Abstract:
:Recent studies have shown that sympathetic nervous system (SNS) activity can be heavily impacted not only by basic threats to survival but also by threats to social bonds. In this study we explored the behavioral and physiological consequences of social exclusion/inclusion in patients with psoriasis, a disease frequently associated with the experience of being ostracized and with deficient emotion regulation skills. We employed a virtual ball-tossing game (Cyberball) to induce the experience of social exclusion/inclusion. We then used a Trust Game to measure the effects of this social modulation on trust. During Cyberball, infrared thermal imaging was used to record participants' facial temperature and thus obtain an online measure of SNS activation. Behavioral data showed that social exclusion shifted participants' trust toward unfamiliar players who had not previously excluded them. Physiological data indicated that in control participants, social exclusion triggered higher SNS activation than inclusion. No such effect was found in patients with psoriasis, whose SNS activity was the same during inclusion as it was during exclusion, suggesting that they benefit less from inclusive experiences than control participants. In addition, in patients but not in controls, higher SNS activation during social exclusion was linked to higher monetary investment toward unfamiliar players, a result in keeping with the social reconnection hypothesis, according to which emotions triggered by social rejection can be regulated by investing in new social interactions. We also found that an increase in periorbital temperature is accompanied by a decrease in happiness ratings after social exclusion was experienced during the Cyberball game. NEW & NOTEWORTHY Previous research on emotional processes in psoriasis has mainly employed self-report measures. In this study we used thermal imaging to obtain an online measure of the sympathetic nervous system (SNS) activity during social exclusion and tested how this experience influenced subsequent trust. We found that being included was a less positive experience for patients compared with controls and that SNS activity during exclusion had a stronger influence on subsequent trust in patients than in controls.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Ponsi G,Monachesi B,Panasiti V,Aglioti SM,Panasiti MSdoi
10.1152/jn.00555.2018subject
Has Abstractpub_date
2019-01-01 00:00:00pages
38-49issue
1eissn
0022-3077issn
1522-1598journal_volume
121pub_type
杂志文章abstract::1. Plasticity at the connections between sensory neurons and their follower cells in Aplysia has been used extensively as a model system to examine mechanisms of simple forms of learning. Earlier studies have concluded that serotonin (5-HT) is a key modulatory transmitter and that it exerts its short-term actions via ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.2.643
更新日期:1992-08-01 00:00:00
abstract::The medial-olivocochlear (MOC) acoustic reflex is thought to provide frequency-specific feedback that adjusts the gain of cochlear amplification, but little is known about how frequency specific the reflex actually is. We measured human MOC tuning through changes in stimulus frequency otoacoustic emissions (SFOAEs) fr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00549.2011
更新日期:2012-03-01 00:00:00
abstract::In humans with temporal lobe epilepsy and kainate-treated rats, the mossy fibers of the dentate granule cells send collateral axons into the inner molecular layer. Prior investigations on kainate-treated rats demonstrated that abnormal hilar-evoked events can occasionally be observed in slices with mossy fiber sprouti...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.1.418
更新日期:1998-01-01 00:00:00
abstract::Population spikes vary in size during prolonged epileptic ("ictal") discharges, indicating variations in neuronal synchronization. Here we investigate the role of changes in tissue electrical resistivity in this process. We used the rat hippocampal slice, low-Ca(2+) model of epilepsy and measured changes in pyramidal ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00123.2004
更新日期:2004-07-01 00:00:00
abstract::Purinoreceptors of the P2 family contribute strongly to signaling in the cochlea, but little is known about the effects of purinergic neurotransmission in the central auditory system. Here we examine P2 receptor-mediated signaling in the large spherical bushy cells (SBCs) of Mongolian gerbils around the onset of acous...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00186.2009
更新日期:2009-09-01 00:00:00
abstract::Thalamic intralaminar and medial nuclei participate mainly in affective and motivational aspects of pain processing. Unique to the present study were identification and characterization of spontaneously active neurons in the central lateral nucleus (CL) of the intralaminar thalamus, which were found to respond only to...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90985.2008
