Abstract:
:The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and autoimmunity. Some models for studying liver injury are APAP-based model, Fas ligand (FasL), D-galactosamine/endotoxin (Gal/ET), Concanavalin A, and carbon tetrachloride-based models. The regeneration of the liver can be carried out using umbilical cord blood stem cells which have various advantages over other stem cell types used in liver transplantation. UCB-derived stem cells lack tumorigenicity, have karyotype stability and high immunomodulatory, low risk of graft versus host disease (GVHD), low risk of transmitting somatic mutations or viral infections, and low immunogenicity. They are readily available and their collection is safe and painless. This review focuses on recent development and modern trends in the use of umbilical cord stem cells for the regeneration of liver fibrosis.
journal_name
Curr Stem Cell Res Therjournal_title
Current stem cell research & therapyauthors
Anwar I,Ashfaq UA,Shokat Zdoi
10.2174/1568026620666200220122536subject
Has Abstractpub_date
2020-01-01 00:00:00pages
219-232issue
3eissn
1574-888Xissn
2212-3946pii
CSCR-EPUB-104687journal_volume
15pub_type
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journal_title:Current stem cell research & therapy
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