Small RNAs, big potential: the role of MicroRNAs in stem cell function.

abstract：:Sharing the same precursor cell lineage located in the bone marrow, mesenchymal stroma/stem cells (MSCs), osteoblasts and adipocytes have a reciprocal relationship in differentiation and function. The nuclear transcription factor peroxisome-proliferator- activated receptor-gamma (PPAR-γ) has been found expressed in bo...

journal_title：Current stem cell research & therapy

authors： Zhuang H,Zhang X,Zhu C,Tang X,Yu F,Shang GW,Cai X

更新日期：2016-01-01 00:00:00

abstract：:The liver has a remarkable capability to restore its functional capacity following liver injury. According to the current paradigm, differentiated and usually quiescent hepatocytes are the primary cell type responsible for liver repair. As reserve compartment, bipotent hepatic progenitor cells are activated, especiall...

journal_title：Current stem cell research & therapy

authors： Wege H,Brümmendorf TH

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The exposure of lung to noxious agents or gasses leads to injury, which further enhances repair mechanisms by promoting the proliferation and differentiation of lung stem cells. These cells could help preserve the anatomical structure and the function of the organ. Unfortunately in many lung diseases, 'this ...

journal_title：Current stem cell research & therapy

authors： Esendagli D,Gunel-Ozcan A

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is a widespread chronic metabolic disease which has high mortality due to its complications. In addition to traditional medication, stem cell transplantation therapeutics has become a brand-new and prospective remedy for DM. With strong self-renewal and multi-potential ability, mesench...

journal_title：Current stem cell research & therapy

authors： Tan J,Zhou L,Zhou Y,Xue P,Wu G,Dong G,Guo H,Wang Q

更新日期：2017-01-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is one of the leading causes of low back pain, which affects a large proportion of the global population at a huge socioeconomic burden. Current treatments focus primarily on symptomatic pain relief or surgery, but offer relatively poor long-term efficacy as they fail to address ...

journal_title：Current stem cell research & therapy

authors： Clarke LE,Richardson SM,Hoyland JA

更新日期：2015-01-01 00:00:00

abstract：:In contrast to their almost unlimited potential for expansion in vivo and despite years of dedicated research and optimization of expansion protocols, the expansion of Hematopoietic Stem Cells (HSCs) in vitro remains remarkably limited. Increased understanding of the mechanisms that are involved in maintenance, expans...

journal_title：Current stem cell research & therapy

authors： Aerts-Kaya F

更新日期：2020-02-24 00:00:00

abstract：:Tendon, the crucial element of the musculoskeletal system, when damaged, never restores the biological and biomechanical properties completely. Recently, tissue engineering and regenerative medicine have enabled the differentiation of postnatal somatic stem cells or mesenchymal stem cells (MSCs) to different cell line...

journal_title：Current stem cell research & therapy

authors： Uysal AC,Mizuno H

更新日期：2010-06-01 00:00:00

abstract：:The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pl...

journal_title：Current stem cell research & therapy

authors： Lin G,Xu RH

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that ha...

journal_title：Current stem cell research & therapy

authors： Huang F,Liu ZM,Zheng SG

更新日期：2018-01-01 00:00:00

abstract：:The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pat...

journal_title：Current stem cell research & therapy

authors： Liang SJ,Li XG,Wang XQ

更新日期：2019-01-01 00:00:00

abstract：:Spinal surgery presents a challenge for both neurosurgery and orthopaedic surgery. Due to the heterogeneous differentiation potential of mesenchymal stem cells, there is much interest in the treatment of spine surgery. Animal and human trials focussing on the efficacy of mesenchymal stem cells in spinal cord injury, s...

journal_title：Current stem cell research & therapy

authors： Khan S,Mafi P,Mafi R,Khan W

更新日期：2018-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor γ (PPARγ) is a versatile member of the ligand-activated nuclear hormone receptor superfamily of transcription factors, with expression in several different cell lines, especially in the digestive system. After being activated by its ligand, PPARγ can suppress the growth of or...

journal_title：Current stem cell research & therapy

authors： Shu L,Huang R,Wu S,Chen Z,Sun K,Jiang Y,Cai X

更新日期：2016-01-01 00:00:00

abstract：:Defects in articular cartilage injury and chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the techniq...

journal_title：Current stem cell research & therapy

authors： Chen Y,Ouyang X,Wu Y,Guo S,Xie Y,Wang G

更新日期：2020-01-01 00:00:00

abstract：:Liver is a major metabolic organ of the body and is known to comprise of two epithelial cell lineages, namely, hepatocytes and cholangiocytes which are known to originate from hepatoblasts during fetal developing stages. Upon acute injury, the hepatocytes and cholangiocytes undergo cellular division to compensate the ...

journal_title：Current stem cell research & therapy

authors： Rehman K,Iqbal MJ,Zahra N,Akash MS

更新日期：2014-01-01 00:00:00

abstract：:Combination antiretroviral therapy (cART) has significantly reduced the mortality rate and morbidity, and has increased the life expectancy of the human immunodeficiency virus (HIV) infected patients. However, the current cART is incapable of eradicating viruses from the human body, and HIV remains one of the most not...

journal_title：Current stem cell research & therapy

authors： Hu J,Feng Y,Ma P,Lai Y

更新日期：2019-01-01 00:00:00

abstract：:Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential o...

journal_title：Current stem cell research & therapy

authors： Li Z,Peroglio M,Alini M,Grad S

更新日期：2015-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound h...

