Abstract：
:Somatic sensory neurons of the dorsal root ganglia are necessary for a large part of our mechanosensory experience. However, we only have a good knowledge of the molecules required for mechanotransduction in simple invertebrates such as the nematode Caenorhabiditis elegans. In C. elegans, a number of so-called mec genes have been isolated that are required for the transduction of body touch. One such gene, mec-2 codes for an integral membrane protein of the stomatin family, a large group of genes with a stomatin homology domain. Using stomatin null mutant mice, we have tested the hypothesis that the founding member of this family, stomatin might play a role in the transduction of mechanical stimuli by primary sensory neurons. We used the in vitro mouse skin nerve preparation to record from a large population of low- and high-threshold mechanoreceptors with myelinated A-fiber (n = 553) and unmyelinated C-fiber (n = 157) axons. One subtype of mechanoreceptor, the d-hair receptor, which is a rapidly adapting mechanoreceptor, had reduced sensitivity to mechanical stimulation in the absence of stomatin. Other cutaneous mechanoreceptors, including nociceptive C-fibers were not affected by the absence of a functional stomatin protein. Patch-clamp analysis of presumptive D-hair receptor mechanoreceptive neurons, which were identified by a characteristic rosette morphology in culture, showed no change in membrane excitability in the absence of the stomatin protein. We conclude that stomatin is required for normal mechanotransduction in a subpopulation of vertebrate sensory neurons.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Martinez-Salgado C,Benckendorff AG,Chiang LY,Wang R,Milenkovic N,Wetzel C,Hu J,Stucky CL,Parra MG,Mohandas N,Lewin GRdoi
10.1152/jn.00860.2007subject
Has Abstractpub_date
2007-12-01 00:00:00pages
3802-8issue
6eissn
0022-3077issn
1522-1598pii
00860.2007journal_volume
98pub_type
杂志文章abstract：:Red and green cones of two turtle species (Pseudemys scripta elegans and Chelydra serpentina) retina have been stained with Golgi procedures and examined by light microscopy of whole-mount tissue and by electron microscopy of serial thin sections. By light microscopy, red and green single cones appear indistinguishabl...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1985.54.2.304
更新日期：1985-08-01 00:00:00
abstract：:In this tribute to Reggie Edgerton, I briefly review the spinal mechanisms that coordinate locomotion and the interaction between the different sensory mechanisms that help coordinate the locomotor movements and the central locomotor network. The step cycle has four distinct parts, the support phase, the lift off, the...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00656.2020
更新日期：2020-12-23 00:00:00
abstract：:A classical question in neuroscience is which features of a stimulus or of an action are represented in brain activity. When several features are interdependent either at a given point in time or at distinct points in time, neural activity related to one feature appears to be correlated with other features. Thus techn...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00981.2005
更新日期：2006-03-01 00:00:00
abstract：:1. Voltage-dependent K+ currents were studied in normal rat anterior pituitary cells using the patch-clamp technique. To obtain cultures enriched for lactotrophs, density gradient centrifugation was performed on pituitary cells isolated from lactating rats. 2. Depolarizations to about -30 mV from a holding potential o...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.72.2.719
更新日期：1994-08-01 00:00:00
abstract：:Whole cell membrane currents induced by the inflammatory mediators, bradykinin, 5-hydroxytryptamine (5-HT) and prostaglandin E2, were investigated in capsaicin-sensitive dorsal root ganglion (DRG) neurons from newborn rats grown on a monolayer of hippocampal glia without nerve growth factor (NGF). When firmly attached...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1998.79.2.670
更新日期：1998-02-01 00:00:00
abstract：:We have investigated the fundamental properties of central auditory glycinergic synapses in early postnatal development in normal and congenitally deaf (dn/dn) mice. Glycinergic miniature inhibitory postsynaptic currents (mIPSCs) were recorded using patch-clamp methods in neurons from a brain slice preparation of the ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00771.2003
更新日期：2004-02-01 00:00:00
abstract：:Retinal Müller cells are highly permeable to potassium as a consequence of their intrinsic membrane properties. Therefore these cells are able to play an important role in maintaining potassium homeostasis in the vertebrate retina during light-induced neuronal activity. Polyamines and other factors present in Müller c...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2001.85.4.1357
