Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis.

abstract：:1. In alert macaque monkeys, multiunit activity is encountered in an alternating sequence of silent and spontaneously active zones as an electrode is lowered through the striate cortex (V1). 2. Individual neurons that are spontaneously active in the dark usually have a maintained discharge in the light. Because both t...

journal_title：Journal of neurophysiology

authors： Snodderly DM,Gur M

更新日期：1995-11-01 00:00:00

abstract：:The GABAergic neurons of the thalamic reticular nucleus (nRt) provide the primary source of inhibition within the thalamus. Using physiology, pharmacology, and immunohistochemistry in mice, we characterized postsynaptic developmental changes in these inhibitory projection neurons. First, at postnatal days 3-5 (P3-5), ...

journal_title：Journal of neurophysiology

authors： Pangratz-Fuehrer S,Sieghart W,Rudolph U,Parada I,Huguenard JR

更新日期：2016-03-01 00:00:00

abstract：:1. To characterize the temporal dynamic responses of ganglion cells and to define the possible inputs giving rise to their responses in catfish retina, we recorded the ganglion cell responses evoked by 1) a step of light presented in the dark, 2) an incremental and decremental step from a background illumination, and ...

journal_title：Journal of neurophysiology

authors： Sakai HM,Naka K

更新日期：1987-12-01 00:00:00

abstract：:The aim of this study was to examine whether subjects who have learned a skilled locomotor task can transfer the acquired performance to conditions involving either a change in the external coordinates or in the sensory input from one leg. Subjects were trained to step over an obstacle with minimal foot clearance with...

journal_title：Journal of neurophysiology

authors： Lam T,Dietz V

更新日期：2004-10-01 00:00:00

abstract：:1. The synaptic inputs to sustained OFF-center ganglion cells of the mudpuppy retina were studied using a superfused retina-eye-cup preparation. Intra- and extracellular electrophysiological recording techniques were carried out during bath application of 2-amino-4-phosphonobutyrate (APB), a glutamate analog that sele...

journal_title：Journal of neurophysiology

authors： Arkin MS,Miller RF

更新日期：1988-09-01 00:00:00

abstract：:The characteristics of the primary afferent depolarization (PAD) of Ia- and Ib-fibers generated by segmental and descending inputs have been analyzed in the spinal cord of anesthetized cats. The PAD was inferred from the changes produced by conditioning inputs on the intraspinal stimulus current required to produce a ...

journal_title：Journal of neurophysiology

authors： Rudomin P,Solodkin M,Jiménez I

更新日期：1986-10-01 00:00:00

abstract：:1. We define an extrinsic frame of reference to represent the location of a point in extrapersonal space relative to a human subject's shoulder, and we define an intrinsic frame of reference to represent the orientation of the arm and forearm. 2. We examined the relations between coordinates in the extrinsic and intri...

journal_title：Journal of neurophysiology

authors： Soechting JF,Flanders M

更新日期：1989-08-01 00:00:00

abstract：:A large number of studies have demonstrated that structures within the medial temporal lobe, such as the hippocampus, are intimately involved in declarative memory for objects and people. Although these items are abstractions of the visual scene, specific visual details can change the speed and accuracy of their recal...

journal_title：Journal of neurophysiology

authors： Steinmetz PN,Cabrales E,Wilson MS,Baker CP,Thorp CK,Smith KA,Treiman DM

更新日期：2011-06-01 00:00:00

abstract：:We charted postnatal changes in the intrinsic electrophysiological properties and synaptic responses of rat intrinsic cardiac ganglion (ICG) neurons. We developed a whole-mount ganglion preparation of the excised right atrial ganglion plexus. Using intracellular recordings and nerve stimulation we tested the hypothesi...

journal_title：Journal of neurophysiology

authors： Rimmer K,Harper AA

更新日期：2006-06-01 00:00:00

abstract：:1. Intracortical microstimulation (ICMS) techniques were used to derive detailed maps of distal forelimb movement representations in primary motor cortex (area 4) of adult squirrel monkeys before and a few months after a focal ischemic infarct. 2. Infarcts caused a marked but transient deficit in use of the contralate...

