Abstract:
:We attempted to analyze the nature of premovement activity of neurons in medial motor areas [supplementary motor area (SMA) and pre-SMA] from a perspective of coding multiple movements. Monkeys were trained to perform a series of two movements with an intervening delay: supination or pronation with either forearm. Movements were initially instructed with visual signals but had to be remembered thereafter. Although a well-known type of premovement activity representing the forthcoming movements was found in the two areas, we found an unexpected type of activity that represented a second-next movement before initiating the first of the two movements. Typically in the pre-SMA, such activity selective for the second-next movement peaked before the initiation of the first movement, decayed thereafter, and remained low in magnitude while initiating the second movement. This type of activity may tentatively hold information for the second movement while initiating the first. That information may be fed into another group of neurons that themselves build a preparatory activity required to plan the second movements. Alternatively, the activity could serve as a signal to inhibit a premature exertion of the motor command for the second movement.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Nakajima T,Hosaka R,Mushiake H,Tanji Jdoi
10.1152/jn.90636.2008subject
Has Abstractpub_date
2009-04-01 00:00:00pages
1883-9issue
4eissn
0022-3077issn
1522-1598pii
90636.2008journal_volume
101pub_type
杂志文章abstract::1. The response properties of accessory optic system (AOS) neurons were assessed using single-unit extracellular recording from each of the three AOS terminal nuclei [medial, lateral, and dorsal terminal nuclei (MTN, LTN, and DTN)] in the anesthetized rabbit. 2. AOS neurons had large, monocular (contralateral) recepti...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.60.6.2037
更新日期:1988-12-01 00:00:00
abstract::1. Models of the saccadic system propose that there is an integration of the pulse signal, and there is good evidence that the integrator is reset gradually (Nichols and Sparks 1994, 1995). Other studies of the superior collicular contribution to the saccadic system have proposed a sensory, not motor, nature for its s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.4.1724
更新日期:1995-04-01 00:00:00
abstract::1. Recent immunocytochemical and receptor binding data have demonstrated a transient somatotopic patterning of serotonin (5-HT)-immunoreactive fibers in the primary somatosensory cortex of developing rats and a transient expression of 5-HT1B receptors on thalamocortical axons from the ventral posteromedial thalamic nu...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.5.2438
更新日期:1994-11-01 00:00:00
abstract::STX1 is a major neuronal syntaxin protein located at the plasma membrane of the neuronal tissues. Rodent STX1 has two highly similar paralogs, STX1A and STX1B, that are thought to be functionally redundant. Interestingly, some studies have shown that the distribution patterns of STX1A and STX1B at the central and peri...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00577.2015
更新日期:2015-10-01 00:00:00
abstract::Sensory adaptation serves to adjust awake brains to changing environments on different time scales. However, adaptation has been studied traditionally under anesthesia and for short time periods. Here, we demonstrate in awake rabbits a novel type of sensory adaptation that persists for >1 h and acts on visual thalamoc...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00116.2015
更新日期:2015-08-01 00:00:00
abstract::1. Effects of substance P (SP) and other tachykinins on membrane currents were investigated using whole cell voltage clamp in cultured sensory neurons isolated from rat dorsal root ganglia. 2. SP (100 nM) evoked an inward current in two-thirds of the cells at negative potentials. In most of the cells that generated th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.2.736
更新日期:1995-02-01 00:00:00
abstract::1. The influence of viewing distance on disparity selectivity was investigated in area V1 of behaving monkeys. While the animals performed a fixation task, cortical cells were recorded extracellularly in the foveal representation of the visual field. Disparity selectivity was assessed by using static random dot stereo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.5.2872
更新日期:1996-11-01 00:00:00
abstract::Monitoring representative fractions of neurons from multiple brain circuits in behaving animals is necessary for understanding neuronal computation. Here, we describe a system that allows high-channel-count recordings from a small volume of neuronal tissue using a lightweight signal multiplexing headstage that permits...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00785.2013
更新日期:2014-03-01 00:00:00
abstract::In this study we present further evidence supporting the reciprocal nature of output effects on forearm flexor and extensor muscles from single corticomotoneuronal (CM) cells. Spike-triggered averaging of rectified EMG activity was used to test the output effects of 105 motor cortex cells in two rhesus monkeys (Macaca...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.53.4.959
更新日期:1985-04-01 00:00:00
abstract::Conjugate eye movements in the horizontal plane are accomplished by the coactivation of the medial rectus (MR) muscle of one orbit and the lateral rectus (LR) muscle of the other. While control of these excursions has been thought to be effected by identical inputs to these muscles, recent studies have demonstrated th...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1986.56.1.50
更新日期:1986-07-01 00:00:00
abstract::A total of 443 pelvic nerve afferent fibers in the L6 dorsal root of the rat were identified by electrical stimulation of the pelvic nerve; 319 (72%) were myelinated A delta fibers with a mean conduction velocity (CV) of 11.8 m/s and 124 (28%) were unmyelinated C fibers with mean CV of 1.9 m/s. Two hundred fifty-two f...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.3.1566
更新日期:1997-03-01 00:00:00
abstract::In a recent study, Wang et al. (J Neurophysiol 113: 1989-2001, 2015) used a precision grip force control task to unveil the contribution of feedforward and feedback mechanisms to sensorimotor dysfunction in autism spectrum disorder (ASD). Impairment of both motor control mechanisms was observed, along with significant...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00647.2015
更新日期:2016-03-01 00:00:00
abstract::Previous studies have shown that regional slow-wave activity (SWA) during non-rapid eye movement (NREM) sleep is modulated by prior experience and learning. Although this effect has been convincingly demonstrated for the sensorimotor domain, attempts to extend these findings to the visual system have provided mixed re...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00085.2019
更新日期:2019-06-01 00:00:00
abstract::Purinoreceptors of the P2 family contribute strongly to signaling in the cochlea, but little is known about the effects of purinergic neurotransmission in the central auditory system. Here we examine P2 receptor-mediated signaling in the large spherical bushy cells (SBCs) of Mongolian gerbils around the onset of acous...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00186.2009
更新日期:2009-09-01 00:00:00
abstract::Animal studies have suggested that tissue injury-related increased levels of glutamate may be involved in peripheral nociceptive mechanisms in deep craniofacial tissues. Indeed, injection of glutamate (0.1-1 M, 10 microl) into the temporomandibular region evokes reflex jaw muscle responses through activation of periph...
journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章
doi:10.1152/jn.2001.86.2.782
更新日期:2001-08-01 00:00:00
abstract::1. Using an optical method for measuring membrane potential, we have been able to monitor action-potential activity simultaneously in 14 neurons of the supraesophageal ganglion of the barnacle. 2. Under favorable conditions, 4-mV synaptic potentials could also be detected optically. ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1977.40.6.1281
更新日期:1977-11-01 00:00:00
abstract::Epiretinal implants for the blind are designed to stimulate surviving retinal neurons, thus bypassing the diseased photoreceptor layer. Single-unit or multielectrode recordings from isolated animal retina are commonly used to inform the design of these implants. However, such electrical recordings provide limited info...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00852.2012
更新日期:2013-04-01 00:00:00
abstract::The discharge of muscle spindle afferents from monkey spindle afferents from monkey jaw-closing muscles was studied during mastication of natural foods by extracellular recording from the fibers or cell bodies of the tract and mesencephalic nucleus of the fifth nerve. In all, 39 muscle afferents were studied. The spin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1975.38.3.560
更新日期:1975-05-01 00:00:00
abstract::The potassium-chloride cotransporter 2 (KCC2) plays a role in epileptiform synchronization, but it remains unclear how it influences such a process. Here, we used tetrode recordings in the in vitro rat entorhinal cortex (EC) to analyze the effects of the KCC2 antagonist VU0463271 on 4-aminopyridine (4AP)-induced ictal...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00266.2019
更新日期:2019-09-01 00:00:00
abstract::The responses of many neurons in primary visual cortex are modulated by stimuli outside the classical receptive field in ways that may contribute to integrative processes like scene segmentation. To explore this issue, single-unit neuronal responses were recorded in monkey cortical areas V1 and V2 to visual stimuli co...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00916.2001
更新日期:2002-11-01 00:00:00
abstract::How does the motor system choose the speed for any given movement? Many current models assume a process that finds the optimal balance between the costs of moving fast and the rewards of achieving the goal. Here, we show that such models also need to take into account a prior representation of preferred movement speed...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00522.2013
更新日期:2014-01-01 00:00:00
abstract::The basal ganglia participate in motor functions and are implicated in the pathophysiology of movement disorders. It has been shown in primates that the activity of many neurons in one of the basal ganglia output nuclei, the internal segment of the globus pallidus, changes with active or passive movements. The involve...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01180.2002
更新日期:2004-02-01 00:00:00
abstract::Spontaneous synchronized bursts of activity play an essential role in the maturation and plasticity of neuronal networks. To investigate the cellular properties that enable spontaneous network activity, we used dissociated cultures of hippocampal neurons that express prolonged network activity bursts. Acute exposure t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91085.2008
更新日期:2009-04-01 00:00:00
abstract::1. Brain ischemia causes excess release and accumulation of glutamate that binds to postsynaptic receptors. This opens ionotropic channels that mediate neuronal depolarization and ionic fluxes that can lead to neuronal death. 2. The CA1 pyramidal cell region of the hippocampus is particularly susceptible to this neuro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1996.76.4.2707
更新日期:1996-10-01 00:00:00
abstract::Most of what we know about the neural control of gaze comes from experiments in head-fixed animals, but several "head-free" studies have suggested that fixing the head dramatically alters the apparent gaze command. We directly investigated this issue by quantitatively comparing head-fixed and head-free gaze trajectori...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00330.2003
更新日期:2003-10-01 00:00:00
abstract::As a vital skill in an evolving world, interception of moving objects relies on accurate prediction of target motion. In natural circumstances, active gaze shifts often accompany hand movements when exploring targets of interest, but how eye and hand movements are coordinated during manual interception and their depen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00476.2017
更新日期:2018-01-01 00:00:00
abstract::Behavioral, ethological, and electrophysiological evidence suggests that the highly unpleasant, bitter taste of a concentrated quinine hydrochloride (QHCL) should activate the human amygdala. In the present study, healthy subjects tasted 0.02 M QHCL or water while regional cerebral blood flow (rCBF) was assayed with H...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00358.2001
更新日期:2002-02-01 00:00:00
abstract::A mathematical model is developed for simulation of action potential propagation through a single branch point of a myelinated nerve fiber with a parent branch bifurcating into two identical daughter branches. This model is based on a previously published multi-layer compartmental model for single unbranched myelinate...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.1.197
更新日期:2001-01-01 00:00:00
abstract::Olfactory bulb (OB) glomeruli, the initial sites of synaptic processing of odor information, exhibit high levels of nicotinic acetylcholine receptor (nAChR) expression and receive strong cholinergic input from the basal forebrain. The role of glomerular nAChRs in olfactory processing, however, remains to be elucidated...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00865.2012
更新日期:2013-10-01 00:00:00
abstract::Stretch reflexes contribute to arm impedance and longer-latency stretch reflexes exhibit increased sensitivity during interactions with compliant or unstable environments. This increased sensitivity is consistent with a regulation of arm impedance to compensate for decreased stability of the environment, but the speci...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00679.2009
更新日期:2010-01-01 00:00:00