Direct recording of theta oscillations in primate prefrontal and anterior cingulate cortices.

Abstract:

:Recent evidence has suggested that theta-frequency (4-7 Hz) oscillations around the human anterior cingulate cortex (ACC) and frontal cortex--that is, frontal midline theta (Fm theta) oscillations--may be involved in attentional processes in the brain. However, little is known about the physiological basis of Fm theta oscillations because invasive study in the human is allowed in only limited cases. In the present study, we developed a monkey model for Fm theta oscillations and located the generators of theta waves using electrodes implanted in various cortical areas. Monkeys were engaged in a self-initiated hand-movement task with a waiting period. The theta power in area 9 (the medial prefrontal cortex) and area 32 (the rostral ACC) was gradually increased from a few seconds before the movement and reached a peak immediately after the movement. When the movement was rewarded, the theta power attained a second peak, whereas it swiftly decreased in the unrewarded trials. Theta oscillations in areas 9 and 32 were coherent and phase locked together. This theta activity may be associated with "executive attention" including self-control, internal timing, and assessment of reward. It is probably a homologue of human Fm theta oscillations, as judged from the similar localization, corresponding frequency, and dependency on attentional processes. The monkey model would be useful for studying executive functions in the frontal cortex.

journal_name

J Neurophysiol

authors

Tsujimoto T,Shimazu H,Isomura Y

doi

10.1152/jn.00730.2005

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

2987-3000

issue

5

eissn

0022-3077

issn

1522-1598

pii

00730.2005

journal_volume

95

pub_type

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