Abstract:
:1. Ionic conductances controlled by type A and type B cholecystokinin (CCK) receptors were studied in neurons of the rat nucleus tractus solitarius (NTS) and dorsal motor nucleus of the vagus (DMNV), using intracellular and whole-cell patch clamp recordings in current or voltage clamp configuration during bath application of agonists (CCK8, CCK4, BC 264) and antagonists. 2. CCKA receptor-related inhibition was associated with a membrane hyperpolarization and a decrease in input resistance that developed 2-6 min after the arrival of drug into the extracellular medium. These effects were induced by 5 nM CCK8 but not BC 264 and they were blocked by the CCKA antagonist, L-364,718, but not by the CCKB antagonist, L-365,260. 3. CCKA receptor-related inhibition was generated by a potassium current that reversed at a reversal potential E(rev) of -73 +/- 1 (mean +/- SE) mV with bathing potassium concentration [K+]o = 6 mM and at -88 +/- 1 with [K+]o = 3 mM, in agreement with the Nernst equation for potassium ions. 4. CCKB receptor-related excitation was associated with a membrane depolarization and an increase of the input resistance induced by the following agonists at threshold concentrations: CCK8 (0.2 nM) > or = BC 264 (0.4 nM) > CCK4 (10.9 nM). The increase of input resistance was abolished by L-365,260 and was maintained after blockade of the CCKA current by L-364,718. 5. CCKB receptor-related excitation, in the neurons (30% of cases) in which clear response reversal was observed, appeared to be generated by a decrease of a potassium conductance. Responses showed a reversal potential E(rev) of -68 +/- 4 mV with [K+]o = 6 mM and -89 +/- 1 mV with [K+]o = 3 mM, verifying predictions from the Nernst equation applied to potassium ions. However, in 70% of cases, clear reversal was not observed at membrane potentials negative to the theoretical potassium equilibrium potential EK. 6. In voltage clamp studies, CCK8 induced a 181 +/- 17 pA inward current associated with a 26 +/- 4% decrease in the instantaneous current (I(ins)) generated by hyperpolarizing voltage steps. This effect on I(ins) was demonstrated in the absence of effects on the outward noninactivating potassium current (IM) and on the inward noninactivating cationic current (IQ). 7. CCKB receptor-mediated excitation was not suppressed by cobalt, a blocker of calcium currents, and was not associated with a change of the calcium-dependent potassium current (IK(Ca)).(ABSTRACT TRUNCATED AT 400 WORDS)
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Branchereau P,Champagnat J,Denavit-Saubié Mdoi
10.1152/jn.1993.70.6.2584subject
Has Abstractpub_date
1993-12-01 00:00:00pages
2584-95issue
6eissn
0022-3077issn
1522-1598journal_volume
70pub_type
杂志文章abstract::The suprachiasmatic nucleus (SCN) receives a dense serotonergic innervation that modulates photic input to the SCN via serotonin 1B (5-HT1B) presynaptic receptors on retinal glutamatergic terminals. However, the majority of 5-HT1B binding sites in the SCN are located on nonretinal terminals and most axonal terminals i...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00770.2004
更新日期:2005-06-01 00:00:00
abstract::The motor pathway responsible for the complex vocalizations of songbirds has been extensively characterized, both in terms of intrinsic and synaptic physiology in vitro and in terms of the spatiotemporal patterns of neural activity in vivo. However, the relationship between the neural architecture of the song motor pa...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01146.2003
更新日期:2004-07-01 00:00:00
abstract::Macaque SEF neurons encode object-centered directions of eye movements regardless of the visual attributes of instructional cues. Neurons in the supplementary eye field (SEF) of the macaque monkey exhibit object-centered direction selectivity in the context of a task in which a spot flashed on the right or left end of...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.5.2340
更新日期:1999-05-01 00:00:00
abstract::The responses of sustaining and dimming fibers were characterized by the time varying firing rates elicited by extrinsic current and flashes of light. These data were simulated by an adaptive integrate-and-fire model. A postimpulse shunt conductance simulated spike-frequency adaptation. The correlation between observe...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00035.2004
更新日期:2004-07-01 00:00:00
abstract::Contrasting theories of visual attention have emphasized selection by spatial location, individual features, and whole objects. We used functional magnetic resonance imaging to ask whether and how attention to one feature of an object spreads to other features of the same object. Subjects viewed two spatially superimp...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00828.2012
更新日期:2013-11-01 00:00:00
abstract::One of the fundamental principles of neuroscience is that direct electrical interactions between neurons are not possible without specialized electrical contacts, gap junctions, because the transmembrane resistance of neurons is typically much higher than the resistance of the adjacent extracellular space. However it ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00098.2005
