Abstract:
:The dorsal lateral geniculate nucleus (dLGN) of the thalamus is the exclusive relay of retinal information en route to the visual cortex. Although much of our understanding about dLGN comes from studies done in higher mammals, such as the cat and primate, the mouse as a model organism has moved to the forefront as a tractable experimental platform to examine cell type-specific relations. This review highlights our current knowledge about the development, structure, and function of the mouse dLGN.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Guido Wdoi
10.1152/jn.00651.2017subject
Has Abstractpub_date
2018-07-01 00:00:00pages
211-225issue
1eissn
0022-3077issn
1522-1598journal_volume
120pub_type
杂志文章,评审abstract::1. The lateral geniculate nucleus is the primary thalamic relay through which retinal signals pass en route to cortex. This relay is gated and can be suppressed by activity among local inhibitory neurons that use gamma-aminobutyric acid (GABA) as a neurotransmitter. In the cat, a major source of this GABAergic inhibit...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.65.6.1528
更新日期:1991-06-01 00:00:00
abstract::1. Patch-clamp methods were used to study recombinant glutamate receptor (GluR) ion channels expressed in human embryonic kidney cells (HEK 293) after transfection of the cells with cDNAs encoding kainate (KA)-type GluR subunits. Cells were transiently or stably transfected with the fully edited (R) version of GluR6 o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.1.510
更新日期:1996-07-01 00:00:00
abstract::1. The discharge of individual neurons in the visual cortex and lateral geniculate nucleus (LGN) of anesthetized and paralyzed cats and kittens was examined for the presence of oscillatory activity. Neural firing was evoked through the monoptic or dichoptic presentation of drifting gratings and random sequences of fla...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.5.1558
更新日期:1992-11-01 00:00:00
abstract::The central axons of peripherally regenerated Abeta primary sensory neurons were impaled in the dorsal columns of alpha-chloralose-anesthetized cats 9-12 mo after axotomy. The adequate peripheral stimulus was determined, and the afferent fibers intracellularly stimulated while simultaneously recording the resulting co...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.4.1636
更新日期:1999-04-01 00:00:00
abstract::Previous studies have described maturational changes in GABAergic inhibitory synaptic transmission in the rodent somatosensory cortex during the early postnatal period. To determine whether alterations in the functional properties of synaptically localized GABA(A) receptors (GABA(A)Rs) contribute to development of inh...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.6.3286
更新日期:1999-12-01 00:00:00
abstract::Leopard frog saccular hair cells exhibit an electrical resonance in response to a depolarizing stimulus that has been proposed to contribute to the tuning properties of the frog sacculus by acting as an electrical band-pass filter. With the whole cell patch-clamp technique, we have investigated the effect of temperatu...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.1.312
更新日期:1998-01-01 00:00:00
abstract::Natural visual scenes are cluttered. In such scenes, many objects in the periphery can be crowded, blocked from identification, simply because of the dense array of clutter. Outside of the fovea, crowding constitutes the fundamental limitation on object recognition and is thought to arise from the limited resolution o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,随机对照试验
doi:10.1152/jn.00904.2010
更新日期:2011-09-01 00:00:00
abstract::Dual whole cell patch-clamp recordings in rat nucleus accumbens, the main component of the ventral striatum, were made to assess the presence of synaptic interconnections between medium-sized spiny neurons, a group of GABAergic and peptidergic neurons that constitute the principal cells of the striatum. Neurons were s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00892.2003
更新日期:2004-03-01 00:00:00
abstract::Paired-pulse transcranial magnetic stimulation (TMS) can be used to examine intracortical inhibition in primary motor cortex (M1), termed short-interval intracortical inhibition (SICI). To our knowledge, SICI has only been demonstrated in contralateral motor evoked potentials (MEPs). Ipsilateral MEPs (iMEPs) are assum...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01139.2015
更新日期:2016-03-01 00:00:00
abstract::In this tribute to Reggie Edgerton, I briefly review the spinal mechanisms that coordinate locomotion and the interaction between the different sensory mechanisms that help coordinate the locomotor movements and the central locomotor network. The step cycle has four distinct parts, the support phase, the lift off, the...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00656.2020
更新日期:2020-12-23 00:00:00
abstract::Substance P (SP) is an undecapeptide that is co-localized with conventional transmitters in the nucleus accumbens (NAc). Its neurochemical and behavioral effects resemble those of cocaine and amphetamine. How SP accomplishes these effects is not known, partly because its cellular and synaptic effects are not well char...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00854.2002
更新日期:2003-02-01 00:00:00
abstract::Evidence first described in reduced animal models over 100 years ago led to deductions about the control of locomotion through spinal locomotor central pattern-generating (CPG) networks. These discoveries in nature were contemporaneous with another form of deductive reasoning found in popular culture, that of Arthur C...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.00554.2017
更新日期:2018-07-01 00:00:00
abstract::Over the past decade neuroscientific research has attempted to probe the neurobiological underpinnings of human prosocial decision making. Such research has almost ubiquitously employed tasks such as the dictator game or similar variations (i.e., ultimatum game). Considering the explicit numerical nature of such tasks...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00372.2017
更新日期:2017-12-01 00:00:00
abstract::Complex patterns of intercellular calcium signaling occur in the CA1 and CA2 regions of hippocampal slice organotypic cultures from neonatal mice. Spontaneous localized intercellular Ca2+ waves involving 5-15 cells propagate concentrically from multiple foci in the stratum oriens and s. radiatum. In these same regions...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.2.1045
更新日期:1998-02-01 00:00:00