journal_title：Journal of neurophysiology

authors： Nudo RJ,Milliken GW

更新日期：1996-05-01 00:00:00

abstract：:1. The homeostatic model of delta sleep has provided a useful framework for basic sleep research. This model is based on the relation of delta EEG to the duration of prior waking in man, a relation highlighted by the marked increase (rebound) in the delta EEG of nonrapid eye movement (NREM) sleep that follows total sl...

journal_title：Journal of neurophysiology

authors： Feinberg I,Campbell IG

更新日期：1993-12-01 00:00:00

abstract：:We have studied how rewards modulate the occurrence of microsaccades by manipulating the size of an expected reward and the location of the cue that sets the expectations for future reward. We found an interaction between the size of the reward and the location of the cue. When monkeys fixated on a cue that signaled t...

journal_title：Journal of neurophysiology

authors： Joshua M,Tokiyama S,Lisberger SG

更新日期：2015-11-01 00:00:00

abstract：:It is well recognized that the brain uses sensory information to accurately produce motor commands. Indeed, most research into the relationship between sensory and motor systems has focused on how sensory information modulates motor function. In contrast, recent studies have begun to investigate the reverse: how senso...

journal_title：Journal of neurophysiology

authors： Wong JD,Wilson ET,Gribble PL

更新日期：2011-05-01 00:00:00

abstract：:Plasticity at the neuronal level commonly involves use-dependent changes in strength of particular synaptic pathways or regulation of postsynaptic properties by modulatory transmitters. Here we analyze a novel form of short-term plasticity mediated by use-dependent facilitation of postsynaptic responsiveness. Using cu...

journal_title：Journal of neurophysiology

authors： Svirskis G,Hounsgaard J

更新日期：1997-09-01 00:00:00

abstract：:1. An electrophysiological study of the D-glucose sensitivity of X-organ (XO) neurosecretory cell bodies in crayfish was carried out with the use of microelectrodes, perforated, and cell-attached patch-clamp techniques. 2. Glucose depolarizes the membrane potential of XO cells in a concentration-dependent manner. 3. D...

journal_title：Journal of neurophysiology

authors： García E,Benítez A,Onetti CG

更新日期：1993-08-01 00:00:00

abstract：:1. It has been suggested that passive diffusion is the principal mechanism of the clearance of locally elevated extracellular potassium, K+o, in the cerebral cortex. This concept was based on the assumption that elevated K+ could be modeled as a point source. In the present study, the functional role of passive diffus...

journal_title：Journal of neurophysiology

authors： Vern BA,Schuette WH,Thibault LE

更新日期：1977-09-01 00:00:00

abstract：:Action potential initiation and conduction along peripheral axons is a dynamic process that displays pronounced activity dependence. In patients with neuropathic pain, differences in the modulation of axonal conduction velocity by activity suggest that this property may provide insight into some of the pathomechanisms...

journal_title：Journal of neurophysiology

authors： Tigerholm J,Petersson ME,Obreja O,Lampert A,Carr R,Schmelz M,Fransén E

更新日期：2014-05-01 00:00:00

abstract：:Nigrostriatal dopamine denervation plays a major role in basal ganglia circuitry disarray and motor abnormalities of Parkinson's disease (PD). Studies in rodent and primate models have revealed that striatal projection neurons, namely, medium spiny neurons (MSNs), increase the firing frequency. However, their activity...

journal_title：Journal of neurophysiology

authors： Singh A,Liang L,Kaneoke Y,Cao X,Papa SM

更新日期：2015-03-01 00:00:00

abstract：:The visual world presents multiple potential targets that can be brought to the fovea by saccadic eye movements. These targets produce activity at multiple sites on a movement map in the superior colliculus (SC), an area of the brain related to saccade generation. The saccade made must result from competition between ...

journal_title：Journal of neurophysiology

authors： Port NL,Wurtz RH

更新日期：2003-09-01 00:00:00

abstract：:Long-term potentiation (LTP) in rat spinal dorsal horn neurons was induced by electrical high-frequency stimulation (HFS) of afferent C fibers. LTP is generally assumed to be a key mechanism of spinal sensitization. To determine the contribution of skin and muscle afferents to LTP induction, the sural nerve (SU, pure ...

journal_title：Journal of neurophysiology

authors： Zhang J,Hoheisel U,Klein T,Magerl W,Mense S,Treede RD

更新日期：2016-02-01 00:00:00

abstract：:The locus coeruleus (LC) noradrenergic (NE) neuromodulatory system is critically involved in regulation of neural excitability via its diffuse ascending projections. Tonic NE release in the forebrain is essential for maintenance of vigilant states and increases the signal-to-noise ratio of cortical sensory responses. ...

