Simulation of different firing patterns in paired spider mechanoreceptor neurons: the role of Na(+) channel inactivation.

Abstract:

:The spider VS-3 slit-sense organ contains two types of primary mechanoreceptor neurons that are morphologically similar but have different electrical behavior. Type A neurons fire only one or two action potentials in response to a mechanical or electrical step of any amplitude above the threshold, whereas type B neurons fire prolonged bursts of action potentials in response to similar stimuli. Voltage-clamp studies have shown that two voltage-activated ion currents, a noninactivating potassium current and an inactivating sodium current, dominate the firing behavior. We simulated the electrical behavior of the two neuron types, using a simplified form of Hodgkin-Huxley model based on published voltage-clamp and current-clamp recordings. Changing only two parameters of sodium inactivation, the slope of the h(infinity) curve and the time constant of recovery from inactivation, allowed a complete switch between the two firing patterns. Our simulations support previous evidence that sodium inactivation controls the firing properties of these neurons and indicate that two parameter changes are needed to achieve complete transformation between the two neuron types.

journal_name

J Neurophysiol

authors

Torkkeli PH,French AS

doi

10.1152/jn.00440.2001

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

1363-8

issue

3

eissn

0022-3077

issn

1522-1598

journal_volume

87

pub_type

杂志文章
  • Chronic exposure to ethanol alters GABA(A) receptor-mediated responses of layer II pyramidal cells in adult rat piriform cortex.

    abstract::This study examined the effect of chronic exposure to ethanol on gamma-aminobutyric acid type-A (GABA(A)) receptor-mediated responses of layer II pyramidal neurons of the piriform cortex. Slices containing the piriform cortex were derived from pair-fed adult rats maintained on ethanol-supplemented or control liquid di...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.1.247

    authors: Signore AP,Yeh HH

    更新日期:2000-07-01 00:00:00

  • Differential effects of corticosterone on the slow afterhyperpolarization in the basolateral amygdala and CA1 region: possible role of calcium channel subunits.

    abstract::The stress hormone corticosterone increases the amplitude of the slow afterhyperpolarization (sAHP) in CA1 pyramidal neurons, without affecting resting membrane potential, input resistance, or action potential characteristics. We here examined how corticosterone affects these properties in the basolateral amygdala (BL...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01137.2007

    authors: Liebmann L,Karst H,Sidiropoulou K,van Gemert N,Meijer OC,Poirazi P,Joëls M

    更新日期:2008-02-01 00:00:00

  • Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex.

    abstract::Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex. J. Neurophysiol. 80: 3392-3397, 1998. We studied movement-related neuronal activity in the dorsolateral prefrontal cortex from the perspective of a general role for the prefrontal cortex in controlling motor behavior to ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.6.3392

    authors: Hoshi E,Shima K,Tanji J

    更新日期:1998-12-01 00:00:00

  • Attentional control of sensory tuning in human visual perception.

    abstract::Attention is known to affect the response properties of sensory neurons in visual cortex. These effects have been traditionally classified into two categories: 1) changes in the gain (overall amplitude) of the response; and 2) changes in the tuning (selectivity) of the response. We performed an extensive series of beh...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00776.2011

    authors: Paltoglou AE,Neri P

    更新日期:2012-03-01 00:00:00

  • Three forms of the scratch reflex in the spinal turtle: movement analyses.

    abstract::The scratch reflex is a motor task exhibited by the hindlimb of a turtle after complete transection of the spinal cord just posterior to the forelimb enlargement. The scratch is elicited by applying gentle tactile stimulation to a site innervated by spinal segments caudal to the level of the transection. During the sc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1985.53.6.1501

    authors: Mortin LI,Keifer J,Stein PS

    更新日期:1985-06-01 00:00:00

  • Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. I. Gaze dysmetria.