更新日期:2009-07-01 00:00:00
abstract::Chronic pain after nerve injury is often accompanied by hypersensitivity to mechanical stimuli, yet whether this reflects altered input, altered processing, or both remains unclear. Spinal nerve ligation or transection results in hypersensitivity to mechanical stimuli in skin innervated by adjacent dorsal root ganglia...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00506.2014
更新日期:2015-01-01 00:00:00
abstract::1. Cats were prepared for chronic recordings from the lumbar enlargement of the spinal dorsal horn. At the beginning of each recording session, a tungsten microelectrode was advanced through the dura in a physiologically intact, awake, drug-free animal, until amplitude discrimination provided a single neuron with a re...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.2.763
更新日期:1995-08-01 00:00:00
abstract::Regulation of feeding behavior involves the integration of multiple physiological and neurological pathways that control both nutrient-seeking and consummatory behaviors. The consummatory phase of ingestion includes stereotyped oromotor movements of the tongue and jaw that are controlled through brain stem pathways. T...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00091.2014
更新日期:2014-08-01 00:00:00
abstract::1. Monkeys were trained to react to an arm perturbation according to an instruction delivered prior to the perturbation. There were two possible instructions (push or pull), and monkeys learned to respond accordingly regardless of the direction (push or pull) of the triggering perturbation. 2. Pyramidal tract neurons ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1976.39.5.1069
更新日期:1976-09-01 00:00:00
abstract::This study was prompted by recent evidence for the existence of positive force feedback in feline locomotor control. Our aim was to establish some basic properties of positive force feedback in relation to load compensation, stability, intrinsic muscle properties, and interaction with displacement feedback. In human s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.6.3226
更新日期:1997-06-01 00:00:00
abstract::Fragile X Syndrome (FXS), the most common inherited form of intellectual disability, is caused by loss of the fragile X mental retardation protein (FMRP). FMRP is a negative regulator of local mRNA translation downstream of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation. In the absence of FMRP there is...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00449.2010
更新日期:2010-08-01 00:00:00
abstract::The dorsal nucleus of the lateral lemniscus (DNLL) receives afferent inputs from many brain stem nuclei and, in turn, is a major source of inhibitory inputs to the inferior colliculus (IC). The goal of this study was to characterize the monaural and binaural response properties of neurons in the DNLL of unanesthetized...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00451.2007
更新日期:2007-09-01 00:00:00
abstract::We studied two human subjects with total deafferentation of one upper limb secondary to traumatic multiple cervical root avulsions. Both subjects developed a phantom limb and underwent elective amputation of the paralyzed, deafferentated limb. Psychophysical study revealed in each subject an area of skin in the pector...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.5.2753
更新日期:1997-05-01 00:00:00
abstract::Frequent gait modifications are often required to navigate our world. These can involve long or wide steps or changes in direction. People generally prefer to minimize the motor cost (or effort) of a movement, although with changes in gait this is not always possible. The decision of when and where to shift gaze is cr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00027.2019
更新日期:2019-07-01 00:00:00
abstract::Natural visual scenes are cluttered. In such scenes, many objects in the periphery can be crowded, blocked from identification, simply because of the dense array of clutter. Outside of the fovea, crowding constitutes the fundamental limitation on object recognition and is thought to arise from the limited resolution o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,随机对照试验
doi:10.1152/jn.00904.2010
更新日期:2011-09-01 00:00:00
abstract::Recent work has investigated the link between motor learning and sensory function in arm movement control. A number of findings are consistent with the idea that motor learning is associated with systematic changes to proprioception (Haith A, Jackson C, Mial R, Vijayakumar S. Adv Neural Inf Process Syst 21: 593-600, 2...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,随机对照试验
doi:10.1152/jn.00122.2012
更新日期:2012-12-01 00:00:00
abstract::1. High-threshold Ca2+ currents were studied in large pyramidal cells acutely dissociated from the rat amygdaloid complex. L-, N-, and P-type currents were present in about equal proportions in these cells and accounted for most of the whole-cell current. ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.71.1.433
更新日期:1994-01-01 00:00:00
