Hyperexcitability of cultured spinal motoneurons from presymptomatic ALS mice.

abstract：:To estimate contour-orientation sensitivity of the cat and the degree to which precortical processing contributes to such estimates, the amplitude of visually evoked potentials (VEP) recorded from the visual cortex of cats in response to a visual stimulus (S2) presented at various intervals after presentation of anoth...

journal_title：Journal of neurophysiology

authors： Tootle JS,Berkley MA

更新日期：1985-05-01 00:00:00

abstract：:Dendritic voltage-dependent currents and inhibition modulate the information flow between synaptic and decision areas. Subthreshold and spike currents are sequentially recruited by synaptic potentials in the apical shaft of pyramidal cells, which may also decide cell output. We studied the global role of proximal apic...

journal_title：Journal of neurophysiology

authors： Canals S,López-Aguado L,Herreras O

更新日期：2005-02-01 00:00:00

abstract：:Electrically excitable cells have voltage-dependent ion channels on the plasma membrane that regulate membrane permeability to specific ions. Voltage-gated Ca(2+) channels (VGCCs) are especially important as Ca(2+) serves as both a charge carrier and second messenger. Zebrafish (Danio rerio) are an important model ver...

journal_title：Journal of neurophysiology

authors： Won YJ,Ono F,Ikeda SR

更新日期：2011-01-01 00:00:00

abstract：:To examine the mechanisms underlying milk-ejection bursts of oxytocin (OT) neurons during suckling, both in vivo and in vitro studies were performed on supraoptic OT neurons from lactating rats. The bursts were first recorded extracellularly in anesthetized rats. Burst-related electrical parameters were essentially th...

journal_title：Journal of neurophysiology

authors： Wang YF,Hatton GI

更新日期：2004-05-01 00:00:00

abstract：:Some neurons in early visual cortex are highly selective for the position of oriented edges in their receptive fields (simple cells), whereas others are largely position insensitive (complex cells). These characteristics are reflected in their sensitivity to the spatial phase of moving sine-wave gratings: simple cell ...

journal_title：Journal of neurophysiology

authors： Cloherty SL,Ibbotson MR

更新日期：2015-01-15 00:00:00

abstract：:1. The role of sensory information in shaping muscle activation patterns to postural perturbations in humans was investigated by varying velocity, amplitude, or duration of the perturbing stimulus. Ten normal subjects were exposed to 120 backward translations of the support surface under conditions of varying velociti...

journal_title：Journal of neurophysiology

authors： Diener HC,Horak FB,Nashner LM

更新日期：1988-06-01 00:00:00

abstract：:The reflex response of the masseter muscle to the rapid unloading of a single maxillary incisor tooth was studied. Unloading of a static force of 2 N in the horizontal direction resulted in a short-latency excitation, inhibition, and long-latency excitation of masseter muscle activity occurring at latencies of approxi...

journal_title：Journal of neurophysiology

authors： Türker KS,Jenkins M

更新日期：2000-08-01 00:00:00

abstract：:Human subjects chose between two color-coded reach targets using multicolored checkerboard-like decision cues (DCs) that presented variable amounts of conflicting sensory evidence supporting both target choices. Different DCs contained different numbers of small squares of the two target colors. The most ambiguous DCs...

journal_title：Journal of neurophysiology

authors： Coallier É,Kalaska JF

更新日期：2014-12-01 00:00:00

abstract：:To examine the activity of somatosensory cortex (S1) neurons to self-generated shear forces on the index and thumb, two monkeys were trained to grasp a stationary metal tab with a key grip and exert forces without the fingers slipping in one of four orthogonal directions for 1 s. A majority (∼85%) of slowly adapting a...

journal_title：Journal of neurophysiology

authors： Fortier-Poisson P,Langlais JS,Smith AM

更新日期：2016-01-01 00:00:00

abstract：:Despite its widespread use, high-resolution imaging with multiphoton microscopy to record neuronal signals in vivo is limited to the surface of brain tissue because of limited light penetration. Moreover, most imaging studies do not simultaneously record electrical neural activity, which is, however, crucial to unders...

