Light treatment for sleep disorders: consensus report. VII. Jet lag.


:Sleep disturbances are an all-too-familiar symptom of jet lag and a prime source of complaints for transmeridian travelers and flight crews alike. They are the result of a temporary loss of synchrony between an abruptly shifted sleep period, timed in accordance with the new local day-night cycle, and a gradually reentraining circadian system. Scheduled exposure to bright light can, in principle, alleviate the symptoms of jet lag by accelerating circadian reentrainment to new time zones. Laboratory simulations, in which sleep time is advanced by 6 to 8 h and the subjects exposed to bright light for 3 to 4 h during late subjective night on 2 to 4 successive days, have not all been successful. The few field studies conducted to date have had encouraging results, but their applicability to the population at large remains uncertain due to very limited sample sizes. Unresolved issues include optimal times for light exposure on the first as well as on subsequent treatment days, whether a given, fixed, light exposure time is likely to benefit a majority of travelers or whether light treatment should be scheduled instead according to some individual circadian phase marker, and if so, can such a phase marker be found that is both practical and reliable.


J Biol Rhythms


Boulos Z,Campbell SS,Lewy AJ,Terman M,Dijk DJ,Eastman CI




Has Abstract


1995-06-01 00:00:00












  • Circadian Health and Light: A Report on the National Heart, Lung, and Blood Institute's Workshop.

    abstract::Despite the omnipresence of artificial and natural light exposure, there exists little guidance in the United States and elsewhere on light exposure in terms of timing, intensity, spectrum, and other light characteristics known to affect human health, performance, and well-being; in parallel, there is little informati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Mason IC,Boubekri M,Figueiro MG,Hasler BP,Hattar S,Hill SM,Nelson RJ,Sharkey KM,Wright KP,Boyd WA,Brown MK,Laposky AD,Twery MJ,Zee PC

    更新日期:2018-10-01 00:00:00

  • Restricted daytime feeding modifies suprachiasmatic nucleus vasopressin release in rats.

    abstract::The authors have shown previously that vasopressin (VP) release from suprachiasmatic nucleus (SCN) efferents in rats is important for the timing of the circadian activity of the hypothalamo-pituitary-adrenal (HPA) axis, resulting in a circadian rise in corticosterone at dusk. When meals are supplied at a fixed time du...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kalsbeek A,van Heerikhuize JJ,Wortel J,Buijs RM

    更新日期:1998-02-01 00:00:00

  • Revealing Oft-cited but Unpublished Papers of Colin Pittendrigh and Coworkers.

    abstract::Among the scientific resources that Colin Pittendrigh passed on to his colleagues after his death in 1996 were two unpublished papers. These manuscripts, developed first in the mid-1960s and continually updated and refined through the late 1970s, centered on the development and experimental exploration of a model of c...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Tackenberg MC,Johnson CH,Page TL,Daan S

    更新日期:2017-08-01 00:00:00

  • Circadian locomotor rhythms, but not photoperiodic responses, survive surgical isolation of the SCN in hamsters.

    abstract::Surgical isolation of the suprachiasmatic nuclei (SCN) within a hypothalamic island is reported to produce loss of circadian rhythmicity. The results have been interpreted to indicate that SCN efferents are necessary for the expression of circadian rhythms. It is not clear, however, whether the loss of circadian rhyth...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Hakim H,DeBernardo AP,Silver R

    更新日期:1991-07-01 00:00:00

  • p38 MAP kinase regulates circadian rhythms in Drosophila.

    abstract::The large repertoire of circadian rhythms in diverse organisms depends on oscillating central clock genes, input pathways for entrainment, and output pathways for controlling rhythmic behaviors. Stress-activated p38 MAP Kinases (p38K), although sparsely investigated in this context, show circadian rhythmicity in mamma...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Vrailas-Mortimer AD,Ryan SM,Avey MJ,Mortimer NT,Dowse H,Sanyal S

