Abstract:
:A follow-up study of capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs) and their children was conducted since 1973. PCB levels in whole blood of workers as well as in breast milk of the exposed lactating mothers were approximately 10 to 100 times those of nonexposed Japanese. Blood PCB levels had a statistically significant correlation with the duration of PCB handling and breast milk PCB levels. The rate of decline of blood PCB levels, as well as the changes of the gas chromatograph of blood PCB over 7 years was found to vary with the kind of PCB handled. The levels of blood PCB tended to be higher in the children fed PCB-contaminated breast milk for a long period. The great majority of workers handling PCBs had dermatologic complaints. Discontinuance of contact with PCB led to gradual improvement of these lesions. Abnormal results in the blood chemistry of the workers were rare, while serum triglyceride concentration was significantly correlated with blood PCB levels in 1974. In the questionnaire study, the number of complaints in children born from mothers who had handled PCBs, especially those fed breast milk for a long period, was conspicuously higher than that in control groups. Several children were found to have the same medical findings as in yusho; however, they have not been diagnosed as PCB-poisoning, because these findings were neither so serious nor related to the blood PCB levels.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Hara Idoi
10.1289/ehp.59-1568101subject
Has Abstractpub_date
1985-02-01 00:00:00pages
85-90eissn
0091-6765issn
1552-9924journal_volume
59pub_type
杂志文章abstract::The purpose of the study was to determine whether the risk of childhood acute lymphoblastic leukemia (ALL) associated with drinking water disinfection by-products was modified in the presence of variants in genes involved in the metabolism of trihalomethanes (THMs). We included a subset of cases from a population-base...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110591
更新日期:2002-06-01 00:00:00
abstract::Biological monitoring of exposure to chemicals in the workplace is an important component of exposure assessment and prevention of adverse health effects. It should be employed in conjunction with ambient air monitoring to provide information on the absorbed dose of a chemical agent and the effect of all routes of exp...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s1105
更新日期:1997-02-01 00:00:00
abstract::Often a compound's biological activity is determined by complex relationships between its structural components. Such a relationship often can only be adequately described and exploited by multivariate structure-activity relationship (SAR) studies that can deal with many variables simultaneously. Pattern recognition (...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8561329
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Traffic noise affects a large number of people, particularly in urbanized areas. Noise causes stress and annoyance, but less is known about the relationship between noise and depression. OBJECTIVE:We investigated the association of residential road traffic noise with depressive symptoms using 5-year follow-...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409400
更新日期:2016-05-01 00:00:00
abstract::The presence of blue-green algae (BGA) toxins in surface waters used for drinking water sources and recreation is receiving increasing attention around the world as a public health concern. However, potential risks from exposure to these toxins in contaminated health food products that contain BGA have been largely ig...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108435
更新日期:2000-05-01 00:00:00
abstract::We analyzed questionnaire and physician examination data for 1560 new immigrants from the former USSR divided into three groups by potential exposure to Chernobyl radiation. Two groups were chosen according to soil contamination by cesium-137 at former residences, as confirmed by our findings in a 137Cs body burden st...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103936
更新日期:1995-10-01 00:00:00
abstract::The binary, ternary, quaternary, and quintary interactions of a five-component mixture of carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) using response surface analyses are described. Initially, lung tumor dose-response curves in strain A/J mice for each of the individual PAHs benzo[a]pyrene (B[a]P...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s61337
更新日期:1998-12-01 00:00:00
abstract::Recent studies have linked air pollution to tens of thousands of premature cardiovascular deaths per year. The mechanisms of such associations remain unclear. In this study we examine the association between blood markers of cardiovascular risk and air pollution in a national sample of the U.S. population. Air polluti...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109s3405
更新日期:2001-06-01 00:00:00
abstract::In an earlier study we established that timely and adequate tissue repair response following the administration of a six-fold dose-range of thioacetamide (TA; 50, 150, and 300 mg/kg) prevented progression of injury and led to recovery and animal survival. Delayed and attenuated repair response after the 600 mg/kg TA d...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104744
更新日期:1996-07-01 00:00:00
abstract::Elucidation of the role of vinyl chloride metabolites in the various reaction sequences which comprise the metabolic pathway, including the interaction of reactive metabolities with some purine and pyrimidine residues of target-organ DNA, provides some explanation for the (oncogenic) properties associated with the ori...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.772155
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10108
更新日期:2007-11-01 00:00:00
abstract::Epidemiological studies examining the association between exposure to tap water contaminants (such as chlorination by-products) and disease outcomes (such as cancer and adverse reproductive outcomes) have been limited by inaccurate exposure assessment. Failure to take into account the variation in beverage and tap wat...