journal_title：Journal of neurophysiology

authors： Hirai Y,Nishino E,Ohmori H

更新日期：2015-06-01 00:00:00

abstract：:1. We studied adenosine's action on synaptic transmission from primary afferent fibers to neurons of the substantia gelatinosa (SG) using tight-seal whole cell recordings in transverse slices of hamster spinal cord. Adenosine had two actions, hyperpolarization of the postsynaptic membrane and depression of the excitat...

journal_title：Journal of neurophysiology

authors： Li J,Perl ER

更新日期：1994-10-01 00:00:00

abstract：:Whole cell voltage-clamp techniques were employed to characterize the sodium (Na) conductances in acutely dissociated, mature guinea-pig cerebellar Purkinje cells. Three phenomenological components were noted: two inactivating and a persistent component (I(P)(Na). All exhibited similar sensitivities to tetrodotoxin (T...

journal_title：Journal of neurophysiology

authors： Kay AR,Sugimori M,Llinás R

更新日期：1998-09-01 00:00:00

abstract：:Here we show that inhibition shapes diverse responses to species-specific calls in the inferior colliculus (IC) of Mexican free-tailed bats. We presented 10 calls to each neuron of which 8 were social communication and 2 were echolocation calls. We also measured excitatory response regions: the range of tone burst fre...

journal_title：Journal of neurophysiology

authors： Klug A,Bauer EE,Hanson JT,Hurley L,Meitzen J,Pollak GD

更新日期：2002-10-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) receives a dense serotonergic innervation that modulates photic input to the SCN via serotonin 1B (5-HT1B) presynaptic receptors on retinal glutamatergic terminals. However, the majority of 5-HT1B binding sites in the SCN are located on nonretinal terminals and most axonal terminals i...

journal_title：Journal of neurophysiology

authors： Bramley JR,Sollars PJ,Pickard GE,Dudek FE

更新日期：2005-06-01 00:00:00

abstract：:1. The medullary reticular formation (MRF) is known to be involved in the modulation of certain reproductive behaviors. Ejaculation in the male, disrupted after spinal transection, may depend on a spinal-bulbo-spinal connection. To determine whether single neurons in the MRF receive sensory input from the male genital...

journal_title：Journal of neurophysiology

authors： Hubscher CH,Johnson RD

更新日期：1996-10-01 00:00:00

abstract：:The role of the nitric oxide (NO)-cGMP signaling cascade in modulation of peripheral nociception is controversial. Although behavioral studies have suggested both pro- and anti-nociceptive effects, little is known about the direct action of this signaling cascade on primary afferent nociceptive neurons that mediate th...

journal_title：Journal of neurophysiology

authors： Levy D,Strassman AM

更新日期：2004-08-01 00:00:00

abstract：:Postural sway during quiet stance is attenuated by actively maintained contact of the index finger with a stationary surface, even if the level of applied force (<1 N) cannot provide mechanical stabilization. In this situation, changes in force level at the fingertip lead changes in center of foot pressure by approxim...

journal_title：Journal of neurophysiology

authors： Rabin E,Bortolami SB,DiZio P,Lackner JR

更新日期：1999-12-01 00:00:00

abstract：:The effect of peripheral lesions on cerebral somatosensory representations is well studied for experimentally induced amputations and deafferentations acquired later in life. However, few studies have investigated the brain's capacity for plastic changes in congenital malformations. We studied somatosensory-evoked fie...

journal_title：Journal of neurophysiology

authors： Stoeckel MC,Pollok B,Witte OW,Seitz RJ,Schnitzler A

更新日期：2005-02-01 00:00:00

abstract：:Cats were reared in total darkness from birth until 4-5 mo of age (DR cats, n = 7) or with very brief visual experience (1 or 2 days) during an otherwise similar period of dark rearing [DR(1) cats, n = 3; DR(2) cats, n = 7]. Single-cell recordings were made in area 17 of visual cortex at the end of this rearing period...

journal_title：Journal of neurophysiology

authors： Mower GD,Christen WG

更新日期：1985-02-01 00:00:00

abstract：:1. The graded, synaptic potentials of first-order visual interneurons (lamina monopolar cells) were examined with intracellular recordings. The spatiotemporal properties were characterized with drifting sine wave gratings and annuli. 2. Annulus-elicited inhibition is maximal for annulus-test pulse intervals of approxi...

