Abstract:
:Recent physiological recording studies in monkeys have suggested that the frontal eye fields (FEFs) are involved in visual scene analysis even when eye movement commands are not required. We examined this proposed function of the human frontal eye fields during performance of visual search tasks in which difficulty was matched and eye movements were neither necessary nor required. Magnetic stimulation over FEF modulated performance on a conjunction search task and a simple feature search task in which the target was unpredictable from trial to trial, primarily by increasing false alarm responses. Simple feature search with a predictable target was not affected. The results establish that human FEFs are critical to visual selection, regardless of the need to generate a saccade command.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Muggleton NG,Juan CH,Cowey A,Walsh Vdoi
10.1152/jn.01086.2002subject
Has Abstractpub_date
2003-06-01 00:00:00pages
3340-3issue
6eissn
0022-3077issn
1522-1598pii
89/6/3340journal_volume
89pub_type
杂志文章abstract::Several identified neurons of the Aplysia buccal ganglia respond to choline. Iontophoretic applications of either choline or acetylcholine (ACh) to voltage-clamped inhibitory follower neurons produce similar currents. Peak amplitudes of choline responses were 10-100% of ACh responses on the same cell. Choline currents...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.51.1.1
更新日期:1984-01-01 00:00:00
abstract::We have used a computer-based mathematical model of alpha-motoneurons and of group Ia synaptic input to them, based on anatomical and electrophysiological data from the cat spinal cord, in order to examine the effects of variations in neuron size and input resistance and of conductance magnitude and duration on the ge...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1983.50.2.399
更新日期:1983-08-01 00:00:00
abstract::When sudden environmental stimuli signaling threat occur in the portion of space surrounding the body (defensive peripersonal space), defensive responses are enhanced. Recently Bisio et al. (Bisio A, Garbarini F, Biggio M, Fossataro C, Ruggeri P, Bove M. J Neurosci 37: 2415-2424, 2017) showed that a marker of defensiv...
journal_title:Journal of neurophysiology
pub_type: 评论,杂志文章
doi:10.1152/jn.00316.2017
更新日期:2017-10-01 00:00:00
abstract::Anabolic-androgenic steroids (AAS) have become significant drugs of abuse in recent years with the highest increase reported in adolescent girls. In spite of the increased use of AAS, the CNS effects of these steroids are poorly understood. We report that in prepubertal female rats, three commonly abused AAS, 17alpha-...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,收录出版
doi:10.1152/jn.2000.83.6.3299
更新日期:2000-06-01 00:00:00
abstract::In songbirds, the basal ganglia outflow nucleus LMAN is a cortical analog that is required for several forms of song plasticity and learning. Moreover, in adults, inactivating LMAN can reverse the initial expression of learning driven via aversive reinforcement. In the present study, we investigated how LMAN contribut...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00311.2011
更新日期:2011-10-01 00:00:00
abstract::Motor behavior often occurs in environments with multiple goal options that can vary during the ongoing action. We explored this situation by requiring subjects to select between different target options during an ongoing reach. During split trials the original target was replaced with a left and a right flanking targ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00336.2020
更新日期:2020-10-01 00:00:00
abstract::1. Whether complex (C) cells are the only truly texture-sensitive units in the cat's primary visual cortex remains controversial. In view of the strong physiological significance of having putatively only one class of cells sensitive to visual noise in the striate cortex, we reinvestigated this issue. Sensitivities of...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.3.1271
更新日期:1995-09-01 00:00:00
abstract::The possibility of using randomly generated stimulus intervals (with a Poisson distribution) to identify the type(s) of intrafusal fiber activated by the stimulation of single static gamma axons was tested in Peroneus tertius muscle spindles of anesthetized cats. Three patterns of random stimulation with different val...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.81.6.2823
更新日期:1999-06-01 00:00:00
abstract::We investigated adaptation to simple force field scaling to determine whether the same strategy is used as during adaptation to more complex changes in the mechanical environment. Subjects initially trained in a force field, consisting of a rightward lateral force with a parabolic spatial profile (PF). The field stren...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00269.2007
更新日期:2007-11-01 00:00:00
abstract::Two forms of undulatory locomotion in the lamprey (a lower vertebrate) have been described earlier: fast forward swimming (FFS) used for long distance migrations and slow backward swimming (SBS) used for escape from adverse tactile stimuli. In the present study, we describe another form of escape behavior: slow forwar...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00903.2007
更新日期:2008-01-01 00:00:00
abstract::1. Voltage-clamp experiments were used to study N-methyl-D-aspartic acid (NMDA) receptor antagonists applied by fast perfusion to mouse hippocampal neurons in dissociated culture. 2. Preincubation with the NMDA antagonists zinc (3-30 microM) and magnesium (30-300 microM) reduced subsequent responses to 100 microM NMDA...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1990.63.6.1373
更新日期:1990-06-01 00:00:00
abstract::1. The retinotopic organization of retinal inputs from the lateral eye of Limulus to the optic ganglia of the brain was determined from microelectrode recordings of nerve impulses. 2. The central connections of the natural subunits of the lateral optic nerve were determined using cobalt impregnation of cut axons. 3. C...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1982.48.2.505
更新日期:1982-08-01 00:00:00
abstract::The transient receptor potential vanilloid-1 (TRPV1) receptor is involved in peripheral and spinal nociceptive processing and is a therapeutic target for pain. We have shown previously that TRPV1 in the ventrolateral periaqueductal gray (VL-PAG) tonically contributes to brain stem descending antinociception by stimula...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91225.2008
更新日期:2009-05-01 00:00:00