    abstract::The cerebellar control of orienting behavior toward visual targets was studied in the head-unrestrained cat by analyzing the deficits of saccadic gaze shifts after unilateral injection of muscimol in the caudal part of the fastigial nucleus (cFN). Gaze shifts are rendered strongly inaccurate by muscimol cFN inactivati...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.4.1942

    authors: Goffart L,Pélisson D

    更新日期:1998-04-01 00:00:00

  • Differential effects of deep cerebellar nuclei inactivation on reaching and adaptive control.

    abstract::This study examined the effects of selective inactivation of the cerebellar nuclei in the cat on the control of multijoint trajectories and trajectory adaptation to avoid obstacles. Animals were restrained in a hammock and trained to perform a prehension task in which they reached to grasp a small cube of meat from a ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.4.1886

    authors: Martin JH,Cooper SE,Hacking A,Ghez C

    更新日期:2000-04-01 00:00:00

  • Total sleep deprivation in the rat transiently abolishes the delta amplitude response to darkness: implications for the mechanism of the "negative delta rebound".

    abstract::1. The homeostatic model of delta sleep has provided a useful framework for basic sleep research. This model is based on the relation of delta EEG to the duration of prior waking in man, a relation highlighted by the marked increase (rebound) in the delta EEG of nonrapid eye movement (NREM) sleep that follows total sl...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.6.2695

    authors: Feinberg I,Campbell IG

    更新日期:1993-12-01 00:00:00

  • Searching for object pointers in the visual cortex.

    abstract::We perceive objects as permanent and stable despite frequent occlusions and eye movements, but their representation in the visual cortex is neither permanent nor stable. Feature selective cells respond only as long as objects are visible, and their responses depend on eye position. We explored the hypothesis that the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00112.2020

    authors: Zhu SD,Zhang LA,von der Heydt R

    更新日期:2020-05-01 00:00:00

  • Large gaze shift generation while standing: the role of the vestibular system.

    abstract::The functional significance of vestibular information for the generation of gaze shifts is controversial and less well established than the vestibular contribution to gaze stability. In this study, we asked seven bilaterally avestibular patients to execute voluntary, whole body pivot turns to visual targets up to 180°...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00343.2019

    authors: Anastasopoulos D,Ziavra N,Bronstein AM

    更新日期:2019-11-01 00:00:00

  • Contributions of optostatic and optokinetic cues to the perception of vertical.

    abstract::While it has been well established that optostatic and optokinetic cues contribute to the perception of vertical, it is unclear how the brain processes their combined presence with the nonvisual vestibular cues. Using a psychometric approach, we examined the percept of vertical in human participants (n = 17) with thei...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00740.2018

    authors: Niehof N,Perdreau F,Koppen M,Medendorp WP

    更新日期:2019-08-01 00:00:00

  • Sleep-like states modulate functional connectivity in the rat olfactory system.

    abstract::The present study was an examination of state-dependent functional connectivity during spontaneous activity between the piriform cortex and its upstream and downstream connections. Rats were anesthetized with urethan and allowed to spontaneously cycle between fast- and slow-wave states similar to fast- and slow-wave s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00711.2010

    authors: Wilson DA,Yan X

    更新日期:2010-12-01 00:00:00

  • Megamap: flexible representation of a large space embedded with nonspatial information by a hippocampal attractor network.

    abstract::The problem of how the hippocampus encodes both spatial and nonspatial information at the cellular network level remains largely unresolved. Spatial memory is widely modeled through the theoretical framework of attractor networks, but standard computational models can only represent spaces that are much smaller than t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00856.2015

    authors: Hedrick KR,Zhang K

    更新日期:2016-08-01 00:00:00

  • Control of dynamic stability during gait termination on a slippery surface.

    abstract::There are three common ways by which to successfully terminate gait: decreased acceleration of whole-body center of mass (COM) through a flexor synergy in the trail leg, increased deceleration of whole-body COM through an extensor synergy in the front limb, and an energy/momentum transfer to dissipate any remaining mo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00423.2004

    authors: Oates AR,Patla AE,Frank JS,Greig MA

    更新日期:2005-01-01 00:00:00

  • Response features across the auditory midbrain reveal an organization consistent with a dual lemniscal pathway.