abstract::Hypercapnia-induced arousal from sleep is an important protective mechanism pertinent to a number of diseases. Most notably among these are the sudden infant death syndrome, obstructive sleep apnea and sudden unexpected death in epilepsy. Serotonin (5-HT) plays a significant role in hypercapnia-induced arousal. The me...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00213.2015
更新日期:2015-07-01 00:00:00
abstract::Beyond being essential for long-term motor-skill development, movement repetition has immediate benefits on performance, increasing speed and accuracy of a second execution. While repetition effects have been reported for single reaching movements, it has yet to be determined whether they also occur for movement seque...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00054.2020
更新日期:2020-05-01 00:00:00
abstract::If a laterally displacing prism is placed in front of one eye of a person or monkey with the other eye occluded, they initially will point to one side of a target that is located directly in front of them. Normally, people and monkeys adapt easily to the displaced vision and correct their aim after a few trials. If th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.4.1960
更新日期:1999-04-01 00:00:00
abstract::We examined the contribution of the motor cortex to the control of intralimb coordination during reaching in the standing cat. We recorded the activity of 151 pyramidal tract neurons (PTNs) in the forelimb representation of three cats during a task in which the cat reached forward from a standing position to press a l...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00469.2010
更新日期:2011-01-01 00:00:00
abstract::1. The induction of long-term weakening of synaptic transmission in rat hippocampal slices was examined in CA1 synapses during cholinergic modulation. 2. Bath application of the cholinergic agonist carbachol (50 microM) activated an oscillation of the local field potential in the theta-frequency range (5-12 Hz), terme...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.75.2.877
更新日期:1996-02-01 00:00:00
abstract::PSD-95-like, disc-large (DLG) family membrane-associated guanylate kinase proteins (PSD/DLG-MAGUKs) are essential for regulating synaptic AMPA receptor (AMPAR) function and activity-dependent trafficking of AMPARs. Using a molecular replacement strategy to replace endogenous PSD-95 with SAP97β, we show that the protot...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00262.2013
更新日期:2014-02-01 00:00:00
abstract::Vision in natural situations is different from the paradigms generally used to study vision in the laboratory. In natural vision, stimuli usually appear in a receptive field as the result of saccadic eye movements rather than suddenly flashing into view. The stimuli themselves are rich with meaningful and recognizable...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00733.2011
更新日期:2012-07-01 00:00:00
abstract::In the orbitofrontal olfactory area (LPOF) which was delineated in a previous paper, the capacity for odor discrimination was studied and compared with that in the anterior pyriform cortex (AP), the medial portion of the amygdala (MA), and the olfactory bulb (OB). Unanesthetized monkeys were used and eight odors were ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1975.38.5.1284
更新日期:1975-09-01 00:00:00
abstract::Nicotine evokes pain in the skin and oral mucosa and excites a subpopulation of cutaneous nociceptors, but little is known about the central transmission of chemogenic pain. We have investigated the responses of lumbar spinal wide dynamic range (WDR)-type dorsal horn neurons to intracutaneous (ic) microinjection of ni...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.6.3046
更新日期:1999-12-01 00:00:00
abstract::Synaptic transmission throughout most of the CNS is steeply dependent on presynaptic calcium influx through the voltage-gated calcium channels Cav2.1-Cav2.3. In addition to triggering exocytosis, this calcium influx also recruits short-term synaptic plasticity. During the complex patterns of presynaptic activity that ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00335.2013
更新日期:2014-06-15 00:00:00
abstract::Synapsin is a synaptic vesicle-associated protein implicated in the regulation of vesicle trafficking and transmitter release, but its role in heterosynaptic plasticity remains elusive. Moreover, contradictory results have obscured the contribution of synapsin to homosynaptic plasticity. We previously reported that th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00604.2007
更新日期:2007-12-01 00:00:00
abstract::The granular layer of the cerebellum has a disproportionately large number of excitatory (granule cells) versus inhibitory neurons (Golgi cells). Its synaptic organization is also unique with a dense reciprocal innervation between granule and Golgi cells but without synaptic contacts among the neurons of either popula...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.5.2521
更新日期:1998-11-01 00:00:00