    更新日期:2014-12-01 00:00:00

  • Plasma melatonin circadian rhythms during the menstrual cycle and after light therapy in premenstrual dysphoric disorder and normal control subjects.

    abstract::The aim of this study was to replicate and extend previous work in which the authors observed lower, shorter, and advanced nocturnal melatonin secretion patterns in premenstrually depressed patients compared to those in healthy control women. The authors also sought to test the hypothesis that the therapeutic effect o...

    journal_title:Journal of biological rhythms

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Parry BL,Berga SL,Mostofi N,Klauber MR,Resnick A

    更新日期:1997-02-01 00:00:00

  • Sex of college students moderates associations among bedtime, time in bed, and circadian phase angle.

    abstract::Sex differences in circadian rhythms have been reported with some conflicting results. The timing of sleep and length of time in bed have not been considered, however, in previous such studies. The current study has 3 major aims: (1) replicate previous studies in a large sample of young adults for sex differences in s...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Van Reen E,Sharkey KM,Roane BM,Barker D,Seifer R,Raffray T,Bond TL,Carskadon MA

    更新日期:2013-12-01 00:00:00

  • Evidence of an annual rhythm in a small proportion of Siberian hamsters exposed to chronic short days.

    abstract::Siberian hamsters are photoperiodic seasonally breeding rodents. To date, there has been no evidence that Siberian hamsters exhibit an annual rhythm in reproductive, thermoregulatory, molt, or body mass changes. However, given that the termination of their winter cycle is under endogenous control, the authors thought ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Anchordoquy HC,Lynch GR

    更新日期:2000-04-01 00:00:00

  • Binocular contributions to the responsiveness and integrative capacity of the circadian rhythm system to light.

    abstract::The retinohypothalamic tract (RHT), a monosynaptic retinal projection to the SCN, is the major path by which light entrains the circadian system to the external photoperiod. The circadian system of rodents effectively integrates or counts photons, and the magnitude of the rhythm phase response is proportional to the t...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Muscat L,Morin LP

    更新日期:2005-12-01 00:00:00

  • Repeated psychosocial stress at night affects the circadian activity rhythm of male mice.

    abstract::We have recently shown that molecular rhythms in the murine suprachiasmatic nucleus (SCN) are affected by repeated social defeat (SD) during the dark/active phase (social defeat dark [SDD]), while repeated SD during the light/inactive phase (social defeat light [SDL]) had no influence on PERIOD2::LUCIFERASE explant rh...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Bartlang MS,Oster H,Helfrich-Förster C

    更新日期:2015-06-01 00:00:00

  • The clockwork orange Drosophila protein functions as both an activator and a repressor of clock gene expression.

    abstract::The Drosophila clock relies on transcriptional feedback loops that generate daily oscillations of the clock gene expression at mRNA and protein levels. In the evening, the CLOCK (CLK) and CYCLE (CYC) basic helix-loop-helix (bHLH) PAS-domain transcription factors activate the expression of the period (per) and timeless...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Richier B,Michard-Vanhée C,Lamouroux A,Papin C,Rouyer F

    更新日期:2008-04-01 00:00:00

  • Temperature sensitivity of the suprachiasmatic nucleus of ground squirrels and rats in vitro.

    abstract::Temperature compensation of circadian rhythms in neuronal firing rate was investigated in the suprachiasmatic nucleus (SCN) of ground squirrels and rats in vitro. A reduction in SCN temperature from 37 to 25 degrees C reduced peak firing rates by > 70% in rats but only by approximately 21% in squirrels; trough firing ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Ruby NF,Heller HC

    更新日期:1996-06-01 00:00:00

  • Predicted microRNAs for mammalian circadian rhythms.

    abstract::There is little evidence for the involvement of microRNAs (miRs) in the regulation of circadian rhythms, despite the potential relevance of these elements in the posttranscriptional regulation of the clock machinery. The present work aimed to identify miRs targeting circadian genes through a predictive analysis of con...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Figueredo Dde S,Barbosa MR,Gitaí DL,de Andrade TG