    abstract::The central auditory system has traditionally been divided into lemniscal and nonlemniscal pathways leading from the midbrain through the thalamus to the cortex. This view has served as an organizing principle for studying, modeling, and understanding the encoding of sound within the brain. However, there is evidence ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00008.2014

    authors: Straka MM,Schmitz S,Lim HH

    更新日期:2014-08-15 00:00:00

  • Single-motor-unit discharge characteristics in human lumbar multifidus muscle.

    abstract::The underlying neurophysiology of postural control of the lower back in humans is poorly understood. We have characterized motor unit (MU) discharge activity in the deep lumbar multifidus (LM) muscle in nine healthy subjects (20-40 yr, 3 females). Bilateral fine wire electrodes were implanted at L4 spinal level using ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00010.2014

    authors: Lothe LR,Raven TJ,Eken T

    更新日期:2015-08-01 00:00:00

  • Nucleus Z: a somatosensory relay to motor thalamus.

    abstract::1. It was the aim of this study to show that nucleus Z of the cat medulla acts as a relay between the spinal cord and the ventral lateral (VL) nucleus of the motor thalamus. For this purpose, extracellular recordings were made from neurons that were antidromically identified by stimulation in the rostral thalamus, par...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.5.1607

    authors: Mackel R,Miyashita E

    更新日期:1993-05-01 00:00:00

  • Persistent synaptic activity produces long-lasting enhancement of endocannabinoid modulation and alters long-term synaptic plasticity.

    abstract::Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). Recent studies have indicated that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannab...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01228.2006

    authors: Zhu PJ,Lovinger DM

    更新日期:2007-06-01 00:00:00

  • GABA- and glycine-mediated fall of intracellular pH in rat medullary neurons in situ.

    abstract::In the region of the ventral respiratory group in brain stem slices from neonatal rats, intracellular pH (pHi) and membrane currents (I(m)) or potentials were measured in neurons dialyzed with the pH-sensitive dye 2',7'-bis-carboxyethyl-5(6)-carboxyfluorescein. Currents and increases in membrane conductance (g(m)) dur...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.4.1844

    authors: Lückermann M,Trapp S,Ballanyi K

    更新日期:1997-04-01 00:00:00

  • Identification of the physical stimulus and the neural basis of fabric-evoked prickle.

    abstract::1. The neurophysiological basis for the sensation of prickle evoked by contact of some fabrics with the skin is reported. 2. Single-unit sensory nerve recordings from the rabbit saphenous nerve were used to identify the receptors responsible for fabric-evoked prickle. These recordings showed that all low-threshold mec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.59.4.1083

    authors: Garnsworthy RK,Gully RL,Kenins P,Mayfield RJ,Westerman RA

    更新日期:1988-04-01 00:00:00

  • Context dependence of receptive field remapping in superior colliculus.

    abstract::Our perception of the positions of objects in our surroundings is surprisingly unaffected by movements of the eyes, head, and body. This suggests that the brain has a mechanism for maintaining perceptual stability, based either on the spatial relationships among visible objects or internal copies of its own motor comm...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00288.2011

    authors: Churan J,Guitton D,Pack CC

    更新日期:2011-10-01 00:00:00

  • The effects of expectancy on corticospinal excitability: passively preparing to observe a movement.

    abstract::The corticospinal tract excitability is modulated when preparing movements. Earlier to movement execution, the excitability of the spinal cord increases waiting for supraspinal commands to release the movement. Movement execution and movement observation share processes within the motor system, although movement obser...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00353.2013

    authors: Arias P,Robles-García V,Espinosa N,Corral-Bergantiños Y,Mordillo-Mateos L,Grieve K,Oliviero A,Cudeiro J

    更新日期:2014-04-01 00:00:00

  • Variability of extracellular spike waveforms of cortical neurons.

