Abstract:
:Since the improvement of chemotherapy and innovation of rituximab, about 60% of patients with diffuse large B cell lymphoma (DLBCL) could receive long-term survival after firstline therapy. Around 30% fail to respond or experience relapse considered as the relapsed/refractory DLBCL, the highdose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) has been used as the second-line treatment. However, the patients relapse after auto-HSCT or not eligible for the auto-HSCT have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the potentially curative way in such kind of patients. In this paper, we collected the published data about patients with relapsed/refractory DLBCL who underwent allo-HSCT, demonstrated the appropriate candidate for allo-HSCT, identified the effect of the donor types on the recipients, presented the major conditioning regimens for allo-HSCT and figured out the outcomes of each conditioning regimen. We also tried to identify the prognostic factors on the outcome which might shed some light on the further clinical application.
journal_name
Curr Stem Cell Res Therjournal_title
Current stem cell research & therapyauthors
Xiao Z,Li J,Miao Kdoi
10.2174/1574888x11666160630172414subject
Has Abstractpub_date
2017-01-01 00:00:00pages
14-18issue
1eissn
1574-888Xissn
2212-3946pii
CSCRT-EPUB-76927journal_volume
12pub_type
杂志文章,评审abstract::Mesenchymal stem cells (MSCs) are ideal candidates for different cellular therapies due to their simple isolation, extensive expansion potential, and low immunogenicity. For various therapeutic approaches, such as bone and cartilage repair, MSCs are expected to replace the damaged tissues by direct differentiation. Ho...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150211162933
更新日期:2015-01-01 00:00:00
abstract::Notch signaling mediates the fates of numerous cells in both invertebrates and vertebrates. In the immune system, Notch signalling contributes to the generation of hematopoietic stem cells (HSCs), the promotion of HSC self-renewal, T lineage commitment, intrathymic T cell development, and peripheral lymphocyte differe...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488811795495459
更新日期:2011-06-01 00:00:00
abstract::In contrast to their almost unlimited potential for expansion in vivo and despite years of dedicated research and optimization of expansion protocols, the expansion of Hematopoietic Stem Cells (HSCs) in vitro remains remarkably limited. Increased understanding of the mechanisms that are involved in maintenance, expans...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200225091339
更新日期:2020-02-24 00:00:00
abstract::Despite the numerous recent advances made in conventional anticancer therapies, metastasis and recurrence still remain the major problems in cancer management. The current treatment modalities kill the bulk of the tumor, leaving cancer stem cells behind and therefore, the agents specifically targeting this cancer init...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666141126122316
更新日期:2015-01-01 00:00:00
abstract::The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pl...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810791824548
更新日期:2010-09-01 00:00:00
abstract::Pyrroloquinoline Quinone (PQQ) is the third coenzyme found after niacinamide and flavone nucleotides and is widely present in microorganisms, plants, animals, and humans. PQQ can stimulate the growth of organisms and is very important for the growth, development and reproduction of animals. Owing to the inherent prope...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X14666181210165539
更新日期:2020-01-01 00:00:00
abstract::Pluripotent stem cells (PSCs) derived from somatic cells represent a powerful experimental tool for investigating the molecular mechanisms underlying the disease phenotype; with prospects to advance medical therapies. They also have significant potential as a renewable source of autologous cells for cellular therapy. ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150220154820
更新日期:2015-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) have been isolated not only from bone marrow, but also from many other tissues such as adipose tissue, skeletal muscle, liver, brain and pancreas. Because MSC were found to have the ability to differentiate into cells of multiple organs and systems such as bone, fat, cartilage, muscle, ne...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488806778226821
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged pa...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X13666180510110055
更新日期:2018-01-01 00:00:00
abstract::Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential o...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150305105114
更新日期:2015-01-01 00:00:00
abstract::Adipose-derived stem cells are adult stem cells which are easy to obtain and multi-potent. Stem-cell therapy has become a promising new treatment for many diseases, and plays an increasingly important role in the field of tissue repair, regeneration and reconstruction. The physicochemical properties of the extracellul...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888X15666200502000343
更新日期:2021-01-01 00:00:00
abstract::Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, ...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11666160201115733
更新日期:2016-01-01 00:00:00
abstract::Stem cells have been long looked at as possible therapeutic vehicles for different health related problems. Among the different existing stem cell populations, Adipose- derived Stem Cells (ASCs) have been gathering attention in the last 10 years. When compared to other stem cells populations and sources, ASCs can be e...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810791268564
更新日期:2010-06-01 00:00:00
abstract::Although the existence of cancer stem cells (CSCs) has been demonstrated in colorectal cancer, further investigation is hindered by controversies over their surface markers. The sphere formation assay is widely used as in vitro method for derivation and characterization of CSCs based on the intrinsic self-renewal prop...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1574888x09666131217114927
