Persistent synaptic activity produces long-lasting enhancement of endocannabinoid modulation and alters long-term synaptic plasticity.

Abstract:

:Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). Recent studies have indicated that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannabinoids play a key role in certain forms of LTD. Here, we show that repetitive low-frequency synaptic stimulation (LFS) produces persistent up-regulation of endocannabinoid signaling at hippocampal CA1 GABAergic synapses. This LFS also produces LTD of inhibitory synapses and facilitates LTP at excitatory, glutamatergic synapses. These endocannabinoid-mediated plastic changes could contribute to information storage within the brain.

journal_name

J Neurophysiol

authors

Zhu PJ,Lovinger DM

doi

10.1152/jn.01228.2006

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

4386-9

issue

6

eissn

0022-3077

issn

1522-1598

pii

01228.2006

journal_volume

97

pub_type

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