    更新日期:2013-04-01 00:00:00

  • Gastrin-releasing peptide modulates fast delayed rectifier potassium current in Per1-expressing SCN neurons.

    abstract::The mammalian circadian clock in the suprachiasmatic nucleus (SCN) drives and maintains 24-h physiological rhythms, the phases of which are set by the local environmental light-dark cycle. Gastrin-releasing peptide (GRP) communicates photic phase setting signals in the SCN by increasing neurophysiological activity of ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Gamble KL,Kudo T,Colwell CS,McMahon DG

    更新日期:2011-04-01 00:00:00

  • Circadian organization of a subarctic rodent, the northern red-backed vole (Clethrionomys rutilus).

    abstract::Arctic and subarctic environments are exposed to extreme light: dark (LD) regimes, including periods of constant light (LL) and constant dark (DD) and large daily changes in day length, but very little is known about circadian rhythms of mammals at high latitudes. The authors investigated the circadian rhythms of a su...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Tavernier RJ,Largen AL,Bult-Ito A

    更新日期:2004-06-01 00:00:00

  • Prior experience with photostimulation enhances photo-induced reproductive response in female house finches.

    abstract::In vertebrates, reproductive output often increases with age. Unlike older birds, first-year photoperiodic birds lack experience with the reproductively stimulatory effects of long day lengths (photostimulation). We examined whether age-related differences in annual reproductive development could be partially attribut...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Salvante KG,Dawson A,Aldredge RA,Sharp PJ,Sockman KW

    更新日期:2013-02-01 00:00:00

  • Photoperiodism in Ostrinia nubilalis: a new protocol for the analysis of the role of the circadian system.

    abstract::A 12-hr dark period, at a temperature high enough to permit time measurement to occur, is necessary for maximal induction of larval diapause in the European corn borer, Ostrinia nubilalis. In the present study, induction of diapause only occurred in a periodic environment. This was in the form of certain (1) light-dar...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Skopik SD,Cain W,Patel NG,Newswanger DL

    更新日期:1986-07-01 00:00:00

  • Subjective well-being is modulated by circadian phase, sleep pressure, age, and gender.

    abstract::Subjective well-being largely depends on mood, which shows circadian rhythmicity and can be linked to rhythms in many physiological circadian markers, such as melatonin and cortisol. In healthy young volunteers mood is influenced by an interaction of circadian phase and the duration of time awake. The authors analyzed...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Birchler-Pedross A,Schröder CM,Münch M,Knoblauch V,Blatter K,Schnitzler-Sack C,Wirz-Justice A,Cajochen C

    更新日期:2009-06-01 00:00:00

  • Metabolic rate changes proportionally to circadian frequency in tau mutant Syrian hamsters.

    abstract::The tau mutation in Syrian hamsters (Mesocricetus auratus) is phenotypically expressed in a period of the circadian rhythm of about 20 h in homozygotes (SS) and about 22 h in heterozygotes (S+). The authors investigate whether this well-defined model for variation in circadian period exhibits associated changes in ene...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Oklejewicz M,Hut RA,Daan S,Loudon AS,Stirland AJ

    更新日期:1997-10-01 00:00:00

  • Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans.

    abstract::Melatonin is secreted systemically from the pineal gland maximally at night but is also produced locally in many tissues. Its chronobiological function is mainly exerted by pineal melatonin. It is a feedback regulator of the main circadian pacemaker in the hypothalamic suprachiasmatic nuclei and of many peripheral osc...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Slawik H,Stoffel M,Riedl L,Veselý Z,Behr M,Lehmberg J,Pohl C,Meyer B,Wiegand M,Krieg SM

    更新日期:2016-02-01 00:00:00

  • Simulation of day-length encoding in the SCN: from single-cell to tissue-level organization.

    abstract::The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rohling J,Wolters L,Meijer JH

    更新日期:2006-08-01 00:00:00

  • Reduced Effective Emotion Regulation in Night Owls.