更新日期:2006-03-01 00:00:00
abstract::1. Reflex responses were elicited in muscles that act at the ankle by electrical stimulation of low-threshold afferents from the foot in human subjects who were reclining supine. During steady voluntary contractions, stimulus trains (5 pulses at 300 Hz) were delivered at two intensities to the sural nerve (1.2-4.0 tim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.67.5.1375
更新日期:1992-05-01 00:00:00
abstract::During priming of pop-out, performance at discriminating a pop-out feature target in visual search is affected by whether the target on the previous trial was defined by the same feature as on the upcoming trial. Recent studies suggest that priming of pop-out relies on attentional processes. With the use of simultaneo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00121.2011
更新日期:2011-12-01 00:00:00
abstract::In rats, forelimb movements are evoked from two cortical regions, the caudal and rostral forelimb areas (CFA and RFA, respectively). These areas are densely interconnected and RFA induces complex and powerful modulations of CFA outputs. CFA and RFA also have interhemispheric connections, and these areas from both hemi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00591.2019
更新日期:2020-04-01 00:00:00
abstract::1. Whether complex (C) cells are the only truly texture-sensitive units in the cat's primary visual cortex remains controversial. In view of the strong physiological significance of having putatively only one class of cells sensitive to visual noise in the striate cortex, we reinvestigated this issue. Sensitivities of...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.3.1271
更新日期:1995-09-01 00:00:00
abstract::Although studies of the principal tongue protrudor muscle genioglossus (GG) suggest that whole muscle GG electromyographic (EMG) activities are preserved in nonrapid eye movement (NREM) sleep, it is unclear what influence sleep exerts on individual GG motor unit (MU) activities. We characterized the firing patterns of...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00865.2007
更新日期:2007-12-01 00:00:00
abstract::Cutaneous reflexes evoked in the muscles of the arms with electrical stimulation of nerves of the foot ("interlimb reflexes") are observed during walking. These reflexes have been suggested to coordinate the actions of the legs and arms when walking is disturbed. Recently, we showed that cutaneous reflexes evoked in t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00746.2006
更新日期:2006-12-01 00:00:00
abstract::1. During alertness, lemniscal thalamocortical neurons in the ventral medial geniculate body (MGBv) encode sound signals by firing action potentials in a tonic mode. When they are in a burst firing mode, characteristic of thalamic neurons during some sleep states, the same stimuli may have an alerting function, leadin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.6.3597
更新日期:1996-12-01 00:00:00
abstract::The development of auditory temporal processing is important for processing complex sounds as well as for acquiring reading and language skills. Neuronal properties and sound processing change dramatically in auditory cortex neurons after the onset of hearing. However, the development of the auditory thalamus or media...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00021.2013
更新日期:2013-06-01 00:00:00
abstract::Single-unit activity was recorded from the caudate nucleus (CD), globus pallidus, and entopeduncular nucleus (GP-ENTO) in awake, partially restrained kittens. The purpose of this experiment was to assess the ability of developing basal ganglia structures to process natural facial somatosensory information and compare ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.54.1.143
更新日期:1985-07-01 00:00:00
abstract::1. Two subtypes of astrocytes that expressed distinctly different ion channel complements were identified in primary cultures from rat spinal cord and hippocampus using whole cell patch-clamp techniques. One population of cells expressed voltage-activated Na+ currents and displayed outwardly rectifying I-V relationshi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.1.626
更新日期:1996-07-01 00:00:00
abstract::Current-clamp recordings were made from the deep cerebellar nuclei (DCN) of 12- to 15-day-old rats to understand the factors that mediate intrinsic spontaneous firing patterns. All of the cells recorded were spontaneously active with spiking patterns ranging continuously from regular spiking to spontaneous bursting wi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.4.1697
更新日期:1999-10-01 00:00:00
abstract::Retinal ganglion cells (RGC) transmit visual signals to thalamocortical relay neurons in the lateral geniculate nucleus via retinogeniculate synapses. Relay neuron spike patterns do not simply reflect those of RGCs, but the mechanisms controlling this transformation are not well understood. We therefore examined synap...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00562.2003
