Nucleus gracilis: an integrator for visceral and somatic information.

Abstract:

:The nucleus gracilis (NG) receives an abundance of visceral input from various abdominal organs and is proposed to play an important role in visceral pain processing. The purpose of this study was to investigate the necessity of the NG for colorectal input into the ventral posterolateral (VPL) nucleus of the thalamus. Single-cell recordings were made from nine VPL cells isolated in nine different male Sprague Dawley rats anesthetized with pentobarbital sodium. Responses of the VPL cells to colorectal distension (CRD) and to cutaneous stimuli were obtained before and after lesioning of the NG. Electrolytic (n = 5) and chemical (n = 4) lesions of the NG were made in different preparations. The chemical lesions were made by injecting a solution of kainic acid into the NG. Kainic acid presumably kills neuronal cell bodies and spares axons of passage. The results indicate that a lesion of the NG, regardless of its type, reduces dramatically the responses of VPL neurons to innocuous cutaneous stimuli, and, to a lesser extent, the responses to CRD. Attenuation of VPL neuronal responses to CRD as well as to innocuous cutaneous stimuli by the NG lesions emphasizes the role of the dorsal column in visceral nociception and suggests that the NG is an integration center for visceral and cutaneous information flowing into the VPL nucleus.

journal_name

J Neurophysiol

authors

Al-Chaer ED,Westlund KN,Willis WD

doi

10.1152/jn.1997.78.1.521

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

521-7

issue

1

eissn

0022-3077

issn

1522-1598

journal_volume

78

pub_type

杂志文章
  • Receptive field of the retinal bipolar cell: a pharmacological study in the tiger salamander.

    abstract::1. It is widely believed that signals contributing to the receptive field surrounds of retinal bipolar cells pass from horizontal cells to bipolar cells via GABAergic synapses. To test this notion, we applied gamma-aminobutyric acid (GABA) agonists and antagonists to isolated, perfused retinas of the salamander Ambyst...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.3.2005

    authors: Hare WA,Owen WG

    更新日期:1996-09-01 00:00:00

  • Prestimulus hemodynamic activity in dorsal attention network is negatively associated with decision confidence in visual perception.

    abstract::Attention is thought to improve most aspects of perception. However, we recently showed that, somewhat surprisingly, endogenous attention can also lead to low subjective perceptual ratings (Rahnev et al., 2011). Here we investigated the neural basis of this effect and tested whether spontaneous fluctuations of the att...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00184.2012

    authors: Rahnev DA,Bahdo L,de Lange FP,Lau H

    更新日期:2012-09-01 00:00:00

  • Memory traces in primate spinal cord produced by operant conditioning of H-reflex.

    abstract::1. Study of memory traces in higher animals requires experimental models possessing well-localized and technically accessible memory traces--plasticity responsible for behavioral change, not dependent on control from elsewhere, and open to detailed investigation. Our purpose has been to develop such a model based on t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1989.61.3.563

    authors: Wolpaw JR,Lee CL

    更新日期:1989-03-01 00:00:00

  • Rapid acquisition of novel interface control by small ensembles of arbitrarily selected primary motor cortex neurons.

    abstract::Pioneering studies demonstrated that novel degrees of freedom could be controlled individually by directly encoding the firing rate of single motor cortex neurons, without regard to each neuron's role in controlling movement of the native limb. In contrast, recent brain-computer interface work has emphasized decoding ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00373.2013

    authors: Law AJ,Rivlis G,Schieber MH

    更新日期:2014-09-15 00:00:00

  • Visual search for object categories is predicted by the representational architecture of high-level visual cortex.

    abstract::Visual search is a ubiquitous visual behavior, and efficient search is essential for survival. Different cognitive models have explained the speed and accuracy of search based either on the dynamics of attention or on similarity of item representations. Here, we examined the extent to which performance on a visual sea...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00569.2016

    authors: Cohen MA,Alvarez GA,Nakayama K,Konkle T

    更新日期:2017-01-01 00:00:00

  • Metabotropic glutamate receptor-mediated depression of the slow afterhyperpolarization is gated by tyrosine phosphatases in hippocampal CA1 pyramidal neurons.

