Developmental changes in electrophysiological properties and synaptic transmission in rat intracardiac ganglion neurons.

Abstract:

:We charted postnatal changes in the intrinsic electrophysiological properties and synaptic responses of rat intrinsic cardiac ganglion (ICG) neurons. We developed a whole-mount ganglion preparation of the excised right atrial ganglion plexus. Using intracellular recordings and nerve stimulation we tested the hypothesis that substantial transformations in the intrinsic electrical characteristics and synaptic transmission accompany postnatal development. Membrane potential (E(m)) did not change but time constant (tau) and cell capacitance increased with postnatal development. Accordingly, input resistance (R(in)) decreased but specific membrane resistance (R(m)) increased postnatally. Comparison of the somatic active membrane properties revealed significant changes in electrical phenotype. All neonatal neurons had somatic action potentials (APs) with small overshoots and small afterhyperpolarizations (AHPs). Adult neurons had somatic APs with large overshoots and large AHP amplitudes. The range of AHP duration was larger in adults than in neonates. The AP characteristics of juvenile neurons resembled those of adults, with the exception of AHP duration, which fell midway between neonate and adult values. Phasic, multiply adapting, and tonic evoked discharge activities were recorded from ICG neurons. Most neurons displayed phasic discharge at each developmental stage. All neurons received excitatory synaptic inputs from the vagus or interganglionic nerve trunk(s), the strength of which did not change significantly with postnatal age. The changes in the electrophysiological properties of the postganglionic neuron suggest that increased complexity of parasympathetic regulation of cardiac function accompanies postnatal development.

journal_name

J Neurophysiol

authors

Rimmer K,Harper AA

doi

10.1152/jn.01220.2005

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

3543-52

issue

6

eissn

0022-3077

issn

1522-1598

pii

01220.2005

journal_volume

95

pub_type

杂志文章
  • Total sleep deprivation in the rat transiently abolishes the delta amplitude response to darkness: implications for the mechanism of the "negative delta rebound".

    abstract::1. The homeostatic model of delta sleep has provided a useful framework for basic sleep research. This model is based on the relation of delta EEG to the duration of prior waking in man, a relation highlighted by the marked increase (rebound) in the delta EEG of nonrapid eye movement (NREM) sleep that follows total sl...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.6.2695

    authors: Feinberg I,Campbell IG

    更新日期:1993-12-01 00:00:00

  • Neural network based on the input organization of an identified neuron signaling impending collision.

    abstract::1. We describe a four-layered neural network (Fig. 1), based on the input organization of a collision signaling neuron in the visual system of the locust, the lobula giant movement detector (LGMD). The 250 photoreceptors ("P" units) in layer 1 are excited by any change in illumination, generated when an image edge pas...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.75.3.967

    authors: Rind FC,Bramwell DI

    更新日期:1996-03-01 00:00:00

  • A method for generating precise temporal patterns of retinal spiking using prosthetic stimulation.

    abstract::The goal of retinal prosthetic devices is to generate meaningful visual information in patients that have lost outer retinal function. To accomplish this, these devices should generate patterns of ganglion cell activity that closely resemble the spatial and temporal components of those patterns that are normally elici...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00849.2005

    authors: Fried SI,Hsueh HA,Werblin FS

    更新日期:2006-02-01 00:00:00

  • Differences in Na+ conductance density and Na+ channel functional properties between dopamine and GABA neurons of the rat substantia nigra.

    abstract::Dopamine (DA) neurons and GABA neurons of the substantia nigra (SN) promote distinct functions in the control of movement and have different firing properties and action potential (AP) waveforms. APs recorded from DA and GABA neurons differed in amplitude, maximal rate of rise, and duration. In addition, the threshold...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00513.2009

    authors: Seutin V,Engel D

    更新日期:2010-06-01 00:00:00

  • Mixtures of octopamine and serotonin have nonadditive effects on the CNS of the medicinal leech.

    abstract::It is well established that neural networks respond to a wide variety of modulatory substances by which they can become reconfigured, yet few studies have examined the effects of neurotransmitter mixtures on such networks. In a previous study of the medicinal leech using triple intracellular recordings, we found that ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.5.2039

    authors: Mesce KA,Crisp KM,Gilchrist LS

    更新日期:2001-05-01 00:00:00

  • Contractile properties of single motor units in human toe extensors assessed by intraneural motor axon stimulation.