更新日期:2003-10-01 00:00:00
abstract::N-methyl-d-aspartate (NMDA) receptors play crucial roles in glutamate-mediated synaptic transmission and plasticity and are involved in a variety of brain functions. Specific single nucleotide polymorphisms (SNPs) in the genes encoding NMDA receptor subunits have been associated with some neuropsychiatric disorders in...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00318.2011
更新日期:2011-10-01 00:00:00
abstract::Exposure to odorants results in a rapid (<10 s) reduction in odor-evoked activity in the rat piriform cortex despite relatively maintained afferent input from olfactory bulb mitral cells. To further understand this form of cortical plasticity, a detailed analysis of its odor specificity was performed. Habituation of o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.1.139
更新日期:2000-01-01 00:00:00
abstract::The same set of stimuli and analytic methods that was used to study the dynamics of horizontal cells () was applied to a study of the response dynamics and signal processing in amacrine cells in the retina of the kissing gourami, Helostoma rudolfi. The retina contains two major classes of amacrine cells that could be ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.4.2018
更新日期:1997-10-01 00:00:00
abstract::Ablation and single-unit studies in primates have shown that inferior temporal (IT) cortex is important for pattern discrimination. The first paper in this series suggested that single units in IT cortex of alert monkeys respond to a set of two-dimensional patterns with complex temporal modulation of their spike train...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.1.162
更新日期:1987-01-01 00:00:00
abstract::1. In order to investigate the effects of an imbalance in stimulation to the eyes without the confounding influence of continuous deprivation of one eye, we reared cats with unequal alternating monocular exposure (AME) and, for comparison, cats with equal AME. We recorded extracellularly from single cells in area 17 o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.49.3.804
更新日期:1983-03-01 00:00:00
abstract::1. We define an extrinsic frame of reference to represent the location of a point in extrapersonal space relative to a human subject's shoulder, and we define an intrinsic frame of reference to represent the orientation of the arm and forearm. 2. We examined the relations between coordinates in the extrinsic and intri...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1989.62.2.595
更新日期:1989-08-01 00:00:00
abstract::The abilities of humans to discriminate the softness of rubber objects of differing compliance with a hand-held tool (a stylus) was measured under experimental conditions that differed as to how the tool was used and the kind of sensory information available. When the subject actively tapped or pressed the compliant o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.4.1777
更新日期:2000-04-01 00:00:00
abstract::Recent discoveries of visceral nociceptive inputs sharing the classical tactile pathway in the dorsal-column medial lemniscus system have opened a new venue for the investigation of somatovisceral interactions. The current study was designed to determine whether somatic innocuous inputs modulate visceral nociceptive t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.88.3.1185
更新日期:2002-09-01 00:00:00
abstract::Neurons integrate subthreshold inputs in a frequency-dependent manner. For sinusoidal stimuli, response amplitudes thus vary with stimulus frequency. Neurons in entorhinal cortex show two types of such resonance behavior: stellate cells in layer II exhibit a prominent peak in the resonance profile at stimulus frequenc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01116.2003
更新日期:2004-07-01 00:00:00
abstract::While the effects of sensory feedback on bimanual tasks have been studied extensively at two ends of the motor control hierarchy, the cortical and behavioral levels, much less is known about how it affects the intermediate levels, including neural control of homologous muscle groups. We investigated the effects of som...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00269.2016
更新日期:2017-02-01 00:00:00
abstract::Facial flushing in rosacea is often induced by trigger events. However, trigger causation mechanisms are currently unclear. This study tested the central hypothesis that rosacea causes sympathetic and axon reflex-mediated alterations resulting in trigger-induced symptomatology. Twenty rosacea patients and age/sex-matc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00458.2015
更新日期:2015-09-01 00:00:00
abstract::Cell-surface glutamate transporters are essential for the proper function of early cortical networks because their dysfunction induces seizures in the newborn rat in vivo. We have now analyzed the consequences of their inhibition by DL-TBOA on the activity of the developing CA1 rat hippocampal network in vitro. DL-TBO...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00378.2007
更新日期:2007-10-01 00:00:00