to 4 h during late subjective night on 2 to 4 successive days, have not all been successful. The few field studies conducted to date have had encouraging results, but their applicability to the population at large remains uncertain due to very limited sample sizes. Unresolved issues include optimal times for light exposure on the first as well as on subsequent treatment days, whether a given, fixed, light exposure time is likely to benefit a majority of travelers or whether light treatment should be scheduled instead according to some individual circadian phase marker, and if so, can such a phase marker be found that is both practical and reliable.


J Biol Rhythms


Boulos Z,Campbell SS,Lewy AJ,Terman M,Dijk DJ,Eastman CI




Has Abstract


1995-06-01 00:00:00












  • Awakening to the behavioral analysis of sleep in Drosophila.

    abstract::Perhaps the most observable of the many circadian oscillations that have been described in both vertebrate and invertebrate animals is the daily alterations in periods of rest and activity. Recent studies in the fruit fly Drosophila melanogaster suggest that these periods of inactivity are not simply rest but share ma...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Shaw P

    更新日期:2003-02-01 00:00:00

  • Clocks within the Master Gland: Hypophyseal Rhythms and Their Physiological Significance.

    abstract::Various aspects of mammalian endocrine physiology show a time-of-day variation with a period of 24 h, which represents an adaptation to the daily environmental fluctuations resulting from the rotation of the earth. These 24-h rhythms in hormone abundance and consequently hormone function may rely on rhythmic signals p...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Lin XW,Blum ID,Storch KF

    更新日期:2015-08-01 00:00:00

  • Investigation of Dose-Response Relationships for Effects of White Light Exposure on Correlates of Alertness and Executive Control during Regular Daytime Working Hours.

    abstract::To date, it is largely unknown which light settings define the optimum to steer alertness and cognitive control during regular daytime working hours. In the current article, we used a multimeasure approach combined with a relatively large sample size ( N = 60) and a large range of intensity levels (20-2000 lux at eye ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Smolders KCHJ,Peeters ST,Vogels IMLC,de Kort YAW

    更新日期:2018-12-01 00:00:00

  • Prior experience with photostimulation enhances photo-induced reproductive response in female house finches.

    abstract::In vertebrates, reproductive output often increases with age. Unlike older birds, first-year photoperiodic birds lack experience with the reproductively stimulatory effects of long day lengths (photostimulation). We examined whether age-related differences in annual reproductive development could be partially attribut...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Salvante KG,Dawson A,Aldredge RA,Sharp PJ,Sockman KW

    更新日期:2013-02-01 00:00:00

  • Evidence of an annual rhythm in a small proportion of Siberian hamsters exposed to chronic short days.

    abstract::Siberian hamsters are photoperiodic seasonally breeding rodents. To date, there has been no evidence that Siberian hamsters exhibit an annual rhythm in reproductive, thermoregulatory, molt, or body mass changes. However, given that the termination of their winter cycle is under endogenous control, the authors thought ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Anchordoquy HC,Lynch GR

    更新日期:2000-04-01 00:00:00

  • The colony environment, but not direct contact with conspecifics, influences the development of circadian rhythms in honey bees.

    abstract::Honey bee (Apis mellifera) workers emerge from the pupae with no circadian rhythms in behavior or brain clock gene expression but show strong rhythms later in life. This postembryonic development of circadian rhythms is reminiscent of that of infants of humans and other primates but contrasts with most insects, which ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Eban-Rothschild A,Shemesh Y,Bloch G

    更新日期:2012-06-01 00:00:00

  • PER2 Differentially Regulates Clock Phosphorylation versus Transcription by Reciprocal Switching of CK1ε Activity.

    abstract::Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Qin X,Mori T,Zhang Y,Johnson CH

    更新日期:2015-06-01 00:00:00

  • Melanopsin, ganglion-cell photoreceptors, and mammalian photoentrainment.

    abstract::An understanding of the retinal mechanisms in mammalian photoentrainment will greatly facilitate optimization of the wavelength, intensity, and duration of phototherapeutic treatments designed to phase shift endogenous biological rhythms. A small population of widely dispersed retinal ganglion cells projecting to the ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Rollag MD,Berson DM,Provencio I

    更新日期:2003-06-01 00:00:00

  • Circadian aspect of photoperiodic time measurement in a female house sparrow, Passer domesticus.

    abstract::Endogenous circadian rhythms are involved in various photoperiodic responses of birds. Investigations involving the mechanisms of photoperiodic time measurement in birds have been confined mainly to temperate zone species using males exclusively. Due to the paucity of experimental evidence on subtropical birds that ha...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Ravikumar G,Senthilkumaran B,Tewary PD,Goel AK

    更新日期:1995-12-01 00:00:00

  • Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling.

