Abstract:
:1. Neuronal mechanisms for decoding sound azimuth and angular movement were studied by recordings of several single units in parallel in the core areas of the auditory cortex of the macaque monkey. The activity of 180 units was recorded during the presentation of moving and static sound stimuli. Both the activity of single units and the interactions between neighboring neurons in response to each stimulus were analyzed. 2. Sixty-two percent of the units showed significant modulation of their firing rates as a function of the stimulus azimuth. Contralateral stimuli were preferred by the majority (approximately 60%) of these neurons. Thirty-five percent of the units showed mild but statistically significant modulation of their firing rates, which was specifically attributed to the angular movement of the sound source. 3. Eighty-nine percent of the "movement-sensitive" units were also "azimuth sensitive." The sound source's azimuth determined the pattern of the response components (on, sustained, off), whereas the source's movement affected only the magnitude of these components, typically the sustained component. Most neurons for which the sustained response to static sounds was greater for contralateral than ipsilateral stimuli preferred moving sounds that were moving into the contralateral hemifield. 4. Cross-correlation analysis was carried out for 245 neuron pairs. Cross-correlograms were computed for each pair under all stimulus conditions to allow comparison of the neuronal interactions under the various conditions. The shapes of some correlograms (after subtraction of direct stimulus effects) were dependent on specific stimulus conditions, suggesting that the effective connectivity between these neurons depended on the location and/or movement of the sound stimuli. Furthermore, joint peristimulus time (JPST) analysis indicated that modifications of connectivity may be temporally related to the stimulus and may occur over short periods of time. These results could not have been predicted from analysis of the independent single-unit responses to the stimuli. 5. The data suggest that both firing rates and correlated activity between adjacent neurons in the auditory cortex encode sound location and movement.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Ahissar M,Ahissar E,Bergman H,Vaadia Edoi
10.1152/jn.1992.67.1.203subject
Has Abstractpub_date
1992-01-01 00:00:00pages
203-15issue
1eissn
0022-3077issn
1522-1598journal_volume
67pub_type
杂志文章abstract::1. Using extracellular recording techniques in the CA1 region of the rat hippocampus, we have evaluated the effects of the redox reagents 5,5O-dithiobis-2-nitrobenzoic acid (DTNB) and tris (carboxyethyl) phosphine (TCEP) on long-term potentiation (LTP) expressed by alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.6.2612
更新日期:1995-06-01 00:00:00
abstract::The temporal lobe is well known for its oscillatory activity associated with exploration, navigation, and learning. Intrinsic membrane potential oscillations (MPOs) and resonance of stellate cells (SCs) in layer II of the entorhinal cortex are thought to contribute to network oscillations and thereby to the encoding o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00743.2011
更新日期:2013-01-01 00:00:00
abstract::1. Evidence for local excitatory synaptic connections in CA1 of the rat hippocampus was obtained by recording excitatory postsynaptic potentials (EPSPs) intracellularly from pyramidal cells during local microapplications of glutamate. 2. Experiments were performed in hippocampal slices cut parallel to (transverse slic...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.59.1.110
更新日期:1988-01-01 00:00:00
abstract::The spider VS-3 slit-sense organ contains two types of primary mechanoreceptor neurons that are morphologically similar but have different electrical behavior. Type A neurons fire only one or two action potentials in response to a mechanical or electrical step of any amplitude above the threshold, whereas type B neuro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00440.2001
更新日期:2002-03-01 00:00:00
abstract::Microelectrode studies in monkeys performing short-term memory tasks show the sustained elevated discharge of cortical neurons during the retention of recalled sensory information. Cortical cells that are part of memory networks are assumed to receive numerous inputs of excitatory as well as inhibitory nature and loca...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.4.2219
更新日期:1997-04-01 00:00:00
abstract::An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00949.2002
更新日期:2003-11-01 00:00:00
