Partial cross-correlation analysis resolves ambiguity in the encoding of multiple movement features.

Abstract:

:A classical question in neuroscience is which features of a stimulus or of an action are represented in brain activity. When several features are interdependent either at a given point in time or at distinct points in time, neural activity related to one feature appears to be correlated with other features. Thus techniques that simultaneously consider multiple features cannot account for delayed interdependencies between features. The result is an ambiguity with respect to the encoded features. Here, we resolve this ambiguity by applying a novel statistical method based on partial cross-correlations. The method yields estimates of linear correlations between neural activity and a given feature that are not affected by linear correlations with other features at multiple time delays. The method also provides a graphical output measured on a scale that allows for comparisons between different features, neurons, and experiments. We use real movement data and neural activity simulated according to a wide range of tuning models to illustrate the method. When applied to real neural activity, the procedure yields results that indicate which of the considered features the neural activity is related to and at what time delays.

journal_name

J Neurophysiol

authors

Stark E,Drori R,Abeles M

doi

10.1152/jn.00981.2005

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

1966-75

issue

3

eissn

0022-3077

issn

1522-1598

pii

00981.2005

journal_volume

95

pub_type

杂志文章
  • Attention and memory-related responses of neurons in the lateral intraparietal area during spatial and shape-delayed match-to-sample tasks.

    abstract::When a monkey attends to, remembers, and looks toward targets, the activity of some neurons in the lateral intraparietal area (LIP) changes. We recorded from isolated neurons during both a spatial and a shape match-to-sample task to examine and characterize voluntary active processes in LIP. Many LIP neurons show spat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00431.2005

    authors: Sereno AB,Amador SC

    更新日期:2006-02-01 00:00:00

  • Recruitment order of cat abducens motoneurons and internuclear neurons.

    abstract::Abducens neurons undergo a dose-dependent synaptic blockade (either disinhibition or complete blockade) when tetanus neurotoxin (TeNT) is injected into the lateral rectus muscle at either a low (0.5) or a high dose (5 ng/kg). We studied the firing pattern and recruitment order in abducens neurons both in control and a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00402.2003

    authors: Pastor AM,Gonzalez-Forero D

    更新日期:2003-10-01 00:00:00

  • Modeling of smooth pursuit-related neuronal responses in the DLPN and NRTP of the rhesus macaque.

    abstract::The dorsolateral pontine nucleus (DLPN) and nucleus reticularis tegmenti pontis (NRTP) comprise obligatory links in the cortico-ponto-cerebellar system supporting smooth pursuit eye movements. We examined the response properties of DLPN and rNRTP neurons during step-ramp smooth pursuit of a small target moving across ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00588.2004

    authors: Ono S,Das VE,Economides JR,Mustari MJ

    更新日期:2005-01-01 00:00:00

  • Computational study of an excitable dendritic spine.

    abstract::1. A compartmental model was employed to investigate the electrical behavior of a dendritic spine having excitable membrane at the spine head. Here we used the Hodgkin and Huxley equations to generate excitable membrane properties; in some cases the kinetics were modified to get a longer duration action potential. Pas...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.60.2.499

    authors: Segev I,Rall W

    更新日期:1988-08-01 00:00:00

  • Baseline cortical excitability determines whether TMS disrupts or facilitates behavior.

    abstract::Transcranial magnetic stimulation (TMS) is increasingly used to modify brain activity noninvasively and to study brain-behavior relations. However, results can be variable and the conditions that affect the functional efficacy of TMS remain unclear. Here we show that on-line TMS can either facilitate or suppress perce...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01392.2007

    authors: Silvanto J,Cattaneo Z,Battelli L,Pascual-Leone A

    更新日期:2008-05-01 00:00:00

  • Effects of caudate microstimulation on spontaneous and purposive saccades.

    abstract::Electrical stimulation has been delivered to the basal ganglia (BG) to treat intractable symptoms of a variety of clinical disorders. However, it is still unknown how such treatments improve behavioral symptoms. A difficulty of this problem is that artificial signals created by electrical stimulation interact with int...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00046.2013

    authors: Watanabe M,Munoz DP

    更新日期:2013-07-01 00:00:00

  • Activity of hindlimb motor units during locomotion in the conscious rat.