journal_title：Journal of neurophysiology

authors： Neves RM,van Keulen S,Yang M,Logothetis NK,Eschenko O

更新日期：2018-03-01 00:00:00

abstract：:1. The effects of gamma-aminobutyric acid (GABA) on non-GABAA receptors were investigated with intracellular recordings in CA1 pyramidal cells of rat hippocampal slices in the presence of antagonists of GABAA receptors (50 microM bicuculline and 50 microM picrotoxin), N-methyl-D-aspartate (NMDA) and non-NMDA receptors...

journal_title：Journal of neurophysiology

authors： Pham TM,Lacaille JC

更新日期：1996-07-01 00:00:00

abstract：:To explore neural mechanisms how olfactory information is processed in the brain and finally converted into behavior, it would be useful to have isolated whole brains that include both olfactory organs and motor output. In the present study, we identified an in vitro index of odor-evoked behavior in the terrestrial mo...

journal_title：Journal of neurophysiology

authors： Inoue T,Inokuma Y,Watanabe S,Kirino Y

更新日期：2004-01-01 00:00:00

abstract：:1. Current- and voltage-clamp studies were conducted on isolated rat adrenal chromaffin cells to identify the voltage-dependent ion channels mediating inward currents. 2. Mean resting membrane potential of the isolated cells was -62 +/- 3 (SE) mV. Evoked action potentials were both Na+ and Ca2+ based, and whole cell v...

journal_title：Journal of neurophysiology

authors： Hollins B,Ikeda SR

更新日期：1996-08-01 00:00:00

abstract：:1. The fast extensor tibiae motor neuron makes direct excitatory central connections with the posterior group of flexor tibiae motor neurons in the locust metathoracic ganglion. The flexor group has a slow, a fast, and an intermediate motor neuron. The motor neurons are involved in the motor program for kicking and ju...

journal_title：Journal of neurophysiology

authors： Parker D

更新日期：1995-08-01 00:00:00

abstract：:1. H reflexes were elicited in the second interosseous muscle of the hindpaw of the anesthetized dog during passive rotation of the shank about the ipsilateral or contralateral knee. Reflexes sampled at four points in the cycle of movement were compared with stationary controls. For both the ipsilateral and contralate...

journal_title：Journal of neurophysiology

authors： Misiaszek JE,Barclay JK,Brooke JD

更新日期：1996-11-01 00:00:00

abstract：:The nucleus gracilis (NG) receives an abundance of visceral input from various abdominal organs and is proposed to play an important role in visceral pain processing. The purpose of this study was to investigate the necessity of the NG for colorectal input into the ventral posterolateral (VPL) nucleus of the thalamus....

journal_title：Journal of neurophysiology

authors： Al-Chaer ED,Westlund KN,Willis WD

更新日期：1997-07-01 00:00:00

abstract：:Apical dendrites of layer 5 pyramidal cells in a slice preparation of rat sensorimotor cortex were depolarized focally by long-lasting glutamate iontophoresis while recording intracellularly from their soma. In most cells the firing pattern evoked by the smallest dendritic depolarization that evoked spikes consisted o...

journal_title：Journal of neurophysiology

authors： Schwindt P,Crill W

更新日期：1999-03-01 00:00:00

abstract：:Mature stellate cells of the rat medial entorhinal cortex (EC), layer II, exhibit subthreshold membrane potential oscillations (MPOs) at theta frequencies (4-12 Hz) in vitro. We find that MPOs appear between postnatal days 14 (P14) and 18 (P18) but show little further change by day 28+ (P28-P32). To identify the facto...

journal_title：Journal of neurophysiology

authors： Burton BG,Economo MN,Lee GJ,White JA

更新日期：2008-12-01 00:00:00

abstract：:Recent physiological recording studies in monkeys have suggested that the frontal eye fields (FEFs) are involved in visual scene analysis even when eye movement commands are not required. We examined this proposed function of the human frontal eye fields during performance of visual search tasks in which difficulty wa...

journal_title：Journal of neurophysiology

authors： Muggleton NG,Juan CH,Cowey A,Walsh V

更新日期：2003-06-01 00:00:00