更新日期：2001-04-01 00:00:00
abstract：:Traumatic brain injury (TBI) is one of the most common neurological disorders causing memory reduction, particularly short-term memory (STM). We showed that, during TBI-induced inflammation, increased blood content of fibrinogen (Fg) enhanced vascular protein transcytosis and deposition of extravasated Fg in vasculo-a...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00224.2020
更新日期：2020-08-01 00:00:00
abstract：:Normative theories posit that value-based decision-making is context independent. However, decisions between two high-value options can be suboptimally biased by the introduction of a third low-value option. This context-dependent modulation is consistent with the divisive normalization of the value of each stimulus b...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00343.2015
更新日期：2015-07-01 00:00:00
abstract：:Nicotine evokes pain in the skin and oral mucosa and excites a subpopulation of cutaneous nociceptors, but little is known about the central transmission of chemogenic pain. We have investigated the responses of lumbar spinal wide dynamic range (WDR)-type dorsal horn neurons to intracutaneous (ic) microinjection of ni...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1999.82.6.3046
更新日期：1999-12-01 00:00:00
abstract：:Microsleeps are brief episodes of arousal level decrease manifested through behavioral signs. Brain activity during microsleep in the presence of external stimulus remains poorly understood. In this study, we sought to understand neural responses to auditory stimulation during microsleep. We gave participants the simp...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00825.2018
更新日期：2019-12-01 00:00:00
abstract：:1. Ionic conductances controlled by type A and type B cholecystokinin (CCK) receptors were studied in neurons of the rat nucleus tractus solitarius (NTS) and dorsal motor nucleus of the vagus (DMNV), using intracellular and whole-cell patch clamp recordings in current or voltage clamp configuration during bath applica...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1993.70.6.2584
更新日期：1993-12-01 00:00:00
abstract：:The innervation patterns of vestibular saccular afferents were quantitatively investigated in pigeons using biotinylated dextran amine as a neural tracer and three-dimensional computer reconstruction. Type I hair cells were found throughout a large portion of the macula, with the highest density observed in the striol...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00817.2001
更新日期：2003-01-01 00:00:00
abstract：:1. We examined the role of gamma-aminobutyric acid (GABA)-mediated inhibition in shaping excitatory tuning curves and creating selectivity for frequency-modulated (FM) sweeps in 29 neurons in the central nucleus of the inferior colliculus (ICC) of the pallid bat, with the use of single-unit recording coupled with the ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1996.76.2.1059
更新日期：1996-08-01 00:00:00
abstract：:Recent evidence has suggested that theta-frequency (4-7 Hz) oscillations around the human anterior cingulate cortex (ACC) and frontal cortex--that is, frontal midline theta (Fm theta) oscillations--may be involved in attentional processes in the brain. However, little is known about the physiological basis of Fm theta...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00730.2005
更新日期：2006-05-01 00:00:00
abstract：:The nucleus tractus solitarii (nTS) is the initial central termination site for visceral afferents and is important for modulation and integration of multiple reflexes including cardiorespiratory reflexes. Glutamate is the primary excitatory neurotransmitter in the nTS and is removed from the extracellular milieu by e...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01054.2015
更新日期：2016-03-01 00:00:00
abstract：:1. Nonlinearity of spatial summation in areas 17 and 18 of cat visual cortex was compared with the type of spatial nonlinearity that differentiates X and Y cells in the lateral geniculate nucleus (LGN) and retina. The comparisons were made to examine to what extent the information from X and Y cells may remain separat...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1991.66.5.1667
更新日期：1991-11-01 00:00:00
abstract：:1. Recent immunocytochemical and receptor binding data have demonstrated a transient somatotopic patterning of serotonin (5-HT)-immunoreactive fibers in the primary somatosensory cortex of developing rats and a transient expression of 5-HT1B receptors on thalamocortical axons from the ventral posteromedial thalamic nu...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.72.5.2438
更新日期：1994-11-01 00:00:00