    abstract::This paper compares the activity of hindlimb motor units from muscles mainly composed of fast-twitch muscle fibers (medial and lateral gastrocnemius: MG/LG, tibialis anterior: TA) to motor units from a muscle mainly composed of slow-twitch muscle fibers (soleus: SOL) during unrestrained walking in the conscious rat. S...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.4.2002

    authors: Gorassini M,Eken T,Bennett DJ,Kiehn O,Hultborn H

    更新日期:2000-04-01 00:00:00

  • Chronic exposure to ethanol alters GABA(A) receptor-mediated responses of layer II pyramidal cells in adult rat piriform cortex.

    abstract::This study examined the effect of chronic exposure to ethanol on gamma-aminobutyric acid type-A (GABA(A)) receptor-mediated responses of layer II pyramidal neurons of the piriform cortex. Slices containing the piriform cortex were derived from pair-fed adult rats maintained on ethanol-supplemented or control liquid di...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.1.247

    authors: Signore AP,Yeh HH

    更新日期:2000-07-01 00:00:00

  • Physiological and behavioral reactivity to social exclusion: a functional infrared thermal imaging study in patients with psoriasis.

    abstract::Recent studies have shown that sympathetic nervous system (SNS) activity can be heavily impacted not only by basic threats to survival but also by threats to social bonds. In this study we explored the behavioral and physiological consequences of social exclusion/inclusion in patients with psoriasis, a disease frequen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00555.2018

    authors: Ponsi G,Monachesi B,Panasiti V,Aglioti SM,Panasiti MS

    更新日期:2019-01-01 00:00:00

  • Simulation of different firing patterns in paired spider mechanoreceptor neurons: the role of Na(+) channel inactivation.

    abstract::The spider VS-3 slit-sense organ contains two types of primary mechanoreceptor neurons that are morphologically similar but have different electrical behavior. Type A neurons fire only one or two action potentials in response to a mechanical or electrical step of any amplitude above the threshold, whereas type B neuro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00440.2001

    authors: Torkkeli PH,French AS

    更新日期:2002-03-01 00:00:00

  • Specificity of color connectivity between primate V1 and V2.

    abstract::To examine the functional interactions between the color and form pathways in the primate visual cortex, we have examined the functional connectivity between pairs of color oriented and nonoriented V1 and V2 neurons in Macaque monkeys. Optical imaging maps for color selectivity, orientation preference, and ocular domi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.82.5.2719

    authors: Roe AW,Ts'o DY

    更新日期:1999-11-01 00:00:00

  • Optical study of interactions among propagation waves of neural excitation in the rat somatosensory cortex evoked by forelimb and hindlimb stimuli.

    abstract::Multisite optical recording has revealed that the neural excitation wave induced by a sensory stimulation begins at a focus and propagates in the cortex. This wave is considered to be important for computation in the sensory cortex, particularly the integration of sensory information; however, the nature of this wave ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00904.2017

    authors: Hama N,Kawai M,Ito SI,Hirota A

    更新日期:2018-05-01 00:00:00

  • Coherent oscillations in membrane potential synchronize impulse bursts in central olfactory neurons of the crayfish.

    abstract::Lateral protocerebral interneurons (LPIs) in the central olfactory pathway of the freshwater crayfish Procambarus clarkii reside within the lateral protocerebrum and receive direct input from projection neurons of the olfactory midbrain. The LPIs exhibit periodic (0.5 Hz) changes in membrane potential that are imposed...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.3.1231

    authors: Mellon D Jr,Wheeler CJ

    更新日期:1999-03-01 00:00:00

  • The neuropeptide FMRFa both inhibits and enhances the Ca2+ current in dissociated Helix neurons via independent mechanisms.