abstract::Complex patterns of intercellular calcium signaling occur in the CA1 and CA2 regions of hippocampal slice organotypic cultures from neonatal mice. Spontaneous localized intercellular Ca2+ waves involving 5-15 cells propagate concentrically from multiple foci in the stratum oriens and s. radiatum. In these same regions...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.2.1045
更新日期:1998-02-01 00:00:00
abstract::Intracellular recordings were made from rhythm-generating interneurons in the Lymnaea feeding system. The feeding pattern is a three-phase rhythm of interneuronal activity (N1, N2, N3) corresponding to protraction, rasp, and swallow. We describe the firing pattern and anatomy of the premotor interneurons, each of whic...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1985.54.6.1396
更新日期:1985-12-01 00:00:00
abstract::The present study was an examination of state-dependent functional connectivity during spontaneous activity between the piriform cortex and its upstream and downstream connections. Rats were anesthetized with urethan and allowed to spontaneously cycle between fast- and slow-wave states similar to fast- and slow-wave s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00711.2010
更新日期:2010-12-01 00:00:00
abstract::The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00057.2002
更新日期:2002-11-01 00:00:00
abstract::It was recently shown that repeated heat stimulation, using brief contacts (<1 s) with a preheated thermode at sufficiently short interstimulus intervals (ISIs <5 s) and high temperatures (> or =51 degrees C), will elicit in humans a sensation of rapidly augmenting "second" (burning) pain with only a weak "first" (sha...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00578.2001
更新日期:2002-04-01 00:00:00
abstract::A large body of data suggests that the pontine respiratory group (PRG) is involved in respiratory phase-switching and the reconfiguration of the brain stem respiratory network. However, connectivity between the PRG and ventral respiratory column (VRC) in computational models has been largely ad hoc. We developed a net...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90416.2008
更新日期:2008-10-01 00:00:00
abstract::Dopamine neurons in freely moving rats often fire behaviorally relevant high-frequency bursts, but depolarization block limits the maximum steady firing rate of dopamine neurons in vitro to ∼10 Hz. Using a reduced model that faithfully reproduces the sodium current measured in these neurons, we show that adding an add...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00578.2014
更新日期:2014-12-01 00:00:00
abstract::We performed a whole-body mapping study of the effect of unilateral muscle vibration, eliciting spindle Ia firing, on the control of standing and walking in humans. During quiet stance, vibration applied to various muscles of the trunk-neck system and of the lower limb elicited a significant tilt in whole body postura...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00764.2006
更新日期:2007-01-01 00:00:00
abstract::A large array of neuroscientific techniques, including in vivo electrophysiology, two-photon imaging, optogenetics, lesions, and microdialysis, require access to the brain through the skull. Ideally, the necessary craniotomies could be performed in a repeatable and automated fashion, without damaging the underlying br...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01055.2014
更新日期:2015-06-01 00:00:00
abstract::1. The electrical threshold of the terminations of single group Ia and II afferent fibers was transiently reduced by the antidromic discharge of the initial segment of spinal motoneurons in the cat. 2. This depolarization of the terminals of afferent fibers known to synapse on motoneurons confirms previous observation...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1979.42.3.635
更新日期:1979-05-01 00:00:00
abstract::We are studying the functional "logic" of neuromodulatory actions in a simple central pattern generator (CPG)-effector system, the heart of the blue crab Callinectes sapidus. The rhythmic contractions of this heart are neurogenic, driven by rhythmic motor patterns generated by the cardiac ganglion (CG). Here we used a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00558.2007
更新日期:2007-11-01 00:00:00
abstract::1. Membrane currents of normal and TEA-injected cat lumbar motoneurons were investigated using the technique of somatic voltage clamp. 2. The current-voltage (I-V) relation of healthy motoneurons contains a region of negative slope conductance caused by a persistent inward current component (Ii). In the most striking ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1980.43.6.1700
更新日期:1980-06-01 00:00:00
abstract::Synaptic dynamics comprise a variety of interacting processes acting on a wide range of time scales. This enables a synapse to perform a large array of computations, from temporal and spatial filtering to associative learning. In this study, we describe how changing synaptic gain via long-term plasticity can act to sh...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00856.2003
