Abstract:
:The spider VS-3 slit-sense organ contains two types of primary mechanoreceptor neurons that are morphologically similar but have different electrical behavior. Type A neurons fire only one or two action potentials in response to a mechanical or electrical step of any amplitude above the threshold, whereas type B neurons fire prolonged bursts of action potentials in response to similar stimuli. Voltage-clamp studies have shown that two voltage-activated ion currents, a noninactivating potassium current and an inactivating sodium current, dominate the firing behavior. We simulated the electrical behavior of the two neuron types, using a simplified form of Hodgkin-Huxley model based on published voltage-clamp and current-clamp recordings. Changing only two parameters of sodium inactivation, the slope of the h(infinity) curve and the time constant of recovery from inactivation, allowed a complete switch between the two firing patterns. Our simulations support previous evidence that sodium inactivation controls the firing properties of these neurons and indicate that two parameter changes are needed to achieve complete transformation between the two neuron types.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Torkkeli PH,French ASdoi
10.1152/jn.00440.2001subject
Has Abstractpub_date
2002-03-01 00:00:00pages
1363-8issue
3eissn
0022-3077issn
1522-1598journal_volume
87pub_type
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