    abstract::A 24-h treatment with the cytokine tumor necrosis factor-alpha (TNF-alpha) suppresses transcription of E-box-driven clock genes (D-site albumin promoter binding protein, Dbp; Tyrotroph embryonic factor, Tef ; Hepatic leukemia factor, Hlf; Period homolog to Drosophila 1/2/3, Per1, Per2, and Per3) by yet unknown molecul...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Petrzilka S,Taraborrelli C,Cavadini G,Fontana A,Birchler T

    更新日期:2009-08-01 00:00:00

  • Effect of circadian phase on performance of rats in the Morris water maze task.

    abstract::The authors examined spatial working memory in the Morris water maze during the activity and rest periods of Wistar rats. Wheel-running activity was measured continuously as a marker of circadian phase. To minimize possible masking effects on performance, animals were placed in constant dim light the day before testin...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Valentinuzzi VS,Menna-Barreto L,Xavier GF

    更新日期:2004-08-01 00:00:00

  • Clock gene expression during chronic inflammation induced by infection with Trypanosoma brucei brucei in rats.

    abstract::African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sleeping sickness, caused by the extracellular parasite Trypanosoma bru...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Lundkvist GB,Sellix MT,Nygård M,Davis E,Straume M,Kristensson K,Block GD

    更新日期:2010-04-01 00:00:00

  • Regulation of circadian photic responses by nitric oxide.

    abstract::A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuate...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Melo L,Golombek DA,Ralph MR

    更新日期:1997-08-01 00:00:00

  • Efficacy of melatonin as a sleep-promoting agent.

    abstract::Numerous studies have demonstrated sleep-promoting effects of melatonin treatment in humans, as evidenced by subjects' self-reports, polysomnographic recordings, and continuous actigraphic registration of motor activity. The sleep-promoting effects of either physiological or pharmacological doses of melatonin typicall...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Zhdanova IV,Wurtman RJ

    更新日期:1997-12-01 00:00:00

  • Food-deprivation-induced phase shifts in Sminthopsis macroura froggatti.

    abstract::Past research has shown that there is a circadian oscillator in laboratory rats that is entrained by restricted feeding schedules. However, in laboratory rats at least, the light-dark (LD) cycle is the dominant zeitgeber in the entrainment of wheel-running activity rhythms. Given that dasyurid marsupials are predomina...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Coleman GJ,O'Reilly HM,Armstrong SM

    更新日期:1989-04-01 00:00:00

  • Daily and photoperiodic melatonin binding changes in the suprachiasmatic nuclei, paraventricular thalamic nuclei, and pars tuberalis of the female Siberian hamster (Phodopus sungorus).

    abstract::Using quantitative autoradiography, 2-(125)I-melatonin binding was investigated throughout the light:dark cycle in the suprachiasmatic nuclei (SCN), paraventricular nuclei (PVT), and pars tuberalis (PT) of adult female Siberian hamsters kept for 10 weeks in either long or short photoperiods (LP or SP, respectively). P...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Recio J,Pévet P,Vivien-Roels B,Míguez JM,Masson-Pévet M

    更新日期:1996-12-01 00:00:00

  • A "melanopic" spectral efficiency function predicts the sensitivity of melanopsin photoreceptors to polychromatic lights.

    abstract::Photoreception in the mammalian retina is not restricted to rods and cones but extends to a small number of intrinsically photosensitive retinal ganglion cells expressing the photopigment melanopsin. These mRGCs are especially important contributors to circadian entrainment, the pupil light reflex, and other so-called...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Enezi Ja,Revell V,Brown T,Wynne J,Schlangen L,Lucas R

    更新日期:2011-08-01 00:00:00

  • An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly's circadian system.

    abstract::A rhythm mutant of Drosophila melanogaster was induced by chemical mutagenesis and isolated by testing for locomotor activity rhythms, which in the new variant had periods of approximately 16 hr. The sex-linked mutation responsible for this ultrashort period causes 20-hr rhythms when heterozygous with a normal X. This...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Konopka RJ,Hamblen-Coyle MJ,Jamison CF,Hall JC

    更新日期:1994-01-01 00:00:00

  • Photoperiodism in humans and other primates: evidence and implications.

    abstract::Most of the anatomical and molecular substrates of the system that encodes changes in photoperiod in the duration of melatonin secretion, and the receptor molecules that read this signal, have been shown to be conserved in monkeys and humans, and the functions of this system appear to be intact from the level of the r...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Wehr TA

    更新日期:2001-08-01 00:00:00

  • Photoperiod, reproduction, and immunity in select strains of inbred mice.

    abstract::The purpose of this study was to determine whether decreased day lengths affect reproduction or the immune system in inbred mice. Irrespective of a nocturnal pineal melatonin rise, the signal for day length information, body and testis weights were the same in various strains 8 weeks after transfer from long to short ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Yellon SM,Tran LT

