Abstract:
:Magnetic resonance spectroscopy (MRS) is ideally suited for physiology-neurochemistry experiments with the living brain and particularly for studies on the primary visual cortex (striate cortex or area V1). Yet, the highly convoluted form of the human V1 has thus far prevented the performance of MRS investigations that are spatially confined within the gray matter of this area. Typically, these studies are compromised by partial volume contaminations originating from white matter tissue, cerebrospinal fluid and other cortical areas. In this study, was exploited the relative flatness of V1 in macaques to enable single-voxel 1H-MRS from a small volume (5 x 1.6 x 5 mm3, 40 microl) that was entirely confined within the V1 gray matter of anesthetized monkeys. Linewidths of 13.5+/-1.9 Hz and 13.0+/-1.3 Hz for water and creatine, respectively, were achieved with a two-step shimming strategy for voxels at the brain surface. The quality of the obtained results paves the way for further neuroscientific research, including studies on the cortical microcircuits and the dynamic longitudinal changes occurring during cortical reorganization and plasticity.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Juchem C,Logothetis NK,Pfeuffer Jdoi
10.1016/j.mri.2007.03.008subject
Has Abstractpub_date
2007-07-01 00:00:00pages
902-12issue
6eissn
0730-725Xissn
1873-5894pii
S0730-725X(07)00222-6journal_volume
25pub_type
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Magnetic resonance imaging
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doi:10.1016/j.mri.2010.07.012
更新日期:2011-01-01 00:00:00
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更新日期:2014-04-01 00:00:00
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更新日期:2020-05-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(99)00074-0
更新日期:1999-11-01 00:00:00
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journal_title:Magnetic resonance imaging
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更新日期:2010-07-01 00:00:00
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2014.08.028
更新日期:2015-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(96)00162-2
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