journal_title：Current stem cell research & therapy

authors： Zahari W,Hashim SN,Yusof MF,Osman ZF,Kannan TP,Mokhtar KI,Ahmad A,Noordin KB

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described. Most commonly, mesenchymal stem cells demonstrate the ability to differentiate into mesenchymal tissues (bone, catailge, fat, etc...), however, under the proper co...

journal_title：Current stem cell research & therapy

authors： Grange S

更新日期：2012-03-01 00:00:00

abstract：:Connections between inflammation and cancer are a rapidly developing field. Some gastrointestinal tract cancers arise from infection, chronic irritation, and ensuing inflammation. Cellular effectors and mediators are important constituents of the tumor microenvironment, including neoplastic, stromal, and migratory hem...

journal_title：Current stem cell research & therapy

authors： Zhang L,Song X,Mohri Y,Qiao L

更新日期：2015-01-01 00:00:00

abstract：:During the past several years, mesenchymal stem cells (MSCs) derived from adult tissue have rapidly moved from in vitro and animal studies into clinical trials as a therapeutic modality for a diverse group of clinical applications, including head and neck reconstruction. For many diseases, cell therapy could affect th...

journal_title：Current stem cell research & therapy

authors： Hanson S,Thibeault SL,Hematti P

更新日期：2010-09-01 00:00:00

abstract：:Differentiation of stem cells, a crucial step in the process of tissue development, repair and regeneration, can be regulated by a variety of mechanical factors such as the stiffness of extracellular matrix. In this review article, the effects of stiffness on the differentiation of stem cells, including bone marrow-de...

journal_title：Current stem cell research & therapy

authors： Zhang W,Chu G,Wang H,Chen S,Li B,Han F

更新日期：2020-01-01 00:00:00

abstract：:The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and...

journal_title：Current stem cell research & therapy

authors： Anwar I,Ashfaq UA,Shokat Z

更新日期：2020-01-01 00:00:00

abstract：:Stem cells are undifferentiated cells with the ability to proliferate and convert to different types of differentiated cells that make up the various tissues and organs in the body. They exist both in embryos as pluripotent stem cells that can differentiate into the three germ layers and as multipotent or unipotent st...

journal_title：Current stem cell research & therapy

authors： Bahmad HF,Elajami MK,Daouk R,Jalloul H,Darwish B,Chalhoub RM,Assi S,Chamaa F,Abou-Kheir W

更新日期：2020-08-31 00:00:00

abstract：:Regenerative medicine (RM) is an interdisciplinary field that uses different approaches to accelerate the repair and regeneration or replace damaged or diseased human cells or tissues to achieve normal tissue function. These approaches include the stimulation of the body's own repair processes, transplantation of prog...

journal_title：Current stem cell research & therapy

authors： Asgharzad S,Alizadeh A,Arab S

更新日期：2021-01-12 00:00:00

abstract：:Reduced-intensity stem cell transplantation (RIST) has opened a new era for hematopoietic stem cell transplantation (HSCT). It was developed based on the knowledge that graft-versus-tumor (GVT) effect is the main anti-tumor effect in allogeneic HSCT. Because RIST is associated with less morbidity and mortality, it can...

journal_title：Current stem cell research & therapy

authors： Kato K,Khaled Y,Mineishi S

更新日期：2007-05-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) is a curative treatment of many hematological disorders. However, although significant advances have been made in donor-recipient matching or conditioning regimens, HSCT is associated with a risk of post transplant complications. Those include generation of toxic lesions...

journal_title：Current stem cell research & therapy

authors： Bogunia-Kubik K,Wysoczanska B,Lange A

更新日期：2006-05-01 00:00:00

abstract：:Although the existence of cancer stem cells (CSCs) has been demonstrated in colorectal cancer, further investigation is hindered by controversies over their surface markers. The sphere formation assay is widely used as in vitro method for derivation and characterization of CSCs based on the intrinsic self-renewal prop...

journal_title：Current stem cell research & therapy

authors： Wu H,Zhang H,Hu Y,Xia Q,Liu C,Li Y,Yu B,Gu T,Zhang X,Yu X,Kong W

更新日期：2014-03-01 00:00:00

abstract：:Spinal cord injury (SCI) is a traumatic disorder resulting in a functional deficit that usually leads to severe and permanent paralysis. After the initial insult to the spinal cord, additional structure and function are lost through an active and complex secondary process. Since there is not effective treatment for SC...

journal_title：Current stem cell research & therapy

authors： Hernández J,Torres-Espín A,Navarro X

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Multiple studies have focused on stem cell-based treatments for rotator cuff disorders; however, the outcomes are not consistent. OBJECTIVES:This systematic review and meta-analysis were performed to evaluate the effects of stem cells on rotator cuff healing. METHODS:A detailed search of relevant studies w...

journal_title：Current stem cell research & therapy

authors： Liu F,Meng Q,Yin H,Yan Z

更新日期：2019-01-01 00:00:00

abstract：:Exosomes and biomimetic nanoparticles have great potential to develop into a wide-scale therapeutic platform within the regenerative medicine industry. Exosomes, a subgroup of EVs with diameter ranging from 30-100 nm, have recently gained attention as an innovative approach for the treatment of various diseases, inclu...

journal_title：Current stem cell research & therapy

authors： Stine SJ,Popowski KD,Su T,Cheng K

更新日期：2020-01-01 00:00:00