abstract::The interstitial nucleus of Cajal (INC) is thought to control torsional and vertical head posture. Unilateral microstimulation of the INC evokes torsional head rotation to positions that are maintained until stimulation offset. Unilateral INC inactivation evokes head position-holding deficits with the head tilted in t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90363.2008
更新日期:2008-09-01 00:00:00
abstract::1. The little brown bat, Myotis lucifugus, employs biosonar pulses containing broadband frequency-modulated (FM) sounds of only one harmonic during the initial phases of echolocation. Neurons throughout the auditory cortex exhibit delay-dependent facilitation to artificial pulses and echoes at particular echo delays. ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.1.366
更新日期:1994-07-01 00:00:00
abstract::The discovery that neuroligin is a key protein involved in synapse formation offers the unprecedented opportunity to induce functional synapses between neurons and heterologous cells. We took this opportunity recording for the first-time synaptic currents in human embryonic kidney 293 (HEK293) cells transfected with n...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00647.2003
更新日期:2003-12-01 00:00:00
abstract::Modulation of sacral spinal dorsal horn neurons by the ventrolateral PAG was studied by extracellular recording combined with microiontophoretic applications of alpha-adrenergic agonists or antagonists. Bicuculline (BIC, 15 ng) microinjected into the ventrolateral PAG produced a consistent inhibition of the responses ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.5.2244
更新日期:1998-11-01 00:00:00
abstract::Rats can readily be trained to jump a gap of around 16 cm in the dark and a considerably larger gap in the light for a food reward. In the light, they use vision to estimate the distance to be jumped. In the dark, they use their vibrissae at the farthest distances. Bilateral whisker shaving or barrel field lesions red...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.84.4.1781
更新日期:2000-10-01 00:00:00
abstract::A description of healthy and pathological brain dynamics requires an understanding of spatiotemporal patterns of neural activity and characteristics of its propagation between interconnected circuits. However, the structure and modulation of the neural activation maps underlying these patterns and their propagation re...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00708.2011
更新日期:2012-07-01 00:00:00
abstract::1. Intracellular recording techniques were used to study individual neurons in the cat parasympathetic vesical pelvic ganglion (VPG). 2. Active and passive electrical properties were determined from 140 ganglion cells (35 preparations). 3. Three types of ganglion cells were distinguished. Type I (A and B) cells were n...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1980.43.2.343
更新日期:1980-02-01 00:00:00
abstract::1. Eleven adult cats were trained to stop inspiration in response to a conditioning stimulus. The conditioning stimuli were presented at the onset of inspiration at intervals of approximately 20-30 s. Intratracheal pressures, diaphragmatic activity, and the extracellular activity of single medullary respiratory neuron...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1989.62.5.1069
更新日期:1989-11-01 00:00:00
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journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90636.2008
更新日期:2009-04-01 00:00:00
abstract::For primary auditory cortex (AI) laminae, there is little evidence of functional specificity despite clearly expressed cellular and connectional differences. Natural sounds are dominated by dynamic temporal and spectral modulations and we used these properties to evaluate local functional differences or constancies ac...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00624.2009
更新日期:2010-01-01 00:00:00
abstract::1. Passive hyperpolarizing potentials (PHPs) have been recorded intracellularly from goldfish medullary neurons in the vicinity of the Mauthner cell (M-cell). They are evoked when this cell is activated antidromically by stimulation of the spinal cord, and orthodromically via the ipsilateral eighth nerve; when appropr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1975.38.2.452
更新日期:1975-03-01 00:00:00
abstract::Respiratory depression is a therapy-limiting side effect of opioid analgesics, yet our understanding of the brain circuits mediating this potentially lethal outcome remains incomplete. Here we studied the contribution of the rostral ventromedial medulla (RVM), a region long implicated in pain modulation and homeostati...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00563.2012
更新日期:2012-11-01 00:00:00
abstract::Limb movement-related neurons in the cerebellar nuclei (CN) typically produce bursts of discharge in association with movement. Consequently, given the inhibitory nature of the Purkinje cell (PC) projection to CN, it is puzzling that only a minority of movement-related PCs pause; the majority burst. Some of the moveme...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00603.2004
更新日期:2005-01-01 00:00:00
abstract::1. Neuronal activity was recorded from the premotor cortex (PM) of Japanese monkeys while they performed hand movements with different amplitudes and directions. On each behavioral trial, two instructions were given sequentially: 1) an amplitude instruction (large or small) and 2) a direction instruction (flexion or e...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.1.187
更新日期:1993-01-01 00:00:00
abstract::1. The somatotopic organization of nociceptive-specific (NS) and wide dynamic range (WDR) units in the nucleus ventralis posterolateralis (VPL) of the ventrobasal (VB) complex was studied. Experiments were carried out on adult cats anesthetized with urethane-chloralose. The recording sites of nociceptive units were ma...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.60.5.1714
更新日期:1988-11-01 00:00:00
abstract::We have examined the spatial integration properties of complex cells to determine whether some of their responses can be described by a maximum operation (MAX)-like computation, as suggested by Riesenhuber and Poggio's model of object recognition. Membrane potential was recorded from anesthetized cats while optimally ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00060.2004
更新日期:2004-11-01 00:00:00
abstract::In sensory systems, the thalamus has historically been considered a relay station. Neural representations of temporal modulations in the auditory system undergo considerable changes as they pass from the inferior colliculus (IC) to the auditory cortex. We sought to determine in awake primates the extent to which audit...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00593.2006
更新日期:2007-02-01 00:00:00