更新日期:2004-02-01 00:00:00
abstract::Eigenmannia, a genus of weakly electric fish, exhibits a specialized behavior known as the jamming avoidance response (JAR). The JAR results in a categorical difference between Eigenmannia that are in groups of conspecifics and those that are alone. Fish in groups exhibit the JAR behavior and thereby experience ongoin...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00311.2006
更新日期:2006-11-01 00:00:00
abstract::Primary auditory cortex (A1) neurons are believed not to carry much information about tonal offsets because A1 neurons in barbiturate-anesthetized animals are usually described as having only onset responses. We investigated tonal offset responses in comparison with onset responses in the caudal part of A1 of awake ca...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00184.2007
更新日期:2007-05-01 00:00:00
abstract::The spike-triggered averaging technique (26) was used to determine whether the synaptic input from medial gastrocnemius (MG) Ia-afferent fibers to homonymous motoneurons is "topographically weighted" (22) by means of differences in projection frequency, excitatory postsynaptic potential (EPSP) amplitude, or a combinat...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1984.51.1.64
更新日期:1984-01-01 00:00:00
abstract::Pioneering studies demonstrated that novel degrees of freedom could be controlled individually by directly encoding the firing rate of single motor cortex neurons, without regard to each neuron's role in controlling movement of the native limb. In contrast, recent brain-computer interface work has emphasized decoding ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00373.2013
更新日期:2014-09-15 00:00:00
abstract::The caudal primate prefrontal cortex (PFC) is involved in target selection and visually guided saccades through both covert attention and overt orienting eye movements. Unilateral damage to the caudal PFC often leads to decreased awareness of a contralesional target alone, referred to as "neglect," or when it is prese...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00078.2019
更新日期:2019-08-01 00:00:00
abstract::Successful negotiation of obstacles during walking relies on the integration of visual information about the environment with ongoing locomotor commands. When information about the body and the environment is removed through occlusion of the lower visual field, individuals increase downward head pitch angle, reduce fo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00931.2017
更新日期:2018-08-01 00:00:00
abstract::Neuroimaging studies in stroke survivors have suggested that adaptive plasticity occurs following stroke. However, the complex temporal dynamics of neural reorganization after injury make the interpretation of functional imaging studies equivocal. In the present study in adult squirrel monkeys, intracortical microstim...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.90447.2008
更新日期:2008-09-01 00:00:00
abstract::Muscle spindles provide exquisitely sensitive proprioceptive information regarding joint position and movement. Through passively driven length changes in the muscle-tendon unit (MTU), muscle spindles detect joint rotations because of their in-parallel mechanical linkage to muscle fascicles. In human microneurography ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00374.2016
更新日期:2017-04-01 00:00:00
abstract::In sensory systems, the thalamus has historically been considered a relay station. Neural representations of temporal modulations in the auditory system undergo considerable changes as they pass from the inferior colliculus (IC) to the auditory cortex. We sought to determine in awake primates the extent to which audit...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00593.2006
更新日期:2007-02-01 00:00:00
abstract::We used laser scanning photostimulation through a focused UV laser of caged glutamate in an in vitro slice preparation through the rat's somatosensory thalamus to study topography and connectivity between the thalamic reticular nucleus and ventral posterior lateral nucleus. This enabled us to focally stimulate the som...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00206.2005
更新日期:2005-10-01 00:00:00
abstract::Smoothness is a hallmark of healthy movement. Past research indicates that smoothness may be a side product of a control strategy that minimizes error. However, this is not the only reason for smooth movements. Our musculoskeletal system itself contributes to movement smoothness: the mechanical impedance (inertia, dam...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00712.2015
更新日期:2017-03-01 00:00:00