Abstract：
:In the region of the ventral respiratory group in brain stem slices from neonatal rats, intracellular pH (pHi) and membrane currents (I(m)) or potentials were measured in neurons dialyzed with the pH-sensitive dye 2',7'-bis-carboxyethyl-5(6)-carboxyfluorescein. Currents and increases in membrane conductance (g(m)) during bath application of 0.1 or 1 mM gamma-aminobutyric acid (GABA) were accompanied by a delayed mean fall of pHi by 0.17 and 0.25 pH units, respectively, from a pHi baseline of 7.33. These effects were reversibly suppressed by 50-100 microM bicuculline. Similar effects on I(m), g(m), and pHi were revealed on administration of 0.1 or 1 mM glycine. These responses were abolished by 10-100 microM strychnine. Dialysis of the cells with 15-30 microM carbonic anhydrase led to an acceleration of the kinetics and a potentiation of the GABA-induced pHi decrease. GABA- and glycine-evoked pHi decreases were very similar during recordings with either high- or low-Cl- patch electrodes, although the reversal potential of the accompanying currents differed by approximately 60 mV. The GABA-induced pHi decrease, but not the accompanying I(m) and g(m) responses, was suppressed in CO2/HCO3(-)-free, N-2-hydroxy-ethylpiperazine-N'-2-ethane sulphonic acid pH-buffered solution. Depolarization from -60 to +30 mV resulted in a sustained fall of pHi by maximally 0.5 pH units. In this situation, the GABA-induced fall of pHi turned into an intracellular alkalosis of 0.09-0.15 pH units. The results confirm and extend previous findings obtained in vivo that GABA- or glycine-induced intracellular acidosis of respiratory neurons is due to efflux of HCO3- via the receptor-coupled Cl- channel.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Lückermann M,Trapp S,Ballanyi Kdoi
10.1152/jn.1997.77.4.1844subject
Has Abstractpub_date
1997-04-01 00:00:00pages
1844-52issue
4eissn
0022-3077issn
1522-1598journal_volume
77pub_type
杂志文章abstract：:Recent studies conducted in our laboratory have suggested that the tongue primary motor cortex (i.e., tongue-MI) plays a critical role in the control of voluntary tongue movements in the primate. However, the possible involvement of tongue-MI in semiautomatic tongue movements, such as those in swallowing, remains unkn...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1997.78.3.1516
更新日期：1997-09-01 00:00:00
abstract：:1. The horizontal eye movements induced by acceleration along the interaural axis were recorded from five monkeys (Macaca mulatta) by the use of the electromagnetic search-coil technique. Animals sat on a sled that was moved briefly in darkness along a linear track (bell-shaped acceleration profile: peak, 400 mm/s2; d...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1991.66.3.851
更新日期：1991-09-01 00:00:00
abstract：:To perform goal-oriented hand movement, humans combine multiple sensory signals (e.g., vision and proprioception) that can be encoded in various reference frames (body centered and/or exo-centered). In a previous study (Tagliabue M, McIntyre J. PLoS One 8: e68438, 2013), we showed that, when aligning a hand to a remem...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00140.2017
更新日期：2017-09-01 00:00:00
abstract：:Voice onset time (VOT) is an important parameter of speech that denotes the time interval between consonant onset and the onset of low-frequency periodicity generated by rhythmic vocal cord vibration. Voiced stop consonants (/b/, /g/, and /d/) in syllable initial position are characterized by short VOTs, whereas unvoi...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1999.82.5.2346
更新日期：1999-11-01 00:00:00
abstract：:Recent work has investigated the link between motor learning and sensory function in arm movement control. A number of findings are consistent with the idea that motor learning is associated with systematic changes to proprioception (Haith A, Jackson C, Mial R, Vijayakumar S. Adv Neural Inf Process Syst 21: 593-600, 2...
journal_title：Journal of neurophysiology
pub_type： 杂志文章,随机对照试验
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abstract：:Through their actions in the nucleus accumbens (NAc), kappa opioid (KOP) receptors and their endogenous ligand, dynorphin, modify behaviors associated with the administration of drugs of abuse and are regulated by exposure to such drugs. Despite their demonstrated behavioral significance, the synaptic actions of KOP r...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01115.2002
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abstract：:The cortical N1 response to balance perturbation is observed in electroencephalography recordings simultaneous to automatic balance-correcting muscle activity. We recently observed larger cortical N1s in individuals who had greater difficulty resisting compensatory steps, suggesting the N1 may be influenced by steppin...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
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abstract：:Recent discoveries of visceral nociceptive inputs sharing the classical tactile pathway in the dorsal-column medial lemniscus system have opened a new venue for the investigation of somatovisceral interactions. The current study was designed to determine whether somatic innocuous inputs modulate visceral nociceptive t...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2002.88.3.1185
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abstract：:The giant barnacle, Balanus nubilus, has three simple eyes, two lateral and one median. We have studied the convergence of the receptors of these ocelli by recording from the second-order cell (I-cell) and from the receptors' terminals. The I-cell's responses to illumination of the median and lateral eyes are similar ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1986.55.5.882
更新日期：1986-05-01 00:00:00
abstract：:Electrical stimulation of the median nerve at the wrist may elicit a blink reflex [hand blink reflex (HBR)] mediated by a neural circuit at brain stem level. As, in a Sherringtonian sense, the blink reflex is a defensive response, in a series of experiments we tested, in healthy volunteers, whether and how the HBR is ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00731.2011
更新日期：2012-02-01 00:00:00
abstract：:The effects of neuronal density on morphological and functional attributes of the evolving networks were studied in cultured dissociated hippocampal neurons. Plating at different densities affected connectivity among the neurons, such that sparse networks exhibited stronger synaptic connections between pairs of record...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00914.2009
更新日期：2010-08-01 00:00:00
abstract：:Motor control relies on multiple sources of information. To estimate the position and motion of the hand, the brain uses both vision and body-position (proprioception and kinesthesia) senses from sensors in the muscles, tendons, joints, and skin. Although performance is better when more than one sensory modality is pr...