journal_title：Journal of neurophysiology

authors： Glantz RM,Bartels A

更新日期：1994-06-01 00:00:00

abstract：:1. We have investigated the electrical properties of neurons acutely dissociated from the substantia nigra zona compacta (SNZC) of the postnatal rat with whole cell patch-clamp recordings. Retrogradely labeled nigrostriatal neurons were identified with the use of rhodamine-labeled fluorescent latex microspheres. Over ...

journal_title：Journal of neurophysiology

authors： Silva NL,Pechura CM,Barker JL

更新日期：1990-07-01 00:00:00

abstract：:1. Brain ischemia causes excess release and accumulation of glutamate that binds to postsynaptic receptors. This opens ionotropic channels that mediate neuronal depolarization and ionic fluxes that can lead to neuronal death. 2. The CA1 pyramidal cell region of the hippocampus is particularly susceptible to this neuro...

journal_title：Journal of neurophysiology

authors： Andrew RD,Adams JR,Polischuk TM

更新日期：1996-10-01 00:00:00

abstract：:The connectivity of large neurons of the nucleus reticularis gigantocellularis (NRGc) in the medullary reticular formation potentially allows both for the integration of stimuli, in several modalities, that would demand immediate action, and for coordinated activation of cortical and motoric activity. We have simultan...

journal_title：Journal of neurophysiology

authors： Martin EM,Pavlides C,Pfaff D

更新日期：2010-05-01 00:00:00

abstract：:Hippocampal mossy fiber axons simultaneously activate CA3 pyramidal cells and stratum lucidum interneurons (SLINs), the latter providing feedforward inhibition to control CA3 pyramidal cell excitability. Filopodial extensions of giant boutons of mossy fibers provide excitatory synaptic input to the SLIN. These filopod...

journal_title：Journal of neurophysiology

authors： Pan E,Zhao Z,McNamara JO

更新日期：2019-02-01 00:00:00

abstract：:The spatial arrangement of preferred directions (PDs) in the primary motor cortex has revealed evidence for columnar organization and short-range order. We investigated the large-scale properties of this arrangement. We recorded neural activity at sites on a grid covering a large region of the arm area of the motor co...

journal_title：Journal of neurophysiology

authors： Naselaris T,Merchant H,Amirikian B,Georgopoulos AP

更新日期：2006-12-01 00:00:00

abstract：:6-((4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl)amino)hexanoic acid ryanodine (BODIPY-ryanodine) binding and Ca(2+) imaging were used to study the properties of ryanodine receptors (RyRs) and cytoplasmic Ca(2+) (Ca) changes in neurons cultured from the embryonic rat hippocampus during the earli...

journal_title：Journal of neurophysiology

authors： Sukhareva M,Smith SV,Maric D,Barker JL

更新日期：2002-09-01 00:00:00

abstract：:Visual search is a ubiquitous visual behavior, and efficient search is essential for survival. Different cognitive models have explained the speed and accuracy of search based either on the dynamics of attention or on similarity of item representations. Here, we examined the extent to which performance on a visual sea...

journal_title：Journal of neurophysiology

authors： Cohen MA,Alvarez GA,Nakayama K,Konkle T

更新日期：2017-01-01 00:00:00

abstract：:1. Monkeys were trained to react to an arm perturbation according to an instruction delivered prior to the perturbation. There were two possible instructions (push or pull), and monkeys learned to respond accordingly regardless of the direction (push or pull) of the triggering perturbation. 2. Pyramidal tract neurons ...

journal_title：Journal of neurophysiology

authors： Evarts EV,Tanji J

更新日期：1976-09-01 00:00:00

abstract：:Saccadic eye movements of different sizes and directions are represented in an orderly topographic map across the intermediate and deep layers of the superior colliculus (SC), where large saccades are encoded caudally and small saccades rostrally. Based on experiments in the cat, it has been suggested that saccades ar...

journal_title：Journal of neurophysiology

authors： Soetedjo R,Kaneko CR,Fuchs AF

更新日期：2002-06-01 00:00:00

abstract：:In one series of experiments, vestibular neurons that could be activated antidromically by stimulation of the contralateral medial reticular formation were studied with extracellular recording in cats under pentobarbital anesthesia. These neurons were found in all of the four main vestibular nuclei, but were less prev...

journal_title：Journal of neurophysiology

authors： Peterson BW,Abzug C

更新日期：1975-11-01 00:00:00