    abstract::1. Single motor axons innervating human toe extensor muscles were selectively stimulated through a tungsten microelectrode inserted percutaneously into the peroneal nerve. Twitch and tetanic forces were measured from a strain gauge over the proximal phalanx of the toe generating the greatest force. Twitch data were ob...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.1996.75.6.2509

    authors: Macefield VG,Fuglevand AJ,Bigland-Ritchie B

    更新日期:1996-06-01 00:00:00

  • Full weight-bearing hindlimb standing following stand training in the adult spinal cat.

    abstract::Behavioral and physiological characteristics of standing were studied in nontrained spinal cats and in spinal cats that received daily stand training of the hindlimbs for 12 wk. Training consisted of assisting the cats to stand with full weight support either on both hindlimbs or on one hindlimb (30 min/day, 5 days/wk...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.1.83

    authors: De Leon RD,Hodgson JA,Roy RR,Edgerton VR

    更新日期:1998-07-01 00:00:00

  • PAD and PAH response patterns of group Ia- and Ib-fibers to cutaneous and descending inputs in the cat spinal cord.

    abstract::The characteristics of the primary afferent depolarization (PAD) of Ia- and Ib-fibers generated by segmental and descending inputs have been analyzed in the spinal cord of anesthetized cats. The PAD was inferred from the changes produced by conditioning inputs on the intraspinal stimulus current required to produce a ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.56.4.987

    authors: Rudomin P,Solodkin M,Jiménez I

    更新日期:1986-10-01 00:00:00

  • Whiskers, barrels, and cortical efferent pathways in gap crossing by rats.

    abstract::Rats can readily be trained to jump a gap of around 16 cm in the dark and a considerably larger gap in the light for a food reward. In the light, they use vision to estimate the distance to be jumped. In the dark, they use their vibrissae at the farthest distances. Bilateral whisker shaving or barrel field lesions red...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.4.1781

    authors: Jenkinson EW,Glickstein M

    更新日期:2000-10-01 00:00:00

  • Instructed delay discharge in primary and secondary somatosensory cortex within the context of a selective attention task.

    abstract::The neuronal mechanisms that contribute to tactile perception were studied using single-unit recordings from the cutaneous hand representation of primate primary (S1) and secondary (S2) somatosensory cortex. This study followed up on our recent observation that S1 and S2 neurons developed a sustained change in dischar...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.91121.2008

    authors: Meftah el-M,Bourgeon S,Chapman CE

    更新日期:2009-05-01 00:00:00

  • Neurotransmitter inputs to directionally sensitive turtle retinal ganglion cells.

    abstract::Synaptic drugs were superfused into turtle eyecup preparation while recording extracellularly from directionally sensitive (DS) retinal ganglion cells. As in previous experiments in intact rabbit retina, both picrotoxin (a GABA antagonist) and physostigmine [an acetylcholine (ACh) potentiator] reduced or eliminated th...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.54.5.1123

    authors: Ariel M,Adolph AR

    更新日期:1985-11-01 00:00:00

  • Coupling multielectrode array recordings with silver labeling of recording sites to study cervical spinal network connectivity.

    abstract::Midcervical spinal interneurons form a complex and diffuse network and may be involved in modulating phrenic motor output. The intent of the current work was to enable a better understanding of midcervical "network-level" connectivity by pairing the neurophysiological multielectrode array (MEA) data with histological ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00638.2016

    authors: Streeter KA,Sunshine MD,Patel SR,Liddell SS,Denholtz LE,Reier PJ,Fuller DD,Baekey DM

    更新日期:2017-03-01 00:00:00

  • Potassium currents in octopus cells of the mammalian cochlear nucleus.

    abstract::Octopus cells in the posteroventral cochlear nucleus (PVCN) of mammals are biophysically specialized to detect coincident firing in the population of auditory nerve fibers that provide their synaptic input and to convey its occurrence with temporal precision. The precision in the timing of action potentials depends on...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.5.2299

    authors: Bal R,Oertel D

    更新日期:2001-11-01 00:00:00

  • Dendritic spikes and their influence on extracellular calcium signaling.