    abstract::Group I metabotropic glutamate receptor (mGluR) agonists increase the excitability of hippocampal CAl pyramidal neurons via depression of the postspike afterhyperpolarization. In adult rats, this is mediated by both mGluR1 and -5, but the signal transduction processes involved are unknown. In this study, we investigat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01236.2003

    authors: Ireland DR,Guevremont D,Williams JM,Abraham WC

    更新日期:2004-11-01 00:00:00

  • Encoding of movement dynamics by Purkinje cell simple spike activity during fast arm movements under resistive and assistive force fields.

    abstract::It is controversial whether simple-spike activity of cerebellar Purkinje cells during arm movements encodes movement kinematics like velocity or dynamics like muscle activities. To examine this issue, we trained monkeys to flex or extend the elbow by 45 degrees in 400 ms under resistive and assistive force fields but ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00206.2006

    authors: Yamamoto K,Kawato M,Kotosaka S,Kitazawa S

    更新日期:2007-02-01 00:00:00

  • Differential effect of visual motion adaption upon visual cortical excitability.

    abstract::The objectives of this study were 1) to probe the effects of visual motion adaptation on early visual and V5/MT cortical excitability and 2) to investigate whether changes in cortical excitability following visual motion adaptation are related to the degree of visual dependency, i.e., an overreliance on visual cues co...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00655.2016

    authors: Lubeck AJ,Van Ombergen A,Ahmad H,Bos JE,Wuyts FL,Bronstein AM,Arshad Q

    更新日期:2017-03-01 00:00:00

  • Plantar cutaneous afferents normalize the reflex modulation patterns during stepping in chronic human spinal cord injury.

    abstract::Plantar cutaneous afferent transmission is critical for recovery of locomotion in spinalized animals, whereas a phase-dependent reflex modulation is apparent during fictive or real locomotion. In nine people with a chronic spinal cord injury (SCI) the effects of foot sole stimulation on the soleus H-reflex and tibiali...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00880.2009

    authors: Knikou M

    更新日期:2010-03-01 00:00:00

  • Tissue resistance changes and the profile of synchronized neuronal activity during ictal events in the low-calcium model of epilepsy.

    abstract::Population spikes vary in size during prolonged epileptic ("ictal") discharges, indicating variations in neuronal synchronization. Here we investigate the role of changes in tissue electrical resistivity in this process. We used the rat hippocampal slice, low-Ca(2+) model of epilepsy and measured changes in pyramidal ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00123.2004

    authors: Fox JE,Bikson M,Jefferys JG

    更新日期:2004-07-01 00:00:00

  • Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.

    abstract::The temporal lobe is well known for its oscillatory activity associated with exploration, navigation, and learning. Intrinsic membrane potential oscillations (MPOs) and resonance of stellate cells (SCs) in layer II of the entorhinal cortex are thought to contribute to network oscillations and thereby to the encoding o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00743.2011

    authors: Boehlen A,Henneberger C,Heinemann U,Erchova I

    更新日期:2013-01-01 00:00:00

  • Presynaptic inhibition of calcium-dependent and -independent release elicited with ionomycin, gadolinium, and alpha-latrotoxin in the hippocampus.

    abstract::1. Presynaptic inhibition of synaptic transmission in the hippocampus was investigated by comparing the effects of several agonists on miniature excitatory and inhibitory postsynaptic currents (mEPSCs and mIPSCs). 2. The Ca2+ ionophore ionomycin increased the frequency of mEPSCs and mIPSCs but did not affect their amp...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.5.2017

    authors: Capogna M,Gähwiler BH,Thompson SM

    更新日期:1996-05-01 00:00:00

  • Phasic and tonic cell types in the zebra finch auditory caudal mesopallium.

    abstract::The caudal mesopallium (CM) is a cortical-level area in the songbird auditory pathway where selective, invariant responses to familiar songs emerge. To characterize the cell types that perform this computation, we made whole cell recordings from brain slices in juvenile zebra finches ( Taeniopygia guttata) of both sex...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00694.2017

    authors: Chen AN,Meliza CD

    更新日期:2018-03-01 00:00:00

  • Hypothalamus-brain stem circuitry responsible for vagal efferent signaling to the pancreas evoked by hypoglycemia in rat.

