Abstract:
:Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). Recent studies have indicated that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannabinoids play a key role in certain forms of LTD. Here, we show that repetitive low-frequency synaptic stimulation (LFS) produces persistent up-regulation of endocannabinoid signaling at hippocampal CA1 GABAergic synapses. This LFS also produces LTD of inhibitory synapses and facilitates LTP at excitatory, glutamatergic synapses. These endocannabinoid-mediated plastic changes could contribute to information storage within the brain.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Zhu PJ,Lovinger DMdoi
10.1152/jn.01228.2006subject
Has Abstractpub_date
2007-06-01 00:00:00pages
4386-9issue
6eissn
0022-3077issn
1522-1598pii
01228.2006journal_volume
97pub_type
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