Chemicals which promote survival of ultraviolet-irradiated lon and ruv mutants of Escherichia coli K12.

Abstract:

:The effects of postirradiation incubation with various chemicals structurally related to pantolactone on the survival of ultraviolet-irradiated Escherichia coli lon and ruv mutants were examined. Certain cyclic compounds with a butyrolactone, tetrahydrofuran, furan, tetrahydropyran, or 2-pyron ring showed substantial rescue activity in lon and (or) ruv mutants. In addition, several aliphatic, monocarboxylic acid salts, including hydrolysis products from pantolactone and butyrolactone, were also active in one or both of these mutants, especially pantoate and other hydroxy acid salts in the ruv bacterium. The two mutants differed considerably in their susceptibility spectra for the rescue actions of these compounds.

journal_name

Can J Microbiol

authors

Kato Y,Shiraki S,Hamada Y,Iyehara-Ogawa H,Nakayama H

doi

10.1139/m80-254

subject

Has Abstract

pub_date

1980-12-01 00:00:00

pages

1518-22

issue

12

eissn

0008-4166

issn

1480-3275

journal_volume

26

pub_type

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