    abstract::Circulating glucose levels significantly affect vagal neural activity, which is important in the regulation of pancreatic functions. Little is known about the mechanisms involved. This study investigates the neural pathways responsible for hypoglycemia-induced vagal efferent signaling to the pancreas and identifies th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00791.2003

    authors: Wu X,Gao J,Yan J,Owyang C,Li Y

    更新日期:2004-04-01 00:00:00

  • High-frequency modulation of rat spinal field potentials: effects of slowly conducting muscle vs. skin afferents.

    abstract::Long-term potentiation (LTP) in rat spinal dorsal horn neurons was induced by electrical high-frequency stimulation (HFS) of afferent C fibers. LTP is generally assumed to be a key mechanism of spinal sensitization. To determine the contribution of skin and muscle afferents to LTP induction, the sural nerve (SU, pure ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00415.2015

    authors: Zhang J,Hoheisel U,Klein T,Magerl W,Mense S,Treede RD

    更新日期:2016-02-01 00:00:00

  • Sleep-like states modulate functional connectivity in the rat olfactory system.

    abstract::The present study was an examination of state-dependent functional connectivity during spontaneous activity between the piriform cortex and its upstream and downstream connections. Rats were anesthetized with urethan and allowed to spontaneously cycle between fast- and slow-wave states similar to fast- and slow-wave s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00711.2010

    authors: Wilson DA,Yan X

    更新日期:2010-12-01 00:00:00

  • Modifications of locomotor pattern underlying escape behavior in the lamprey.

    abstract::Two forms of undulatory locomotion in the lamprey (a lower vertebrate) have been described earlier: fast forward swimming (FFS) used for long distance migrations and slow backward swimming (SBS) used for escape from adverse tactile stimuli. In the present study, we describe another form of escape behavior: slow forwar...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00903.2007

    authors: Islam SS,Zelenin PV

    更新日期:2008-01-01 00:00:00

  • A color-based visualization technique for multielectrode spike trains.

    abstract::Multi electrode recordings of neuronal activity provide an overwhelming amount of data that is often difficult to analyze and interpret. Although various methods exist for treating multielectrode datasets quantitatively, there is a particularly prominent lack of techniques that enable a quick visual exploration of suc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00758.2009

    authors: Jurjut OF,Nikolić D,Pipa G,Singer W,Metzler D,Mureşan RC

    更新日期:2009-12-01 00:00:00

  • Generalization of dynamics learning across changes in movement amplitude.

    abstract::Studies on generalization show the nature of how learning is encoded in the brain. Previous studies have shown rather limited generalization of dynamics learning across changes in movement direction, a finding that is consistent with the idea that learning is primarily local. In contrast, studies show a broader patter...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00886.2009

    authors: Mattar AA,Ostry DJ

    更新日期:2010-07-01 00:00:00

  • The magnitude of the somatosensory cortical activity is related to the mobility and strength impairments seen in children with cerebral palsy.

    abstract::The noted disruption of thalamocortical connections and abnormalities in tactile sensory function has resulted in a new definition of cerebral palsy (CP) that recognizes the sensorimotor integration process as central to the motor impairments seen in these children. Despite this updated definition, the connection betw...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00602.2014

    authors: Kurz MJ,Heinrichs-Graham E,Becker KM,Wilson TW

    更新日期:2015-05-01 00:00:00

  • Repetition suppression in monkey inferotemporal cortex: relation to behavioral priming.

    abstract::In tasks requiring judgments about visual stimuli, humans exhibit repetition priming, responding with increased speed when a stimulus is repeated. Repetition priming might depend on repetition suppression, a phenomenon first observed in monkey inferotemporal cortex (IT) whereby, when a stimulus is repeated, the streng...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01042.2006

    authors: McMahon DB,Olson CR

    更新日期:2007-05-01 00:00:00

  • Macaque SEF neurons encode object-centered directions of eye movements regardless of the visual attributes of instructional cues.

    abstract::Macaque SEF neurons encode object-centered directions of eye movements regardless of the visual attributes of instructional cues. Neurons in the supplementary eye field (SEF) of the macaque monkey exhibit object-centered direction selectivity in the context of a task in which a spot flashed on the right or left end of...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.5.2340

    authors: Olson CR,Gettner SN

    更新日期:1999-05-01 00:00:00

  • Effects of spaceflight on rhesus quadrupedal locomotion after return to 1G.