    abstract::Extracellular calcium is critical for many neural functions, including neurotransmission, cell adhesion, and neural plasticity. Experiments have shown that normal neural activity is associated with changes in extracellular calcium, which has motivated recent computational work that employs such fluctuations in an info...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.3.1329

    authors: Wiest MC,Eagleman DM,King RD,Montague PR

    更新日期:2000-03-01 00:00:00

  • Vestibular function modulates the impact of nGVS on postural control in older adults.

    abstract::Previous studies have reported an important relationship between increasing age, vestibular impairment, and increased risk of falls. Recently, noisy galvanic vestibular stimulation (nGVS) has been shown to improve postural control in older adults during and potentially following stimulation. However, this effect of nG...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00512.2020

    authors: Nooristani M,Bigras C,Lafontaine L,Bacon BA,Maheu M,Champoux F

    更新日期:2020-12-09 00:00:00

  • The role of prestin in the generation of electrically evoked otoacoustic emissions in mice.

    abstract::Electrically evoked otoacoustic emissions are sounds emitted from the inner ear when alternating current is injected into the cochlea. Their temporal structure consists of short- and long-delay components and they have been attributed to the motile responses of the sensory-motor outer hair cells of the cochlea. The na...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01216.2007

    authors: Drexl M,Lagarde MM,Zuo J,Lukashkin AN,Russell IJ

    更新日期:2008-04-01 00:00:00

  • Maximal intermittent contractions of the first dorsal interosseous inhibits voluntary activation of the contralateral homologous muscle.

    abstract::The aim of this study was to investigate how maximal intermittent contractions for a hand muscle influence cortical and reflex activity, as well as the ability to voluntarily activate, the homologous muscle in the opposite limb. Twelve healthy subjects (age: 24 ± 3 years, all right hand dominant) performed maximal con...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00367.2016

    authors: Kavanagh JJ,Feldman MR,Simmonds MJ

    更新日期:2016-11-01 00:00:00

  • Zinc downmodulates thf GABAc receptor current in cone horizontal cells acutely isolated from the catfish retina.

    abstract::1. We studied the effect of zinc on the gamma-aminobutyric acid-C (GABAC) receptor in acutely isolated catfish cone horizontal cells using the whole cell patch-clamp technique. 2. GABA activates the GABAC receptor with a half-activation concentration (EC50) of 2.99 microM. The Hill coefficient is 1.32. Desensitization...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.2.916

    authors: Dong CJ,Werblin FS

    更新日期:1995-02-01 00:00:00

  • Neural ensemble coding in inferior temporal cortex.

    abstract::1. Isolated, single-neuron extracellular potentials were recorded sequentially in area TE of the inferior temporal cortex (IT) of two macaque monkeys (n = 58 and n = 41 neurons). Data were obtained while the animals were performing a paired-associate task. The task utilized five stimuli and eight stimulus pairings (4 ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.6.2325

    authors: Gochin PM,Colombo M,Dorfman GA,Gerstein GL,Gross CG

    更新日期:1994-06-01 00:00:00

  • Receptive-field properties of neurons in binocular and monocular segments of striate cortex in cats raised with binocular lid suture.

    abstract::1. We studied the receptive fields of 171 striate cortical neurons from 17 cats raised with binocular lid suture. Of these, 102 fields were within 10 degrees of the area centralis and the remaining 69 were at least 38 degrees from the vertical meridian. 2. Based on their different response properties, cells were divid...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1978.41.2.322

    authors: Watkins DW,Wilson JR,Sherman SM

    更新日期:1978-03-01 00:00:00

  • Functional CB1 receptors are broadly expressed in neocortical GABAergic and glutamatergic neurons.

    abstract::The cannabinoid receptor CB1 is found in abundance in brain neurons, whereas CB2 is essentially expressed outside the brain. In the neocortex, CB1 is observed predominantly on large cholecystokinin (CCK)-expressing interneurons. However, physiological evidence suggests that functional CB1 are present on other neocorti...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00603.2006

    authors: Hill EL,Gallopin T,Férézou I,Cauli B,Rossier J,Schweitzer P,Lambolez B

    更新日期:2007-04-01 00:00:00

  • Ocular responses to translation and their dependence on viewing distance. I. Motion of the observer.