abstract::An orthodromically evoked late hyperpolarizing potential (LHP) was studied using intracellular recording techniques in rat hippocampal CA1 pyramidal cells in vitro. Several tests indicated that the LHP is not blocked by GABA antagonists, but rather comprises the initial portion of the stimulation-induced burst afterhy...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.52.5.892
更新日期:1984-11-01 00:00:00
abstract::A large number of studies have demonstrated that structures within the medial temporal lobe, such as the hippocampus, are intimately involved in declarative memory for objects and people. Although these items are abstractions of the visual scene, specific visual details can change the speed and accuracy of their recal...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00977.2010
更新日期:2011-06-01 00:00:00
abstract::Dopaminergic modulation of neuronal networks in the dorsolateral prefrontal cortex (PFC) is believed to play an important role in information processing during working memory tasks in both humans and nonhuman primates. To understand the basic cellular mechanisms that underlie these actions of dopamine (DA), we have in...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.84.6.2799
更新日期:2000-12-01 00:00:00
abstract::Rhythm generation by the pyloric motor network in the stomatogastric ganglion (STG) of the spiny lobster requires permissive neuromodulatory inputs from other central ganglia. When these inputs to the STG are suppressed by cutting the single, mainly afferent stomatogastric nerve (stn), pyloric neurons cease to burst a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00482.2001
更新日期:2002-12-01 00:00:00
abstract::To estimate contour-orientation sensitivity of the cat and the degree to which precortical processing contributes to such estimates, the amplitude of visually evoked potentials (VEP) recorded from the visual cortex of cats in response to a visual stimulus (S2) presented at various intervals after presentation of anoth...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.53.5.1287
更新日期:1985-05-01 00:00:00
abstract::1. Whole-cell recordings were performed on acutely isolated pyramidal neurons from rat sensorimotor cortex 2 to 21 days postnatal to study the expression of a tetrodotoxin (TTX) sensitive, voltage dependent, persistent Na+ current (INaP) during different stages of postnatal development. 2. INaP was activated positive ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.1.290
更新日期:1993-01-01 00:00:00
abstract::Spontaneous calcium oscillations in mushroom bodies of late stage pupal and adult Drosophila brains have been implicated in memory consolidation during olfactory associative learning. This study explores the cellular mechanisms regulating calcium dynamics in Kenyon cells, principal neurons in mushroom bodies. Fura-2 i...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00096.2005
更新日期:2005-07-01 00:00:00
abstract::The corticospinal tract excitability is modulated when preparing movements. Earlier to movement execution, the excitability of the spinal cord increases waiting for supraspinal commands to release the movement. Movement execution and movement observation share processes within the motor system, although movement obser...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00353.2013
更新日期:2014-04-01 00:00:00
abstract::The octopus cells of the posteroventral cochlear nucleus receive inputs from auditory-nerve fibers and form one of the major ascending auditory pathways. They respond to acoustic and electrical stimulation transiently and are believed to carry temporal information in the precise timing of their action potentials. The ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.2.872
更新日期:1997-08-01 00:00:00
abstract::Many have recently questioned whether all levels of actions understanding, from lower kinematic levels to the higher goal or intention levels of action understanding, are processed in the action observation network (a network of neurons that are active during action execution and observation). A recent study by Wurm a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00819.2015
更新日期:2016-03-01 00:00:00
abstract::The effects of neuronal density on morphological and functional attributes of the evolving networks were studied in cultured dissociated hippocampal neurons. Plating at different densities affected connectivity among the neurons, such that sparse networks exhibited stronger synaptic connections between pairs of record...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00914.2009
更新日期:2010-08-01 00:00:00
abstract::In acute experiments performed in decerebrated and spinalized (T13) cats, an intraspinal injection of clonidine, a noradrenergic agonist, restricted to mid-lumbar segments L3-L4, can induce hindlimb locomotion, whereas yohimbine, a noradrenergic antagonist, can block spinal locomotion, and a second spinal lesion at L4...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00909.2004
更新日期:2005-05-01 00:00:00
abstract::Rodents shift their nose from side to side when they actively explore and lateralize odors in the space. This motor action is driven by a pair of muscles, the deflector nasi. We studied the premotor control of this motion. We used replication-competent rabies virus to transsynaptically label inputs to the deflector na...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00608.2018
更新日期:2019-01-01 00:00:00
abstract::Proteinase-activated receptors (PARs) have a unique activation mechanism in that a proteolytically exposed N-terminal region acts as a tethered ligand. A potential impact of PAR on sensory processing has not been fully examined yet. Here we report that synthetic peptides with sequences corresponding to PAR ligands enh...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91117.2008
更新日期:2009-07-01 00:00:00
abstract::Distractions affect postural control, but this mechanism is not well understood. Diversion of resources during cognitive stress may lead to decreased motor drive and postural muscle tone. This may appear as decreased postural stiffness and increased postural sway amplitude. We hypothesized that dual tasking leads to d...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00820.2009
更新日期:2010-12-01 00:00:00
abstract::We studied the eye movements evoked by applying small amounts of current (2-50 microA) within the oculomotor vermis of two monkeys. We first compared the eye movements evoked by microstimulation applied either during maintained pursuit or during fixation. Smooth, pursuitlike changes in eye velocity caused by the micro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.4.2046
更新日期:1998-10-01 00:00:00