Abstract:
:1. High-threshold Ca2+ currents were studied in large pyramidal cells acutely dissociated from the rat amygdaloid complex. L-, N-, and P-type currents were present in about equal proportions in these cells and accounted for most of the whole-cell current.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Foehring RC,Scroggs RSdoi
10.1152/jn.1994.71.1.433subject
Has Abstractpub_date
1994-01-01 00:00:00pages
433-6issue
1eissn
0022-3077issn
1522-1598journal_volume
71pub_type
杂志文章abstract::1. We studied the blocking properties of a spider (Nephila clavata) toxin (JSTX) purified from venom on the spiny lobster neuromuscular junction. 2. When a small amount of JSTX was applied to the neuromuscular junction, the excitatory postsynaptic potential (EPSP) was partially suppressed. The amplitude of EPSPs remai...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.58.2.319
更新日期:1987-08-01 00:00:00
abstract::1. Axonal transection triggers a cascade of pathological processes that frequently lead to the degeneration of the injured neuron. It is generally believed that the degenerative process is triggered by an overwhelming influx of calcium through the cut end of the axon. 2. Theoretical considerations and indirect observa...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.6.2625
更新日期:1995-12-01 00:00:00
abstract::The reward value of a stimulus can be learned through two distinct mechanisms: reinforcement learning through repeated stimulus-reward pairings and abstract inference based on knowledge of the task at hand. The reinforcement mechanism is often identified with midbrain dopamine neurons. Here we show that a neural pathw...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00158.2010
更新日期:2010-08-01 00:00:00
abstract::In the visual, auditory, and electrosensory modalities, stimuli are defined by first- and second-order attributes. The fast time-pressure signal of a sound, a first-order attribute, is important, for instance, in sound localization and pitch perception, while its slow amplitude-modulated envelope, a second-order attri...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00132.2014
更新日期:2014-07-15 00:00:00
abstract::The objective of this project was to examine the influence of stimulus waveform and frequency on extracellular stimulation of neurons with their cell bodies near the electrode (local cells) and fibers of passage in the CNS. Detailed computer-based models of CNS cells and axons were developed that accurately reproduced...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.88.4.1592
更新日期:2002-10-01 00:00:00
abstract::Itch is often triggered by warming the skin in patients with itchy dermatitis, but the underlying mechanism is largely unknown. We presently investigated if warming the skin enhances histamine- or serotonin (5-HT)-evoked itch behavior or responses of sensory dorsal root ganglion (DRG) cells, and if responses of superf...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00703.2016
更新日期:2017-01-01 00:00:00
abstract::Microstimulation within the motor regions of the spinal cord is often assumed to activate motoneurons and propriospinal neurons close to the electrode tip. However, previous work has shown that intraspinal microstimulation (ISMS) in the gray matter activates sensory afferent axons as well as alpha-motoneurons (MNs). H...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00061.2006
更新日期:2006-12-01 00:00:00
abstract::Fear conditioning involves the transmission of sensory stimuli to the amygdala from the thalamus and cortex. These input synapses are prime candidates for sites of plasticity critical to the learning in fear conditioning. Because N-methyl-D-aspartate (NMDA)-dependent mechanisms have been implicated in fear learning, w...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.2.930
更新日期:1999-02-01 00:00:00
abstract::There are many theories on the purpose of neural adaptation, but evidence remains elusive. Here, we discuss the recent work by Benucci et al. (Nat Neurosci 16: 724-729, 2013), who measured for the first time the immediate effects of adaptation on the overall activity of a neuronal population. These measurements confir...
journal_title:Journal of neurophysiology
pub_type: 评论,杂志文章
doi:10.1152/jn.00521.2013
更新日期:2014-08-01 00:00:00
abstract::Interpretation of hemodynamic responses in epilepsy is hampered by an incomplete understanding of the underlying neurovascular coupling, especially the contributions of excitation and inhibition. We made simultaneous multimodal recordings of local field potentials (LFPs), firing of individual neurons, blood flow, and ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00994.2014
更新日期:2016-03-01 00:00:00
abstract::Monoamines are strong modulators and/or activators of spinal locomotor networks. Thus monoaminergic fibers likely contact neurons involved in generating locomotion. The aim of the present study was to investigate the serotonergic innervation of locomotor-activated neurons within the thoraco-lumbar spinal cord followin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91179.2008
更新日期:2009-09-01 00:00:00
abstract::The short-term (3-51 days) and long-term (31-42 wk) effects of corpus callosum transection on the receptive-field properties of neurons were assessed at the single-cell, architectural, and topographical levels of organization in the cat striate cortex. Corpus callosum transection decreased the proportion of neurons th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.52.3.570
更新日期:1984-09-01 00:00:00
abstract::The potassium-chloride cotransporter 2 (KCC2) plays a role in epileptiform synchronization, but it remains unclear how it influences such a process. Here, we used tetrode recordings in the in vitro rat entorhinal cortex (EC) to analyze the effects of the KCC2 antagonist VU0463271 on 4-aminopyridine (4AP)-induced ictal...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00266.2019
更新日期:2019-09-01 00:00:00
abstract::To further understand the excitatory effects of motoneurons on spinal network function, we investigated the entrainment of disinhibited rhythms by ventral root (VR) stimulation in the neonatal mouse spinal cord. A brief train of stimuli applied to a VR triggered bursting reliably in 31/32 experiments. The same roots t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90740.2008
更新日期:2009-06-01 00:00:00