journal_title：Journal of neurophysiology
pub_type： 杂志文章,随机对照试验
doi：10.1152/jn.90544.2008
更新日期：2009-02-01 00:00:00
abstract：:N-Acetylaspartylglutamate (NAAG) is an agonist at the type 3 metabotropic glutamate receptor (mGluR3), which is coupled to a Gi/o protein. When activated, the mGluR3 receptor inhibits adenylyl cyclase and reduces the cAMP-mediated second-messenger cascade. Long-term potentiation (LTP) in the medial perforant path (MPP...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2001.85.3.1097
更新日期：2001-03-01 00:00:00
abstract：:In recent years, electroencephalography and magnetoencephalography (MEG) have both been used to investigate the response in human auditory cortex to musical sounds that are perceived as consonant or dissonant. These studies have typically focused on the transient components of the physiological activity at sound onset...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00876.2018
更新日期：2020-04-01 00:00:00
abstract：:Fast inhibitory synaptic transmission in the brain relies on ionotropic GABA(A) receptors (GABA(A)R). Eighteen genes code for GABA(A)R subunits, but little is known about the epsilon subunit. Our aim was to identify the synaptic transmission properties displayed by native receptors incorporating epsilon. Immunogold lo...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00227.2009
更新日期：2009-10-01 00:00:00
abstract：:Monocular deprivation (MD) during the critical period for the development of visual cortex causes a loss of binocular response of neurons and a shift to the open eye, a normal ocular dominance (OD) shift. However, when MD is combined with chronic inactivation of the visual cortex by muscimol, the OD distribution of th...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00313.2003
更新日期：2003-12-01 00:00:00
abstract：:1. Patch-clamp methods were used to study recombinant glutamate receptor (GluR) ion channels expressed in human embryonic kidney cells (HEK 293) after transfection of the cells with cDNAs encoding kainate (KA)-type GluR subunits. Cells were transiently or stably transfected with the fully edited (R) version of GluR6 o...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1996.76.1.510
更新日期：1996-07-01 00:00:00
abstract：:Rhythmic movements of the gastric mill and pyloric regions of the crustacean foregut are controlled by two stomatogastric neuronal networks that have been intensively studied in vitro. By using electromyographic recordings from the European lobster, Homarus gammarus, we have monitored simultaneously the motor activity...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1998.79.3.1396
更新日期：1998-03-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2013-12-01 00:00:00
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journal_title：Journal of neurophysiology
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journal_title：Journal of neurophysiology
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更新日期：2012-10-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：1992-01-01 00:00:00
abstract：:The effect of HCO(3)(-)/CO(2) on membrane properties of isolated hippocampal CA1 neurons was studied with the use of the whole cell configuration of the patch-clamp technique. Neurons were acutely dissociated from 21- to 30-day-old mice. In the current-clamp mode, HCO(3)(-)/CO(2) significantly hyperpolarized CA1 neuro...
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1989.62.2.437
更新日期：1989-08-01 00:00:00
abstract：:1. Behavioral studies in the monkey and clinical studies in humans show that some visuomotor functions are spared in case of a V1 lesion. This residual vision appears to be subserved at least partially by visual activity in extrastriate cortex. Earlier studies have demonstrated that neurons in area V2 lose their visua...
journal_title：Journal of neurophysiology
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更新日期：1991-11-01 00:00:00
abstract：:Slowness of voluntary movements in patients with multiple sclerosis (MS) may be due to various factors, including attentional and cognitive deficits, delays in motor conduction time, and impairment of specific central nervous system circuits. In 13 healthy volunteers and 20 mildly disabled, relapsing-remitting MS pati...
journal_title：Journal of neurophysiology
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更新日期：2015-03-01 00:00:00
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journal_title：Journal of neurophysiology
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更新日期：2005-10-01 00:00:00
abstract：:The aim of this study was to examine the effects of kappa-opioid receptor selective agonists on responses of mechanosensitive afferent fibers in the pelvic nerve. Single-fiber recordings were made from pelvic nerve afferents in the decentralized S1 dorsal root of the rat. A total of 572 afferent fibers in the S1 dorsa...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：1997-08-01 00:00:00
abstract：:To examine the activity of somatosensory cortex (S1) neurons to self-generated shear forces on the index and thumb, two monkeys were trained to grasp a stationary metal tab with a key grip and exert forces without the fingers slipping in one of four orthogonal directions for 1 s. A majority (∼85%) of slowly adapting a...
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