    abstract::Effects of spaceflight on Rhesus quadrupedal locomotion after return to 1G. Locomotor performance, activation patterns of the soleus (Sol), medial gastrocnemius (MG), vastus lateralis (VL), and tibialis anterior (TA) and MG tendon force during quadrupedal stepping were studied in adult Rhesus before and after 14 days ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.5.2451

    authors: Recktenwald MR,Hodgson JA,Roy RR,Riazanski S,McCall GE,Kozlovskaya I,Washburn DA,Fanton JW,Edgerton VR

    更新日期:1999-05-01 00:00:00

  • Deficits in anticipatory inhibition of postural muscle activity associated with load release while standing in individuals with spastic diplegic cerebral palsy.

    abstract::This study aimed to determine whether individuals with spastic diplegic cerebral palsy (SDCP) have deficits in anticipatory inhibition of postural muscle activity. Nine individuals with SDCP (SDCP group, 3 female and 6 male, 13-24 yr of age) and nine age- and sex-matched individuals without disability (control group) ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00253.2012

    authors: Tomita H,Fukaya Y,Totsuka K,Tsukahara Y

    更新日期:2013-04-01 00:00:00

  • Differential activation and classification of cutaneous afferents in the rat.

    abstract::1. A total of 312 cutaneous afferent units identified in the rat foot as belonging to one of nine major types of sensory receptors were included in the present study. A natural stimulus set was defined to differentiate optimally among those receptor types according to the distinguishing response patterns that it produ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.6.2411

    authors: Leem JW,Willis WD,Weller SC,Chung JM

    更新日期:1993-12-01 00:00:00

  • Nonlinearity of spatial summation in simple cells of areas 17 and 18 of cat visual cortex.

    abstract::1. Nonlinearity of spatial summation in areas 17 and 18 of cat visual cortex was compared with the type of spatial nonlinearity that differentiates X and Y cells in the lateral geniculate nucleus (LGN) and retina. The comparisons were made to examine to what extent the information from X and Y cells may remain separat...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.5.1667

    authors: Ferster D,Jagadeesh B

    更新日期:1991-11-01 00:00:00

  • Changes in the electrophysiological properties of cat spinal motoneurons following the intramuscular injection of adriamycin compared with changes in the properties of motoneurons in aged cats.

    abstract::1. This study was undertaken to investigate the effects of adriamycin (ADM, Doxorubicin) on the basic electrophysiological properties of spinal cord motoneurons in the adult cat. ADM was injected into the biceps, gastrocnemius, semitendinosus, and semimembranosus muscles of the left hindlimb (1.2 mg per muscle). Intra...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.5.1972

    authors: Liu RH,Yamuy J,Xi MC,Morales FR,Chase MH

    更新日期:1995-11-01 00:00:00

  • Varying the degree of single-whisker stimulation differentially affects phases of intrinsic signals in rat barrel cortex.

    abstract::Using intrinsic signal optical imaging (ISI), we have shown previously that the point spread of evoked activity in the rat barrel cortex in response to single-whisker stimulation encompasses a surprisingly large area. Given that our typical stimulation consists of five deflections at 5 Hz, the large area of evoked act...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1999.81.2.692

    authors: Polley DB,Chen-Bee CH,Frostig RD

    更新日期:1999-02-01 00:00:00

  • Differential activation of lumbar and sacral motor pools during walking at different speeds and slopes.

    abstract::Organization of spinal motor output has become of interest for investigating differential activation of lumbar and sacral motor pools during locomotor tasks. Motor pools are associated with functional grouping of motoneurons of the lower limb muscles. Here we examined how the spatiotemporal organization of lumbar and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00167.2019

    authors: Dewolf AH,Ivanenko YP,Zelik KE,Lacquaniti F,Willems PA

    更新日期:2019-08-01 00:00:00

  • Contribution of execution noise to arm movement variability in three-dimensional space.

    abstract::Reaching movements are subject to noise associated with planning and execution, but precisely how these noise sources interact to determine patterns of endpoint variability in three-dimensional space is not well understood. For frontal plane movements, variability is largest along the depth axis (the axis along which ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00495.2011

    authors: Apker GA,Buneo CA

    更新日期:2012-01-01 00:00:00