Abstract:
:1. Intracellular recording techniques were used to study individual neurons in the cat parasympathetic vesical pelvic ganglion (VPG). 2. Active and passive electrical properties were determined from 140 ganglion cells (35 preparations). 3. Three types of ganglion cells were distinguished. Type I (A and B) cells were nonaccommodating cells in response to depolarizing current pulses. Type II cells showed accommodation to depolarizing current pulses. Other cells, presumably glia, were also impaled. 4. Type IB cells exhibited two kinds of nonsynaptic spontaneous activity, spontaneous action potentials (60-70 mV) and small spontaneous potentials (up to 5 mV). Characteristics of the spontaneous activity were examined. 5. The duration of the spikes' afterhyperpolarization resulting from either orthodromic or antidromic train stimulation was dependent on the frequency of train stimulation. No long-lasting posttrain hyperpolarization was observed. 6. Chlorisondamine (10(-6) M), d-tubocurarine (10(-5) M), and hexamethonium (10(-5) M) reversibly blocked orthodromic responses. 7. The VPG is a useful model to study parasympathetic ganglionic transmission at the cellular level.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Griffith WH 3rd,Gallagher JP,Shinnick-Gallagher Pdoi
10.1152/jn.1980.43.2.343subject
Has Abstractpub_date
1980-02-01 00:00:00pages
343-54issue
2eissn
0022-3077issn
1522-1598journal_volume
43pub_type
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