    更新日期:2002-02-01 00:00:00

  • Pineal melatonin rhythms in the lizard Anolis carolinensis: II. Photoreceptive inputs.

    abstract::The pineal organ of the lizard Anolis carolinensis acts as a transducer of photoperiodic information, since light can affect the pineal melatonin rhythm (PMR). The synthesis and secretion of melatonin may be a major mechanism whereby a circadian pacemaker within the pineal can control circadian clocks located elsewher...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Underwood H,Calaban M

    更新日期:1987-10-01 00:00:00

  • Cycle of period gene expression in a diurnal mammal (Spermophilus tridecemlineatus): implications for nonphotic phase shifting.

    abstract::Ground squirrels, Spermophilus tridecemlineatus, were kept in a 12:12 h light-dark cycle. As expected for a diurnal species, their locomotor activity occurred almost entirely in the daytime. Expression of mPer1 and mPer2 in the suprachiasmatic nucleus was studied at six time points by in situ hybridization. For both t...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Mrosovsky N,Edelstein K,Hastings MH,Maywood ES

    更新日期:2001-10-01 00:00:00

  • Control of annual endocrine rhythms in the edible dormouse: nonprimary effect of photoperiod.

    abstract::We investigated the extent to which photoperiodic fluctuations synchronize annual thyroid and gonadal rhythmicity in edible dormice. The effects of different daylength manipulations (LD 4:20, LD 6:18, LD 18:6, LD 20:4) were examined during the two critical ascending and regressive phases of the annual plasma testoster...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Jallageas M,Mas N,Nouguier-Soulé J

    更新日期:1991-01-01 00:00:00

  • Masking and temporal niche switches in spiny mice.

    abstract::Activity patterns are the product of interactions between an internal circadian clock and direct responses to photic and nonphotic features of the environment that are said to "mask" the influence of that clock. Evolutionary transitions between nocturnality and diurnality involve changes in mechanisms underlying both ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Cohen R,Smale L,Kronfeld-Schor N

    更新日期:2010-02-01 00:00:00

  • Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons.

    abstract::Female Drosophila melanogaster, like many other organisms, exhibit different behavioral repertoires after mating with a male. These postmating responses (PMRs) include increased egg production and laying, increased rejection behavior (avoiding further male advances), decreased longevity, altered gustation and decrease...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Garbe DS,Vigderman AS,Moscato E,Dove AE,Vecsey CG,Kayser MS,Sehgal A

    更新日期:2016-12-01 00:00:00

  • The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression.

    abstract::The Drosophila clock relies on transcriptional feedback loops that generate daily oscillations of the clock gene expression at mRNA and protein levels. In the evening, the CLOCK (CLK) and CYCLE (CYC) basic helix-loop-helix (bHLH) PAS-domain transcription factors activate the expression of the period (per) and timeless...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Richier B,Michard-Vanhée C,Lamouroux A,Papin C,Rouyer F

    更新日期:2008-04-01 00:00:00

  • Thyroid circadian timing: roles in physiology and thyroid malignancies.

    abstract::The circadian clock represents an anticipatory mechanism, well preserved in evolution. It has a critical impact on most aspects of the physiology of light-sensitive organisms. These rhythmic processes are governed by environmental cues (fluctuations in light intensity and temperature), an internal circadian timing sys...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Philippe J,Dibner C

    更新日期:2015-04-01 00:00:00

  • Magnesium Regulates the Circadian Oscillator in Cyanobacteria.

    abstract::The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Jeong YM,Dias C,Diekman C,Brochon H,Kim P,Kaur M,Kim YS,Jang HI,Kim YI

    更新日期:2019-08-01 00:00:00

  • Cell-intrinsic, Bmal1-dependent Circadian Regulation of Temozolomide Sensitivity in Glioblastoma.

    abstract::The safety and efficacy of chemotherapeutics can vary as a function of the time of their delivery during the day. This study aimed to improve the treatment of glioblastoma (GBM), the most common brain cancer, by testing whether the efficacy of the DNA alkylator temozolomide (TMZ) varies with the time of its administra...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Slat EA,Sponagel J,Marpegan L,Simon T,Kfoury N,Kim A,Binz A,Herzog ED,Rubin JB

    更新日期:2017-04-01 00:00:00

  • The circatidal rhythm persists without the optic lobe in the mangrove cricket Apteronemobius asahinai.

    abstract::Whether the circatidal rhythm is generated by a machinery common to the circadian clock is one of the important and interesting questions in chronobiology. The mangrove cricket Apteronemobius asahinai shows a circatidal rhythm generating active and inactive phases and a circadian rhythm modifying the circatidal rhythm...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Takekata H,Numata H,Shiga S

    更新日期:2014-02-01 00:00:00