    abstract::Previous research has demonstrated a clear link between late chronotype and depression. The vulnerability factors underpinning this link, however, are unclear. Here the relationship between two specific emotion regulation strategies, cognitive reappraisal and expressive suppression, and chronotype was investigated usi...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Watts AL,Norbury R

    更新日期:2017-08-01 00:00:00

  • Searching for biological rhythms: peak detection in the periodogram of unequally spaced data.

    abstract::The classical power spectrum, computed in the frequency domain, outranks traditionally used periodograms derived in the time domain (such as the chi2 periodogram) regarding the search for biological rhythms. Unfortunately, classical power spectral analysis is not possible with unequally spaced data (e.g., time series ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Van Dongen HP,Olofsen E,VanHartevelt JH,Kruyt EW

    更新日期:1999-12-01 00:00:00

  • Microarray analysis of natural socially regulated plasticity in circadian rhythms of honey bees.

    abstract::Honey bee workers care for ("nurse") the brood around the clock without circadian rhythmicity, but then they forage outside with strong circadian rhythms and a consolidated nightly rest. This chronobiological plasticity is associated with variation in the expression of the canonical "clock genes" that regulate the cir...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rodriguez-Zas SL,Southey BR,Shemesh Y,Rubin EB,Cohen M,Robinson GE,Bloch G

    更新日期:2012-02-01 00:00:00

  • Circannual rhythms in starlings: response of castrated birds to 12-hr days depends on photoperiodic history.

    abstract::The annual cycle of reproductive function in starlings (Sturnus vulgaris) is driven by seasonal changes in daylength and consists of a 6-month period of photosensitivity, culminating in maximal gonadal development, followed by a 6-month period of photorefractoriness. If male starlings are held under a constant photope...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Dawson A,McNaughton FJ

    更新日期:1993-07-01 00:00:00

  • Magnesium Regulates the Circadian Oscillator in Cyanobacteria.

    abstract::The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Jeong YM,Dias C,Diekman C,Brochon H,Kim P,Kaur M,Kim YS,Jang HI,Kim YI

    更新日期:2019-08-01 00:00:00

  • Pineal melatonin rhythms in the lizard Anolis carolinensis: II. Photoreceptive inputs.

    abstract::The pineal organ of the lizard Anolis carolinensis acts as a transducer of photoperiodic information, since light can affect the pineal melatonin rhythm (PMR). The synthesis and secretion of melatonin may be a major mechanism whereby a circadian pacemaker within the pineal can control circadian clocks located elsewher...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Underwood H,Calaban M

    更新日期:1987-10-01 00:00:00

  • Circadian aspect of photoperiodic time measurement in a female house sparrow, Passer domesticus.

    abstract::Endogenous circadian rhythms are involved in various photoperiodic responses of birds. Investigations involving the mechanisms of photoperiodic time measurement in birds have been confined mainly to temperate zone species using males exclusively. Due to the paucity of experimental evidence on subtropical birds that ha...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Ravikumar G,Senthilkumaran B,Tewary PD,Goel AK

    更新日期:1995-12-01 00:00:00

  • Season- and latitude-dependent effects of simulated twilights on circadian entrainment.

    abstract::Groups of Syrian hamsters were exposed to LD cycles with twilight transitions and photoperiods simulating natural lighting conditions at the summer solstice (SS), equinox, and winter solstice (WS) at 41 degrees N and at the winter solstice at the Arctic Circle (WS 66 degrees N) but with daytime illuminance truncated a...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Boulos Z,Macchi MM

    更新日期:2005-04-01 00:00:00

  • Independence of genetic geographical variation between photoperiodic diapause, circadian eclosion rhythm, and Thr-Gly repeat region of the period gene in Drosophila littoralis.

    abstract::Drosophila littoralis is a latitudinally widespread European species of the Drosophila virilis group. The species has ample genetic variation in photoperiodism (adult diapause) and circadian rhythmicity (pupal eclosion rhythm), with adaptive latitudinal clines in both of them. The possible common genetic basis between...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Lankinen P,Forsman P

    更新日期:2006-02-01 00:00:00