journal_title:Environmental health perspectives
pub_type: 临床试验,杂志文章
doi:10.1289/ehp.9810655
更新日期:1998-02-01 00:00:00
abstract::Occupational and environmental asbestos exposure continues to represent a public health problem, despite increasingly restrictive laws adopted by most industrialized countries. Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6542
更新日期:2004-04-01 00:00:00
abstract::This paper summarizes two roundtable discussions held at the conclusion of the International Conference on Biopersistence of Respirable Synthetic Fibres and Minerals. The first round table addressed the role of biopersistence in the pathogenicity of fiber-induced disease. The panel included T. W. Hesterberg (Chairman)...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.94102s5277
更新日期:1994-10-01 00:00:00
abstract::We found an epidemic of juvenile hypothyroidism among a population of self-defined "downwinders" living near the Hanford nuclear facility located in southeast Washington State. The episode followed massive releases of 131I. Self-reported data on 60 cases of juvenile hypothyroidism (<20 years of age) among a group of 8...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107303
更新日期:1999-04-01 00:00:00
abstract::In the National Toxicology Program 2-year inhalation study of dichloromethane (DCM), there was a significant increase in pulmonary neoplasms in female B6C3F1 mice exposed to 2000 ppm (overall rates of 30/48 versus 5/50 in control). Replicative DNA synthesis was examined to evaluate the potential role of treatment-indu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s5271
更新日期:1993-12-01 00:00:00
abstract::Concern about apparent increases in the prevalence of hypospadias--a congenital male reproductive-tract abnormality--in the 1960s to 1980s and the possible connection to increasing exposures to endocrine-disrupting chemicals have underlined the importance of effective surveillance of hypospadias prevalence in the popu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6398
更新日期:2004-03-01 00:00:00
abstract::32P-Postlabeling analysis and enzyme-linked immunosorbent assay (ELISA) have been used to detect DNA adducts in peripheral blood lymphocytes from primary aluminum production plant workers who were exposed occupationally to a mixture of polycyclic aromatic hydrocarbons (PAHs). Preliminary results reported here are from...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9399307
更新日期:1993-03-01 00:00:00
abstract::Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of various forms of cancer and of noncancerous diseases. Metabolic conversions of iAs that yield highly toxic and genotoxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII) may play a significant role in determining the extent an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7519
更新日期:2005-03-01 00:00:00
abstract::Many populations of amphibians are declining on all six continents on which they occur. Some causes of amphibian declines, such as habitat destruction, direct application of xenobiotics, and introduction of predators or competitors, are clearly attributable to human activities. Infectious disease appears to be the dir...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108s1143
更新日期:2000-03-01 00:00:00
abstract::We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detect...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108323
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Few studies have examined the relationship between long-term exposure to ambient fine particulate matter (PM2.5) and nonaccidental mortality in rural populations. OBJECTIVE:We examined the relationship between PM2.5 and nonaccidental and cardiovascular mortality in the U.S. Agricultural Health Study cohort....
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307277
更新日期:2014-06-01 00:00:00
abstract::Hemoglobin adducts of the common metabolite of the tobacco-specific nitrosamine (TSNA) 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and of 4-aminobiphenyl (4-ABP) were quantified in blood samples from smokers and nonsmokers to test their suitability for biomonitoring tobacco smoke exposure. Additionally, TSNA adducts were...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99-1567014
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimer's disease (AD). OBJECTIVES:We attempted to assess the relationship between early-life lead exposure and potential biomarkers for AD among young men and women. We also attempte...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104474
更新日期:2012-05-01 00:00:00
abstract::Hamsters were exposed to an aerosol of fused aluminosilicate particles (FAP) labeled with 57Co. Three groups of animals were given bronchopulmonary lavage, beginning at either 1 week, 1 month, or 6 months after exposure. Each treated group was lavaged eight times over a period of 25 days. Each lavage involved 10 salin...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9297209
更新日期:1992-07-01 00:00:00
abstract::Cytotoxic chemicals have in common the ability to act specifically on cells in cycle. Bacteria are more sensitive in the exponential growth phase than when growing slowly in media. Similar observations have been made on a variety of systems ranging from bacteria, yeast, higher plants and invertebrates to vertebrates i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782487
更新日期:1978-06-01 00:00:00
abstract::The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091145
更新日期:2001-11-01 00:00:00
abstract::In this article we summarize the results of a series of studies that measured the relative bioavailability (RBA) of lead in a variety of soil and soil-like test materials. Reference material (Pb acetate) or Pb-contaminated soils were administered orally to juvenile swine twice a day for 15 days. Blood samples were col...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8852
更新日期:2006-08-01 00:00:00
abstract::Many naturally occurring and man-made chemicals present in the environment possess estrogenic activity. Examples include plant and fungal products, pesticides, plasticizers, and other agricultural and industrial chemicals. These environmental estrogens as well as endogenous ovarian estrogens are thought to initiate th...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s729
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Epidemiologic and experimental studies have reported a variety of health effects in response to ozone (O3) exposure, and some have indicated that certain populations may be at increased or decreased risk of O3-related health effects. OBJECTIVES:We sought to identify potential response-modifying factors to d...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1307541
更新日期:2014-11-01 00:00:00