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Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children.

Abstract：

BACKGROUND:Organophosphate (OP) pesticides are widely used in agriculture and homes. Animal studies suggest that even moderate doses are neurodevelopmental toxicants, but there are few studies in humans. OBJECTIVES:We investigated the relationship of prenatal and child OP urinary metabolite levels with children's neurodevelopment. METHODS:Participating children were from a longitudinal birth cohort of primarily Latino farm-worker families in California. We measured six nonspecific dialkylphosphate (DAP) metabolites in maternal and child urine as well as metabolites specific to malathion (MDA) and chlorpyrifos (TCPy) in maternal urine. We examined their association with children's performance at 6 (n = 396), 12 (n = 395), and 24 (n = 372) months of age on the Bayley Scales of Infant Development [Mental Development (MDI) and Psychomotor Development (PDI) Indices] and mother's report on the Child Behavior Checklist (CBCL) (n = 356). RESULTS:Generally, pregnancy DAP levels were negatively associated with MDI, but child measures were positively associated. At 24 months of age, these associations reached statistical significance [per 10-fold increase in prenatal DAPs: beta = -3.5 points; 95% confidence interval (CI), -6.6 to -0.5; child DAPs: beta = 2.4 points; 95% CI, 0.5 to 4.2]. Neither prenatal nor child DAPs were associated with PDI or CBCL attention problems, but both prenatal and postnatal DAPs were associated with risk of pervasive developmental disorder [per 10-fold increase in prenatal DAPs: odds ratio (OR) = 2.3, p = 0.05; child DAPs OR = 1.7, p = 0.04]. MDA and TCPy were not associated with any outcome. CONCLUSIONS:We report adverse associations of prenatal DAPs with mental development and pervasive developmental problems at 24 months of age. Results should be interpreted with caution given the observed positive relationship with postnatal DAPs.

journal_name

Environ Health Perspect

journal_title

Environmental health perspectives

authors

Eskenazi B,Marks AR,Bradman A,Harley K,Barr DB,Johnson C,Morga N,Jewell NP

doi

10.1289/ehp.9828

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

792-8

issue

eissn

0091-6765

issn

1552-9924

journal_volume

115

pub_type

杂志文章

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Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children.