    abstract::1. The modulation of the voltage-activated Ca2+ current by the neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFa) was investigated in dissociated central neurons from Helix aspersa using whole-cell voltage-clamp recording techniques. External Ba2+ was always used as the charge carrier in this study, and the intracellular Ca2+ c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.65.6.1517

    authors: Yakel JL

    更新日期:1991-06-01 00:00:00

  • Encoding of sound-source location and movement: activity of single neurons and interactions between adjacent neurons in the monkey auditory cortex.

    abstract::1. Neuronal mechanisms for decoding sound azimuth and angular movement were studied by recordings of several single units in parallel in the core areas of the auditory cortex of the macaque monkey. The activity of 180 units was recorded during the presentation of moving and static sound stimuli. Both the activity of s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.67.1.203

    authors: Ahissar M,Ahissar E,Bergman H,Vaadia E

    更新日期:1992-01-01 00:00:00

  • Slow oscillating population activity in developing cortical networks: models and experimental results.

    abstract::During early development neuronal networks express slow oscillating synchronized activity. The activity can be driven by several, not necessarily mutually exclusive, mechanisms. Each mechanism might have distinctive consequences for the phenomenology, formation, or sustainment of the early activity pattern. Here we st...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00889.2010

    authors: Baltz T,Herzog A,Voigt T

    更新日期:2011-09-01 00:00:00

  • Ionic mechanism of substance P actions on neurons in trigeminal root ganglia.

    abstract::1. Responses of primary sensory neurons to substance P applications by perfusion were studied with intracellular recording techniques in in vitro slice preparations of trigeminal root ganglia (guinea pigs). Application of substance P in micromolar doses produced reversible depolarizations of 2-47 mV in 48 out of 64 ne...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1990.64.1.273

    authors: Spigelman I,Puil E

    更新日期:1990-07-01 00:00:00

  • Adaptations in biceps brachii motor unit activity after repeated bouts of eccentric exercise in elbow flexor muscles.

    abstract::The purpose of this study was to examine changes in motor unit activity in the biceps brachii muscle after an initial (Bout 1) and repeated (Bout 2) session of eccentric exercise separated by 1 wk. Eight subjects (aged 22 ± 2 yr) participated in experimental assessments of neuromuscular function obtained before, immed...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00854.2010

    authors: Dartnall TJ,Nordstrom MA,Semmler JG

    更新日期:2011-03-01 00:00:00

  • Vestibular modulation of muscle sympathetic nerve activity assessed over a 100-fold frequency range of sinusoidal galvanic vestibular stimulation.

    abstract::We have previously shown that sinusoidal galvanic vestibular stimulation (sGVS), delivered at 0.2-2.0 Hz, evokes a partial entrainment of muscle sympathetic nerve activity (MSNA). Moreover, at lower frequencies of stimulation (0.08-0.18 Hz) sGVS produces two peaks of modulation: one (primary) peak associated with the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00679.2018

    authors: Singh N,Hammam E,Macefield VG

    更新日期:2019-05-01 00:00:00

  • NMDA and non-NMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus.

    abstract::1. We have examined the effects of iontophoresing specific antagonists to excitatory amino acid receptors on the visual responses of cells in lamina A or A1 of the cat's lateral geniculate nucleus (LGN). 2. Cells were classified as On- or Off-center, X or Y, and lagged or nonlagged. The effects of antagonists were stu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.2.414

    authors: Kwon YH,Esguerra M,Sur M

    更新日期:1991-08-01 00:00:00

  • Developmental changes in evoked Purkinje cell complex spike responses.

    abstract::The development of synaptic interconnections between the cerebellum and inferior olive, the sole source of climbing fibers, could contribute to the ontogeny of certain forms of motor learning (e.g., eyeblink conditioning). Purkinje cell complex spikes are produced exclusively by climbing fibers and exhibit short- and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00481.2003

    authors: Nicholson DA,Freeman JH Jr

    更新日期:2003-10-01 00:00:00

  • Visuomotor learning is dependent on direction-specific error saliency.

    abstract::People perceive better in cardinal directions compared with oblique ones. This directional effect, called oblique effect, has been documented in perception studies for a long time. However, typical motor studies do not differentiate learning in different directions. In this study we identify a significant directional ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00787.2017

    authors: Jiang W,Yuan X,Yin C,Wei K

    更新日期:2018-07-01 00:00:00

  • The visual encoding of purely proprioceptive intermanual tasks is due to the need of transforming joint signals, not to their interhemispheric transfer.

