Neutralizing response of rabbits to an experimental rubella subunit vaccine made from immunostimulating complexes.

Abstract:

:The purpose of this study was to evaluate experimentally the immunogenicity in rabbits of rubella subunits adsorbed to the adjuvant Quil A. The adsorbed viral proteins form structurally defined ImmunoStimulating COMplexes (ISCOMs). Rubella ISCOMs were tested for their capacity to induce neutralizing and hemagglutination-inhibiting antibodies, in comparison with a commercial live attenuated vaccine. Rubella ISCOMs were as efficient as the live vaccine in inducing neutralizing and hemagglutination inhibiting antibodies, suggesting the possibility of developing an ISCOMs subunit vaccine.

journal_name

Can J Microbiol

authors

Trudel M,Nadon F,Séguin C,Payment P

doi

10.1139/m88-238

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

1351-4

issue

12

eissn

0008-4166

issn

1480-3275

journal_volume

34

pub_type

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