更新日期:2014-03-01 00:00:00
abstract::Angiogenesis is a complex process in which capillaries are produced from blood vessels that already exists. Endothelial cells (ECs) and endothelial progenitor cells (EPCs) are pivotal for this process and for the maintenance/restorage of the endothelium. Decreased numbers and dysfunction of these cells have been relat...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x1103160303181155
更新日期:2016-01-01 00:00:00
abstract::Protein kinases (PKs) mediate the reversible conversion of substrate proteins to phosphorylated forms, a key process in controlling intracellular signaling transduction cascades. Pluripotency is, among others, characterized by specifically expressed PKs forming a highly interconnected regulatory network that culminate...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x09666140616130217
更新日期:2014-01-01 00:00:00
abstract::Cell repair/replacing strategies for neurodegenerative diseases such as Parkinson's disease depend on well-characterized dopaminergic neuronal candidates that are healthy and show promising effect on the rejuvenation of degenerated area of the brain. Therefore, it is imperative to develop innovative therapeutic strate...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X12666161114122059
更新日期:2017-01-01 00:00:00
abstract::Stem/progenitor cells for cell therapy and regenerative medicine should ideally be available in large numbers, after having been isolated using minimally invasive or non-invasive methodologies. Also, they should exhibit wide differentiation potential into multiple lineages, as well as capability to be used successfull...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章
doi:10.2174/1381612824666180426120459
更新日期:2018-01-01 00:00:00
abstract::Spinal surgery presents a challenge for both neurosurgery and orthopaedic surgery. Due to the heterogeneous differentiation potential of mesenchymal stem cells, there is much interest in the treatment of spine surgery. Animal and human trials focussing on the efficacy of mesenchymal stem cells in spinal cord injury, s...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666170907120030
更新日期:2018-01-01 00:00:00
abstract::Postnatal skeletogenesis is a highly regulated process that subpopulations of bone marrow stem cells differentiate into mature skeletal tissues to maintain and repair the postnatal skeletons. Based on their skeletogenic capacity, purified bone marrow stem cells have been used to repair and replace damaged skeletal tis...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x10666150519093626
更新日期:2015-01-01 00:00:00
abstract::The liver is a vital organ for life and the only internal organ that is capable of natural regeneration. Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol, hepatitis, and...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1568026620666200220122536
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is a widespread chronic metabolic disease which has high mortality due to its complications. In addition to traditional medication, stem cell transplantation therapeutics has become a brand-new and prospective remedy for DM. With strong self-renewal and multi-potential ability, mesench...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X10666151001114527
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Revascularisation therapy is the current gold standard of care for critical limb ischemia (CLI), although a significant proportion of patients with CLI either are not fit for or do not respond well to this procedure. Recently, novel angiogenic therapies such as the use of autologous cellbased therapy (CBT) h...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,meta分析,评审
doi:10.2174/1574888X13666180313141416
更新日期:2018-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound h...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X11666160614103404
更新日期:2017-01-01 00:00:00
abstract::About 30 years ago circulating endothelial cells (CEC) were first observed in peripheral blood. Since then CEC have been established as a reliable indicator of vascular injury and damage and more sophisticated detection techniques, such as immunomagnetic isolation and fluorescence-activated cell sorting (FACS), have b...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488810793351721
更新日期:2010-12-01 00:00:00
abstract::Connections between inflammation and cancer are a rapidly developing field. Some gastrointestinal tract cancers arise from infection, chronic irritation, and ensuing inflammation. Cellular effectors and mediators are important constituents of the tumor microenvironment, including neoplastic, stromal, and migratory hem...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x09666140812112305
更新日期:2015-01-01 00:00:00
abstract::Parkinson's disease (PD) is characterized by loss of dopaminergic neurons, oxidative stress and neuroinflammation. The classical therapeutic approach with L-DOPA is not able to control motor symptoms in the long term, thus new disease-modifying or neuroprotective treatments are urgently required in order to match such...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888X14666190301150210
更新日期:2019-01-01 00:00:00
abstract::The liver has a remarkable capability to restore its functional capacity following liver injury. According to the current paradigm, differentiated and usually quiescent hepatocytes are the primary cell type responsible for liver repair. As reserve compartment, bipotent hepatic progenitor cells are activated, especiall...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488807779317062
更新日期:2007-01-01 00:00:00
abstract::Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described. Most commonly, mesenchymal stem cells demonstrate the ability to differentiate into mesenchymal tissues (bone, catailge, fat, etc...), however, under the proper co...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/157488812799218983
更新日期:2012-03-01 00:00:00
abstract::Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth f...
journal_title:Current stem cell research & therapy
pub_type: 杂志文章,评审
doi:10.2174/1574888x11308030006
更新日期:2013-05-01 00:00:00