abstract::1. In the intact pond snail Planorbis corneus, a rapid tilt in any plane evoked a defense reaction consisting of a fast movement of the shell towards the head, shortening of the foot, inhibition of locomotion and of rhythmical feeding movements. This reaction was similar to the first phase of the general defense react...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.71.3.898
更新日期:1994-03-01 00:00:00
abstract::We propose that the descending command from area 4 that is responsible, in part, for the change in limb trajectory required to step over an obstacle in one's path also plays a role in triggering the anticipatory postural modifications that accompany this movement. To test this hypothesis, we recorded the discharge cha...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.1.406
更新日期:1998-07-01 00:00:00
abstract::Complex movements are generally thought to consist of a series of simpler elements. If this is so, how does the sensorimotor system assemble the pieces? This study recorded and evaluated sequences of arm movements to various targets placed in three-dimensional (3D) space. Subjects performed sequences consisting of sin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01062.2002
更新日期:2003-06-01 00:00:00
abstract::The complementary DNA encoding gustatory cyclic nucleotide--gated ion channel (or gustCNG channel) cloned from rat tongue epithelial tissue was expressed in Xenopus oocytes, and its electrophysiological characteristics were investigated using tight-seal patch-clamp recordings of single and macroscopic channel currents...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.6.2335
更新日期:2001-06-01 00:00:00
abstract::Endotoxin-induced uveitis (EIU) is commonly used in animals to mimic ocular inflammation in humans. Although the peripheral aspects of EIU have been well studied, little is known of the central neural effects of anterior eye inflammation. EIU was induced in male rats by endotoxin or lipopolysaccharide (LPS, 1 mg/kg ip...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00616.2005
更新日期:2005-12-01 00:00:00
abstract::Despite the importance of the thumb to hand function, little is known about the origins of thumb impairment poststroke. Accordingly, the primary purpose of this study was to assess whether thumb flexors have heightened stretch reflexes (SRs) following stroke-induced hand impairment. The secondary purpose was to compar...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00423.2009
更新日期:2010-10-01 00:00:00
abstract::Most retinal bipolar cells (BCs) transmit visual input from photoreceptors to ganglion cells using graded potentials, but some also generate calcium or sodium spikes. Sodium spikes are thought to increase temporal precision of light-evoked BC signaling; however, the role of calcium spikes in BCs is not fully understoo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00378.2014
更新日期:2015-01-15 00:00:00
abstract::1. The physiology and pharmacology of the connections made by stress-sensitive campaniform sensilla on the proximal dorsal tibia of a locust hind leg with a fast extensor tibiae motor neuron (FETi) have been examined. 2. Mechanical stimulation of a campaniform sensillum on the anterior surface of the tibia elicited bu...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.2.586
更新日期:1995-02-01 00:00:00
abstract::Monocular organization of the goldfish horizontal neural integrator was studied during spontaneous scanning saccadic and fixation behaviors. Analysis of neuronal firing rates revealed a population of ipsilateral (37%), conjugate (59%), and contralateral (4%) eye position neurons. When monocular optokinetic stimuli wer...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00313.2010
更新日期:2011-02-01 00:00:00
abstract::1. Electrical stimulation applied within the dorsolateral funiculus of the spinal cord of an intact, unanesthetized turtle can elicit rhythmic limb movements similar to those observed during swimming. 2. A spontaneous display of hindlimb swimming movements is not observed in adult turtles whose spinal cord is transect...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1977.40.4.768
更新日期:1977-07-01 00:00:00
abstract::Multi electrode recordings of neuronal activity provide an overwhelming amount of data that is often difficult to analyze and interpret. Although various methods exist for treating multielectrode datasets quantitatively, there is a particularly prominent lack of techniques that enable a quick visual exploration of suc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00758.2009
更新日期:2009-12-01 00:00:00
abstract::Single, teased fiber recordings were made from the decentralized right cervical vagus nerve (hyponodal) of the rat. A total of 67 afferent fibers that responded to gastric distension (GD) were studied: 9 fibers were stimulated by phasic balloon GD, 58 by more natural fluid GD. All balloon GD-responsive fibers had rest...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.5.2210
更新日期:1999-11-01 00:00:00
abstract::Electrical transmission is a dynamically regulated form of communication and key to synchronizing neuronal activity. The bag cell neurons of Aplysia are a group of electrically coupled neuroendocrine cells that initiate ovulation by secreting egg-laying hormone during a prolonged period of synchronous firing called th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00603.2014
更新日期:2015-02-01 00:00:00
abstract::Plantar cutaneous afferent transmission is critical for recovery of locomotion in spinalized animals, whereas a phase-dependent reflex modulation is apparent during fictive or real locomotion. In nine people with a chronic spinal cord injury (SCI) the effects of foot sole stimulation on the soleus H-reflex and tibiali...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00880.2009
更新日期:2010-03-01 00:00:00
abstract::1. In Aplysia buccal ganglia, in which dual presynaptic neurons innervate multiple postsynaptic cells, strengths of the same identified synapses differ from animal to animal, consistent with developmental or plastic modulation. Synaptic strengths are specified by the postsynaptic neuron, so that synaptic current ampli...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1991.66.6.2150
更新日期:1991-12-01 00:00:00
abstract::We investigated the postnatal development of axon sensitivity to the withdrawal of oxygen, glucose, or the combined withdrawal of oxygen + glucose in the isolated rat optic nerve (a CNS white matter tract). Removal of either oxygen or glucose for 60 min resulted in irreversible injury in optic nerves from adult rats, ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.1.95
更新日期:1998-01-01 00:00:00