    abstract::To perform goal-oriented hand movement, humans combine multiple sensory signals (e.g., vision and proprioception) that can be encoded in various reference frames (body centered and/or exo-centered). In a previous study (Tagliabue M, McIntyre J. PLoS One 8: e68438, 2013), we showed that, when aligning a hand to a remem...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00140.2017

    authors: Arnoux L,Fromentin S,Farotto D,Beraneck M,McIntyre J,Tagliabue M

    更新日期:2017-09-01 00:00:00

  • Brief trains of action potentials enhance pyramidal neuron excitability via endocannabinoid-mediated suppression of inhibition.

    abstract::Depolarization-induced suppression of inhibition (DSI) is a form of retrograde signaling at GABAergic synapses that is initiated by the calcium- and depolarization-dependent release of endocannabinoids from postsynaptic neurons. In the neocortex, pyramidal neurons (PNs) appear to use DSI as a mechanism for regulating ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00351.2004

    authors: Fortin DA,Trettel J,Levine ES

    更新日期:2004-10-01 00:00:00

  • Development and long-term integration of MGE-lineage cortical interneurons in the heterochronic environment.

    abstract::Interneuron precursors transplanted into visual cortex induce network plasticity during their heterochronic maturation. Such plasticity can have a significant impact on the function of the animal and is normally present only during a brief critical period in early postnatal development. Elucidating the synaptic and ph...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00096.2017

    authors: Larimer P,Spatazza J,Stryker MP,Alvarez-Buylla A,Hasenstaub AR

    更新日期:2017-07-01 00:00:00

  • Temporal and spatial tuning of dorsal lateral geniculate nucleus neurons in unanesthetized rats.

    abstract::Visual response properties of neurons in the dorsolateral geniculate nucleus (dLGN) have been well described in several species, but not in rats. Analysis of responses from the unanesthetized rat dLGN will be needed to develop quantitative models that account for visual behavior of rats. We recorded visual responses f...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00812.2014

    authors: Sriram B,Meier PM,Reinagel P

    更新日期:2016-06-01 00:00:00

  • Effects of short-term training on sensory and motor function in severed nerves of long-term human amputees.

    abstract::Much has been studied and written about plastic changes in the CNS of humans triggered by events such as limb amputation. However, little is known about the extent to which the original pathways retain residual function after peripheral amputation. Our earlier, acute study on long-term amputees indicated that central ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00937.2004

    authors: Dhillon GS,Krüger TB,Sandhu JS,Horch KW

    更新日期:2005-05-01 00:00:00

  • Sherlock Holmes and the curious case of the human locomotor central pattern generator.

    abstract::Evidence first described in reduced animal models over 100 years ago led to deductions about the control of locomotion through spinal locomotor central pattern-generating (CPG) networks. These discoveries in nature were contemporaneous with another form of deductive reasoning found in popular culture, that of Arthur C...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00554.2017

    authors: Klarner T,Zehr EP

    更新日期:2018-07-01 00:00:00

  • Development, form, and function of the mouse visual thalamus.

    abstract::The dorsal lateral geniculate nucleus (dLGN) of the thalamus is the exclusive relay of retinal information en route to the visual cortex. Although much of our understanding about dLGN comes from studies done in higher mammals, such as the cat and primate, the mouse as a model organism has moved to the forefront as a t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00651.2017

    authors: Guido W

    更新日期:2018-07-01 00:00:00

  • Voltage-activated potassium outward currents in two types of spider mechanoreceptor neurons.

    abstract::We studied the properties of voltage-activated outward currents in two types of spider cuticular mechanoreceptor neurons to learn if these currents contribute to the differences in their adaptation properties. Both types of neurons adapt rapidly to sustained stimuli, but type A neurons usually only fire one or two act...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.6.2937

    authors: Sekizawa SI,French AS,Höger U,Torkkeli PH

    更新日期:1999-06-01 00:00:00