Advances in reprogramming to pluripotency.

Abstract:

:Pluripotent stem cells (PSCs) derived from somatic cells represent a powerful experimental tool for investigating the molecular mechanisms underlying the disease phenotype; with prospects to advance medical therapies. They also have significant potential as a renewable source of autologous cells for cellular therapy. Various approaches for PSC derivation from somatic cells have been reported in the literature. The method used for reprogramming is particularly relevant as it may affect the characteristics and quality of PSCs. This review will present an overview of the basic strategies and methods for reprogramming to pluripotency. These strategies will be briefly discussed in the context of how the mechanism of reprogramming could influence PSC characteristics with respect to safety and quality. Aspects of the reprogramming approach that can influence PSC properties, such as culture conditions and donor cell source, are also discussed.

authors

Alateeq S,Fortuna PR,Wolvetang E

doi

10.2174/1574888x10666150220154820

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

193-207

issue

3

eissn

1574-888X

issn

2212-3946

pii

CSCRT-EPUB-65332

journal_volume

10

pub_type

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