    abstract::1. The horizontal eye movements induced by acceleration along the interaural axis were recorded from five monkeys (Macaca mulatta) by the use of the electromagnetic search-coil technique. Animals sat on a sled that was moved briefly in darkness along a linear track (bell-shaped acceleration profile: peak, 400 mm/s2; d...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.3.851

    authors: Schwarz U,Miles FA

    更新日期:1991-09-01 00:00:00

  • Low-threshold neuronal activity of spinal dorsal horn neurons increases during REM sleep in cats: comparison with effects of anesthesia.

    abstract::1. Cats were prepared for chronic recordings from the lumbar enlargement of the spinal dorsal horn. At the beginning of each recording session, a tungsten microelectrode was advanced through the dura in a physiologically intact, awake, drug-free animal, until amplitude discrimination provided a single neuron with a re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.2.763

    authors: Kishikawa K,Uchida H,Yamamori Y,Collins JG

    更新日期:1995-08-01 00:00:00

  • Questioning the depolarizing effects of GABA during early brain development.

    abstract::During early brain development, γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, has been thought to be an important source of excitatory neurotransmission. This view, however, was recently challenged by a series of studies that claim that the excitatory effect of GABA is due to non...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00293.2011

    authors: Khakhalin AS

    更新日期:2011-09-01 00:00:00

  • Flexible explicit but rigid implicit learning in a visuomotor adaptation task.

    abstract::There is mounting evidence for the idea that performance in a visuomotor rotation task can be supported by both implicit and explicit forms of learning. The implicit component of learning has been well characterized in previous experiments and is thought to arise from the adaptation of an internal model driven by sens...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00009.2015

    authors: Bond KM,Taylor JA

    更新日期:2015-06-01 00:00:00

  • A biocompatible titanium headpost for stabilizing behaving monkeys.

    abstract::Many neurophysiological experiments involving monkeys require that the head be stabilized while the animal performs a task. Often a post is attached to the skull to accomplish this goal, using a headcap formed from dental acrylic. We describe a new headpost, developed by refinement of several prototypes, and supply an...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00102.2007

    authors: Adams DL,Economides JR,Jocson CM,Horton JC

    更新日期:2007-08-01 00:00:00

  • Midbrain periaqueductal gray (PAG) inhibits nociceptive inputs to sacral dorsal horn nociceptive neurons through alpha2-adrenergic receptors.

    abstract::Modulation of sacral spinal dorsal horn neurons by the ventrolateral PAG was studied by extracellular recording combined with microiontophoretic applications of alpha-adrenergic agonists or antagonists. Bicuculline (BIC, 15 ng) microinjected into the ventrolateral PAG produced a consistent inhibition of the responses ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.5.2244

    authors: Budai D,Harasawa I,Fields HL

    更新日期:1998-11-01 00:00:00

  • Sensory control and organization of neural networks mediating coordination of multisegmental organs for locomotion.

    abstract::It is well established that locomotor patterns result from the interaction between central pattern generating networks in the nervous system, local feedback from sensory neurons about movements and forces generated in the locomotor organs, and coordinating signals from neighboring segments or appendages. This review a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00615.2004

    authors: Büschges A

    更新日期:2005-03-01 00:00:00

  • Neural response properties of primary, rostral, and rostrotemporal core fields in the auditory cortex of marmoset monkeys.

    abstract::The core region of primate auditory cortex contains a primary and two primary-like fields (AI, primary auditory cortex; R, rostral field; RT, rostrotemporal field). Although it is reasonable to assume that multiple core fields provide an advantage for auditory processing over a single primary field, the differential r...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00884.2007

    authors: Bendor D,Wang X

    更新日期:2008-08-01 00:00:00

  • Intraspinal stimulation caudal to spinal cord transections in rats. Testing the propriospinal hypothesis.

    abstract::Many laboratories have reported the successful regeneration of neurons across damaged portions of the spinal cord. Associated improvements in hindlimb locomotor movements have been attributed to the formation of functional neuronal connections with the locomotor central pattern generator (CPG). However, regenerating a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00814.2006

    authors: Yakovenko S,Kowalczewski J,Prochazka A

    更新日期:2007-03-01 00:00:00