abstract：:Over the past 3 decades, various algorithms used to decompose the electromyographic (EMG) signal into its constituent motor unit action potentials (MUAPs) have been reported. All are limited to decomposing EMG signals from isometric contraction. In this report, we describe a successful approach to decomposing the surf...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00555.2014
更新日期：2015-03-15 00:00:00
abstract：:We investigated object representation in area TE, the anterior part of monkey inferotemporal (IT) cortex, with a combination of optical and extracellular recordings in anesthetized monkeys. We found neurons that respond to visual stimuli composed of naturally distinguishable parts. These neurons were sensitive to a pa...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01224.2005
更新日期：2006-12-01 00:00:00
abstract：:A powerful early inhibition is seen in triceps surae after transcutaneous electrical stimulation of the Achilles tendon [tendon electrical stimulation (TES)]. The aim of the present study was to confirm results from surface electromyogram (SEMG) recordings that the inhibition is not wholly or partly due to stimulation...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00751.2011
更新日期：2012-01-01 00:00:00
abstract：:1. The role of sensory information in shaping muscle activation patterns to postural perturbations in humans was investigated by varying velocity, amplitude, or duration of the perturbing stimulus. Ten normal subjects were exposed to 120 backward translations of the support surface under conditions of varying velociti...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1988.59.6.1888
更新日期：1988-06-01 00:00:00
abstract：:Annexin I is a local mediator in neural-endocrine feedback control of inflammation. J. Neurophysiol. 80: 3120-3126, 1998. Activation of primary afferent nociceptors induces a neural endocrine-mediated inhibition of the inflammatory response via a circuit that includes ascending spinal pathways and activation of the hy...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1998.80.6.3120
更新日期：1998-12-01 00:00:00
abstract：:We developed a physiologically realistic mathematical model of the Golgi tendon organ (GTO) whose elements correspond to anatomical features of the biological receptor. The mechanical interactions of these elements enable it to capture all salient aspects of GTO afferent behavior reported in the literature. The model ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00869.2005
更新日期：2006-10-01 00:00:00
abstract：:Low-voltage-activated Ca(2+) currents (LVA-I(Ca)) are believed to perform several roles in neurons such as lowering the threshold for action potentials, promoting burst firing and oscillatory behavior, and enhancing synaptic excitation. They also may allow rapid increases in intracellular Ca(2+) concentration. We disc...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2000.83.2.746
更新日期：2000-02-01 00:00:00
abstract：:Seizures may cause brain damage due to mechanisms initiated by excessive excitatory synaptic transmission. One such mechanism is the activation of death-promoting intracellular cascades by the influx and the perturbed homeostasis of Ca2+. The neuroprotective effects of preventing the entry of Ca2+ from voltage-depende...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1999.81.6.3054
更新日期：1999-06-01 00:00:00
abstract：:Multiple studies have demonstrated that brain-derived neurotrophic factor (BDNF) is a potent modulator of neuronal structure and function in the hippocampus. However, the majority of studies to date have relied on the application of recombinant BDNF. We herein report that endogenous BDNF, released via theta burst stim...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01140.2009
更新日期：2010-05-01 00:00:00
abstract：:1. Monkeys were trained to react to an arm perturbation according to an instruction delivered prior to the perturbation. There were two possible instructions (push or pull), and monkeys learned to respond accordingly regardless of the direction (push or pull) of the triggering perturbation. 2. Pyramidal tract neurons ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1976.39.5.1069
更新日期：1976-09-01 00:00:00
abstract：:1. Large, projection-like neurons from the adult (> 3 wk post-natal) rat globus pallidus (GP) were acutely isolated and subjected to whole-cell voltage-clamp (n = 37). Ca2+ currents were isolated pharmacologically in cells with whole-cell capacitances of 15-34 pF. 2. With 5 mM Ba2+ as a charge carrier, whole-cell curr...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.71.3.1272
更新日期：1994-03-01 00:00:00
abstract：:Animals are adapted to respond quickly to threats in their environment. In many invertebrate and some vertebrate species, the evolutionary pressures have resulted in rapidly conducting giant axons, which allow short response times. Although neural circuits mediating escape behavior are identified in several species, l...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00507.2010
更新日期：2011-01-01 00:00:00