    abstract::1. Here we study the variability in extracellular records of action potentials. Our work is motivated, in part, by the need to construct effective algorithms to classify single-unit waveforms from multiunit recordings. 2. We used microwire electrode pairs (stereotrodes) to record from primary somatosensory cortex of a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.6.3823

    authors: Fee MS,Mitra PP,Kleinfeld D

    更新日期:1996-12-01 00:00:00

  • Mechanoafferent neuron with an inexcitable somatic region: consequences for the regulation of spike propagation and afferent transmission.

    abstract::In the Aplysia mechanoafferent B21, afferent transmission is in part regulated via the control of active spike propagation. When B21 is peripherally activated at its resting membrane potential, spikes fail to propagate to an output process, and afferent transmission does not occur. In this report, we show that the pro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01341.2006

    authors: Evans CG,Ludwar BCh,Cropper EC

    更新日期:2007-04-01 00:00:00

  • Directionally sensitive ganglion cells in the rabbit retina: specificity for stimulus direction, size, and speed.

    abstract::The receptive fields of directionally sensitive ganglion cells in the rabbit retina were analyzed. Several types of experiment showed that each point within the receptive field of the cell is inhibited by a fairly wide area of points around it, lying on each side of the preferred-null axis as well as along the preferr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1975.38.3.613

    authors: Wyatt HJ,Daw NW

    更新日期:1975-05-01 00:00:00

  • A step toward understanding the human ventral visual pathway.

    abstract::The human ventral visual pathway is implicated in higher order form processing, but the organizational principles within this region are not yet well understood. Recently, Lafer-Sousa, Conway, and Kanwisher (J Neurosci 36: 1682-1697, 2016) used functional magnetic resonance imaging to demonstrate that functional respo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00358.2016

    authors: Goddard E

    更新日期:2017-03-01 00:00:00

  • Rhythmicity of spinal neurons activated during each form of fictive scratching in spinal turtles.

    abstract::Are behaviors that rely on common muscles and motoneurons generated by separate or overlapping groups of pattern-generating neurons? This question was investigated for the three forms of scratching in immobilized, spinal turtles. Individual neurons were recorded extracellularly from the gray matter through most of the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.86.2.1026

    authors: Berkowitz A

    更新日期:2001-08-01 00:00:00

  • Characteristics of glutamate-evoked temporomandibular joint afferent activity in the rat.

    abstract::Injection of glutamate into the rat temporomandibular joint (TMJ) capsule can reflexly induce a prolonged increase in the electromyographic (EMG) activity of the jaw muscles, however, the characteristics of TMJ afferents activated by glutamate have not been investigated. In the present study, we examined the effect of...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.6.2446

    authors: Cairns BE,Sessle BJ,Hu JW

    更新日期:2001-06-01 00:00:00

  • KChIP1 and frequenin modify shal-evoked potassium currents in pyloric neurons in the lobster stomatogastric ganglion.

    abstract::The transient potassium current (I(A)) plays an important role in shaping the firing properties of pyloric neurons in the stomatogastric ganglion (STG) of the spiny lobster, Panulirus interruptus. The shal gene encodes I(A) in pyloric neurons. However, when we over-expressed the lobster Shal protein by shal RNA inject...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00837.2002

    authors: Zhang Y,MacLean JN,An WF,Lanning CC,Harris-Warrick RM

    更新日期:2003-04-01 00:00:00

  • Endocannabinoid-mediated depolarization-induced suppression of inhibition in hilar mossy cells of the rat dentate gyrus.

    abstract::Hilar mossy cells represent a unique population of local circuit neurons in the hippocampus and dentate gyrus. Here we use electrophysiological techniques in acute preparations of hippocampal slices to demonstrate that depolarization of a single hilar mossy cell can produce robust inhibition of local GABAergic afferen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00310.2006

    authors: Hofmann ME,Nahir B,Frazier CJ

    更新日期:2006-11-01 00:00:00